DE60220180D1 - 14 bis 15 gliedrige makrolide mit antibakterieller aktivität - Google Patents

14 bis 15 gliedrige makrolide mit antibakterieller aktivität

Info

Publication number
DE60220180D1
DE60220180D1 DE60220180T DE60220180T DE60220180D1 DE 60220180 D1 DE60220180 D1 DE 60220180D1 DE 60220180 T DE60220180 T DE 60220180T DE 60220180 T DE60220180 T DE 60220180T DE 60220180 D1 DE60220180 D1 DE 60220180D1
Authority
DE
Germany
Prior art keywords
makrolids
low
antibacterial activity
antibacterial
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60220180T
Other languages
English (en)
Other versions
DE60220180T2 (de
Inventor
Sulejman Alihodzic
Daniele Andreotti
Andrea Berdik
Ilaria Bientinesi
Stefano Biondi
Manuela Ciraco
Federica Damiani
Marko Djerek
Miljenko Dumic
Vesna Erakovic
Antun Hutinec
Gorjana Lazarevski
Sergio Lociuro
Natasa Marsic
Zorica Marusic-Istuk
Stjepan Mutak
Alfredo Paio
Drazen Pavlovic
Anna Quaglia
Vlado Stimac
Jessica Tibasco
Wolfgang Schoenfeld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Fidelta doo
Original Assignee
Glaxo Group Ltd
GlaxoSmithKline Istrazivacki Centar Zagreb doo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, GlaxoSmithKline Istrazivacki Centar Zagreb doo filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of DE60220180D1 publication Critical patent/DE60220180D1/de
Publication of DE60220180T2 publication Critical patent/DE60220180T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
DE60220180T 2001-11-14 2002-11-13 14 bis 15 gliedrige makrolide mit antibakterieller aktivität Expired - Fee Related DE60220180T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0127349.9A GB0127349D0 (en) 2001-11-14 2001-11-14 Macrolides
GB0127349 2001-11-14
PCT/GB2002/005101 WO2003042228A1 (en) 2001-11-14 2002-11-13 Macrolides

Publications (2)

Publication Number Publication Date
DE60220180D1 true DE60220180D1 (de) 2007-06-28
DE60220180T2 DE60220180T2 (de) 2008-01-17

Family

ID=9925777

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60220180T Expired - Fee Related DE60220180T2 (de) 2001-11-14 2002-11-13 14 bis 15 gliedrige makrolide mit antibakterieller aktivität

Country Status (20)

Country Link
US (1) US7202221B2 (de)
EP (1) EP1453846B1 (de)
JP (1) JP2005515978A (de)
CN (1) CN1307194C (de)
AR (1) AR037371A1 (de)
AT (1) ATE362479T1 (de)
BR (1) BR0214132A (de)
CA (1) CA2466975A1 (de)
DE (1) DE60220180T2 (de)
EA (1) EA007433B1 (de)
ES (1) ES2287332T3 (de)
GB (1) GB0127349D0 (de)
HR (1) HRP20040433A2 (de)
HU (1) HUP0402225A3 (de)
IL (1) IL161710A0 (de)
PL (1) PL371472A1 (de)
RS (1) RS41904A (de)
UA (1) UA77210C2 (de)
WO (1) WO2003042228A1 (de)
ZA (1) ZA200403684B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6995143B2 (en) * 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
WO2005070918A1 (en) 2002-05-13 2005-08-04 Enanta Pharmaceuticals, Inc. Process for the preparation of t-11 bicyclic erythromycin derivatives
US6764998B1 (en) 2003-06-18 2004-07-20 Enanta Pharmaceuticals, Inc. 6,11-4C-bicyclic 9a-azalide derivatives
US7135573B2 (en) 2002-05-13 2006-11-14 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
US7910558B2 (en) 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
DK1503759T3 (da) * 2002-05-14 2009-04-14 Univ California Substituerede quinoloncarboxylsyrer, deres derivater, virkningssted og anvendelser heraf
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
GB0225384D0 (en) * 2002-10-31 2002-12-11 Glaxo Group Ltd Novel compounds
US6645941B1 (en) 2003-03-26 2003-11-11 Enanta Pharmaceuticals, Inc. 6,11-3C-bicyclic 9a-azalide derivatives
GB0310980D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
US20070293472A1 (en) * 2003-05-13 2007-12-20 Glaxo Group Limited Novel 14 and 15 Membered Ring Compounds
GB0310986D0 (en) 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
GB0310979D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
GB0310984D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
WO2005070113A2 (en) 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
EP1723159B1 (de) 2004-02-27 2019-06-12 Melinta Therapeutics, Inc. Makrozyklische verbindungen, deren herstellung und verwendung
EP1756134A1 (de) * 2004-05-06 2007-02-28 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Carbamatgebundene makrolide, die sich für die behandlung von mikrobiellen infektionen eignen
WO2005108412A1 (en) * 2004-05-06 2005-11-17 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Ester linked macrolides useful for the treatment of microbial infections
WO2006047167A2 (en) * 2004-10-21 2006-05-04 Janssen Pharmaceutica, N.V. 9 alkyl and 9 alkylidenyl 6-0 alkyl-11, 12 carbamate ketolide antimicrobials
GB0424961D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424951D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424959D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424958D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
PL2049556T3 (pl) 2006-08-09 2013-12-31 Basilea Pharmaceutica Ag Nowe makrolidy użyteczne przeciw chorobom zapalnym i alergicznym
CN101541331A (zh) 2006-08-24 2009-09-23 沃克哈特研究中心 具有抗微生物活性的新颖大环内酯和酮内酯
BRPI0908343A2 (pt) 2008-02-08 2020-08-18 Basilea Pharmaceutica Ag macrolídeos e seu uso
MX2011012614A (es) 2009-05-27 2012-02-22 Wockhardt Ltd Compuestos de quetolida que tienen actividad antimicrobiana.
RU2601550C2 (ru) 2010-12-09 2016-11-10 Вокхардт Лимитед Кетолидные соединения
KR20140004187A (ko) * 2011-01-31 2014-01-10 메이지 세이카 파루마 가부시키가이샤 신규 마크로라이드 유도체
JP5718488B2 (ja) 2011-03-01 2015-05-13 ウォックハート リミテッド ケトライド中間体の調製方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126344A2 (de) 1983-05-20 1984-11-28 Abbott Laboratories Tripeptidester von therapeutischen Mitteln
US4742049A (en) * 1986-06-04 1988-05-03 Abbott Laboratories Semisynthetic erythromycin antibiotics
NZ233117A (en) 1989-03-28 1991-05-28 Abbott Lab 9-deoxo-9,12-epoxy-erythromycin derivatives and pharmaceutical compositions
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
EP1007530B1 (de) 1996-05-07 2005-11-16 Abbott Laboratories 6-0-substitutierte eryththromycin-verbindungen und verfahrenen zu ihrer herstellung
EP0895999A1 (de) * 1997-08-06 1999-02-10 Pfizer Products Inc. C-4"-substituierte Macrolidantibiotica
US6262030B1 (en) 1998-11-03 2001-07-17 Pfizer Inc. Erythromycin derivatives
HUP0201516A3 (en) 1999-05-24 2003-03-28 Pfizer Prod Inc 13-methyl-erythromycin derivatives, process for their preparation and pharmaceutical compositions containing them
AU6748500A (en) 1999-08-24 2001-03-19 Abbott Laboratories 9a-azalides with antibacterial activity
CA2398848C (en) 2000-02-24 2007-09-25 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
JP2002173498A (ja) 2000-09-27 2002-06-21 Hokuriku Seiyaku Co Ltd エリスロマイシン誘導体
GB0025688D0 (en) 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides

Also Published As

Publication number Publication date
PL371472A1 (en) 2005-06-13
GB0127349D0 (en) 2002-01-02
ATE362479T1 (de) 2007-06-15
ES2287332T3 (es) 2007-12-16
EA007433B1 (ru) 2006-10-27
US20050080025A1 (en) 2005-04-14
BR0214132A (pt) 2004-09-14
EA200400536A1 (ru) 2004-12-30
CN1612888A (zh) 2005-05-04
AR037371A1 (es) 2004-11-03
DE60220180T2 (de) 2008-01-17
RS41904A (en) 2006-10-27
UA77210C2 (en) 2006-11-15
IL161710A0 (en) 2004-09-27
ZA200403684B (en) 2005-09-13
CN1307194C (zh) 2007-03-28
US7202221B2 (en) 2007-04-10
CA2466975A1 (en) 2003-05-22
HRP20040433A2 (en) 2005-04-30
JP2005515978A (ja) 2005-06-02
HUP0402225A2 (hu) 2005-02-28
HUP0402225A3 (en) 2006-01-30
EP1453846A1 (de) 2004-09-08
EP1453846B1 (de) 2007-05-16
WO2003042228A1 (en) 2003-05-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee