JP2006524227A5 - - Google Patents
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- Publication number
- JP2006524227A5 JP2006524227A5 JP2006506588A JP2006506588A JP2006524227A5 JP 2006524227 A5 JP2006524227 A5 JP 2006524227A5 JP 2006506588 A JP2006506588 A JP 2006506588A JP 2006506588 A JP2006506588 A JP 2006506588A JP 2006524227 A5 JP2006524227 A5 JP 2006524227A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- medicament according
- independently
- unsubstituted
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45863503P | 2003-03-28 | 2003-03-28 | |
| PCT/IB2004/001429 WO2004084796A2 (en) | 2003-03-28 | 2004-03-29 | Compounds for the treatment of flaviviridae infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006524227A JP2006524227A (ja) | 2006-10-26 |
| JP2006524227A5 true JP2006524227A5 (https=) | 2007-05-24 |
Family
ID=33098273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006506588A Pending JP2006524227A (ja) | 2003-03-28 | 2004-03-29 | フラビウイルス科ウイルス感染の治療のための化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20050049204A1 (https=) |
| EP (1) | EP1626692A4 (https=) |
| JP (1) | JP2006524227A (https=) |
| CN (1) | CN1980678A (https=) |
| AU (1) | AU2004224575A1 (https=) |
| BR (1) | BRPI0408846A (https=) |
| CA (1) | CA2529311A1 (https=) |
| MX (1) | MXPA05010419A (https=) |
| RU (1) | RU2005133093A (https=) |
| WO (1) | WO2004084796A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| KR20080021797A (ko) | 2000-05-26 | 2008-03-07 | 이데닉스(케이만)리미티드 | 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물 |
| NZ537662A (en) | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| PL374781A1 (en) | 2002-06-28 | 2005-10-31 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| HUE033832T2 (en) | 2002-11-15 | 2018-01-29 | Idenix Pharmaceuticals Llc | 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation |
| RU2005121904A (ru) | 2002-12-12 | 2006-01-20 | Айденикс (Кайман) Лимитед (Ky) | Способ получения 2`-разветвленных нуклеозидов |
| US20090270431A1 (en) * | 2005-10-19 | 2009-10-29 | The University Of Georgia Research Foundation | Cyclopentenol Nucleoside Compounds Intermediates for their Synthesis and Methods of Treating Viral Infections |
| BRPI0715714A2 (pt) * | 2006-08-25 | 2014-03-11 | Wyeth Corp | Métodos para diminuir a frequência de emergência de uma infecção viral de hepatite c resistente ao tratamento, para atrasar a emergência de uma infecção viral de hepatite c resistente ao tratamento, para diminuir o nível de resistência de uma infecção viral de hepatite c resistente ao tratamento, para diminuir a emergência de uma infecção viral de hepatite c resistente a hcv-796, para identificar um indivíduo com uma probabilidade diminuída de responder a uma terapia viral anti-hepatite c, para monitorar, diagnosticar ou prognosticar a infecção viral de hepatite c resistente ao tratamento em um paciente, para monitorar o curso de tratamento de uma infecção viral de hepatite c em um paciente, para prognosticar o desenvolvimento de um ainfecção viral de hepatite c resistente ao tratamento em um paciente, para monitorar a infecção viral de hepatite c em um paciente e para diagnosticar o desenvolvimento de uma infecção viral de hepatite ao tratamento em um paciente |
| CA2663618A1 (en) * | 2006-09-11 | 2008-06-05 | Southern Research Institute | Azole nucleosides and use as inhibitors of rna and dna viral polymerases |
| GB2471806B (en) * | 2008-04-03 | 2012-12-19 | Spring Bank Pharmaceuticals Inc | Compositions and methods for treating viral infections |
| CN102123706B (zh) | 2008-06-17 | 2013-08-14 | 米纳斯吉拉斯联合大学 | 血小板活化因子受体在治疗黄病毒科病毒引起的感染中的用途 |
| WO2014186435A2 (en) | 2013-05-14 | 2014-11-20 | University Of Georgia Research Foundation, Inc. | Compositions and methods for reducing neointima formation |
| US20210353660A1 (en) * | 2018-10-04 | 2021-11-18 | Octagon Therapeutics Inc. | Pre-Activated Nucleoside IMPDH Inhibitors As Anti-Infective Drugs |
| CN114828859A (zh) * | 2019-12-06 | 2022-07-29 | 南京明德新药研发有限公司 | siRNA缀合物、双链siRNA缀合物及其盐和应用 |
| US20230123911A1 (en) * | 2020-01-31 | 2023-04-20 | Octagon Therapeutics, Inc. | Modulation of immune cells |
| WO2021249352A1 (zh) * | 2020-06-10 | 2021-12-16 | 正大天晴药业集团股份有限公司 | 双链siRNA类似物的缀合物 |
| EP4166144A4 (en) * | 2020-06-11 | 2024-07-10 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | DOUBLE-STRANDED SIRNA ANALOGUE CONJUGATE |
| WO2023155909A1 (zh) * | 2022-02-18 | 2023-08-24 | 南京明德新药研发有限公司 | 三氮唑核苷类似物及其作为嵌入基团的应用 |
| CN116808058A (zh) * | 2023-07-25 | 2023-09-29 | 徐州医科大学 | Pyrazofurin在制备治疗戊型肝炎疾病药物中的应用 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE29835E (en) * | 1971-06-01 | 1978-11-14 | Icn Pharmaceuticals | 1,2,4-Triazole nucleosides |
| US4211771A (en) * | 1971-06-01 | 1980-07-08 | Robins Ronald K | Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide |
| US3798209A (en) * | 1971-06-01 | 1974-03-19 | Icn Pharmaceuticals | 1,2,4-triazole nucleosides |
| GB1414841A (en) * | 1972-02-11 | 1975-11-19 | Syntex Inc | 2,5-anhydro-dalloses derivatives thereof and c-glycosylnucleosides derived therefrom |
| US3960836A (en) * | 1974-07-22 | 1976-06-01 | Eli Lilly And Company | Acylated derivatives of pyrazofurin and process for their preparation |
| US5102883A (en) * | 1989-10-31 | 1992-04-07 | Du Pont Merck Pharmaceutical Company | Pyrimidine biosynthesis inhibitors useful as immunosuppressive agents |
| ZA931934B (en) * | 1992-03-18 | 1993-03-18 | Us Bioscience | Compostitions of N-(phosphonoacetyl)-L-aspartic acid and methods of their use as broad spectrum antivirals |
| GB9226729D0 (en) * | 1992-12-22 | 1993-02-17 | Wellcome Found | Therapeutic combination |
| US6387365B1 (en) * | 1995-05-19 | 2002-05-14 | Schering Corporation | Combination therapy for chronic hepatitis C infection |
| US5767097A (en) * | 1996-01-23 | 1998-06-16 | Icn Pharmaceuticals, Inc. | Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes |
| US6150337A (en) * | 1996-01-23 | 2000-11-21 | Icn Pharmaceuticals, Inc. | Specific modulation of Th1/Th2 cytokine expression by Ribavirin in activated T-lymphocytes |
| RU2186569C2 (ru) * | 1996-01-23 | 2002-08-10 | Ай-Си-Эн ФАРМАСЬЮТИКАЛЗ | Модуляция экспрессии тн1/тн2 цитокинов рибавирином и аналогами рибавирина в активированных т-лимфоцитах |
| US20020137696A1 (en) * | 1996-01-23 | 2002-09-26 | Robert Tam | Specific modulation of TH1/TH2 cytokine expression by ribavirin in activated T-lymphocytes |
| ATE271063T1 (de) * | 1996-10-16 | 2004-07-15 | Icn Pharmaceuticals | Purin-l-nukleoside, deren analoga und verwendungen |
| IL129126A0 (en) * | 1996-10-16 | 2000-02-17 | Icn Pharmaceuticals | Monocyclic l-nucleosides analogs and uses thereof |
| US6455690B1 (en) * | 1996-10-16 | 2002-09-24 | Robert Tam | L-8-oxo-7-propyl-7,8-dihydro-(9H)-guanosine |
| US6509320B1 (en) * | 1996-10-16 | 2003-01-21 | Icn Pharmaceuticals, Inc. | Purine L-nucleosides, analogs and uses thereof |
| EP0948256A4 (en) * | 1996-10-28 | 2007-10-24 | Univ Washington | INDUCTION OF VIRAL MUTATIONS BY INTRODUCTION TO ERROR-CODED RIBONUCLEOSIDE ANALOGUES IN VIRAL RNA |
| US6887707B2 (en) * | 1996-10-28 | 2005-05-03 | University Of Washington | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA |
| ATE234103T1 (de) * | 1997-12-22 | 2003-03-15 | Schering Corp | Feste, oral verabreichbare ribavirin dosisformen und verfahren zu deren herstellung |
| US6423695B1 (en) * | 1998-01-13 | 2002-07-23 | Ribapharm, Inc. | Cytokine related treatments of disease |
| KR100719606B1 (ko) * | 1998-02-25 | 2007-05-17 | 에모리 유니버시티 | 2'-플루오로뉴클레오사이드 |
| CA2331823A1 (en) * | 1998-05-15 | 1999-11-25 | Schering Corporation | Combination therapy comprising ribavirin and interferon alpha in antiviral treatment naive patients having g chronic hepatitis c infection |
| US6833361B2 (en) * | 1998-05-26 | 2004-12-21 | Ribapharm, Inc. | Nucleosides having bicyclic sugar moiety |
| JP2002527522A (ja) * | 1998-10-16 | 2002-08-27 | シェリング・コーポレーション | 慢性C型肝炎感染を有する患者における検出可能HCV−RNA根絶用リバビリン−インターフェロン−α併用療法 |
| MY125300A (en) * | 1999-02-26 | 2006-07-31 | Inst Of Molecular And Cell Biology | Synergistic combination for treatment of viral-mediated diseases |
| US6455508B1 (en) * | 2000-02-15 | 2002-09-24 | Kanda S. Ramasamy | Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides |
| US7056895B2 (en) * | 2000-02-15 | 2006-06-06 | Valeant Pharmaceuticals International | Tirazole nucleoside analogs and methods for using same |
| US6495677B1 (en) * | 2000-02-15 | 2002-12-17 | Kanda S. Ramasamy | Nucleoside compounds |
| CN1427722A (zh) * | 2000-02-18 | 2003-07-02 | 希拉生物化学股份有限公司 | 用核苷类似物治疗或预防黄病毒感染的方法 |
| EP1964569A3 (en) * | 2000-04-13 | 2009-07-22 | Pharmasset, Inc. | 3'-or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of viral infections |
| MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| KR20080021797A (ko) * | 2000-05-26 | 2008-03-07 | 이데닉스(케이만)리미티드 | 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물 |
| US6815542B2 (en) * | 2000-06-16 | 2004-11-09 | Ribapharm, Inc. | Nucleoside compounds and uses thereof |
| US20030008841A1 (en) * | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
| KR20090089922A (ko) * | 2000-10-18 | 2009-08-24 | 파마셋 인코포레이티드 | 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드 |
| NZ575481A (en) * | 2000-10-18 | 2010-10-29 | Pharmasset Inc | Simultaneous quantification of nucleic acids in diseased cells |
| US7105499B2 (en) * | 2001-01-22 | 2006-09-12 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| WO2002057425A2 (en) * | 2001-01-22 | 2002-07-25 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| GB0112617D0 (en) * | 2001-05-23 | 2001-07-18 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| GB0114286D0 (en) * | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
| JP2005536440A (ja) * | 2001-09-28 | 2005-12-02 | イデニクス(ケイマン)リミテツド | 4’位が修飾されたヌクレオシドを使用するフラビウイルスおよびペスチウイルスの治療のための方法および組成物 |
| AU2002330154A1 (en) * | 2001-09-28 | 2003-04-07 | Centre National De La Recherche Scientifique | Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides |
| KR20040094692A (ko) * | 2002-02-14 | 2004-11-10 | 파마셋, 리미티드 | 변형된 불소화 뉴클레오사이드 유사체 |
| PL374781A1 (en) * | 2002-06-28 | 2005-10-31 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| US20040067877A1 (en) * | 2002-08-01 | 2004-04-08 | Schinazi Raymond F. | 2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections |
| JP2006507235A (ja) * | 2002-08-01 | 2006-03-02 | フアーマセツト・インコーポレイテツド | フラビウイルス科ウイルス感染治療のためのビシクロ[4.2.1]ノナン系を有する化合物 |
-
2004
- 2004-03-29 RU RU2005133093/04A patent/RU2005133093A/ru not_active Application Discontinuation
- 2004-03-29 AU AU2004224575A patent/AU2004224575A1/en not_active Abandoned
- 2004-03-29 CA CA002529311A patent/CA2529311A1/en not_active Abandoned
- 2004-03-29 WO PCT/IB2004/001429 patent/WO2004084796A2/en not_active Ceased
- 2004-03-29 JP JP2006506588A patent/JP2006524227A/ja active Pending
- 2004-03-29 MX MXPA05010419A patent/MXPA05010419A/es not_active Application Discontinuation
- 2004-03-29 BR BRPI0408846-8A patent/BRPI0408846A/pt not_active IP Right Cessation
- 2004-03-29 US US10/812,448 patent/US20050049204A1/en not_active Abandoned
- 2004-03-29 EP EP04724085A patent/EP1626692A4/en not_active Withdrawn
- 2004-03-29 CN CNA2004800117467A patent/CN1980678A/zh active Pending
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