ATE415969T1 - (s)-benzochinolizincarbonsäuren und ihre verwendung als antibakterielle mittel - Google Patents

(s)-benzochinolizincarbonsäuren und ihre verwendung als antibakterielle mittel

Info

Publication number
ATE415969T1
ATE415969T1 AT00939047T AT00939047T ATE415969T1 AT E415969 T1 ATE415969 T1 AT E415969T1 AT 00939047 T AT00939047 T AT 00939047T AT 00939047 T AT00939047 T AT 00939047T AT E415969 T1 ATE415969 T1 AT E415969T1
Authority
AT
Austria
Prior art keywords
benzoquinolicin
carboxylic acids
antibiotic
compounds
antibacterial agents
Prior art date
Application number
AT00939047T
Other languages
English (en)
Inventor
M V Patel
S V Gupte
Y Chugh
D G Saogi
S K Agarwal
Souza N J De
H F Khorakiwala
Original Assignee
Wockhardt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Ltd filed Critical Wockhardt Ltd
Application granted granted Critical
Publication of ATE415969T1 publication Critical patent/ATE415969T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D455/00Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT00939047T 1999-05-07 2000-05-08 (s)-benzochinolizincarbonsäuren und ihre verwendung als antibakterielle mittel ATE415969T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN9900016 1999-05-07
US17067699P 1999-12-14 1999-12-14

Publications (1)

Publication Number Publication Date
ATE415969T1 true ATE415969T1 (de) 2008-12-15

Family

ID=26324122

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00939047T ATE415969T1 (de) 1999-05-07 2000-05-08 (s)-benzochinolizincarbonsäuren und ihre verwendung als antibakterielle mittel

Country Status (5)

Country Link
US (3) US7247642B2 (de)
EP (2) EP1175217B8 (de)
AT (1) ATE415969T1 (de)
DE (1) DE60040979D1 (de)
WO (1) WO2000068229A2 (de)

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EP1175217B8 (de) 1999-05-07 2009-03-18 Wockhardt Limited (s)-benzochinolizincarbonsäuren und ihre verwendung als antibakterielle mittel
US6514986B2 (en) * 2000-11-22 2003-02-04 Wockhardt Limited Chiral fluoroquinolone arginine salt forms
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
WO2001085095A2 (en) * 2000-05-08 2001-11-15 Wockhardt Limited Chiral fluoroquinolizinone arginine salt forms
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
US6964966B2 (en) * 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
EP1453824A1 (de) * 2001-12-13 2004-09-08 Wockhardt Limited Triple-targeting chirale breitspektrumantimicrobielle piperidino-quinolon-carbonsäurederivate der neuen generation, ihre herstellung, zusammensetzungen und gebrauch als medikamente
EP1918289A3 (de) 2002-05-28 2009-08-19 Wockhardt Limited Kristalline Form eines Fluorchinolon-Argininsalzes
US6664267B1 (en) * 2002-05-28 2003-12-16 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
ES2279217T3 (es) * 2002-08-20 2007-08-16 Lonza, Inc. Composiciones antimicrobianas sinergicas, estables, a base de donadores de aldehidos y acido dehidroacetico y que son de bajo contenido en formaldehido libre.
WO2004058262A1 (en) * 2002-12-31 2004-07-15 Wockhardt Limited Benzoquinolizine-2-carboxylic acid-containing compositions
AU2003303367A1 (en) * 2002-12-31 2004-07-22 Noel J. De Souza Compositions of benzoquinolizine carboxylic acid antibiotic drugs
WO2004091504A2 (en) * 2003-04-07 2004-10-28 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs
WO2005023805A1 (en) * 2003-09-04 2005-03-17 Wockhardt Limited Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
CN101500564B (zh) * 2006-03-07 2012-07-25 沃克哈特有限公司 苯并喹嗪-2-羧酸的前药
WO2008038122A2 (en) * 2006-09-29 2008-04-03 Wockhardt Research Centre Processes for the preparation of 7-substituted 3,3-dimethyl-4-amino-piperidino-quinolone carboxylic acid derivatives
WO2008053295A2 (en) * 2006-10-30 2008-05-08 Wockhardt Research Centre Pharmaceutical compositions of benzoquinolizine-2-carboxylic acid
WO2009027762A2 (en) * 2007-08-24 2009-03-05 Wockhardt Research Centre Liquid dosage forms of fluoroquinolone antibiotics or salt thereof for ophthalmic, otic and nasal administration
WO2009040754A2 (en) * 2007-09-27 2009-04-02 Wockhardt Research Centre Polymorphs of s-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1h,5h-benzo[i,j]quinolizine-2-carboxylic acid lysine salt
CN101513406A (zh) * 2008-02-21 2009-08-26 南京长澳医药科技有限公司 一种稳定的s-(-)-那氟沙星l-精氨酸盐组合物、其制备方法及用途
EP2536408A1 (de) * 2010-02-16 2012-12-26 Wockhardt Research Centre Effluxpumpenhemmer
CN102532131B (zh) * 2010-12-22 2015-09-16 南京长澳医药科技有限公司 一种s-(-)-那氟沙星-l-精氨酸盐的制备方法
KR20140054307A (ko) * 2011-09-28 2014-05-08 욱크하르트 리미티드 순수한 S-(-)-9-플루오로-6,7-디히드로-8-(4-히드록시피페리딘-1-일)-5-메틸-1-옥소-1H,-5H-벤조[i,j]퀴놀리진-2-카르복실산 L-아르기닌 염 테트라하이드레이트 및 이의 제조 방법
CA2976441A1 (en) * 2015-05-08 2016-11-17 Wockhardt Limited Stable pharmaceutical compositions comprising antibacterial agent
JP2019522052A (ja) * 2017-04-14 2019-08-08 ウォックハート リミテッド 抗細菌組成物

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US6514986B2 (en) * 2000-11-22 2003-02-04 Wockhardt Limited Chiral fluoroquinolone arginine salt forms
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Also Published As

Publication number Publication date
US7247642B2 (en) 2007-07-24
WO2000068229A2 (en) 2000-11-16
EP1175217A2 (de) 2002-01-30
US8507519B2 (en) 2013-08-13
EP2030620A8 (de) 2009-06-24
DE60040979D1 (de) 2009-01-15
US20080108646A1 (en) 2008-05-08
EP1175217B1 (de) 2008-12-03
US20030207908A1 (en) 2003-11-06
US20080044466A1 (en) 2008-02-21
EP2030620A1 (de) 2009-03-04
EP1175217B8 (de) 2009-03-18
WO2000068229A3 (en) 2001-03-22

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