ES2089863T3 - 9a,11-carbamatos ciclicos de 9-desoxo-9a-aza-11-desoxi-9a-homoeritromicina a. - Google Patents

9a,11-carbamatos ciclicos de 9-desoxo-9a-aza-11-desoxi-9a-homoeritromicina a.

Info

Publication number
ES2089863T3
ES2089863T3 ES94100032T ES94100032T ES2089863T3 ES 2089863 T3 ES2089863 T3 ES 2089863T3 ES 94100032 T ES94100032 T ES 94100032T ES 94100032 T ES94100032 T ES 94100032T ES 2089863 T3 ES2089863 T3 ES 2089863T3
Authority
ES
Spain
Prior art keywords
aza
co2ch2c6h5
homoeritromicina
desoxi
desoxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94100032T
Other languages
English (en)
Inventor
Gabrijela Kobrehel
Gorjana Lazarevski
Slobodan Djokic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pliva Farmaceutika dd
Original Assignee
Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd filed Critical Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd
Application granted granted Critical
Publication of ES2089863T3 publication Critical patent/ES2089863T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA INVENCION ES RELATIVA A 9 XI -9AHOMOERITROMICINA A 9A,11 IOTICOS MACROLIDOS SEMISINTETICOS DEL GENERO DE LOS AZOLIDOS, DE LA FORMULA (I) EN DONDE (IA) R1 = R2 = CO2CH2C6H5, R3 = R4 =CH3, (IB) R1 = R2 = CO2CH2C6H5, R3 = CH3, R4 = H, (IC) R1 = R2 = CO2CH2C6H5, R3 = R4 = H, (ID) R1 = R2 = H, R3 = R4 = CH3, (IE) R1 = R2 = R4 = H, R3 = CH3, (IF) R1 = R2 = R3 = R4 = H, (IG) R1 = H, R2 = R3 = R4 = CH3, (IH) R1 = R4 = H, R2 = R3 = CH3, (IJ) R1 = R3 = R4 = H, R2 = CH3, A SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES DE ELLOS CON ACIDOS INORGANICOS U ORGANICOS, A PRODUCTOS INTERMEDIOS Y A PROCESOS PARA LA PREPARACION DE ELLOS, A UN PROCESO PARA PREPARAR COMPOSICIONES FARMACEUTICAS ASI COMO AL USO DE LAS COMPOSICIONES FARMACEUTICAS OBTENIDAS EN TRATAMIENTO DE INFECCIONES BACTERIANAS.
ES94100032T 1993-01-08 1994-01-03 9a,11-carbamatos ciclicos de 9-desoxo-9a-aza-11-desoxi-9a-homoeritromicina a. Expired - Lifetime ES2089863T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR930014A HRP930014A2 (en) 1993-01-08 1993-01-08 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates

Publications (1)

Publication Number Publication Date
ES2089863T3 true ES2089863T3 (es) 1996-10-01

Family

ID=10945869

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94100032T Expired - Lifetime ES2089863T3 (es) 1993-01-08 1994-01-03 9a,11-carbamatos ciclicos de 9-desoxo-9a-aza-11-desoxi-9a-homoeritromicina a.

Country Status (7)

Country Link
US (1) US5434140A (es)
EP (1) EP0606062B1 (es)
JP (1) JP3056035B2 (es)
AT (1) ATE136550T1 (es)
DE (1) DE69400125T2 (es)
ES (1) ES2089863T3 (es)
HR (1) HRP930014A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2727969B1 (fr) * 1994-12-09 1997-01-17 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
JP2007204490A (ja) * 1995-08-03 2007-08-16 Chugai Pharmaceut Co Ltd エリスロマイシン誘導体の製造方法
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6787342B2 (en) * 2000-02-16 2004-09-07 Merial Limited Paste formulations
HRP20020779A2 (en) * 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7271155B2 (en) * 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
CN102993250B (zh) * 2011-07-06 2016-02-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331893A (en) * 1976-09-24 1982-05-25 Giddings & Lewis, Inc. Boolean logic processor without accumulator output feedback
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
US4492688A (en) * 1983-11-25 1985-01-08 Pfizer Inc. Antibacterial cyclic ethers of 9-deoxo-9a-aza-9a-homoerythromycin A and intermediates therefor
DE3461803D1 (en) * 1983-05-23 1987-02-05 Pfizer Antibacterial cyclic ethers of 9-deoxo-9a-aza-9a-homoerythromycin a and intermediates therefor
SI9011409A (en) * 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
KR0166096B1 (ko) * 1990-11-28 1999-01-15 우에하라 아키라 6-0-메틸에리쓰로마이신 a 유도체

Also Published As

Publication number Publication date
ATE136550T1 (de) 1996-04-15
JP3056035B2 (ja) 2000-06-26
DE69400125D1 (de) 1996-05-15
EP0606062A1 (en) 1994-07-13
HRP930014B1 (es) 1998-12-31
HRP930014A2 (en) 1994-08-31
EP0606062B1 (en) 1996-04-10
US5434140A (en) 1995-07-18
JPH0789980A (ja) 1995-04-04
DE69400125T2 (de) 1996-11-28

Similar Documents

Publication Publication Date Title
ES2089863T3 (es) 9a,11-carbamatos ciclicos de 9-desoxo-9a-aza-11-desoxi-9a-homoeritromicina a.
CA2349338A1 (en) Novel macrolide antibiotics
ES2096401T3 (es) Derivados de 9a-n-(n'-carbamoil) y de 9a-n-(n'-tiocarbamoil) de 9-desoxo-9a-aza-9a-homoeritromicina a.
DK0992509T3 (da) Nye makrolid-derivater
IL123776A0 (en) Novel derivatives of cyclodepsipeptide PF 1022
WO2002068438A3 (en) 9a-n-[n'-(phenylsulfonyl)carbamoyl] derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin a and of 5-0-desosaminyl-9-deoxo-9-dihydro-9a-aza-9a-homoerythronolide a
PT838470E (pt) Derivados 9-n-etenilo de 9(s)-eritromicilamina
PT1175429E (pt) Derivados halo de 9-desoxo-9a-aza-9a-homoeritromicina a
PT927722E (pt) Derivados beta beta-dissubstituidos de 9-desoxo-9a-n-etenil-9a-aza-9aza-9a-homoeritromicina
DK0490311T3 (da) Derivater af 10,11,12,13-tetrahydro-desmycosin, fremgangsmåder til fremstilling deraf og anvendelse deraf til opnåelse af farmaceutiske præparater
PT952157E (pt) Derivados 9a, 11b-desidro de 9-oxima-3-ceto-6-o-metileritromicina

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 606062

Country of ref document: ES

FG2A Definitive protection

Ref document number: 606062

Country of ref document: ES