CA2523134A1 - Pyridyl substituted ketolide antibiotics - Google Patents

Pyridyl substituted ketolide antibiotics Download PDF

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Publication number
CA2523134A1
CA2523134A1 CA002523134A CA2523134A CA2523134A1 CA 2523134 A1 CA2523134 A1 CA 2523134A1 CA 002523134 A CA002523134 A CA 002523134A CA 2523134 A CA2523134 A CA 2523134A CA 2523134 A1 CA2523134 A1 CA 2523134A1
Authority
CA
Canada
Prior art keywords
substituted
alkyl
hydrogen
compound
previously defined
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002523134A
Other languages
English (en)
French (fr)
Inventor
Matthew Burger
Georgia Carroll
Daniel Chu
Xiaodong Lin
Jacob Plattner
Alice Rico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2523134A1 publication Critical patent/CA2523134A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA002523134A 2003-04-25 2004-04-23 Pyridyl substituted ketolide antibiotics Abandoned CA2523134A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46529403P 2003-04-25 2003-04-25
US60/465,294 2003-04-25
PCT/US2004/012645 WO2004096822A2 (en) 2003-04-25 2004-04-23 Pyridyl substituted ketolide antibiotics

Publications (1)

Publication Number Publication Date
CA2523134A1 true CA2523134A1 (en) 2004-11-11

Family

ID=33418219

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002523134A Abandoned CA2523134A1 (en) 2003-04-25 2004-04-23 Pyridyl substituted ketolide antibiotics

Country Status (5)

Country Link
US (1) US7332476B2 (https=)
EP (1) EP1618119A2 (https=)
JP (1) JP2006524702A (https=)
CA (1) CA2523134A1 (https=)
WO (1) WO2004096822A2 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2552682T3 (es) 2003-03-10 2015-12-01 Merck Sharp & Dohme Corp. Agentes antibacterianos novedosos
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
JP2008508322A (ja) * 2004-07-28 2008-03-21 ランバクシー ラボラトリーズ リミテッド 抗菌剤としてのケトライド誘導体
EP3290427A1 (en) 2005-08-24 2018-03-07 Melinta Therapeutics, Inc. Triazole compounds and methods of making and using the same
CN105732745A (zh) 2007-10-25 2016-07-06 森普拉制药公司 大环内酯类抗菌剂的制备方法
AU2009308182B2 (en) 2008-10-24 2016-05-19 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
CN105198944B (zh) 2010-05-20 2018-06-01 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
EP2613630A4 (en) * 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES
EP2658855A2 (en) 2010-12-31 2013-11-06 Acies Bio d.o.o. Novel polyketide compounds and methods of making same
KR101567658B1 (ko) * 2011-03-01 2015-11-09 욱크하르트 리미티드 케톨리드 중간체의 제조 방법
MX2014011537A (es) 2012-03-27 2015-02-10 Cempra Pharmaceuticals Inc Formulaciones parenterales para la administracion de antibioticos macrolidos.
HK1217665A1 (zh) 2013-03-14 2017-01-20 森普拉制药公司 用於治療呼吸道疾病的方法及其製劑
RU2015138797A (ru) 2013-03-15 2017-04-24 Семпра Фармасьютикалс, Инк. Конвергентные способы получения макролидных антибактериальных агентов
MX2019002444A (es) * 2016-08-29 2019-09-02 Univ Texas Inhibidores de cinasa de cremallera de leucina dual (dlk) para el tratamiento de enfermedades.
JP2019533669A (ja) * 2016-10-04 2019-11-21 バイオファーマティ ソシエテ アノニム 抗菌活性を有するケトライド
JP7128816B2 (ja) 2016-12-08 2022-08-31 ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム 疾患の治療のための二重ロイシンジッパー（ｄｌｋ）キナーゼのビシクロ［１．１．１］ペンタン阻害剤
US11560366B2 (en) 2019-10-21 2023-01-24 Board Of Regents, The University Of Texas System Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857641A (en) 1987-08-14 1989-08-15 Pfizer Inc. C.12 modified erythromycin A derivatives
US6063561A (en) * 1991-01-17 2000-05-16 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
CA2253338C (en) * 1996-05-07 2007-05-08 Abbott Laboratories 6-o-substituted erythromycins and method for making them
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
AU720921B2 (en) 1996-11-27 2000-06-15 Taisho Pharmaceutical Co., Ltd. Erythromycin A derivatives
US6140479A (en) 1997-03-24 2000-10-31 Taisho Pharmaceuticals Co., Ltd. Erythromycin a derivatives
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives

Also Published As

Publication number Publication date
US7332476B2 (en) 2008-02-19
US20050009764A1 (en) 2005-01-13
WO2004096822A3 (en) 2004-12-16
WO2004096822A2 (en) 2004-11-11
EP1618119A2 (en) 2006-01-25
JP2006524702A (ja) 2006-11-02

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