JP2020527570A - 組み合わせ薬物療法 - Google Patents
組み合わせ薬物療法 Download PDFInfo
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- JP2020527570A JP2020527570A JP2020502228A JP2020502228A JP2020527570A JP 2020527570 A JP2020527570 A JP 2020527570A JP 2020502228 A JP2020502228 A JP 2020502228A JP 2020502228 A JP2020502228 A JP 2020502228A JP 2020527570 A JP2020527570 A JP 2020527570A
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- 230000003612 virological effect Effects 0.000 description 1
- WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 description 1
- 229960000237 vorinostat Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229960000523 zalcitabine Drugs 0.000 description 1
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- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
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Abstract
Description
本発明者らは、薬剤単独又は他の点では同様の薬剤の以前の組み合わせよりも改善された特性を提供するHIV阻害剤の特定の組み合わせを同定した。特に、インテグラーゼ鎖転移阻害剤(INSTI)、カボテグラビル(cabotegravir)又はその薬学的に許容可能な塩若しくは溶媒和物を、ヌクレオシド逆転写酵素移動阻害剤(NRTTI)、4'-エチニル-2-フルオロ-2'-デオキシアデノシン(EFdA(MK-8591)として知られる)又はその薬学的に許容可能な塩若しくは溶媒和物と共に含む組み合わせ、それを含む医薬組成物、並びにHIVインテグラーゼ若しくは逆転写酵素の阻害が有益である状態(例えば、HIV)の治療におけるそのような組み合わせ及び組成物の使用方法が本明細書に記載される。
(i)式(I)
(i)式(I):
(i)式(I):
(i)式(I):
(i)式(I):
(i)治療有効量の式(I)
定義
本明細書で使用される場合、用語「同時投与する」は、例えば、臨床治療レジメンの一部としての、互いに24時間以内の2つ以上の薬剤の投与を指す。他の実施形態では、「同時投与する」は、互いに2時間以内の2つ以上の薬剤の投与を指す。他の実施形態では、「同時投与する」は、互いに30分以内の2つ以上の薬剤の投与を指す。他の実施形態では、「同時投与する」は、互いに15分以内の2つ以上の薬剤の投与を指す。他の実施形態では、「同時投与する」は、単一の製剤の一部として、又は同じ若しくは異なる経路によって投与される複数の製剤としてのいずれかで、同時に投与することを指す。
特定の実施形態では、化合物A及び化合物Bは、例えば経口投与のための固体投薬形態として、患者への同時投与のための単一投薬形態中にある。同時投与は、一般に、治療有効量の化合物が両方とも患者の体内に存在するような同時又は連続投与を指す。
Claims (13)
- 化合物(i)が、ナトリウム塩の形態におけるものである、請求項1に記載の組み合わせ。
- HIVの治療のための医薬の製造における、請求項1〜2のいずれか一項に記載の組み合わせの使用。
- 療法に使用するための、請求項1〜2のいずれか一項に記載の組み合わせ。
- HIVの治療に使用するための、請求項4に記載の組み合わせ。
- 請求項1に記載の組み合わせを、薬学的に許容可能な希釈剤又は担体と共に含む、医薬組成物。
- 化合物(i)が、ナトリウム塩の形態におけるものである、請求項7に記載の方法。
- 化合物(i)又は(ii)のうちの少なくとも1つが、経口的に投与される、請求項7に記載の方法。
- 化合物(i)又は(ii)のうちの少なくとも1つが、非経口的に投与される、請求項7に記載の方法。
- 化合物が、4週毎に1回以下の頻度で投与される、請求項7に記載の方法。
- 化合物が、8週毎に1回以下の頻度で投与される、請求項7に記載の方法。
- 化合物が、単一投薬形態で同時投与される、請求項7に記載の方法。
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US201762533696P | 2017-07-18 | 2017-07-18 | |
US62/533,696 | 2017-07-18 | ||
PCT/IB2018/055257 WO2019016679A1 (en) | 2017-07-18 | 2018-07-16 | COMBINATION THERAPY |
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US (1) | US20200138845A1 (ja) |
EP (1) | EP3655106A4 (ja) |
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WO2020154656A1 (en) | 2019-01-25 | 2020-07-30 | Brown University | Compositions and methods for treating, preventing or reversing age-associated inflammation and disorders |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005090349A1 (ja) * | 2004-03-24 | 2005-09-29 | Yamasa Corporation | 4’−c−置換−2−ハロアデノシン誘導体 |
JP2011529070A (ja) * | 2008-07-25 | 2011-12-01 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 化合物 |
JP2013518107A (ja) * | 2010-01-27 | 2013-05-20 | ヴィーブ ヘルスケア カンパニー | 抗ウイルス療法 |
JP2014500849A (ja) * | 2010-09-16 | 2014-01-16 | ヴィーブ ヘルスケア カンパニー | 医薬組成物 |
JP2015534973A (ja) * | 2012-10-23 | 2015-12-07 | シプラ・リミテッド | 抗レトロウイルス医薬組成物 |
Family Cites Families (4)
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EP1874117B8 (en) * | 2005-04-28 | 2014-03-12 | VIIV Healthcare Company | Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity |
WO2009126293A2 (en) * | 2008-04-11 | 2009-10-15 | Yale University | Potent chimeric nrti-nnrti bifunctional inhibitors of hiv-1 reverse transcriptase |
AU2016328303B2 (en) * | 2015-09-23 | 2019-05-02 | Merck Sharp & Dohme (Uk) Limited | 4'-substituted nucleoside reverse transcriptase inhibitors and preparations thereof |
JOP20170038B1 (ar) * | 2016-02-12 | 2021-08-17 | Merck Sharp & Dohme | مركبات للاستخدام لعلاج عدوى بفيروس hiv والوقاية منه |
-
2018
- 2018-07-16 US US16/631,014 patent/US20200138845A1/en not_active Abandoned
- 2018-07-16 EP EP18834420.4A patent/EP3655106A4/en not_active Withdrawn
- 2018-07-16 JP JP2020502228A patent/JP2020527570A/ja active Pending
- 2018-07-16 WO PCT/IB2018/055257 patent/WO2019016679A1/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005090349A1 (ja) * | 2004-03-24 | 2005-09-29 | Yamasa Corporation | 4’−c−置換−2−ハロアデノシン誘導体 |
JP2011529070A (ja) * | 2008-07-25 | 2011-12-01 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 化合物 |
JP2013518107A (ja) * | 2010-01-27 | 2013-05-20 | ヴィーブ ヘルスケア カンパニー | 抗ウイルス療法 |
JP2014500849A (ja) * | 2010-09-16 | 2014-01-16 | ヴィーブ ヘルスケア カンパニー | 医薬組成物 |
JP2015534973A (ja) * | 2012-10-23 | 2015-12-07 | シプラ・リミテッド | 抗レトロウイルス医薬組成物 |
Non-Patent Citations (2)
Title |
---|
ANTIVIRAL RESEARCH, vol. 137, JPN6022033097, 1 November 2016 (2016-11-01), pages 23 - 40, ISSN: 0005027572 * |
HTTPS://WWW.CROICONFERENCE.ORG/ABSTRACT/LONG-ACTING-ORAL-AND-PARENTERAL-DOSING-MK-8591-HIV-TREATMENT, JPN6022033095, ISSN: 0005027573 * |
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EP3655106A4 (en) | 2021-04-21 |
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US20200138845A1 (en) | 2020-05-07 |
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