JP2016531895A5 - - Google Patents
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- Publication number
- JP2016531895A5 JP2016531895A5 JP2016520004A JP2016520004A JP2016531895A5 JP 2016531895 A5 JP2016531895 A5 JP 2016531895A5 JP 2016520004 A JP2016520004 A JP 2016520004A JP 2016520004 A JP2016520004 A JP 2016520004A JP 2016531895 A5 JP2016531895 A5 JP 2016531895A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- conjugate according
- patient
- polyethylene glycol
- peg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361887111P | 2013-10-04 | 2013-10-04 | |
| US61/887,111 | 2013-10-04 | ||
| PCT/US2014/059146 WO2015051307A1 (en) | 2013-10-04 | 2014-10-03 | Slow-release conjugates of sn-38 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019010029A Division JP6842479B2 (ja) | 2013-10-04 | 2019-01-24 | Ｓｎ−３８の徐放性コンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016531895A JP2016531895A (ja) | 2016-10-13 |
| JP2016531895A5 true JP2016531895A5 (https=) | 2017-11-09 |
| JP6473145B2 JP6473145B2 (ja) | 2019-02-20 |
Family
ID=51871275
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016520004A Active JP6473145B2 (ja) | 2013-10-04 | 2014-10-03 | Ｓｎ−３８の徐放性コンジュゲート |
| JP2019010029A Active JP6842479B2 (ja) | 2013-10-04 | 2019-01-24 | Ｓｎ−３８の徐放性コンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019010029A Active JP6842479B2 (ja) | 2013-10-04 | 2019-01-24 | Ｓｎ−３８の徐放性コンジュゲート |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10016411B2 (https=) |
| EP (1) | EP3052101B1 (https=) |
| JP (2) | JP6473145B2 (https=) |
| KR (1) | KR102320753B1 (https=) |
| CN (1) | CN106061483B (https=) |
| AU (2) | AU2014331591B2 (https=) |
| BR (1) | BR112016007410B1 (https=) |
| CA (1) | CA2925132C (https=) |
| DK (1) | DK3052101T3 (https=) |
| ES (1) | ES2759905T3 (https=) |
| MX (1) | MX371201B (https=) |
| SG (2) | SG10201811365RA (https=) |
| TW (1) | TWI716342B (https=) |
| WO (1) | WO2015051307A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3052101T3 (da) * | 2013-10-04 | 2019-12-16 | Prolynx Llc | Konjugater af sn-38 med langsom frigivelse |
| CN107375288B (zh) * | 2016-05-16 | 2019-08-23 | 博瑞生物医药（苏州）股份有限公司 | 多臂的聚合靶向抗癌偶联物 |
| EP3613792B1 (en) | 2017-04-21 | 2021-02-24 | Bright Gene Bio-Medical Technology Co., Ltd. | Multi-arm targeted anti-cancer conjugate |
| MX2020007306A (es) * | 2018-01-12 | 2020-09-25 | Prolynx Llc | Tratamiento sinergico de cancer. |
| JP7546552B2 (ja) | 2018-09-17 | 2024-09-06 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア | ポリマーベースの高分子プロドラッグ |
| WO2020206358A1 (en) | 2019-04-05 | 2020-10-08 | Prolynx Llc | Improved conjugation linkers |
| CN114615978A (zh) * | 2019-08-28 | 2022-06-10 | 普罗林科斯有限责任公司 | Dna损伤响应的偶联抑制剂 |
| IL301558A (en) | 2020-09-28 | 2023-05-01 | Fundacio Inst De Recerca Biomedica Irb Barcelona | Peptidic conjugates of sn38 useful in the treatment of cancer |
| US11976196B2 (en) * | 2021-04-14 | 2024-05-07 | Cambridge Crops, Inc. | Silk packaging applications |
| IL315988A (en) | 2022-03-28 | 2024-11-01 | Sant Joan De Deu Hospital | Peptidic water-soluble delivery system of anticancer drugs |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6011042A (en) * | 1997-10-10 | 2000-01-04 | Enzon, Inc. | Acyl polymeric derivatives of aromatic hydroxyl-containing compounds |
| US20040176270A1 (en) * | 2002-07-12 | 2004-09-09 | Biomarin Pharmaceutical Inc. | Use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates |
| EP1580216B1 (en) | 2002-10-31 | 2014-05-14 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight derivatives of camptothecins |
| US20040247624A1 (en) * | 2003-06-05 | 2004-12-09 | Unger Evan Charles | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
| ES2629696T3 (es) * | 2003-09-17 | 2017-08-14 | Nektar Therapeutics | Profármacos poliméricos multibrazo |
| US7462627B2 (en) | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| MX2009002855A (es) * | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Profarmacos polimericos dirigidos que contienen enlazadores multifuncionales. |
| CA2738807A1 (en) * | 2008-10-21 | 2010-04-29 | Enzon Pharmaceuticals, Inc. | Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| JP2012509469A (ja) | 2008-11-18 | 2012-04-19 | バクスター・インターナショナル・インコーポレイテッド | ポリエチレングリコールサンプルの多分散度および／または分子量分布を決定する方法 |
| WO2010138719A1 (en) | 2009-05-28 | 2010-12-02 | Mersana Therapeutics, Inc. | Polyal drug conjugates comprising variable rate-releasing linkers |
| ME03396B (me) * | 2009-11-18 | 2020-01-20 | Nektar Therapeutics | Oblici kisele soli konjugata polimer-lek |
| US8703907B2 (en) * | 2010-05-05 | 2014-04-22 | Prolynx Llc | Controlled drug release from dendrimers |
| EP2566335B1 (en) | 2010-05-05 | 2016-06-29 | Prolynx Llc | Controlled release of active compounds from macromolecular conjugates |
| JP2012000072A (ja) * | 2010-06-18 | 2012-01-05 | Japan Health Science Foundation | 新規な抗フィブリン抗体 |
| TW201215412A (en) * | 2010-08-30 | 2012-04-16 | Sun Pharma Advanced Res Co Ltd | Stable pharmaceutical composition |
| WO2012088282A1 (en) * | 2010-12-21 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds |
| WO2013036857A1 (en) * | 2011-09-07 | 2013-03-14 | Prolynx Llc | Sulfone linkers |
| DK3052101T3 (da) * | 2013-10-04 | 2019-12-16 | Prolynx Llc | Konjugater af sn-38 med langsom frigivelse |
-
2014
- 2014-10-03 DK DK14796322.7T patent/DK3052101T3/da active
- 2014-10-03 JP JP2016520004A patent/JP6473145B2/ja active Active
- 2014-10-03 AU AU2014331591A patent/AU2014331591B2/en active Active
- 2014-10-03 MX MX2016004299A patent/MX371201B/es active IP Right Grant
- 2014-10-03 US US15/026,579 patent/US10016411B2/en active Active
- 2014-10-03 EP EP14796322.7A patent/EP3052101B1/en active Active
- 2014-10-03 CA CA2925132A patent/CA2925132C/en active Active
- 2014-10-03 ES ES14796322T patent/ES2759905T3/es active Active
- 2014-10-03 TW TW103134678A patent/TWI716342B/zh active
- 2014-10-03 SG SG10201811365RA patent/SG10201811365RA/en unknown
- 2014-10-03 WO PCT/US2014/059146 patent/WO2015051307A1/en not_active Ceased
- 2014-10-03 SG SG11201602258WA patent/SG11201602258WA/en unknown
- 2014-10-03 KR KR1020167011936A patent/KR102320753B1/ko active Active
- 2014-10-03 CN CN201480062543.4A patent/CN106061483B/zh active Active
- 2014-10-03 BR BR112016007410-6A patent/BR112016007410B1/pt active IP Right Grant
-
2018
- 2018-06-14 US US16/009,078 patent/US10342792B2/en active Active
- 2018-11-01 AU AU2018256608A patent/AU2018256608A1/en not_active Abandoned
-
2019
- 2019-01-24 JP JP2019010029A patent/JP6842479B2/ja active Active
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