JP2006518765A5 - - Google Patents
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- Publication number
- JP2006518765A5 JP2006518765A5 JP2006503887A JP2006503887A JP2006518765A5 JP 2006518765 A5 JP2006518765 A5 JP 2006518765A5 JP 2006503887 A JP2006503887 A JP 2006503887A JP 2006503887 A JP2006503887 A JP 2006503887A JP 2006518765 A5 JP2006518765 A5 JP 2006518765A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- substituted
- lower alkyl
- hydroxy
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 19
- 229910052739 hydrogen Inorganic materials 0.000 claims description 19
- 239000001257 hydrogen Substances 0.000 claims description 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
- 150000002431 hydrogen Chemical class 0.000 claims description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 229910052760 oxygen Inorganic materials 0.000 claims description 7
- 239000001301 oxygen Substances 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- -1 xanthine epoxide Chemical class 0.000 claims description 5
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 4
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- 125000002947 alkylene group Chemical group 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 239000011593 sulfur Substances 0.000 claims description 4
- LRFVTYWOQMYALW-UHFFFAOYSA-N Xanthine Natural products O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims 3
- 229940075420 xanthine Drugs 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44995303P | 2003-02-24 | 2003-02-24 | |
| US45050003P | 2003-02-25 | 2003-02-25 | |
| US45049903P | 2003-02-25 | 2003-02-25 | |
| US45132603P | 2003-02-28 | 2003-02-28 | |
| US46481503P | 2003-04-21 | 2003-04-21 | |
| US46481203P | 2003-04-21 | 2003-04-21 | |
| US46481103P | 2003-04-21 | 2003-04-21 | |
| US46481303P | 2003-04-21 | 2003-04-21 | |
| PCT/US2004/005755 WO2004075856A2 (en) | 2003-02-24 | 2004-02-24 | Adenosine a1 receptor antagonist for the treatment of cardiac and renal diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006518765A JP2006518765A (ja) | 2006-08-17 |
| JP2006518765A5 true JP2006518765A5 (https=) | 2007-02-22 |
Family
ID=32931788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503887A Pending JP2006518765A (ja) | 2003-02-24 | 2004-02-24 | アデノシンａ１受容体アンタゴニストを使って疾患を処置する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040229901A1 (https=) |
| EP (2) | EP1603545A2 (https=) |
| JP (1) | JP2006518765A (https=) |
| KR (1) | KR20050106038A (https=) |
| AU (1) | AU2004216133B2 (https=) |
| BR (1) | BRPI0407494A (https=) |
| CA (1) | CA2516730A1 (https=) |
| MX (1) | MXPA05008805A (https=) |
| WO (1) | WO2004075856A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2522971A1 (en) * | 2003-04-25 | 2004-11-11 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
| US20060293312A1 (en) * | 2003-04-25 | 2006-12-28 | Howard Dittrich | Method of improved diuresis in individuals with impaired renal function |
| AU2005237466A1 (en) * | 2004-04-16 | 2005-11-10 | Novacardia, Inc. | Combination therapy comprising an adenosine A1 receptor antagonist and an aldosterone inhibitor |
| CN104788540B (zh) * | 2005-09-16 | 2019-10-18 | 科内尔研究基金会 | 用于减少cd36表达的方法 |
| CA2648281A1 (en) * | 2006-04-06 | 2007-10-18 | Novacardia, Inc. | Co-administration of adenosine a1 receptor antagonists and anticonvulsants |
| CN101466383A (zh) * | 2006-06-16 | 2009-06-24 | 美国诺华卡迪亚公司 | 包含低频率投与aa1ra的肾功能延长改善 |
| TW200808819A (en) * | 2006-06-19 | 2008-02-16 | Solvay Pharm Gmbh | Use of adenosine A1 antagonists in radiocontrast media induced nephrophaty |
| WO2008121893A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist |
| WO2008121882A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Improved methods of administration of adenosine a1 receptor antagonists |
| US8722736B2 (en) | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
| US8426467B2 (en) | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
| EP2234609A1 (en) * | 2007-12-27 | 2010-10-06 | Bayer Animal Health GmbH | Treatment of heart disease using -blockers |
| US11291641B2 (en) * | 2016-10-03 | 2022-04-05 | The Children's Medical Center Corporation | Prevention and treatment of diabetic nephropathy |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4769377A (en) * | 1983-02-18 | 1988-09-06 | The Johns Hopkins University | Adenosine receptor antagonists |
| DE8817122U1 (de) * | 1988-12-22 | 1993-02-04 | Boehringer Ingelheim Kg, 55218 Ingelheim | Neue Xanthinderivate mit Adenosinantogenistischer Wirkung |
| JPH06102662B2 (ja) * | 1989-09-01 | 1994-12-14 | 協和醗酵工業株式会社 | キサンチン誘導体 |
| US5290782A (en) * | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
| SE9000207L (sv) * | 1990-01-22 | 1991-07-23 | Nobel Chemicals Ab | Laekemedel samt anvaendningen av detsamma |
| DE4019892A1 (de) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
| AU2297192A (en) * | 1991-06-28 | 1993-01-25 | Sepracor, Inc. | Optically pure s(-) nadolol for treatment of cardiovascular disorders |
| ATE180482T1 (de) * | 1991-11-08 | 1999-06-15 | Kyowa Hakko Kogyo Kk | Xanthinderivate zur behandlung der demenz |
| DE4238367A1 (de) * | 1992-11-13 | 1994-05-19 | Boehringer Ingelheim Kg | Diuretisches Mittel |
| US5395836A (en) * | 1993-04-07 | 1995-03-07 | Kyowa Hakko Kogyo Co., Ltd. | 8-tricycloalkyl xanthine derivatives |
| US5736528A (en) * | 1993-10-28 | 1998-04-07 | University Of Florida Research Foundation, Inc. | N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists |
| US5446046A (en) * | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
| CA2167314A1 (en) * | 1994-05-17 | 1995-11-23 | Junichi Shimada | Process for producing xanthine derivative |
| CN1049117C (zh) * | 1994-09-16 | 2000-02-09 | 赵明玉 | 预防和治疗偏头痛的偏头痛片 |
| DE69628276T2 (de) * | 1995-07-26 | 2004-04-08 | Kyowa Hakko Kogyo Co., Ltd. | Zubereitung von xanthinderivaten als feste dispersion |
| US6210687B1 (en) * | 1996-08-07 | 2001-04-03 | Kyowa Hakko Kogyo Co., Ltd. | Fat emulsion containing xanthine derivative |
| US6187780B1 (en) * | 1998-04-16 | 2001-02-13 | Boehringer Ingelheim Pharma Kg | Assymetrically substituted xanthine derivatives having adenosine A1 antagonistic activity |
| US20020115687A1 (en) * | 1998-04-24 | 2002-08-22 | Evan Beckman | Method and composition for restoring diuretic and renal function |
| UA74141C2 (uk) * | 1998-12-09 | 2005-11-15 | Дж.Д. Сірл Енд Ко. | Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти) |
| SE9903028D0 (sv) * | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| CN100390178C (zh) * | 1999-11-12 | 2008-05-28 | 拜奥根Idec马萨诸塞公司 | 作为腺苷受体拮抗剂的多环烷基嘌呤 |
| HUP0203371A3 (en) * | 1999-11-12 | 2005-02-28 | Biogen Idec Ma Inc Cambridge | Adenosine receptor antagonists and methods of making and using the same |
| US20050038017A1 (en) * | 1999-12-22 | 2005-02-17 | Wolff Andrew A. | Method and composition for restoring diuretic and renal function |
| WO2002009760A2 (en) * | 2000-07-27 | 2002-02-07 | Pharmacia Corporation | Epoxy-steroidal aldosterone antagonist and beta-adrenergic antagonist combination therapy for treatment of congestive heart failure |
| CZ20031513A3 (cs) * | 2000-12-01 | 2003-09-17 | Biogen, Inc. | Kondenzované purinové deriváty jako antagonisty A1 adenosinového receptoru |
| HUP0302455A3 (en) * | 2000-12-18 | 2005-05-30 | Novartis Ag | Combination pharmaceutical compositions containing amplodipine and benazepril and their use |
| UA80258C2 (en) * | 2001-09-06 | 2007-09-10 | Biogen Inc | Methods of treating pulmonary disease |
| CA2522971A1 (en) * | 2003-04-25 | 2004-11-11 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
| US20060293312A1 (en) * | 2003-04-25 | 2006-12-28 | Howard Dittrich | Method of improved diuresis in individuals with impaired renal function |
| US20050070524A1 (en) * | 2003-06-06 | 2005-03-31 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and an anticonvulsant agent for the treatment of central nervous system disorders |
| WO2005105107A2 (en) * | 2004-04-21 | 2005-11-10 | Roby Russell R | Hormone treatment of multiple sclerosis |
| CA2565037A1 (en) * | 2004-04-28 | 2005-11-10 | Cv Therapeutics, Inc. | Purine derivatives as a1 adenosine receptor antagonists |
| CA2648281A1 (en) * | 2006-04-06 | 2007-10-18 | Novacardia, Inc. | Co-administration of adenosine a1 receptor antagonists and anticonvulsants |
| CN101466435A (zh) * | 2006-06-16 | 2009-06-24 | 美国诺华卡迪亚公司 | Kw-3902在充血性心脏衰竭和急性体液超负荷患者中实现利尿作用的用途 |
| CN101466383A (zh) * | 2006-06-16 | 2009-06-24 | 美国诺华卡迪亚公司 | 包含低频率投与aa1ra的肾功能延长改善 |
| EP2061793A2 (en) * | 2006-08-22 | 2009-05-27 | Novacardia, Inc. | Kw-3902 conjugates that do not cross the blood-brain barrier |
-
2004
- 2004-02-23 US US10/785,446 patent/US20040229901A1/en not_active Abandoned
- 2004-02-24 EP EP04714224A patent/EP1603545A2/en not_active Withdrawn
- 2004-02-24 JP JP2006503887A patent/JP2006518765A/ja active Pending
- 2004-02-24 WO PCT/US2004/005755 patent/WO2004075856A2/en not_active Ceased
- 2004-02-24 KR KR1020057015605A patent/KR20050106038A/ko not_active Ceased
- 2004-02-24 CA CA002516730A patent/CA2516730A1/en not_active Abandoned
- 2004-02-24 AU AU2004216133A patent/AU2004216133B2/en not_active Ceased
- 2004-02-24 BR BRPI0407494-7A patent/BRPI0407494A/pt not_active IP Right Cessation
- 2004-02-24 EP EP09160652A patent/EP2087888A1/en not_active Withdrawn
- 2004-02-24 MX MXPA05008805A patent/MXPA05008805A/es not_active Application Discontinuation
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