UA96568C2 - Polycyclic carbamoyl pyridone derivative as hiv-integrase inhibitor - Google Patents

Polycyclic carbamoyl pyridone derivative as hiv-integrase inhibitor

Info

Publication number
UA96568C2
UA96568C2 UAA200711345A UAA200711345A UA96568C2 UA 96568 C2 UA96568 C2 UA 96568C2 UA A200711345 A UAA200711345 A UA A200711345A UA A200711345 A UAA200711345 A UA A200711345A UA 96568 C2 UA96568 C2 UA 96568C2
Authority
UA
Ukraine
Prior art keywords
hiv
compound
ris
integrase inhibitor
optionally substituted
Prior art date
Application number
UAA200711345A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Брайан Элвин Джонс
Такаси Кавасудзи
Теругико Тайси
Йосиюки Таода
Original Assignee
Глаксосмиткляйн Ллк
Сёноги Энд Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39612449&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA96568(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Глаксосмиткляйн Ллк, Сёноги Энд Ко., Лтд. filed Critical Глаксосмиткляйн Ллк
Publication of UA96568C2 publication Critical patent/UA96568C2/en

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The present invention is to provide a novel compound (I), having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. Compound (I) wherein Zis NR; Ris hydrogen or lower alkyl; X is a single bond, a hetero atom group selected from O, S, SO, SOand NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene; Ris optionally substituted aryl; Ris hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc; and Rand Zpart taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound., (I)
UAA200711345A 2005-04-28 2006-04-28 Polycyclic carbamoyl pyridone derivative as hiv-integrase inhibitor UA96568C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005131161 2005-04-28

Publications (1)

Publication Number Publication Date
UA96568C2 true UA96568C2 (en) 2011-11-25

Family

ID=39612449

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200711345A UA96568C2 (en) 2005-04-28 2006-04-28 Polycyclic carbamoyl pyridone derivative as hiv-integrase inhibitor

Country Status (3)

Country Link
CN (1) CN101212903B (en)
UA (1) UA96568C2 (en)
ZA (1) ZA200708970B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101695807B1 (en) * 2008-07-25 2017-01-13 비이브 헬쓰케어 컴퍼니 Chemical compounds
ES2964383T3 (en) * 2008-12-11 2024-04-05 Viiv Healthcare Co Processes and intermediates for carbamoylpyridone HIV integrase inhibitors
WO2010147068A1 (en) * 2009-06-15 2010-12-23 塩野義製薬株式会社 Substituted polycyclic carbamoylpyridone derivative
KR20170078868A (en) * 2010-01-27 2017-07-07 비이브 헬쓰케어 컴퍼니 Antibiral therapy
TWI582097B (en) * 2010-03-23 2017-05-11 Ｖｉｉｖ醫療保健公司 Process for preparing carbamoylpyridone derivatives and intermediates
CN103154004B (en) * 2010-08-05 2016-07-06 盐野义制药株式会社 There is the manufacture method of the compound of hiv integrase inhibitory activity
MX2013003139A (en) * 2010-09-24 2013-06-18 Shionogi & Co Substituted polycyclic carbamoyl pyridone derivative prodrug.
AP2016009157A0 (en) * 2013-09-27 2016-04-30 Merck Sharp & Dohme Substituted quinolizine derivatives useful as hiv integrase inhibitors
NO2717902T3 (en) * 2014-06-20 2018-06-23
ES2837383T3 (en) * 2015-04-02 2021-06-30 Gilead Sciences Inc Polycyclic carbamoylpyridone compounds and their pharmaceutical use
CN109789144B (en) * 2016-08-12 2022-04-15 马德拉医疗公司 Protein kinase modulators
CN106565747A (en) * 2016-11-10 2017-04-19 顾世海 Novel method for preparing dolutegravir
JOP20190130A1 (en) * 2016-12-02 2019-06-02 Merck Sharp & Dohme Tetracyclic heterocycle compounds useful as hiv integrase inhibitors
CN108250215B (en) * 2016-12-28 2022-04-19 华创合成制药股份有限公司 Novel anti-HIV medicine, preparation method and application thereof
US11040986B2 (en) * 2017-02-16 2021-06-22 Sandoz Ag Crystalline forms of cabotegravir sodium
CN110526930B (en) * 2018-05-23 2022-06-03 莫云芬 anti-HIV (human immunodeficiency virus) sulfur-containing polycyclic-hydroxypyridone formamide analogue and application thereof
CN113795491B (en) * 2019-04-30 2024-09-03 上海拓界生物医药科技有限公司 Bridged ring-3, 4-dihydro-pyrido [1,2-a ] pyrazine-1, 8-dione compounds and pharmaceutical uses thereof
CN114426540B (en) * 2020-10-29 2024-04-26 上海拓界生物医药科技有限公司 Pyrido [1,2-a ] pyrazine-1, 8-dione prodrug derivatives, preparation method and application thereof
TW202227445A (en) * 2020-10-30 2022-07-16 大陸商上海拓界生物醫藥科技有限公司 Use of inhibiting genetically defective hiv virus
WO2022253294A1 (en) * 2021-06-03 2022-12-08 江苏恒瑞医药股份有限公司 Pyridone compound having integrase inhibitory activity and pharmaceutical use thereof
CN114230579A (en) * 2021-11-12 2022-03-25 南京艾迪医药科技有限公司 Polycyclic carbamoylpyridone derivatives, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CN101212903B (en) 2013-07-24
ZA200708970B (en) 2008-07-30
CN101212903A (en) 2008-07-02

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