JP2005527575A5 - - Google Patents
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- Publication number
- JP2005527575A5 JP2005527575A5 JP2003581774A JP2003581774A JP2005527575A5 JP 2005527575 A5 JP2005527575 A5 JP 2005527575A5 JP 2003581774 A JP2003581774 A JP 2003581774A JP 2003581774 A JP2003581774 A JP 2003581774A JP 2005527575 A5 JP2005527575 A5 JP 2005527575A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- substituted
- group
- oxazolidinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 8
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 230000003115 biocidal effect Effects 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- -1 sulfa Chemical class 0.000 claims 5
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 4
- 208000008960 Diabetic foot Diseases 0.000 claims 3
- 206010037660 Pyrexia Diseases 0.000 claims 3
- 241000191967 Staphylococcus aureus Species 0.000 claims 3
- 230000003902 lesion Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 241000295644 Staphylococcaceae Species 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 229930186147 Cephalosporin Natural products 0.000 claims 1
- 206010015150 Erythema Diseases 0.000 claims 1
- 102000002068 Glycopeptides Human genes 0.000 claims 1
- 108010015899 Glycopeptides Proteins 0.000 claims 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 1
- 239000004098 Tetracycline Substances 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 229940126575 aminoglycoside Drugs 0.000 claims 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 claims 1
- 229960000723 ampicillin Drugs 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 229940124587 cephalosporin Drugs 0.000 claims 1
- 150000001780 cephalosporins Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 231100000321 erythema Toxicity 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- TYZROVQLWOKYKF-ZDUSSCGKSA-N linezolid Chemical group O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 claims 1
- 244000144972 livestock Species 0.000 claims 1
- 239000007937 lozenge Substances 0.000 claims 1
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 1
- 229940041033 macrolides Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960003085 meticillin Drugs 0.000 claims 1
- 230000001937 non-anti-biotic effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 238000002559 palpation Methods 0.000 claims 1
- 150000002961 penems Chemical class 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000007660 quinolones Chemical class 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 235000019364 tetracycline Nutrition 0.000 claims 1
- 150000003522 tetracyclines Chemical class 0.000 claims 1
- 229940040944 tetracyclines Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36910402P | 2002-03-29 | 2002-03-29 | |
| PCT/US2003/008882 WO2003084534A1 (en) | 2002-03-29 | 2003-03-21 | Parenteral, intravenous, and oral administration of oxazolidinones for treating diabetic foot infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005527575A JP2005527575A (ja) | 2005-09-15 |
| JP2005527575A5 true JP2005527575A5 (https=) | 2006-05-18 |
Family
ID=28791924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003581774A Withdrawn JP2005527575A (ja) | 2002-03-29 | 2003-03-21 | 糖尿病性足病変感染を治療するためのオキサゾリジノンの非経口、静脈内および経口投与 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20030216330A1 (https=) |
| EP (1) | EP1490059A1 (https=) |
| JP (1) | JP2005527575A (https=) |
| KR (1) | KR20040095328A (https=) |
| CN (1) | CN1642543A (https=) |
| AU (1) | AU2003223334A1 (https=) |
| BR (1) | BR0308806A (https=) |
| CA (1) | CA2476545A1 (https=) |
| IL (1) | IL164195A0 (https=) |
| MX (1) | MXPA04009356A (https=) |
| NO (1) | NO20044672L (https=) |
| NZ (1) | NZ535648A (https=) |
| PL (1) | PL372661A1 (https=) |
| RU (1) | RU2354372C2 (https=) |
| WO (1) | WO2003084534A1 (https=) |
| ZA (1) | ZA200407734B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200404069A (en) * | 2002-06-28 | 2004-03-16 | Upjohn Co | Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent |
| JP4579502B2 (ja) * | 2003-05-02 | 2010-11-10 | キヤノン株式会社 | 構造体及びその製造方法、該構造体を含むトナー並びにそれを用いた画像形成方法及び装置 |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| EP1656370B1 (en) | 2003-06-03 | 2012-08-15 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic compounds and methods of making and using the same |
| AR046782A1 (es) * | 2003-12-17 | 2005-12-21 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos. |
| WO2006008640A1 (en) * | 2004-07-15 | 2006-01-26 | Pharmacia & Upjohn Company Llc | Non-aqueous suspension containing a drug having an unpleasant taste |
| PE20060619A1 (es) * | 2004-07-29 | 2006-07-11 | Ferrer Int | Derivados de oxazolidinona como antibacterianos |
| JP5534497B2 (ja) | 2005-06-08 | 2014-07-02 | メリンタ セラピューティクス，インコーポレイテッド | トリアゾール類の合成方法 |
| EP1745784A1 (en) * | 2005-06-27 | 2007-01-24 | Ferrer Internacional, S.A. | Oxazolidinone derivatives and use thereof as antibiotics |
| DE602006010702D1 (de) | 2005-06-29 | 2010-01-07 | Pharmacia & Upjohn Co Llc | Homomorpholinoxazolidinone als antibakterielle mittel |
| US9427468B2 (en) * | 2007-08-22 | 2016-08-30 | Trustees Of Dartmouth College | Compositions and methods for diagnosing and treating community-acquired methicillin-resistant Staphylococcus aureus |
| UY32493A (es) * | 2009-03-16 | 2010-10-29 | Astrazeneca Ab | " (5r)-3-[4-[1-[(2s)-2,3-dihidroxipropanoil]-3,6-dihidro-2h-piridin-4-il]-3,5-difluorofenil]-5-(isoxazol-3-iloximetil)oxazolidin-2-ona, sus sales farmacéuticamente aceptables, sus ésteres hidrolizables y aplicaciones" |
| WO2012082992A1 (en) * | 2010-12-15 | 2012-06-21 | Biovista, Inc. | Compositions and methods for cancer treatment |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
| US5254577A (en) * | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| US5043443A (en) * | 1988-07-29 | 1991-08-27 | Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives |
| US5164510A (en) * | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
| US5225565A (en) * | 1988-09-15 | 1993-07-06 | The Upjohn Company | Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones |
| US5182403A (en) * | 1988-09-15 | 1993-01-26 | The Upjohn Company | Substituted 3(5'indazolyl) oxazolidin-2-ones |
| US5231188A (en) * | 1989-11-17 | 1993-07-27 | The Upjohn Company | Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents |
| EP0610265B1 (en) * | 1991-11-01 | 1996-12-27 | PHARMACIA & UPJOHN COMPANY | Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| WO1994013649A1 (en) * | 1992-12-08 | 1994-06-23 | The Upjohn Company | Tropone-substituted phenyloxazolidinone antibacterial agents |
| US5688792A (en) * | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
| CA2174107C (en) * | 1993-11-22 | 2005-04-12 | Steven J. Brickner | Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones |
| DE4425609A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | Benzofuranyl- und Benzothienyloxazolidinone |
| DE4425612A1 (de) * | 1994-07-20 | 1996-04-04 | Bayer Ag | 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone |
| DE4425613A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | 5-gliedrige Heteroaryl-oxazolidinone |
| DE19514313A1 (de) * | 1994-08-03 | 1996-02-08 | Bayer Ag | Benzoxazolyl- und Benzothiazolyloxazolidinone |
| PT792273E (pt) * | 1994-11-15 | 2003-06-30 | Upjohn Co | Produtos antibacterianos de oxazolidinona substituida com oxazina e tiazina biciclicas |
| HRP960159A2 (en) * | 1995-04-21 | 1997-08-31 | Bayer Ag | Benzocyclopentane oxazolidinones containing heteroatoms |
| HUP9901979A3 (en) * | 1995-09-01 | 2000-03-28 | Upjohn Co | Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings and pharmaceutical compositions containing the same |
| DE19601264A1 (de) * | 1996-01-16 | 1997-07-17 | Bayer Ag | Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone |
| DE19604223A1 (de) * | 1996-02-06 | 1997-08-07 | Bayer Ag | Neue substituierte Oxazolidinone |
| BR9907183A (pt) * | 1998-01-23 | 2003-06-10 | Versicor Inc | Colet neas combinatórias de oxazolidinona, composições e processos de preparação |
| MY122454A (en) * | 1998-06-05 | 2006-04-29 | Upjohn Co | Use of oxazolidinones for the preparation of a medicament for transdermal delivery |
| AU2001272961A1 (en) * | 2000-06-30 | 2002-01-14 | Pharmacia & Upjohn Company | Compositions for treating bacterial infections containing oxazolidinone compound, sulbactam and an ampicillin |
-
2003
- 2003-03-21 EP EP03719451A patent/EP1490059A1/en not_active Withdrawn
- 2003-03-21 BR BR0308806-5A patent/BR0308806A/pt not_active IP Right Cessation
- 2003-03-21 US US10/394,912 patent/US20030216330A1/en not_active Abandoned
- 2003-03-21 IL IL16419503A patent/IL164195A0/xx unknown
- 2003-03-21 MX MXPA04009356A patent/MXPA04009356A/es not_active Application Discontinuation
- 2003-03-21 JP JP2003581774A patent/JP2005527575A/ja not_active Withdrawn
- 2003-03-21 WO PCT/US2003/008882 patent/WO2003084534A1/en not_active Ceased
- 2003-03-21 KR KR10-2004-7015307A patent/KR20040095328A/ko not_active Ceased
- 2003-03-21 AU AU2003223334A patent/AU2003223334A1/en not_active Abandoned
- 2003-03-21 PL PL03372661A patent/PL372661A1/xx not_active Application Discontinuation
- 2003-03-21 CN CNA038073471A patent/CN1642543A/zh active Pending
- 2003-03-21 CA CA002476545A patent/CA2476545A1/en not_active Abandoned
- 2003-03-21 RU RU2004131830/14A patent/RU2354372C2/ru not_active IP Right Cessation
- 2003-03-21 NZ NZ535648A patent/NZ535648A/en unknown
-
2004
- 2004-09-23 ZA ZA200407734A patent/ZA200407734B/en unknown
- 2004-10-28 NO NO20044672A patent/NO20044672L/no not_active Application Discontinuation
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