JP2008545695A5 - - Google Patents
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- Publication number
- JP2008545695A5 JP2008545695A5 JP2008513610A JP2008513610A JP2008545695A5 JP 2008545695 A5 JP2008545695 A5 JP 2008545695A5 JP 2008513610 A JP2008513610 A JP 2008513610A JP 2008513610 A JP2008513610 A JP 2008513610A JP 2008545695 A5 JP2008545695 A5 JP 2008545695A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- polyanhydride
- carbon atoms
- acid
- unbranched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 229920002732 Polyanhydride Polymers 0.000 claims 32
- 125000004432 carbon atom Chemical group C* 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 18
- 239000003963 antioxidant agent Substances 0.000 claims 16
- 230000003078 antioxidant effect Effects 0.000 claims 16
- 229920006395 saturated elastomer Polymers 0.000 claims 15
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 15
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims 15
- 239000003755 preservative agent Substances 0.000 claims 12
- 230000002335 preservative effect Effects 0.000 claims 12
- YQUVCSBJEUQKSH-UHFFFAOYSA-N protochatechuic acid Natural products OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 claims 9
- 125000005862 (C1-C6)alkanoyl group Chemical group 0.000 claims 7
- 239000003242 anti bacterial agent Substances 0.000 claims 7
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 6
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 6
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 6
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- NGSWKAQJJWESNS-UHFFFAOYSA-N 4-coumaric acid Chemical compound OC(=O)C=CC1=CC=C(O)C=C1 NGSWKAQJJWESNS-UHFFFAOYSA-N 0.000 claims 6
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000004104 aryloxy group Chemical group 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims 6
- 125000001475 halogen functional group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 125000004043 oxo group Chemical group O=* 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- JMSVCTWVEWCHDZ-UHFFFAOYSA-N syringic acid Chemical compound COC1=CC(C(O)=O)=CC(OC)=C1O JMSVCTWVEWCHDZ-UHFFFAOYSA-N 0.000 claims 6
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 claims 6
- 125000004423 acyloxy group Chemical group 0.000 claims 5
- 239000004599 antimicrobial Substances 0.000 claims 5
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 5
- 239000004005 microsphere Substances 0.000 claims 5
- 230000002421 anti-septic effect Effects 0.000 claims 4
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 claims 3
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims 3
- NGSWKAQJJWESNS-ZZXKWVIFSA-M 4-Hydroxycinnamate Natural products OC1=CC=C(\C=C\C([O-])=O)C=C1 NGSWKAQJJWESNS-ZZXKWVIFSA-M 0.000 claims 3
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 claims 3
- DFYRUELUNQRZTB-UHFFFAOYSA-N Acetovanillone Natural products COC1=CC(C(C)=O)=CC=C1O DFYRUELUNQRZTB-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 230000000844 anti-bacterial effect Effects 0.000 claims 3
- 235000004883 caffeic acid Nutrition 0.000 claims 3
- 229940074360 caffeic acid Drugs 0.000 claims 3
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 claims 3
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims 3
- 235000001785 ferulic acid Nutrition 0.000 claims 3
- 229940114124 ferulic acid Drugs 0.000 claims 3
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims 3
- 229940074391 gallic acid Drugs 0.000 claims 3
- 235000004515 gallic acid Nutrition 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000001737 promoting effect Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- PCMORTLOPMLEFB-ONEGZZNKSA-N sinapic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC(OC)=C1O PCMORTLOPMLEFB-ONEGZZNKSA-N 0.000 claims 3
- PCMORTLOPMLEFB-UHFFFAOYSA-N sinapinic acid Natural products COC1=CC(C=CC(O)=O)=CC(OC)=C1O PCMORTLOPMLEFB-UHFFFAOYSA-N 0.000 claims 3
- YIBXWXOYFGZLRU-UHFFFAOYSA-N syringic aldehyde Natural products CC12CCC(C3(CCC(=O)C(C)(C)C3CC=3)C)C=3C1(C)CCC2C1COC(C)(C)C(O)C(O)C1 YIBXWXOYFGZLRU-UHFFFAOYSA-N 0.000 claims 3
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims 3
- WKOLLVMJNQIZCI-UHFFFAOYSA-N vanillic acid Chemical group COC1=CC(C(O)=O)=CC=C1O WKOLLVMJNQIZCI-UHFFFAOYSA-N 0.000 claims 3
- TUUBOHWZSQXCSW-UHFFFAOYSA-N vanillic acid Natural products COC1=CC(O)=CC(C(O)=O)=C1 TUUBOHWZSQXCSW-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 238000013160 medical therapy Methods 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 238000011200 topical administration Methods 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- -1 hydroxyaryl carboxylic acid Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68383105P | 2005-05-23 | 2005-05-23 | |
| PCT/US2006/019848 WO2006127667A1 (en) | 2005-05-23 | 2006-05-23 | Fast degrading polymers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008545695A JP2008545695A (ja) | 2008-12-18 |
| JP2008545695A5 true JP2008545695A5 (https=) | 2009-07-16 |
Family
ID=37452349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008513610A Withdrawn JP2008545695A (ja) | 2005-05-23 | 2006-05-23 | 迅速分解ポリマー |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8263060B2 (https=) |
| EP (1) | EP1898832A4 (https=) |
| JP (1) | JP2008545695A (https=) |
| WO (1) | WO2006127667A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6486214B1 (en) * | 1997-09-10 | 2002-11-26 | Rutgers, The State University Of New Jersey | Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby |
| US7122615B1 (en) * | 1998-09-10 | 2006-10-17 | Rutgers, The State University Of New Jersey | Polyanhydrides with therapeutically useful degradation products |
| US7985415B2 (en) * | 1997-09-10 | 2011-07-26 | Rutgers, The State University Of New Jersey | Medical devices employing novel polymers |
| US20040038948A1 (en) * | 1999-12-07 | 2004-02-26 | Uhrich Kathryn E. | Therapeutic compositions and methods |
| CA2771263A1 (en) | 2000-07-27 | 2002-02-07 | Rutgers, The State University | Therapeutic polyesters and polyamides |
| AU2007256626A1 (en) | 2006-06-06 | 2007-12-13 | Rutgers, The State University Of New Jersey | Iodinated polymers |
| US20150005720A1 (en) | 2006-07-18 | 2015-01-01 | E Ink California, Llc | Electrophoretic display |
| EP2102144A4 (en) | 2006-09-13 | 2011-03-23 | Univ Rutgers | ACTIVE SUBSTANCES AND THEIR OLIGOMERS AND POLYMERS |
| US8747832B2 (en) * | 2007-04-12 | 2014-06-10 | Rutgers, The State University Of New Jersey | Biodegradable polyanhydrides with natural bioactive molecules |
| US8741317B2 (en) | 2010-08-19 | 2014-06-03 | Rutgers, The State University Of New Jersey | Slow-degrading polymers comprising salicylic acid for undelayed and sustained drug delivery |
| US9144579B2 (en) | 2012-08-17 | 2015-09-29 | Rutgers, The State University Of New Jersey | Polyesters and methods of use thereof |
| US20140120057A1 (en) | 2012-10-25 | 2014-05-01 | Rutgers, The State University Of New Jersey | Polymers and methods thereof for wound healing |
| US9387250B2 (en) | 2013-03-15 | 2016-07-12 | Rutgers, The State University Of New Jersey | Therapeutic compositions for bone repair |
| WO2014194055A1 (en) | 2013-05-29 | 2014-12-04 | Rutgers, The State University Of New Jersey | Antioxidant-based poly(anhydride-esters) |
| US10023521B2 (en) | 2014-06-13 | 2018-07-17 | Rutgers, The State University Of New Jersey | Process and intermediates for preparing poly(anhydride-esters) |
| JP6930918B6 (ja) | 2015-04-10 | 2021-12-15 | ラトガーズ， ザ ステイト ユニバーシティ オブ ニュー ジャージー | コウジ酸ポリマー |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6468519B1 (en) * | 1997-09-10 | 2002-10-22 | Rutgers, The State University Of New Jersey | Polyanhydrides with biologically active degradation products |
| PT1032605E (pt) | 1997-09-10 | 2007-12-12 | Univ Rutgers | Polianidridos com produtos de degradação terapeuticamente úteis |
| US7122615B1 (en) * | 1998-09-10 | 2006-10-17 | Rutgers, The State University Of New Jersey | Polyanhydrides with therapeutically useful degradation products |
| US7985415B2 (en) * | 1997-09-10 | 2011-07-26 | Rutgers, The State University Of New Jersey | Medical devices employing novel polymers |
| US6486214B1 (en) * | 1997-09-10 | 2002-11-26 | Rutgers, The State University Of New Jersey | Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby |
| US20040038948A1 (en) * | 1999-12-07 | 2004-02-26 | Uhrich Kathryn E. | Therapeutic compositions and methods |
| ATE444086T1 (de) | 1999-12-07 | 2009-10-15 | Univ Rutgers | Therapeutische zusammensetzungen und verfahren zur behandlung von periodontitis mit entzündunshemmenden mitteln |
| US6685928B2 (en) * | 1999-12-07 | 2004-02-03 | Rutgers, The State University Of New Jersey | Therapeutic compositions and methods |
| US6602915B2 (en) * | 2000-07-27 | 2003-08-05 | Rutgers, The State University Of New Jersey | Therapeutic azo-compounds for drug delivery |
| CA2771263A1 (en) * | 2000-07-27 | 2002-02-07 | Rutgers, The State University | Therapeutic polyesters and polyamides |
| JP2005510571A (ja) * | 2001-11-23 | 2005-04-21 | ラトガーズ， ザ ステート ユニバーシティー | ポリ無水物の改善された合成 |
| AU2003212955A1 (en) * | 2002-02-07 | 2003-09-02 | Rutgers, The State University Of New Jersey | Therapeutic polyesters and polyamides |
| CN1642503A (zh) | 2002-02-07 | 2005-07-20 | 拉特格斯·新泽西州立大学 | 用于药物送递的治疗聚酐化合物 |
| AU2003210925A1 (en) | 2002-02-07 | 2003-09-02 | Rutgers, The State University | Antibiotic polymers |
| US20040096476A1 (en) * | 2002-07-17 | 2004-05-20 | Uhrich Kathryn E. | Therapeutic devices for patterned cell growth |
| CA2503841A1 (en) | 2002-10-28 | 2004-05-13 | Polymerix Corporation | Therapeutic compositions |
| CN1735404A (zh) | 2002-11-18 | 2006-02-15 | 波利梅里斯公司 | 使用新聚合物的医疗装置 |
| US7662864B2 (en) * | 2003-06-04 | 2010-02-16 | Rutgers, The State University Of New Jersey | Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent |
| WO2005042600A2 (en) | 2003-06-04 | 2005-05-12 | Polymerix Corporation | High molecular weight polymers, devices and method for making and using same |
| US20050249697A1 (en) * | 2003-09-24 | 2005-11-10 | Uhrich Kathryn E | Compositions and methods for the inhibition of bone growth and resorption |
| AU2007256626A1 (en) * | 2006-06-06 | 2007-12-13 | Rutgers, The State University Of New Jersey | Iodinated polymers |
| EP2102144A4 (en) * | 2006-09-13 | 2011-03-23 | Univ Rutgers | ACTIVE SUBSTANCES AND THEIR OLIGOMERS AND POLYMERS |
| US20100291180A1 (en) * | 2007-02-20 | 2010-11-18 | Uhrich Kathryn E | Nerve guidance tubes |
| US8747832B2 (en) * | 2007-04-12 | 2014-06-10 | Rutgers, The State University Of New Jersey | Biodegradable polyanhydrides with natural bioactive molecules |
| WO2009026544A1 (en) | 2007-08-22 | 2009-02-26 | Rutgers, The State University Of New Jersey | Ampicillin and amoxicillin-based poly(anhydride-amides) |
| US8741317B2 (en) * | 2010-08-19 | 2014-06-03 | Rutgers, The State University Of New Jersey | Slow-degrading polymers comprising salicylic acid for undelayed and sustained drug delivery |
-
2006
- 2006-05-23 JP JP2008513610A patent/JP2008545695A/ja not_active Withdrawn
- 2006-05-23 WO PCT/US2006/019848 patent/WO2006127667A1/en not_active Ceased
- 2006-05-23 EP EP06770908A patent/EP1898832A4/en not_active Withdrawn
- 2006-05-23 US US11/915,284 patent/US8263060B2/en not_active Expired - Fee Related
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