ATE415969T1 - (s)-benzochinolizincarbonsäuren und ihre verwendung als antibakterielle mittel - Google Patents
(s)-benzochinolizincarbonsäuren und ihre verwendung als antibakterielle mittelInfo
- Publication number
- ATE415969T1 ATE415969T1 AT00939047T AT00939047T ATE415969T1 AT E415969 T1 ATE415969 T1 AT E415969T1 AT 00939047 T AT00939047 T AT 00939047T AT 00939047 T AT00939047 T AT 00939047T AT E415969 T1 ATE415969 T1 AT E415969T1
- Authority
- AT
- Austria
- Prior art keywords
- benzoquinolicin
- carboxylic acids
- antibiotic
- compounds
- antibacterial agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN9900016 | 1999-05-07 | ||
US17067699P | 1999-12-14 | 1999-12-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE415969T1 true ATE415969T1 (de) | 2008-12-15 |
Family
ID=26324122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00939047T ATE415969T1 (de) | 1999-05-07 | 2000-05-08 | (s)-benzochinolizincarbonsäuren und ihre verwendung als antibakterielle mittel |
Country Status (5)
Country | Link |
---|---|
US (3) | US7247642B2 (de) |
EP (2) | EP1175217B8 (de) |
AT (1) | ATE415969T1 (de) |
DE (1) | DE60040979D1 (de) |
WO (1) | WO2000068229A2 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1175217B8 (de) | 1999-05-07 | 2009-03-18 | Wockhardt Limited | (s)-benzochinolizincarbonsäuren und ihre verwendung als antibakterielle mittel |
US6514986B2 (en) * | 2000-11-22 | 2003-02-04 | Wockhardt Limited | Chiral fluoroquinolone arginine salt forms |
US6608078B2 (en) | 2000-05-08 | 2003-08-19 | Wockhardt Limited | Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment |
WO2001085095A2 (en) * | 2000-05-08 | 2001-11-15 | Wockhardt Limited | Chiral fluoroquinolizinone arginine salt forms |
US7098219B2 (en) | 2000-08-01 | 2006-08-29 | Wockhart Limited | Inhibitors of cellular efflux pumps of microbes |
US6964966B2 (en) * | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US6878713B2 (en) | 2001-04-25 | 2005-04-12 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
EP1453824A1 (de) * | 2001-12-13 | 2004-09-08 | Wockhardt Limited | Triple-targeting chirale breitspektrumantimicrobielle piperidino-quinolon-carbonsäurederivate der neuen generation, ihre herstellung, zusammensetzungen und gebrauch als medikamente |
EP1918289A3 (de) | 2002-05-28 | 2009-08-19 | Wockhardt Limited | Kristalline Form eines Fluorchinolon-Argininsalzes |
US6664267B1 (en) * | 2002-05-28 | 2003-12-16 | Wockhardt Limited | Crystalline fluoroquinolone arginine salt form |
ES2279217T3 (es) * | 2002-08-20 | 2007-08-16 | Lonza, Inc. | Composiciones antimicrobianas sinergicas, estables, a base de donadores de aldehidos y acido dehidroacetico y que son de bajo contenido en formaldehido libre. |
WO2004058262A1 (en) * | 2002-12-31 | 2004-07-15 | Wockhardt Limited | Benzoquinolizine-2-carboxylic acid-containing compositions |
AU2003303367A1 (en) * | 2002-12-31 | 2004-07-22 | Noel J. De Souza | Compositions of benzoquinolizine carboxylic acid antibiotic drugs |
WO2004091504A2 (en) * | 2003-04-07 | 2004-10-28 | Cylene Pharmaceuticals, Inc. | Substituted quinobenzoxazine analogs |
WO2005023805A1 (en) * | 2003-09-04 | 2005-03-17 | Wockhardt Limited | Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate |
CN101500564B (zh) * | 2006-03-07 | 2012-07-25 | 沃克哈特有限公司 | 苯并喹嗪-2-羧酸的前药 |
WO2008038122A2 (en) * | 2006-09-29 | 2008-04-03 | Wockhardt Research Centre | Processes for the preparation of 7-substituted 3,3-dimethyl-4-amino-piperidino-quinolone carboxylic acid derivatives |
WO2008053295A2 (en) * | 2006-10-30 | 2008-05-08 | Wockhardt Research Centre | Pharmaceutical compositions of benzoquinolizine-2-carboxylic acid |
WO2009027762A2 (en) * | 2007-08-24 | 2009-03-05 | Wockhardt Research Centre | Liquid dosage forms of fluoroquinolone antibiotics or salt thereof for ophthalmic, otic and nasal administration |
WO2009040754A2 (en) * | 2007-09-27 | 2009-04-02 | Wockhardt Research Centre | Polymorphs of s-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1h,5h-benzo[i,j]quinolizine-2-carboxylic acid lysine salt |
CN101513406A (zh) * | 2008-02-21 | 2009-08-26 | 南京长澳医药科技有限公司 | 一种稳定的s-(-)-那氟沙星l-精氨酸盐组合物、其制备方法及用途 |
EP2536408A1 (de) * | 2010-02-16 | 2012-12-26 | Wockhardt Research Centre | Effluxpumpenhemmer |
CN102532131B (zh) * | 2010-12-22 | 2015-09-16 | 南京长澳医药科技有限公司 | 一种s-(-)-那氟沙星-l-精氨酸盐的制备方法 |
KR20140054307A (ko) * | 2011-09-28 | 2014-05-08 | 욱크하르트 리미티드 | 순수한 S-(-)-9-플루오로-6,7-디히드로-8-(4-히드록시피페리딘-1-일)-5-메틸-1-옥소-1H,-5H-벤조[i,j]퀴놀리진-2-카르복실산 L-아르기닌 염 테트라하이드레이트 및 이의 제조 방법 |
CA2976441A1 (en) * | 2015-05-08 | 2016-11-17 | Wockhardt Limited | Stable pharmaceutical compositions comprising antibacterial agent |
JP2019522052A (ja) * | 2017-04-14 | 2019-08-08 | ウォックハート リミテッド | 抗細菌組成物 |
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US2131483A (en) * | 1933-06-30 | 1938-09-27 | John A Dienner | Ignition coil |
US4007266A (en) * | 1968-05-03 | 1977-02-08 | Choay S.A. | Pharmaceutical composition containing vitamin B12, process of making the same and method of treatment |
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US3924042A (en) | 1973-03-26 | 1975-12-02 | Minnesota Mining & Mfg | Method for treatment of bacterial plant disease |
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JPS5781486A (en) | 1980-11-10 | 1982-05-21 | Otsuka Pharmaceut Co Ltd | Benzo(ij)quinolidine-2-carboxylic acid derivative |
JPS57176987A (en) | 1981-04-24 | 1982-10-30 | Otsuka Pharmaceut Co Ltd | Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivative |
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JPH05339238A (ja) * | 1992-06-10 | 1993-12-21 | Otsuka Pharmaceut Co Ltd | テトラヒドロキノリン誘導体のラセミ化方法 |
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TW301607B (de) | 1993-03-09 | 1997-04-01 | Takeda Pharm Industry Co Ltd | |
US6034100A (en) | 1993-03-10 | 2000-03-07 | Otsuka Pharmaceutical Co., Ltd. | Method for inhibiting cytokine secretion |
EP0806421A4 (de) | 1995-01-24 | 1998-04-15 | Hokuriku Pharmaceutical | Derivate der chinolincarbonsäure |
US6121285A (en) | 1995-11-22 | 2000-09-19 | Daiichi Pharmaceutical Co., Ltd. | Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives |
EP0908181B8 (de) | 1996-05-20 | 2009-04-15 | Otsuka Pharmaceutical Co., Ltd. | Heilmittel fuer rosazea |
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AU735186B2 (en) | 1997-09-15 | 2001-07-05 | Warner Chilcott Company, Llc | Antimicrobial quinolones, their compositions and uses |
US6229323B1 (en) * | 1998-04-23 | 2001-05-08 | Micron Technology, Inc. | Automated multi-chip module handler, method of module handling, and module magazine |
EP1175217B8 (de) | 1999-05-07 | 2009-03-18 | Wockhardt Limited | (s)-benzochinolizincarbonsäuren und ihre verwendung als antibakterielle mittel |
US6750224B1 (en) * | 1999-05-07 | 2004-06-15 | Wockhardt Limited | Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment |
US6514986B2 (en) * | 2000-11-22 | 2003-02-04 | Wockhardt Limited | Chiral fluoroquinolone arginine salt forms |
US6608078B2 (en) * | 2000-05-08 | 2003-08-19 | Wockhardt Limited | Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment |
WO2004058262A1 (en) * | 2002-12-31 | 2004-07-15 | Wockhardt Limited | Benzoquinolizine-2-carboxylic acid-containing compositions |
AU2003303367A1 (en) * | 2002-12-31 | 2004-07-22 | Noel J. De Souza | Compositions of benzoquinolizine carboxylic acid antibiotic drugs |
WO2005023805A1 (en) * | 2003-09-04 | 2005-03-17 | Wockhardt Limited | Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate |
-
2000
- 2000-05-08 EP EP00939047A patent/EP1175217B8/de not_active Expired - Lifetime
- 2000-05-08 DE DE60040979T patent/DE60040979D1/de not_active Expired - Lifetime
- 2000-05-08 WO PCT/IN2000/000054 patent/WO2000068229A2/en active Application Filing
- 2000-05-08 EP EP08011257A patent/EP2030620A1/de not_active Withdrawn
- 2000-05-08 US US09/566,875 patent/US7247642B2/en not_active Expired - Lifetime
- 2000-05-08 AT AT00939047T patent/ATE415969T1/de not_active IP Right Cessation
-
2007
- 2007-05-21 US US11/804,770 patent/US8507519B2/en not_active Expired - Fee Related
- 2007-07-23 US US11/880,645 patent/US20080108646A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US7247642B2 (en) | 2007-07-24 |
WO2000068229A2 (en) | 2000-11-16 |
EP1175217A2 (de) | 2002-01-30 |
US8507519B2 (en) | 2013-08-13 |
EP2030620A8 (de) | 2009-06-24 |
DE60040979D1 (de) | 2009-01-15 |
US20080108646A1 (en) | 2008-05-08 |
EP1175217B1 (de) | 2008-12-03 |
US20030207908A1 (en) | 2003-11-06 |
US20080044466A1 (en) | 2008-02-21 |
EP2030620A1 (de) | 2009-03-04 |
EP1175217B8 (de) | 2009-03-18 |
WO2000068229A3 (en) | 2001-03-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |