JP2004502752A5 - - Google Patents
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- Publication number
- JP2004502752A5 JP2004502752A5 JP2002509074A JP2002509074A JP2004502752A5 JP 2004502752 A5 JP2004502752 A5 JP 2004502752A5 JP 2002509074 A JP2002509074 A JP 2002509074A JP 2002509074 A JP2002509074 A JP 2002509074A JP 2004502752 A5 JP2004502752 A5 JP 2004502752A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- compound according
- pharmaceutically acceptable
- minocycline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960004023 minocycline Drugs 0.000 description 8
- -1 minocycline compound Chemical class 0.000 description 8
- 208000035143 Bacterial infection Diseases 0.000 description 5
- 125000003282 alkyl amino group Chemical group 0.000 description 5
- 208000022362 bacterial infectious disease Diseases 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 239000000651 prodrug Substances 0.000 description 4
- 229940002612 prodrug Drugs 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000004098 Tetracycline Substances 0.000 description 3
- 229960002180 tetracycline Drugs 0.000 description 3
- 229930101283 tetracycline Natural products 0.000 description 3
- 235000019364 tetracycline Nutrition 0.000 description 3
- 150000003522 tetracyclines Chemical class 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 125000004663 dialkyl amino group Chemical group 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical class C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 125000004894 pentylamino group Chemical group C(CCCC)N* 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229940072172 tetracycline antibiotic Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21665900P | 2000-07-07 | 2000-07-07 | |
| US60/216,659 | 2000-07-07 | ||
| US27562101P | 2001-03-13 | 2001-03-13 | |
| US60/275,621 | 2001-03-13 | ||
| PCT/US2001/020721 WO2002004406A2 (en) | 2000-07-07 | 2001-06-29 | 9-substituted minocycline compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008157219A Division JP5037436B2 (ja) | 2000-07-07 | 2008-06-16 | ９−置換ミノサイクリン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004502752A JP2004502752A (ja) | 2004-01-29 |
| JP2004502752A5 true JP2004502752A5 (https=) | 2008-08-07 |
| JP4925549B2 JP4925549B2 (ja) | 2012-04-25 |
Family
ID=26911221
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002509074A Expired - Lifetime JP4925549B2 (ja) | 2000-07-07 | 2001-06-29 | ９−置換ミノサイクリン化合物 |
| JP2008157219A Expired - Lifetime JP5037436B2 (ja) | 2000-07-07 | 2008-06-16 | ９−置換ミノサイクリン化合物 |
| JP2012034839A Pending JP2012107045A (ja) | 2000-07-07 | 2012-02-21 | ９−置換ミノサイクリン化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008157219A Expired - Lifetime JP5037436B2 (ja) | 2000-07-07 | 2008-06-16 | ９−置換ミノサイクリン化合物 |
| JP2012034839A Pending JP2012107045A (ja) | 2000-07-07 | 2012-02-21 | ９−置換ミノサイクリン化合物 |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US6846939B2 (https=) |
| EP (4) | EP3461808A1 (https=) |
| JP (3) | JP4925549B2 (https=) |
| KR (2) | KR100674047B1 (https=) |
| CN (2) | CN1690047B (https=) |
| AT (2) | ATE544745T1 (https=) |
| AU (4) | AU8638801A (https=) |
| BR (1) | BRPI0112269B8 (https=) |
| CA (1) | CA2415178C (https=) |
| CY (1) | CY1107524T1 (https=) |
| CZ (2) | CZ303702B6 (https=) |
| DE (1) | DE60122341T2 (https=) |
| DK (2) | DK1301467T3 (https=) |
| EA (3) | EA013908B1 (https=) |
| ES (2) | ES2701599T3 (https=) |
| HR (1) | HRP20030091B1 (https=) |
| HU (1) | HU229577B1 (https=) |
| IL (2) | IL153639A0 (https=) |
| MX (1) | MXPA03000055A (https=) |
| PT (1) | PT1301467E (https=) |
| SI (1) | SI1301467T1 (https=) |
| TW (2) | TWI305528B (https=) |
| WO (1) | WO2002004406A2 (https=) |
| ZA (1) | ZA200300749B (https=) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| CA2318580A1 (en) * | 1998-01-23 | 1999-07-29 | Mark L. Nelson | Pharmaceutically active compounds and methods of use thereof |
| US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| EP2327687A3 (en) * | 1999-09-14 | 2012-08-15 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| AU3105801A (en) | 2000-01-24 | 2001-07-31 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
| MXPA02009482A (es) * | 2000-03-31 | 2004-05-14 | Tufts College | Compuestos tetraciclinas sustituidos con grupos 7- y 9- carbamato, urea, tiourea, tiocarbamato y heteroaril-amino. |
| WO2001087824A2 (en) * | 2000-05-15 | 2001-11-22 | Paratek Pharmaceuticals, Inc. | 7-substituted fused ring tetracycline compounds |
| US20020128238A1 (en) * | 2000-06-16 | 2002-09-12 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US20040224927A1 (en) | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| EA013908B1 (ru) | 2000-07-07 | 2010-08-30 | Трастис Оф Тафтс Коллидж | Замещенные соединения миноциклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего |
| WO2002072506A2 (en) * | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| WO2002072532A1 (en) * | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7, 9-substituted tetracycline compounds |
| US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| EP1241160A1 (en) * | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracycline derivatives and their use as antibiotic agents |
| WO2002072031A2 (en) | 2001-03-14 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as synergistic antifungal agents |
| US8088820B2 (en) * | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| EP2329826A1 (en) | 2001-07-13 | 2011-06-08 | Paratek Pharmaceuticals, Inc. | Tetracyclines for the treatment of multiple sclerosis |
| AU2002365120A1 (en) | 2001-08-02 | 2003-07-15 | Paratek Pharmaceuticals, Inc. | Medicaments |
| EP2311799A1 (en) * | 2002-01-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
| JP2005526754A (ja) | 2002-03-08 | 2005-09-08 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノメチル置換されたテトラサイクリン化合物 |
| KR101083498B1 (ko) * | 2002-03-21 | 2011-11-16 | 파라테크 파마슈티컬스, 인크. | 치환된 테트라시클린 화합물 |
| AU2003218242A1 (en) * | 2002-03-21 | 2003-10-08 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| CA2492273C (en) * | 2002-07-12 | 2013-02-05 | Paratek Pharmaceuticals, Inc. | 3, 10, and 12a substituted tetracycline compounds |
| WO2004038001A2 (en) * | 2002-10-24 | 2004-05-06 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| CA2503446C (en) | 2002-10-24 | 2012-12-18 | Paratek Pharmaceuticals, Inc. | Methods of using substituted tetracycline compounds to modulate rna |
| WO2004091513A2 (en) * | 2003-04-10 | 2004-10-28 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| CA2531728A1 (en) * | 2003-07-09 | 2005-02-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| JP4738333B2 (ja) * | 2003-07-09 | 2011-08-03 | パラテック ファーマシューティカルズ インコーポレイテッド | ９−アミノメチルテトラサイクリン化合物のプロドラッグ |
| US8691258B2 (en) * | 2003-12-12 | 2014-04-08 | Medtronic, Inc. | Anti-infective medical device |
| CA2553510C (en) * | 2004-01-15 | 2012-09-25 | Paratek Pharmaceuticals, Inc. | Aromatic a-ring derivatives of tetracycline compounds |
| CA2892332C (en) * | 2004-05-21 | 2017-03-21 | President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
| TWI261038B (en) * | 2004-08-11 | 2006-09-01 | Bo-Cheng Chen | Bicycle gear-shifting handgrip |
| AU2005299294B2 (en) * | 2004-10-25 | 2012-06-07 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| EP2269985A3 (en) * | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| WO2006084265A1 (en) | 2005-02-04 | 2006-08-10 | Paratek Pharmaceuticals, Inc. | 11a, 12-DERIVATIVES OF TETRACYCLINE COMPOUNDS |
| AR057032A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos de preparacion |
| AR057324A1 (es) * | 2005-05-27 | 2007-11-28 | Wyeth Corp | Tigeciclina y metodos para preparar 9-aminominociclina |
| AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
| JP2009502809A (ja) * | 2005-07-21 | 2009-01-29 | パラテック ファーマシューティカルズ インコーポレイテッド | １０−置換テトラサイクリンおよびその使用方法 |
| WO2007075794A2 (en) * | 2005-12-22 | 2007-07-05 | Wyeth | Oral formulations comprising tigecycline |
| BRPI0620430A2 (pt) * | 2005-12-22 | 2011-11-08 | Wyeth Corp | métodos para tratar infecções do trato gastrointestinal com tigeciclina |
| EP2298324A1 (en) | 2006-01-24 | 2011-03-23 | Paratek Pharmaceuticals, Inc. | Methods of increasing oral bioavailability of tetracyclines |
| JP5335664B2 (ja) | 2006-04-07 | 2013-11-06 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | テトラサイクリンおよびその類似体の合成 |
| AU2007249695A1 (en) * | 2006-05-15 | 2007-11-22 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
| WO2008127361A2 (en) | 2006-10-11 | 2008-10-23 | President And Fellows Of Harvard College | Synthesis of enone intermediate |
| WO2008045507A2 (en) | 2006-10-11 | 2008-04-17 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of bacillus anthracis infections |
| PT2120963T (pt) * | 2006-12-21 | 2018-12-17 | Paratek Pharm Innc | Compostos tetraciclina substituídos para tratamento de distúrbios inflamatórios da pele |
| PL2109602T3 (pl) * | 2006-12-21 | 2014-09-30 | Paratek Pharm Innc | Pochodne tetracyliny do leczenia zakażeń bakteryjnych, wirusowych i pasożytniczych |
| JP2010523684A (ja) | 2007-04-12 | 2010-07-15 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物を用いる、脊髄筋委縮症を治療するための方法 |
| JP2010525069A (ja) * | 2007-04-27 | 2010-07-22 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノアルキルテトラサイクリン化合物の合成方法および精製方法 |
| BRPI0823405A2 (pt) * | 2007-07-06 | 2012-12-25 | Paratek Pharmaceuticals, Inc. | mÉtodos para sintetizar compostos de tetraciclina substituÍda |
| EP2225253B1 (en) | 2007-11-29 | 2012-06-27 | Actelion Pharmaceuticals Ltd. | Phosphonic acid derivates and their use as p2y12 receptor antagonists |
| CA2717703A1 (en) * | 2008-03-05 | 2009-09-11 | Paratek Pharmaceuticals, Inc. | Minocycline compounds and methods of use thereof |
| PT2271348T (pt) * | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
| JP2011517697A (ja) * | 2008-04-14 | 2011-06-16 | パラテック ファーマシューティカルズ インコーポレイテッド | 置換テトラサイクリン化合物 |
| TW202216656A (zh) * | 2008-05-19 | 2022-05-01 | 美商Ｐｒｔｋ Ｓｐｖ２公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| PT2323972E (pt) * | 2008-08-08 | 2013-10-09 | Tetraphase Pharmaceuticals Inc | Compostos de tetraciclina substituídos com c7-flúor |
| JP5443720B2 (ja) * | 2008-09-05 | 2014-03-19 | 住友化学株式会社 | 組成物、光学フィルム及びその製造方法、光学部材ならびに表示装置 |
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| CN101684083B (zh) * | 2008-09-16 | 2011-10-05 | 山东轩竹医药科技有限公司 | 胍基烷酰胺基取代的四环素衍生物 |
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| CN101759599B (zh) * | 2008-09-17 | 2012-05-30 | 山东轩竹医药科技有限公司 | 具有氨基肟基的四环素类化合物 |
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| WO2010126607A2 (en) | 2009-04-30 | 2010-11-04 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
| EP2427425B1 (en) | 2009-05-08 | 2017-03-08 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| IN2012DN02502A (https=) | 2009-08-28 | 2015-08-28 | Tetraphase Pharmaceuticals Inc | |
| CA2842838C (en) * | 2011-07-26 | 2017-04-25 | Kbp Biosciences Co., Ltd. | 9-aminomethyl substituted tetracycline compounds |
| AU2013289892A1 (en) * | 2012-07-13 | 2015-02-19 | Paratek Pharmaceuticals, Inc. | Tetracycline compounds for treating neurodegenerative disorders |
| BR112015004523B1 (pt) | 2012-08-31 | 2020-08-04 | Tetraphase Pharmaceuticals, Inc | Compostos de tetraciclina, composições farmacêuticas e seus usos |
| KR102237887B1 (ko) | 2013-03-15 | 2021-04-07 | 멜린타 서브시디어리 코프. | 항생제를 사용하여 과체중 및 비만 환자에서 감염을 치료하는 방법 |
| US20170304286A1 (en) * | 2014-10-24 | 2017-10-26 | Launx Biomedical Co., Ltd. | New indication of paroxetine pharmaceutical composition for treating cancer |
| IL254622B2 (en) | 2015-03-24 | 2024-01-01 | Paratek | Minocycline compounds for biodefense |
| WO2017165729A1 (en) * | 2016-03-24 | 2017-09-28 | Paratek Pharmaceuticals, Inc. | Methods for treating and preventing c. difficile infection |
| CN110582486B (zh) | 2016-10-19 | 2024-01-12 | 四相制药公司 | 艾若威四环素的结晶形式 |
| BR112019008897A2 (pt) | 2016-11-01 | 2019-08-13 | Paratek Pharm Innc | método para tratar pneumonia bacteriana adquirida na comunidade. |
| CA3111447A1 (en) | 2018-09-04 | 2020-03-12 | Paratek Pharmaceuticals, Inc. | Methods of treating mycobacterial infections using tetracycline compounds |
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