BR0113472A - Macrolìdeos com atividade antibacteriana - Google Patents

Macrolìdeos com atividade antibacteriana

Info

Publication number
BR0113472A
BR0113472A BR0113472-8A BR0113472A BR0113472A BR 0113472 A BR0113472 A BR 0113472A BR 0113472 A BR0113472 A BR 0113472A BR 0113472 A BR0113472 A BR 0113472A
Authority
BR
Brazil
Prior art keywords
macrolides
heterocyclyl
hydrogen
antibacterial activity
formula
Prior art date
Application number
BR0113472-8A
Other languages
English (en)
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of BR0113472A publication Critical patent/BR0113472A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

"MACROLìDEOS COM ATIVIDADE ANTIBACTERIANA". A invenção fornece novos antibióticos de macrolídeos de fórmula (I) com propriedades biológicas e estabilidade aperfeiçoadas de fórmula (I): em que R^ 1^ é hidrogênio, ciano, -S(L)~ m~R^ 2^, -S(O)(L)~ m~R^ 2^, ou -S(O)~ 2~(L)~ m~R^ 2^; L representa -(CH~ 2~)~ n~- ou -(CH~ 2~)~ n~Z(CH~ 2~)~ n'~-; m é 0 ou 1; n é 1, 2, 3, ou 4; n' é 0, 1, 2, 3, ou 4; Z é O, S ou NH; R^ 2^ é hidrogênio, alquila, heterociclila ou arila; cuja heterociclila e os grupos arila podem ser ainda substituídos; * indica um centro quiral o qual está sob a forma (R) ou (S) e sais de adição ácidos farmaceuticamente aceitáveis ou ésteres cliváveis in vivo dos mesmos.
BR0113472-8A 2000-08-22 2001-08-20 Macrolìdeos com atividade antibacteriana BR0113472A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00117971 2000-08-22
PCT/EP2001/009560 WO2002016380A1 (en) 2000-08-22 2001-08-20 New macrolides with antibacterial activity

Publications (1)

Publication Number Publication Date
BR0113472A true BR0113472A (pt) 2003-07-01

Family

ID=8169600

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113472-8A BR0113472A (pt) 2000-08-22 2001-08-20 Macrolìdeos com atividade antibacteriana

Country Status (14)

Country Link
US (1) US6740642B2 (pt)
EP (1) EP1313751B1 (pt)
JP (1) JP4162992B2 (pt)
KR (1) KR100502031B1 (pt)
CN (1) CN1234718C (pt)
AT (1) ATE408614T1 (pt)
AU (1) AU2001282105A1 (pt)
BR (1) BR0113472A (pt)
CA (1) CA2419296C (pt)
DE (1) DE60135859D1 (pt)
ES (1) ES2313975T3 (pt)
MX (1) MXPA03001607A (pt)
WO (1) WO2002016380A1 (pt)
ZA (1) ZA200301047B (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002050091A1 (en) * 2000-12-21 2002-06-27 Glaxo Group Limited Macrolide antibiotics
FR2826274B1 (fr) * 2001-06-21 2003-09-26 Aventis Pharma Sa Formulation pharmaceutique au gout masque et son procede de preparation
CA2460947A1 (en) * 2001-09-17 2003-03-27 Ortho-Mcneil Pharmaceutical, Inc. 6-o-carbamate-11,12-lacto-ketolide antimicrobials
US6995143B2 (en) * 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US6727229B2 (en) 2002-08-19 2004-04-27 Enanta Pharmaceuticals, Inc. 11,12-substituted lactone ketolide derivatives having antibacterial activity
US6720308B1 (en) 2002-11-07 2004-04-13 Enanta Pharmaceuticals, Inc. Anhydrolide derivatives having antibacterial activity
US6790835B1 (en) 2003-06-05 2004-09-14 Enanta Pharmaceuticals, Inc. Bicyclic macrolide derivatives
WO2004108745A2 (en) * 2003-06-05 2004-12-16 Enanta Pharmaceuticals, Inc. 11-12 bicyclic erythromycin derivatives
US6765016B1 (en) 2003-06-05 2004-07-20 Enanta Pharmaceuticals, Inc. Bicyclic ketolide derivatives
US6716820B1 (en) 2003-06-05 2004-04-06 Enanta Pharmaceuticals, Inc. 6-O-substituted bicyclic macrolides
US6774115B1 (en) 2003-06-05 2004-08-10 Enanta Pharmaceuticals, Inc. 6-O-substituted bicyclic ketolides
US20040254126A1 (en) * 2003-06-05 2004-12-16 Yao-Ling Qiu 11-12 Bicyclic erythromycin derivatives
US7291602B2 (en) * 2004-12-13 2007-11-06 Enanta Pharmaceuticals, Inc. 11,12-lactone bicyclolides
CN101115764B (zh) * 2005-02-09 2012-09-26 巴斯利尔药物股份公司 大环内酯类化合物
AU2006212626B2 (en) * 2005-02-09 2010-04-29 Basilea Pharmaceutica Ag New macrolides
US7517859B2 (en) * 2005-05-04 2009-04-14 Enanta Pharmaceuticals, Inc. Spirocyclic bicyclolides
US8278281B2 (en) 2005-08-24 2012-10-02 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
ES2428874T3 (es) 2006-08-09 2013-11-12 Basilea Pharmaceutica Ag Nuevos macrólidos útiles contra las enfermedades inflamatorias y alérgicas
EP2056844A4 (en) * 2006-08-24 2010-11-24 Wockhardt Research Center NEW MACROLIDS AND KETOLIDS WITH ANTIMICROBIAL EFFECT
WO2009098320A2 (en) * 2008-02-08 2009-08-13 Basilea Pharmaceutica Ag Macrolides and uses of macrolides
US8410065B2 (en) 2008-02-08 2013-04-02 Basilea Pharmaceutica Ag Macrolides and their use
CA2763246C (en) * 2009-05-27 2013-10-29 Wockhardt Research Centre Ketolide compounds having antimicrobial activity
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
CN102417530A (zh) * 2010-09-26 2012-04-18 中国医学科学院药物研究所 广谱抗菌素红霉素a大环酮内酯类衍生物的合成方法和用途
CA2820451C (en) 2010-12-09 2017-12-12 Wockhardt Limited Ketolide compounds
CN103619849B (zh) 2011-03-01 2016-05-25 沃克哈特有限公司 酮内酯中间体的制备方法
EP2938623B1 (en) * 2012-12-31 2016-10-05 Basilea Pharmaceutica AG Selected macrolides with pde4-inhibiting activity
CA3014741A1 (en) 2016-01-12 2017-07-20 Wockhardt Limited Pharmaceutical compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
AU2001282105A1 (en) 2002-03-04
JP2004506740A (ja) 2004-03-04
KR100502031B1 (ko) 2005-07-25
EP1313751B1 (en) 2008-09-17
ATE408614T1 (de) 2008-10-15
EP1313751A1 (en) 2003-05-28
CA2419296A1 (en) 2002-02-28
WO2002016380A1 (en) 2002-02-28
DE60135859D1 (de) 2008-10-30
CN1234718C (zh) 2006-01-04
US20030199459A1 (en) 2003-10-23
CA2419296C (en) 2008-12-09
US6740642B2 (en) 2004-05-25
ZA200301047B (en) 2004-05-06
ES2313975T3 (es) 2009-03-16
JP4162992B2 (ja) 2008-10-08
CN1464880A (zh) 2003-12-31
KR20030029839A (ko) 2003-04-16
MXPA03001607A (es) 2003-06-04

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]