JP2017525718A5 - - Google Patents
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- Publication number
- JP2017525718A5 JP2017525718A5 JP2017510576A JP2017510576A JP2017525718A5 JP 2017525718 A5 JP2017525718 A5 JP 2017525718A5 JP 2017510576 A JP2017510576 A JP 2017510576A JP 2017510576 A JP2017510576 A JP 2017510576A JP 2017525718 A5 JP2017525718 A5 JP 2017525718A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- unit dosage
- oral unit
- form composition
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 40
- 239000000203 mixture Substances 0.000 claims 35
- 239000002552 dosage form Substances 0.000 claims 33
- 229930003427 Vitamin E Natural products 0.000 claims 16
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 16
- 229940046009 vitamin E Drugs 0.000 claims 16
- 239000011709 vitamin E Substances 0.000 claims 16
- 235000019165 vitamin E Nutrition 0.000 claims 16
- 239000000546 pharmaceutical excipient Substances 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 11
- -1 elixir Substances 0.000 claims 10
- 229920001223 polyethylene glycol Polymers 0.000 claims 10
- 239000002202 Polyethylene glycol Substances 0.000 claims 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 8
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 8
- 229960000984 tocofersolan Drugs 0.000 claims 8
- 239000002076 α-tocopherol Substances 0.000 claims 8
- 235000004835 α-tocopherol Nutrition 0.000 claims 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- 125000001020 α-tocopherol group Chemical group 0.000 claims 5
- 239000002775 capsule Substances 0.000 claims 4
- 239000006184 cosolvent Substances 0.000 claims 4
- 229940057847 polyethylene glycol 600 Drugs 0.000 claims 4
- 239000003586 protic polar solvent Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 206010019860 Hereditary angioedema Diseases 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 3
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical group N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 229940124532 absorption promoter Drugs 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000006186 oral dosage form Substances 0.000 claims 2
- 229940113116 polyethylene glycol 1000 Drugs 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid group Chemical group C(CCC(=O)O)(=O)O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 2
- 239000006188 syrup Substances 0.000 claims 2
- 235000020357 syrup Nutrition 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims 2
- 102000003827 Plasma Kallikrein Human genes 0.000 claims 1
- 108090000113 Plasma Kallikrein Proteins 0.000 claims 1
- 208000005707 acquired angioedema Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000001384 succinic acid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462040836P | 2014-08-22 | 2014-08-22 | |
| US62/040,836 | 2014-08-22 | ||
| PCT/US2015/046578 WO2016029214A1 (en) | 2014-08-22 | 2015-08-24 | Compositions and uses of amidine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017525718A JP2017525718A (ja) | 2017-09-07 |
| JP2017525718A5 true JP2017525718A5 (https=) | 2018-09-27 |
| JP6824876B2 JP6824876B2 (ja) | 2021-02-03 |
Family
ID=54012341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017510576A Active JP6824876B2 (ja) | 2014-08-22 | 2015-08-24 | アミジン誘導体組成物及びそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10905683B2 (https=) |
| EP (1) | EP3182962B1 (https=) |
| JP (1) | JP6824876B2 (https=) |
| AU (1) | AU2015305214B2 (https=) |
| CA (1) | CA2959026C (https=) |
| DK (1) | DK3182962T3 (https=) |
| ES (1) | ES2954451T3 (https=) |
| WO (1) | WO2016029214A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
| GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
| IL263235B (en) | 2016-05-31 | 2022-07-01 | Kalvista Pharmaceuticals Ltd | History of pyrazoles as plasma kallikrein inhibitors |
| GB201609603D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
| GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
| CN106632223B (zh) * | 2016-08-24 | 2019-04-23 | 浙江美诺华药物化学有限公司 | 2-(3-溴-4-(3-氟苄氧基)苯基)-1,3-二氧戊环及其制备方法 |
| CN106565442B (zh) * | 2016-08-24 | 2019-07-16 | 浙江美诺华药物化学有限公司 | 3-(3-氟苄基)-4-(3-氟苄氧基)苯甲醛的制备方法 |
| CN106565521B (zh) * | 2016-08-24 | 2019-03-08 | 浙江美诺华药物化学有限公司 | (s)-2-[3-(3-氟苄基)-4-(3-氟苄氧基)苄氨基]丙酰胺及其盐的制备方法 |
| AU2017348305B2 (en) * | 2016-10-31 | 2022-04-21 | Biocryst Pharmaceuticals, Inc. | Prodrugs of kallikrein inhibitors |
| CN106977382A (zh) * | 2017-04-28 | 2017-07-25 | 山东新华制药股份有限公司 | 4‑（3‑氟苄氧基）苯甲醛的制备方法 |
| GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
| HUE057912T2 (hu) | 2017-11-29 | 2022-06-28 | Kalvista Pharmaceuticals Ltd | Plazma kallikrein inhibitort tartalmazó dózisformák |
| JP7668227B2 (ja) * | 2019-04-08 | 2025-04-24 | バイオクライスト ファーマシューティカルズ， インコーポレイテッド | 血漿カリクレイン阻害剤および眼障害におけるその使用方法 |
| WO2021028645A1 (en) | 2019-08-09 | 2021-02-18 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| WO2022006232A2 (en) * | 2020-07-01 | 2022-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Drug repurposing for treatment of viral infections |
| MX2023009293A (es) * | 2021-02-09 | 2023-10-06 | Phebra Pty Ltd | Metodo para preparar una composicion farmaceutica topica. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1540979A (en) | 1923-04-11 | 1925-06-09 | Swift & Co | Machine for testing jelly strength of glues, gelatins, and the like |
| MXPA03009130A (es) | 2000-10-20 | 2004-02-26 | Biocryst Pharm Inc | Compuestos de biarilo que funcionan como inhibidores de proteasa serina. |
| RU2003132706A (ru) * | 2001-04-06 | 2005-04-20 | Байокрист Фармасьютикалз, Инк. (Us) | Диариловые соединения в качестве ингибиторов сериновых протеаз |
| CA3061802C (en) * | 2011-09-08 | 2022-04-05 | Intrexon Corporation | Crystalline diacylhydrazine and the use thereof |
| US20150273027A1 (en) * | 2012-10-10 | 2015-10-01 | Novo Nordisk Healthcare Ag | Liquid pharmaceutical composition of factor vii polypeptide |
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2015
- 2015-08-24 US US15/505,534 patent/US10905683B2/en active Active
- 2015-08-24 CA CA2959026A patent/CA2959026C/en active Active
- 2015-08-24 WO PCT/US2015/046578 patent/WO2016029214A1/en not_active Ceased
- 2015-08-24 AU AU2015305214A patent/AU2015305214B2/en active Active
- 2015-08-24 DK DK15756791.8T patent/DK3182962T3/da active
- 2015-08-24 ES ES15756791T patent/ES2954451T3/es active Active
- 2015-08-24 JP JP2017510576A patent/JP6824876B2/ja active Active
- 2015-08-24 EP EP15756791.8A patent/EP3182962B1/en active Active