JP2004502752A5 - - Google Patents
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- Publication number
- JP2004502752A5 JP2004502752A5 JP2002509074A JP2002509074A JP2004502752A5 JP 2004502752 A5 JP2004502752 A5 JP 2004502752A5 JP 2002509074 A JP2002509074 A JP 2002509074A JP 2002509074 A JP2002509074 A JP 2002509074A JP 2004502752 A5 JP2004502752 A5 JP 2004502752A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- compound according
- pharmaceutically acceptable
- minocycline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960004023 minocycline Drugs 0.000 description 8
- -1 minocycline compound Chemical class 0.000 description 8
- 208000035143 Bacterial infection Diseases 0.000 description 5
- 125000003282 alkyl amino group Chemical group 0.000 description 5
- 208000022362 bacterial infectious disease Diseases 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 239000000651 prodrug Substances 0.000 description 4
- 229940002612 prodrug Drugs 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000004098 Tetracycline Substances 0.000 description 3
- 229960002180 tetracycline Drugs 0.000 description 3
- 229930101283 tetracycline Natural products 0.000 description 3
- 235000019364 tetracycline Nutrition 0.000 description 3
- 150000003522 tetracyclines Chemical class 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 125000004663 dialkyl amino group Chemical group 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical class C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 125000004894 pentylamino group Chemical group C(CCCC)N* 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229940072172 tetracycline antibiotic Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21665900P | 2000-07-07 | 2000-07-07 | |
| US60/216,659 | 2000-07-07 | ||
| US27562101P | 2001-03-13 | 2001-03-13 | |
| US60/275,621 | 2001-03-13 | ||
| PCT/US2001/020721 WO2002004406A2 (en) | 2000-07-07 | 2001-06-29 | 9-substituted minocycline compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008157219A Division JP5037436B2 (ja) | 2000-07-07 | 2008-06-16 | ９−置換ミノサイクリン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004502752A JP2004502752A (ja) | 2004-01-29 |
| JP2004502752A5 true JP2004502752A5 (https=) | 2008-08-07 |
| JP4925549B2 JP4925549B2 (ja) | 2012-04-25 |
Family
ID=26911221
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002509074A Expired - Lifetime JP4925549B2 (ja) | 2000-07-07 | 2001-06-29 | ９−置換ミノサイクリン化合物 |
| JP2008157219A Expired - Lifetime JP5037436B2 (ja) | 2000-07-07 | 2008-06-16 | ９−置換ミノサイクリン化合物 |
| JP2012034839A Pending JP2012107045A (ja) | 2000-07-07 | 2012-02-21 | ９−置換ミノサイクリン化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008157219A Expired - Lifetime JP5037436B2 (ja) | 2000-07-07 | 2008-06-16 | ９−置換ミノサイクリン化合物 |
| JP2012034839A Pending JP2012107045A (ja) | 2000-07-07 | 2012-02-21 | ９−置換ミノサイクリン化合物 |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US6846939B2 (https=) |
| EP (4) | EP3461808A1 (https=) |
| JP (3) | JP4925549B2 (https=) |
| KR (2) | KR100699390B1 (https=) |
| CN (2) | CN100473644C (https=) |
| AT (2) | ATE544745T1 (https=) |
| AU (4) | AU8638801A (https=) |
| BR (1) | BRPI0112269B8 (https=) |
| CA (1) | CA2415178C (https=) |
| CY (1) | CY1107524T1 (https=) |
| CZ (2) | CZ303702B6 (https=) |
| DE (1) | DE60122341T2 (https=) |
| DK (2) | DK1679305T3 (https=) |
| EA (3) | EA009175B1 (https=) |
| ES (2) | ES2271070T3 (https=) |
| HR (1) | HRP20030091B1 (https=) |
| HU (1) | HU229577B1 (https=) |
| IL (2) | IL153639A0 (https=) |
| MX (1) | MXPA03000055A (https=) |
| PT (1) | PT1301467E (https=) |
| SI (1) | SI1301467T1 (https=) |
| TW (2) | TWI305528B (https=) |
| WO (1) | WO2002004406A2 (https=) |
| ZA (1) | ZA200300749B (https=) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| WO1999037306A1 (en) * | 1998-01-23 | 1999-07-29 | Trustees Of Tufts College | Pharmaceutically active compounds and methods of use thereof |
| US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| EA016099B1 (ru) * | 1999-09-14 | 2012-02-28 | Трастис Оф Тафтс Коллидж | Замещенный аналог тетрациклина (варианты) и способ получения замещенного аналога тетрациклина |
| AU3105801A (en) * | 2000-01-24 | 2001-07-31 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
| EA200201046A1 (ru) * | 2000-03-31 | 2003-04-24 | Трастис Оф Тафтс Коллидж | 7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производное |
| CA2409063A1 (en) * | 2000-05-15 | 2001-11-22 | Mark L. Nelson | 7-substituted fused ring tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| AU2001268475A1 (en) * | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| US20040224927A1 (en) * | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| EA009175B1 (ru) * | 2000-07-07 | 2007-12-28 | Трастис Оф Тафтс Коллидж | Замещенные соединения миноциклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего |
| US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| WO2002072506A2 (en) * | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| EA013835B1 (ru) * | 2001-03-13 | 2010-08-30 | Пэрэтек Фамэсьютикэлс, Инк. | Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния субъекта |
| EP1241160A1 (en) | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracycline derivatives and their use as antibiotic agents |
| EP1381372A2 (en) | 2001-03-14 | 2004-01-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as synergistic antifungal agents |
| US8088820B2 (en) * | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| EP2327409A1 (en) | 2001-07-13 | 2011-06-01 | Paratek Pharmaceuticals, Inc. | Tetracycline compound having target therapeutic activities |
| AU2002365120A1 (en) * | 2001-08-02 | 2003-07-15 | Paratek Pharmaceuticals, Inc. | Medicaments |
| ES2551708T3 (es) * | 2002-01-08 | 2015-11-23 | Paratek Pharmaceuticals, Inc. | Compuestos de 4-desdimetilamino tetraciclina |
| EP2311451A1 (en) | 2002-03-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | Amino-methyl substituted tetracycline compounds |
| WO2003079983A2 (en) * | 2002-03-21 | 2003-10-02 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| EP1503981A4 (en) * | 2002-03-21 | 2007-08-15 | Paratek Pharm Innc | SUBSTITUTED TETRACYCLINE COMPOUNDS |
| AU2003261161B2 (en) * | 2002-07-12 | 2009-09-10 | Paratek Pharmaceuticals, Inc | 3, 10, and 12a substituted tetracycline compounds |
| EP1556007A4 (en) * | 2002-10-24 | 2008-12-17 | Paratek Pharm Innc | SUBSTITUTED TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF MALARIA |
| CA2503446C (en) | 2002-10-24 | 2012-12-18 | Paratek Pharmaceuticals, Inc. | Methods of using substituted tetracycline compounds to modulate rna |
| WO2004091513A2 (en) * | 2003-04-10 | 2004-10-28 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| US20050143352A1 (en) | 2003-07-09 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| AU2004259661B2 (en) * | 2003-07-09 | 2011-11-10 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| US8691258B2 (en) * | 2003-12-12 | 2014-04-08 | Medtronic, Inc. | Anti-infective medical device |
| JP5010284B2 (ja) * | 2004-01-15 | 2012-08-29 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物の芳香族ａ環誘導体 |
| SI1753713T1 (sl) | 2004-05-21 | 2017-01-31 | President And Fellows Of Harvard College | Sinteza tetraciklinov in njihovih analogov |
| TWI261038B (en) * | 2004-08-11 | 2006-09-01 | Bo-Cheng Chen | Bicycle gear-shifting handgrip |
| EP1805134B1 (en) | 2004-10-25 | 2012-06-20 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| EP2033950A1 (en) * | 2004-10-25 | 2009-03-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| CA2597212A1 (en) | 2005-02-04 | 2006-08-10 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| AR057032A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos de preparacion |
| AR057324A1 (es) * | 2005-05-27 | 2007-11-28 | Wyeth Corp | Tigeciclina y metodos para preparar 9-aminominociclina |
| AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
| US20070093455A1 (en) * | 2005-07-21 | 2007-04-26 | Paul Abato | 10-substituted tetracyclines and methods of use thereof |
| BRPI0620646A2 (pt) * | 2005-12-22 | 2011-11-22 | Wyeth Corp | composição farmacêutica compreendendo tigeciclina e seu uso |
| RU2008121238A (ru) * | 2005-12-22 | 2010-01-27 | Вайет (Us) | Способы лечения инфекций желудочно-кишечного тракта с применением тайгециклина |
| AU2007208214B2 (en) | 2006-01-24 | 2013-02-14 | Paratek Pharmaceuticals, Inc. | Methods of increasing oral bioavailability of tetracyclines |
| WO2007117639A2 (en) * | 2006-04-07 | 2007-10-18 | The President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
| EP2431469A3 (en) * | 2006-05-15 | 2012-05-30 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
| US8440646B1 (en) | 2006-10-11 | 2013-05-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of Bacillus anthracis infections |
| EP2487160B1 (en) | 2006-10-11 | 2016-02-03 | President and Fellows of Harvard College | Synthesis of Enone Intermediate |
| WO2008079339A2 (en) * | 2006-12-21 | 2008-07-03 | Paratek Pharmaceuticals, Inc. | Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections |
| CA2892739A1 (en) | 2006-12-21 | 2008-07-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
| AU2008239606A1 (en) | 2007-04-12 | 2008-10-23 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
| EP2216323A3 (en) * | 2007-04-27 | 2010-12-29 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
| EP2176216B1 (en) * | 2007-07-06 | 2012-04-25 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing 9-substituted minocycline |
| ES2388958T3 (es) | 2007-11-29 | 2012-10-22 | Actelion Pharmaceuticals Ltd. | Derivados de acido fosfonico y su uso como antagonista del receptor P2Y12 |
| CA2717703A1 (en) * | 2008-03-05 | 2009-09-11 | Paratek Pharmaceuticals, Inc. | Minocycline compounds and methods of use thereof |
| PT2271348T (pt) * | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
| WO2009128913A1 (en) * | 2008-04-14 | 2009-10-22 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| TWI680117B (zh) * | 2008-05-19 | 2019-12-21 | 派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| KR101746795B1 (ko) * | 2008-08-08 | 2017-06-13 | 테트라페이즈 파마슈티컬스, 인코포레이티드 | Ｃ７-플루오로 치환된 테트라시클린 화합물 |
| JP5443720B2 (ja) * | 2008-09-05 | 2014-03-19 | 住友化学株式会社 | 組成物、光学フィルム及びその製造方法、光学部材ならびに表示装置 |
| CN101759598B (zh) * | 2008-09-12 | 2011-11-09 | 山东轩竹医药科技有限公司 | 具有氨基烷基脒的四环素化合物 |
| CN101684083B (zh) * | 2008-09-16 | 2011-10-05 | 山东轩竹医药科技有限公司 | 胍基烷酰胺基取代的四环素衍生物 |
| CN101684080B (zh) * | 2008-09-16 | 2011-12-14 | 山东轩竹医药科技有限公司 | 含有甲酰肼基的四环素化合物 |
| CN101759599B (zh) * | 2008-09-17 | 2012-05-30 | 山东轩竹医药科技有限公司 | 具有氨基肟基的四环素类化合物 |
| US20100190755A1 (en) * | 2008-09-19 | 2010-07-29 | Paul Abato | Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment |
| WO2010126607A2 (en) | 2009-04-30 | 2010-11-04 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
| WO2010129057A2 (en) | 2009-05-08 | 2010-11-11 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| NO2470500T3 (https=) | 2009-08-28 | 2018-03-03 | ||
| KR101732084B1 (ko) | 2011-07-26 | 2017-05-02 | 케이비피 바이오사이언시즈 씨오., 엘티디. | 9-아미노메틸 치환된 테트라사이클린 화합물 |
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| CA2904387C (en) | 2013-03-15 | 2021-12-07 | Melinta Therapeutics, Inc. | Methods of treating infections in overweight and obese patients using antibiotics |
| WO2016062279A1 (zh) * | 2014-10-24 | 2016-04-28 | 朗齐生物医学股份有限公司 | 苹果酸丙氯陪拉辛锭用于制备治疗癌症药物的用途 |
| AU2016235151A1 (en) | 2015-03-24 | 2017-10-12 | Paratek Pharmaceuticals, Inc. | Minocycline compounds for biodefense |
| CA3018872A1 (en) * | 2016-03-24 | 2017-09-28 | Paratek Pharmaceuticals, Inc. | Methods of treating a bacterial infection in a subject at risk of developing c. difficile infection |
| HUE066360T2 (hu) | 2016-10-19 | 2024-07-28 | Tetraphase Pharmaceuticals Inc | Eravaciklin kristályformái |
| BR112019008897A2 (pt) | 2016-11-01 | 2019-08-13 | Paratek Pharm Innc | método para tratar pneumonia bacteriana adquirida na comunidade. |
| EP3846805A4 (en) * | 2018-09-04 | 2022-08-24 | Paratek Pharmaceuticals, Inc. | Methods of treating mycobacterial infections using tetracycline compounds |
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