JP2011529070A5 - - Google Patents
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- JP2011529070A5 JP2011529070A5 JP2011520187A JP2011520187A JP2011529070A5 JP 2011529070 A5 JP2011529070 A5 JP 2011529070A5 JP 2011520187 A JP2011520187 A JP 2011520187A JP 2011520187 A JP2011520187 A JP 2011520187A JP 2011529070 A5 JP2011529070 A5 JP 2011529070A5
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- JP
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- Prior art keywords
- methyl
- oxy
- carbonyl
- amino
- formula
- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8362108P | 2008-07-25 | 2008-07-25 | |
| US61/083,621 | 2008-07-25 | ||
| PCT/US2009/051499 WO2010011814A1 (en) | 2008-07-25 | 2009-07-23 | Chemical compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014106310A Division JP5738457B2 (ja) | 2008-07-25 | 2014-05-22 | 化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011529070A JP2011529070A (ja) | 2011-12-01 |
| JP2011529070A5 true JP2011529070A5 (https=) | 2012-09-06 |
| JP5586602B2 JP5586602B2 (ja) | 2014-09-10 |
Family
ID=41570595
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011520187A Active JP5586602B2 (ja) | 2008-07-25 | 2009-07-23 | 化合物 |
| JP2014106310A Active JP5738457B2 (ja) | 2008-07-25 | 2014-05-22 | 化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014106310A Active JP5738457B2 (ja) | 2008-07-25 | 2014-05-22 | 化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US8580967B2 (https=) |
| EP (2) | EP2660239B1 (https=) |
| JP (2) | JP5586602B2 (https=) |
| KR (3) | KR101700267B1 (https=) |
| CN (3) | CN103951643B (https=) |
| ES (2) | ES2562452T3 (https=) |
| PT (1) | PT2660239T (https=) |
| SG (1) | SG192550A1 (https=) |
| WO (1) | WO2010011814A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010011814A1 (en) | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Chemical compounds |
| WO2010067176A1 (en) | 2008-12-11 | 2010-06-17 | Shionogi & Co., Ltd. | Maltol ether processes and intermediates |
| CN102245572B (zh) | 2008-12-11 | 2015-03-25 | 盐野义制药株式会社 | 氨甲酰基吡啶酮hiv整合酶抑制剂的方法和中间体 |
| KR101733625B1 (ko) | 2008-12-11 | 2017-05-10 | 시오노기세야쿠 가부시키가이샤 | 카르바모일피리돈 ｈｉｖ 인테그라제 억제제 및 중간체의 합성 |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| TWI582097B (zh) * | 2010-03-23 | 2017-05-11 | Ｖｉｉｖ醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
| TWI577377B (zh) * | 2010-09-16 | 2017-04-11 | Ｖｉｉｖ醫療保健公司 | 醫藥組合物 |
| DK2620436T3 (en) * | 2010-09-24 | 2018-07-30 | Shionogi & Co | Substituted polycyclic carbamoylpyridone derivative prodrug |
| EA030003B1 (ru) | 2012-12-21 | 2018-06-29 | Джилид Сайэнс, Инк. | Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции |
| ES2859102T3 (es) | 2013-07-12 | 2021-10-01 | Gilead Sciences Inc | Compuestos de carbamoilpiridona policíclica y su uso para el tratamiento de infecciones por VIH |
| NO2865735T3 (https=) | 2013-07-12 | 2018-07-21 | ||
| WO2015108945A2 (en) | 2014-01-14 | 2015-07-23 | Board Of Regents Of The University Of Nebraska | Compositions and methods for the delivery of therapeutics |
| TWI677489B (zh) | 2014-06-20 | 2019-11-21 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| NO2717902T3 (https=) | 2014-06-20 | 2018-06-23 | ||
| WO2016057866A1 (en) | 2014-10-09 | 2016-04-14 | Board Of Regents Of The University Of Nebraska | Compositions and methods for the delivery of therapeutics |
| TWI695003B (zh) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| KR20190057158A (ko) | 2015-04-02 | 2019-05-27 | 길리애드 사이언시즈, 인코포레이티드 | 폴리시클릭-카르바모일피리돈 화합물 및 그의 제약 용도 |
| US11117904B2 (en) * | 2016-06-23 | 2021-09-14 | Viiv Healthcare Company | Compositions and methods for the delivery of therapeutics |
| JP2020527570A (ja) * | 2017-07-18 | 2020-09-10 | ヴィーブ ヘルスケア カンパニー | 組み合わせ薬物療法 |
| CN111386276B (zh) | 2017-10-06 | 2023-06-23 | 盐野义制药株式会社 | 制备取代的多环吡啶酮衍生物的立体选择性方法 |
| TWI795462B (zh) | 2017-11-17 | 2023-03-11 | 日商鹽野義製藥股份有限公司 | 光安定性及溶出性優異的醫藥製劑 |
| CA3126348A1 (en) | 2018-01-12 | 2020-07-18 | Board Of Regents Of The University Of Nebraska | Antiviral prodrugs and formulations thereof |
| US11458136B2 (en) | 2018-04-09 | 2022-10-04 | Board Of Regents Of The University Of Nebraska | Antiviral prodrugs and formulations thereof |
| EP3870174B1 (en) | 2018-10-22 | 2023-11-01 | Board of Regents of the University of Nebraska | Antiviral prodrugs and nanoformulations thereof |
| CN120535538A (zh) | 2018-11-29 | 2025-08-26 | 内布拉斯加大学董事会 | 抗病毒前药及其纳米制剂 |
| MY201239A (en) | 2019-03-22 | 2024-02-13 | Gilead Sciences Inc | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
| WO2020221294A1 (zh) * | 2019-04-30 | 2020-11-05 | 上海拓界生物医药科技有限公司 | 桥环-3,4-二氢-吡啶并[1,2-a]吡嗪-1,8-二酮化合物及其药物用途 |
| WO2021129602A1 (zh) * | 2019-12-23 | 2021-07-01 | 石家庄迪斯凯威医药科技有限公司 | 取代的多环化合物及其药物组合物和用途 |
| PE20221569A1 (es) | 2020-02-24 | 2022-10-06 | Gilead Sciences Inc | Compuestos tetraciclicos para el tratamiento de infecciones por vih |
| ES3064867T3 (en) | 2020-09-30 | 2026-04-29 | Gilead Sciences Inc | Bridged tricyclic carbamoylpyridone compounds for a use in the treatment of hiv |
| CN114426540B (zh) * | 2020-10-29 | 2024-04-26 | 上海拓界生物医药科技有限公司 | 吡啶并[1,2-a]吡嗪-1,8-二酮类前药衍生物、其制备方法及其应用 |
| US11613546B2 (en) | 2021-01-19 | 2023-03-28 | Gilead Sciences, Inc. | Substituted pyridotriazine compounds and uses thereof |
| MX2023009445A (es) * | 2021-02-16 | 2023-08-25 | Merck Sharp & Dohme Llc | Compuestos de heterociclos tetraciclicos utiles como inhibidores de la integrasa del vih. |
| TW202446773A (zh) | 2022-04-06 | 2024-12-01 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| CN120424092B (zh) * | 2025-07-02 | 2025-09-12 | 中国人民解放军军事科学院军事医学研究院 | 布尼亚病毒抑制剂及其制备方法和用途 |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US1544199A (en) * | 1922-08-21 | 1925-06-30 | Herman Christensen | Condenser |
| GB427857A (en) | 1934-08-02 | 1935-05-01 | Newsum Sons & Company Ltd H | A new or improved system of construction for skeleton structures, particularly vehicle body frames and door frames |
| US4524149A (en) * | 1982-03-15 | 1985-06-18 | Sterling Drug Inc. | 5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and their cardiotonic use |
| US4769380A (en) * | 1983-04-29 | 1988-09-06 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates |
| US4603144A (en) | 1984-08-16 | 1986-07-29 | G. D. Searle & Co. | Kojic acid ether-ester derivatives |
| US4812474A (en) * | 1984-08-16 | 1989-03-14 | G. D. Searle & Co. | Kojic acid ether-ester derivatives |
| US4735964A (en) * | 1984-08-16 | 1988-04-05 | G. D. Searle & Co. | Kojic acid ether-ester derivatives |
| CA1317298C (en) * | 1987-03-03 | 1993-05-04 | Upjohn Company (The) | Antibiotic sulfonylaminocarbonyl activated .beta.-lactams |
| GB2280435A (en) | 1993-07-29 | 1995-02-01 | Merck & Co Inc | Anti-viral agent |
| ES2244967T3 (es) * | 1995-09-29 | 2005-12-16 | Novartis Ag | Nuevas hidroxipiridinonas. |
| GB9711093D0 (en) | 1997-05-29 | 1997-07-23 | British Tech Group | Novel orally active iron (III) chelators |
| US6452008B2 (en) * | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
| US7256286B2 (en) * | 1999-11-30 | 2007-08-14 | The Board Of Trustees Of The Leland Stanford Junior University | Bryostatin analogues, synthetic methods and uses |
| US6939883B2 (en) * | 2001-08-02 | 2005-09-06 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| US6426418B1 (en) * | 2001-11-02 | 2002-07-30 | Apotex, Inc. | Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide |
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| CA2498111A1 (en) | 2002-09-11 | 2004-03-25 | Merck & Co., Inc. | Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors |
| WO2004035577A2 (en) * | 2002-10-16 | 2004-04-29 | Gilead Sciences, Inc. | Pre-organized tricyclic integrase inhibitor compounds |
| TW200510425A (en) * | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| DE10349500A1 (de) | 2003-10-23 | 2005-06-02 | Bayer Cropscience Ag | Verfahren zum Herstellen von 2-Dihalogenacyl-3-amino-acrylsäureestern und 3-Dihalogenmethyl-pyrazol-4-carbonsäureestern |
| JP4847677B2 (ja) * | 2003-10-28 | 2011-12-28 | 富士通株式会社 | 化合物半導体装置の製造方法 |
| JP2005134333A (ja) * | 2003-10-31 | 2005-05-26 | Espec Corp | 気体流量測定装置、及び気体流量測定方法 |
| NZ529657A (en) * | 2003-11-20 | 2004-07-30 | Apotex Inc | Iron chelating cycloalkyl derivatives of 3-hydroxy-4-pyridinones |
| US20070161639A1 (en) | 2004-03-09 | 2007-07-12 | Philip Jones | Hiv integrase inhibitors |
| US7820680B2 (en) | 2004-03-09 | 2010-10-26 | Merck & Co., Inc. | HIV integrase inhibitors |
| WO2005117904A2 (en) * | 2004-04-14 | 2005-12-15 | Gilead Sciences, Inc. | Phosphonate analogs of hiv integrase inhibitor compounds |
| WO2005110399A2 (en) * | 2004-04-29 | 2005-11-24 | The Regents Of The University Of California | Zinc-binding groups for metalloprotein inhibitors |
| US6994683B1 (en) * | 2004-08-04 | 2006-02-07 | David Starr | Portable lumbar traction device |
| JP4953297B2 (ja) * | 2004-09-15 | 2012-06-13 | 塩野義製薬株式会社 | Ｈｉｖインテグラーゼ阻害活性を有するカルバモイルピリドン誘導体 |
| US20060066414A1 (en) * | 2004-09-28 | 2006-03-30 | Rockwell Scientific Licensing, Llc | Method and apparatus for changing the polarization of a signal |
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| CA2488034C (en) * | 2004-11-19 | 2009-10-06 | Apotex Inc. | Process for the manufacture of 3-hydroxy-n-alkyl-1-cycloalkyl-6-alkyl-4-oxo-1,4-dihydropyridine-2-carboxamide and its related analogues |
| WO2006066414A1 (en) | 2004-12-23 | 2006-06-29 | Virochem Pharma Inc. | Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase |
| ATE516026T1 (de) | 2005-02-21 | 2011-07-15 | Shionogi & Co | Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkung |
| US7730384B2 (en) * | 2005-02-28 | 2010-06-01 | Agere Systems Inc. | Method and apparatus for evaluating performance of a read channel |
| US20060246196A1 (en) | 2005-04-27 | 2006-11-02 | Lawson John A | Low-alcohol, low-calorie wine |
| UA96568C2 (en) * | 2005-04-28 | 2011-11-25 | Глаксосмиткляйн Ллк | Polycyclic carbamoyl pyridone derivative as hiv-integrase inhibitor |
| KR101363875B1 (ko) * | 2005-04-28 | 2014-02-21 | 시오노기세야쿠 가부시키가이샤 | Ｈｉｖ 통합효소 억제 활성을 가지는 다환식카르바모일피리돈 유도체 |
| AR057023A1 (es) | 2005-05-16 | 2007-11-14 | Gilead Sciences Inc | Compuestos heterociclicos con propiedades inhibidoras de hiv-integrasa |
| JP2006342115A (ja) | 2005-06-10 | 2006-12-21 | Shionogi & Co Ltd | Ｈｉｖインテグラーゼ阻害活性を有する多環性化合物 |
| US20100098640A1 (en) * | 2005-06-20 | 2010-04-22 | Cohen Seth M | Multidentate Pyrone-Derived Chelators for Medicinal Imaging and Chelation |
| JP2007056107A (ja) * | 2005-08-23 | 2007-03-08 | Sumitomo Rubber Ind Ltd | タイヤ用ゴム組成物およびそれからなる補強層を有するランフラットタイヤ |
| EP1762250A1 (en) * | 2005-09-12 | 2007-03-14 | Fresenius Kabi Deutschland GmbH | Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine |
| MX2008005137A (es) * | 2005-10-27 | 2008-09-29 | Shionogi & Co | Derivado de carbamoilpiridona policiclica que tiene actividad inhibidora en vih integrasa. |
| GB0623768D0 (en) * | 2006-11-28 | 2007-01-10 | Chopra Sunil | A bleomycin preparation for use against skin tumours |
| WO2008071387A1 (en) | 2006-12-11 | 2008-06-19 | Topotarget A/S | Prodrugs of diphenyl ox- indol- 2 -one compounds for the treatment of cancers |
| JP5074042B2 (ja) * | 2007-01-10 | 2012-11-14 | Ｈｏｙａ株式会社 | 情報記録媒体基板用素材、情報記録媒体基板、情報記録媒体それぞれの製造方法 |
| MX2009008531A (es) | 2007-02-16 | 2009-08-26 | Amgen Inc | Cetonas de heterociclilo que contienen nitrogeno y su uso como inhibidores de c-met. |
| ES2448766T3 (es) * | 2008-07-25 | 2014-03-17 | Viiv Healthcare Company | Profármacos de dolutegravir |
| JP5551697B2 (ja) * | 2008-07-25 | 2014-07-16 | ビーブ・ヘルスケア・カンパニー | 化合物 |
| WO2010011814A1 (en) | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Chemical compounds |
| US8309008B2 (en) * | 2008-10-30 | 2012-11-13 | Molecular Imprints, Inc. | Separation in an imprint lithography process |
| KR101733625B1 (ko) * | 2008-12-11 | 2017-05-10 | 시오노기세야쿠 가부시키가이샤 | 카르바모일피리돈 ｈｉｖ 인테그라제 억제제 및 중간체의 합성 |
| CN102245572B (zh) * | 2008-12-11 | 2015-03-25 | 盐野义制药株式会社 | 氨甲酰基吡啶酮hiv整合酶抑制剂的方法和中间体 |
| TWI518084B (zh) * | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Ｖｉｉｖ醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
| ES2608377T3 (es) | 2010-08-05 | 2017-04-10 | Shionogi & Co., Ltd. | Procedimiento de preparación de un compuesto que tiene actividad inhibidora de la integrasa del HIV |
-
2009
- 2009-07-23 WO PCT/US2009/051499 patent/WO2010011814A1/en not_active Ceased
- 2009-07-23 CN CN201310734307.XA patent/CN103951643B/zh active Active
- 2009-07-23 KR KR1020167033294A patent/KR101700267B1/ko active Active
- 2009-07-23 EP EP13178055.3A patent/EP2660239B1/en active Active
- 2009-07-23 EP EP09800991.3A patent/EP2320909B8/en active Active
- 2009-07-23 US US13/054,847 patent/US8580967B2/en active Active
- 2009-07-23 CN CN200980135216.6A patent/CN102149385B/zh active Active
- 2009-07-23 ES ES09800991.3T patent/ES2562452T3/es active Active
- 2009-07-23 KR KR1020117004493A patent/KR101695807B1/ko active Active
- 2009-07-23 SG SG2013056528A patent/SG192550A1/en unknown
- 2009-07-23 PT PT131780553T patent/PT2660239T/pt unknown
- 2009-07-23 JP JP2011520187A patent/JP5586602B2/ja active Active
- 2009-07-23 ES ES13178055.3T patent/ES2607403T3/es active Active
- 2009-07-23 KR KR1020167033296A patent/KR101772610B1/ko active Active
- 2009-07-23 CN CN201510553892.2A patent/CN105198804B/zh active Active
-
2013
- 2013-10-02 US US14/044,258 patent/US8940912B2/en active Active
- 2013-10-02 US US14/044,285 patent/US8765965B2/en active Active
-
2014
- 2014-05-20 US US14/282,049 patent/US8981129B2/en active Active
- 2014-05-21 US US14/283,465 patent/US9012650B2/en active Active
- 2014-05-22 JP JP2014106310A patent/JP5738457B2/ja active Active
-
2015
- 2015-03-17 US US14/660,063 patent/US9133216B2/en active Active
- 2015-08-05 US US14/818,539 patent/US9707246B2/en active Active
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