JP2003506354A5 - - Google Patents

Info

Publication number

JP2003506354A5

JP2003506354A5 JP2001514299A JP2001514299A JP2003506354A5 JP 2003506354 A5 JP2003506354 A5 JP 2003506354A5 JP 2001514299 A JP2001514299 A JP 2001514299A JP 2001514299 A JP2001514299 A JP 2001514299A JP 2003506354 A5 JP2003506354 A5 JP 2003506354A5

Authority

JP

Japan

Prior art keywords

hydrogen

formula

alkyl

compound

embedded image

Prior art date

2000-07-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 229910052739 hydrogen Inorganic materials 0.000 description 18
• 239000001257 hydrogen Substances 0.000 description 18
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 15
• 150000001875 compounds Chemical class 0.000 description 15
• 125000000217 alkyl group Chemical group 0.000 description 11
• -1 3- (piperidin-2-yl-carbonylamino) -phenyl-sulfanylacetyl Chemical group 0.000 description 6
• OBUUFWIMEGVAQS-UHFFFAOYSA-N Pleuromutenol Natural products CC1C(O)C(C)(C=C)CC(O)C2(C)C(C)CCC31C2C(=O)CC3 OBUUFWIMEGVAQS-UHFFFAOYSA-N 0.000 description 6
• STZYTFJPGGDRJD-NHUWBDDWSA-N retapamulin Chemical compound C([C@H]([C@@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CS[C@@H]3C[C@H]4CC[C@H](N4C)C3)C)C[C@]32[C@H]1C(=O)CC3 STZYTFJPGGDRJD-NHUWBDDWSA-N 0.000 description 6
• 229960002771 retapamulin Drugs 0.000 description 6
• YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 5
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
• 229910052805 deuterium Inorganic materials 0.000 description 5
• 239000001301 oxygen Chemical group 0.000 description 5
• 229910052760 oxygen Inorganic materials 0.000 description 5
• 239000003814 drug Substances 0.000 description 4
• 125000003118 aryl group Chemical group 0.000 description 3
• 201000010099 disease Diseases 0.000 description 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
• 230000000813 microbial effect Effects 0.000 description 3
• 150000003839 salts Chemical class 0.000 description 3
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
• 150000001450 anions Chemical class 0.000 description 2
• 125000000623 heterocyclic group Chemical group 0.000 description 2
• 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
• 238000004519 manufacturing process Methods 0.000 description 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
• 229910052757 nitrogen Inorganic materials 0.000 description 2
• 125000004433 nitrogen atom Chemical group N* 0.000 description 2
• 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
• 239000012453 solvate Substances 0.000 description 2
• PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 description 2
• 229910052717 sulfur Inorganic materials 0.000 description 2
• 239000011593 sulfur Substances 0.000 description 2
• 239000000273 veterinary drug Substances 0.000 description 2
• 241000894006 Bacteria Species 0.000 description 1
• HYNZNBYSUKYELY-UHFFFAOYSA-N CC(C)C(C(N(CCC1)CC1SCC(O)=O)=O)N Chemical compound CC(C)C(C(N(CCC1)CC1SCC(O)=O)=O)N HYNZNBYSUKYELY-UHFFFAOYSA-N 0.000 description 1
• 0 CC(CCC1(CC2(*)*)[C@@](C)C(C(CC3)=C=C)O)[C@]3(C)C1(*)C2=O Chemical compound CC(CCC1(CC2(*)*)[C@@](C)C(C(CC3)=C=C)O)[C@]3(C)C1(*)C2=O 0.000 description 1
• RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
• 229930182555 Penicillin Natural products 0.000 description 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
• 108010059993 Vancomycin Proteins 0.000 description 1
• 239000004599 antimicrobial Substances 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 150000002431 hydrogen Chemical class 0.000 description 1
• 238000000034 method Methods 0.000 description 1
• 229960003085 meticillin Drugs 0.000 description 1
• 239000000203 mixture Substances 0.000 description 1
• 229940049954 penicillin Drugs 0.000 description 1
• 239000008194 pharmaceutical composition Substances 0.000 description 1
• 239000008024 pharmaceutical diluent Substances 0.000 description 1
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 229960003165 vancomycin Drugs 0.000 description 1
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
• MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 1