JP2005527628A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005527628A5 JP2005527628A5 JP2004507466A JP2004507466A JP2005527628A5 JP 2005527628 A5 JP2005527628 A5 JP 2005527628A5 JP 2004507466 A JP2004507466 A JP 2004507466A JP 2004507466 A JP2004507466 A JP 2004507466A JP 2005527628 A5 JP2005527628 A5 JP 2005527628A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrimidin
- diethylamino
- phenylalanine
- ylcarbonyloxy
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 25
- 229960005190 phenylalanine Drugs 0.000 claims 19
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 19
- 201000010099 disease Diseases 0.000 claims 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 125000002393 azetidinyl group Chemical group 0.000 claims 8
- 230000001404 mediated effect Effects 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 8
- 125000003386 piperidinyl group Chemical group 0.000 claims 8
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000001309 chloro group Chemical group Cl* 0.000 claims 6
- 125000001153 fluoro group Chemical group F* 0.000 claims 6
- 239000003937 drug carrier Substances 0.000 claims 5
- 108010008212 Integrin alpha4beta1 Proteins 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 108010044426 integrins Proteins 0.000 claims 4
- 102000006495 integrins Human genes 0.000 claims 4
- -1 2,5-dihydropyrrol-1-yl Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38302002P | 2002-05-24 | 2002-05-24 | |
| PCT/US2003/016804 WO2003099809A1 (en) | 2002-05-24 | 2003-05-27 | HETEROCYCLIC COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY α4 INTEGRINS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005527628A JP2005527628A (ja) | 2005-09-15 |
| JP2005527628A5 true JP2005527628A5 (https=) | 2006-07-06 |
| JP4469715B2 JP4469715B2 (ja) | 2010-05-26 |
Family
ID=29584493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004507466A Expired - Fee Related JP4469715B2 (ja) | 2002-05-24 | 2003-05-27 | α４インテグリンにより媒介される白血球接着を阻害する複素環化合物 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US7026328B2 (https=) |
| EP (1) | EP1507775B1 (https=) |
| JP (1) | JP4469715B2 (https=) |
| KR (1) | KR100978832B1 (https=) |
| CN (1) | CN1314682C (https=) |
| AT (1) | ATE419243T1 (https=) |
| AU (1) | AU2003240823C1 (https=) |
| BR (1) | BR0308881A (https=) |
| CA (1) | CA2481926C (https=) |
| DE (1) | DE60325583D1 (https=) |
| DK (1) | DK1507775T3 (https=) |
| EA (1) | EA008256B1 (https=) |
| EC (1) | ECSP045425A (https=) |
| ES (1) | ES2320436T3 (https=) |
| IL (2) | IL164225A0 (https=) |
| MX (1) | MXPA04010995A (https=) |
| NO (1) | NO329933B1 (https=) |
| NZ (1) | NZ535504A (https=) |
| TW (1) | TWI281470B (https=) |
| UA (1) | UA76339C2 (https=) |
| WO (1) | WO2003099809A1 (https=) |
| ZA (1) | ZA200407590B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE455106T1 (de) * | 1999-01-22 | 2010-01-15 | Elan Pharm Inc | Acyl derivate zur behandlung von krankheiten die in zusammenhang mit vla-4 stehen |
| TWI281470B (en) * | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
| US7605166B2 (en) * | 2003-06-25 | 2009-10-20 | Elan Pharmaceuticals Inc. | Methods and compositions for treating rheumatoid arthritis |
| US7205310B2 (en) | 2004-04-30 | 2007-04-17 | Elan Pharmaceuticals, Inc. | Pyrimidine hydantoin analogues which inhibit leukocyte adhesion mediated by VLA-4 |
| US7794700B2 (en) * | 2004-07-08 | 2010-09-14 | Elan Pharmaceuticals Inc. | Multimeric VLA-4 antagonists comprising polymer moieties |
| MX2007014267A (es) * | 2005-05-20 | 2008-02-07 | Elan Pharm Inc | Derivados de imidazolona fenilamina como antagonistas vla-4. |
| CA2624524C (en) | 2005-09-29 | 2014-07-08 | Elan Pharmaceuticals, Inc. | Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4 |
| BRPI0616687A2 (pt) * | 2005-09-29 | 2011-06-28 | Elan Pharm Inc | compostos de pirimidinil amida que inibem a adesão leucocitária mediada por vla-4 |
| CA2643838A1 (en) * | 2006-02-27 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4 |
| US20070207141A1 (en) * | 2006-02-28 | 2007-09-06 | Ivan Lieberburg | Methods of treating inflammatory and autoimmune diseases with natalizumab |
| US8410115B2 (en) * | 2006-02-28 | 2013-04-02 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
| MX2008011176A (es) | 2006-03-03 | 2008-09-10 | Elan Pharm Inc | Metodos para tratar padecimientos inflamatorios y autoinmunes con natalizumab. |
| CA2708262A1 (en) * | 2007-12-07 | 2009-06-18 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating liquid tumors |
| EP2085407A1 (en) | 2008-02-04 | 2009-08-05 | Sahltech I Göteborg AB | Treatment of idiopathic thrombocytopenic purpura |
| MX2010011724A (es) * | 2008-04-29 | 2010-11-30 | Nsab Af Neurosearch Sweden Ab | Moduladores de neurotransmision de dopamina. |
| WO2010126914A1 (en) * | 2009-04-27 | 2010-11-04 | Elan Pharmaceuticals, Inc. | Pyridinone antagonists of alpha-4 integrins |
| CN102906278A (zh) | 2010-01-11 | 2013-01-30 | 比奥根艾迪克Ma公司 | 用于jc病毒抗体的测定 |
| US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
| DK2715352T3 (da) | 2011-05-31 | 2019-05-20 | Biogen Ma Inc | Fremgangsmåde til vurdering af risiko for pml |
| JP6080521B2 (ja) * | 2012-11-30 | 2017-02-15 | インターナショナル・ビジネス・マシーンズ・コーポレーションＩｎｔｅｒｎａｔｉｏｎａｌ Ｂｕｓｉｎｅｓｓ Ｍａｃｈｉｎｅｓ Ｃｏｒｐｏｒａｔｉｏｎ | 広域分散医療情報ネットワークのデータ管理機構 |
| WO2014193804A1 (en) | 2013-05-28 | 2014-12-04 | Biogen Idec Ma Inc. | Method of assessing risk of pml |
| SG11201805387RA (en) * | 2015-12-30 | 2018-07-30 | Univ Saint Louis | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists |
| JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ， インコーポレイテッド | アルファ４ベータ７インテグリンの阻害のための化合物 |
| ES3013256T3 (en) | 2018-10-30 | 2025-04-11 | Gilead Sciences Inc | Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases |
| FI3873884T3 (fi) | 2018-10-30 | 2025-02-24 | Gilead Sciences Inc | 3-(kinolin-8-yyli)-1,4-dihydropyrido[3,4-d]pyrimidiini-2,4-dionijohdannaisia alfa-4-beta-7-integriinin estäjinä tulehdussairauksien hoidossa |
| EP3873605B1 (en) | 2018-10-30 | 2024-10-23 | Gilead Sciences, Inc. | Compounds for inhibition of alpha4beta7 integrin |
| CN109541237A (zh) * | 2018-12-28 | 2019-03-29 | 吴江近岸蛋白质科技有限公司 | 纤维连接蛋白的生物学活性测定方法 |
| WO2021030438A1 (en) | 2019-08-14 | 2021-02-18 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2525656A1 (de) | 1974-06-19 | 1976-01-15 | Sandoz Ag | Verfahren zur herstellung neuer heterocyclischer verbindungen |
| US4096255A (en) * | 1974-11-08 | 1978-06-20 | Mitsubishi Chemical Industries Limited | N2 -naphthalenesulfonyl-L-argininamides, and pharmaceutical salts, compositions and methods |
| US4073914A (en) * | 1974-11-08 | 1978-02-14 | Mitsubishi Chemical Industries Limited | N2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
| US4055636A (en) * | 1974-11-08 | 1977-10-25 | Mitsubishi Chemical Industries Ltd. | N2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
| US4070457A (en) * | 1974-11-08 | 1978-01-24 | Mitsubishi Chemical Industries Ltd. | N2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
| US4104392A (en) * | 1974-11-08 | 1978-08-01 | Mitsubishi Chemical Industries Ltd. | N2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof, and antithrombotic compositions and methods employing them |
| US4041156A (en) * | 1974-11-08 | 1977-08-09 | Mitsubishi Chemical Industries Limited | N2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
| US4046876A (en) * | 1974-11-08 | 1977-09-06 | Mitsubishi Chemical Industries Limited | N2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
| US4055651A (en) * | 1974-11-08 | 1977-10-25 | Mitsubishi Chemical Industries Ltd. | N2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
| US4018915A (en) * | 1976-01-05 | 1977-04-19 | Mitsubishi Chemical Industries Ltd. | N2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
| JPS5727454B2 (https=) * | 1975-02-21 | 1982-06-10 | ||
| CA1102316A (en) | 1975-12-09 | 1981-06-02 | Shosuke Okamoto | N su2 xx-arylsulfonyl-l-argininamides and the pharmaceutically acceptable salts thereof |
| US4018913A (en) * | 1976-01-14 | 1977-04-19 | Mitsubishi Chemical Industries Ltd. | N2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
| US4036955A (en) * | 1976-07-22 | 1977-07-19 | Mitsubishi Chemical Industries Ltd. | N2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
| DE2742173A1 (de) * | 1977-09-20 | 1979-03-29 | Bayer Ag | Phenoxy-pyridinyl(pyrimidinyl)-alkanole, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide |
| US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| IT1211096B (it) * | 1981-08-20 | 1989-09-29 | Lpb Ist Farm | Pirimidine e s.triazinici adattivita' ipolipidemizzante. |
| US4672065A (en) * | 1982-11-19 | 1987-06-09 | Chevron Research Company | N-substituted phenoxyacetamide fungicides |
| US4501728A (en) * | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| CA1218655A (en) | 1983-01-28 | 1987-03-03 | Kathleen Biziere | Process for the preparation of pyridazine derivatives having a psychotropic action |
| JPS59212480A (ja) | 1983-05-17 | 1984-12-01 | Nippon Soda Co Ltd | ピリダジン誘導体及び除草剤 |
| DE3322720A1 (de) * | 1983-06-24 | 1985-01-03 | Chemische Werke Hüls AG, 4370 Marl | Verwendung von in 2-stellung mit (substituierten) aminogruppen substituierten 4-dl-alkylester-(alpha)-alaninyl-6-chlor-s-triazinen als herbizide, insbesondere gegen flughafer |
| US4505910A (en) * | 1983-06-30 | 1985-03-19 | American Home Products Corporation | Amino-pyrimidine derivatives, compositions and use |
| NZ210669A (en) | 1983-12-27 | 1988-05-30 | Syntex Inc | Benzoxazin-4-one derivatives and pharmaceutical compositions |
| US4595364A (en) * | 1984-02-15 | 1986-06-17 | Molten Corp. | Dental prosthesis and process for preparing the same |
| PH22520A (en) * | 1984-11-12 | 1988-10-17 | Yamanouchi Pharma Co Ltd | Heterocyclic compounds having 4-lover alkyl-3-hydroxy-2-lower alkyl phenoxy-lower alkylene-y-group, and process of producing them |
| US4959364A (en) | 1985-02-04 | 1990-09-25 | G. D. Searle & Co. | Method of treating inflammation, allergy, asthma and proliferative skin disease using heterocyclic amides |
| US5023252A (en) * | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US4837028A (en) * | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| JPH0784424B2 (ja) | 1987-04-15 | 1995-09-13 | 味の素株式会社 | チロシン誘導体及びその用途 |
| EP0330506A3 (en) | 1988-02-26 | 1990-06-20 | Dana Farber Cancer Institute | Vla proteins |
| DE3904931A1 (de) * | 1989-02-17 | 1990-08-23 | Bayer Ag | Pyridyl-substituierte acrylsaeureester |
| US5030644A (en) * | 1989-07-31 | 1991-07-09 | Merck & Co., Inc. | Imidazole compounds and their use as transglutaminase inhibitors |
| US5260210A (en) | 1989-09-27 | 1993-11-09 | Rubin Lee L | Blood-brain barrier model |
| US4992439A (en) * | 1990-02-13 | 1991-02-12 | Bristol-Myers Squibb Company | Pyridazine carboxylic acids and esters |
| FR2679903B1 (fr) | 1991-08-02 | 1993-12-03 | Elf Sanofi | Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant. |
| NZ239846A (en) * | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
| DE4108029A1 (de) * | 1991-03-13 | 1992-09-17 | Bayer Ag | Triazinyl-substituierte acrylsaeureester |
| AU1354292A (en) | 1991-03-18 | 1992-10-21 | Pentapharm Ag | Parasubstituted phenylalanine derivates |
| IT1247509B (it) * | 1991-04-19 | 1994-12-17 | Univ Cagliari | Composti di sintesi atti all'impiego nella terapia delle infezioni da rhinovirus |
| US5296486A (en) | 1991-09-24 | 1994-03-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Leukotriene biosynthesis inhibitors |
| WO1993012809A1 (en) | 1991-12-24 | 1993-07-08 | Fred Hutchinson Cancer Research Center | Competitive inhibition of high-avidity alpha4-beta1 receptor using tripeptide ldv |
| JPH07504654A (ja) * | 1992-03-11 | 1995-05-25 | ナルヘックス リミテッド | オキソ及びヒドロキシ置換炭化水素のアミン誘導体 |
| DE4227748A1 (de) * | 1992-08-21 | 1994-02-24 | Bayer Ag | Pyridyloxy-acrylsäureester |
| JP2848232B2 (ja) * | 1993-02-19 | 1999-01-20 | 武田薬品工業株式会社 | アルデヒド誘導体 |
| US5770573A (en) * | 1993-12-06 | 1998-06-23 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
| TW530047B (en) * | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
| US5510332A (en) * | 1994-07-07 | 1996-04-23 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin α4 62 1 to VCAM-1 or fibronectin and linear peptides therefor |
| AU2964295A (en) | 1994-07-11 | 1996-02-09 | Athena Neurosciences, Inc. | Inhibitors of leukocyte adhesion |
| US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| IL117659A (en) * | 1995-04-13 | 2000-12-06 | Dainippon Pharmaceutical Co | Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same |
| IL123164A (en) * | 1995-08-30 | 2001-03-19 | Searle & Co | Meta-guanidine urea thiourea or azacyclic amino benzoic acid derivatives and pharmaceutical compositions containing them |
| PT765879E (pt) * | 1995-09-29 | 2001-05-31 | Sankyo Co | Derivados 13-substituidos de milbemicina-5-oxima sua preparacao e utilizacao contra insectos e outras pragas |
| DE19536891A1 (de) | 1995-10-04 | 1997-04-10 | Basf Ag | Neue Aminosäurederivate, ihre Herstellung und Verwendung |
| DE19548709A1 (de) | 1995-12-23 | 1997-07-03 | Merck Patent Gmbh | Tyrosinderivate |
| DK0910575T3 (da) | 1996-06-21 | 2003-02-03 | Takeda Chemical Industries Ltd | Fremgangsmåde til fremstilling af peptider |
| EP0907637A1 (de) | 1996-06-28 | 1999-04-14 | MERCK PATENT GmbH | Phenylalanin-derivate als integrin-inhibitoren |
| DE19629817A1 (de) * | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
| DE19647317A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Schering Agrevo Gmbh | Substituierte Stickstoff-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
| DE19647381A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| JP2001505204A (ja) | 1996-11-22 | 2001-04-17 | エラン・ファーマシューティカルズ・インコーポレイテッド | Ｎ―（アリール／ヘテロアリールアセチル）アミノ酸エステル、それを含有する医薬組成物および該化合物を用いてβ―アミロイドペプチドの放出および／または合成を阻害する方法 |
| AU6264898A (en) | 1997-02-04 | 1998-08-25 | Versicor Inc | Solid phase and combinatorial library syntheses of 3,1-benzoxazine-4-ones |
| DE19713000A1 (de) | 1997-03-27 | 1998-10-01 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
| JP2001517245A (ja) | 1997-05-29 | 2001-10-02 | メルク エンド カンパニー インコーポレーテッド | 細胞接着阻害薬としてのビアリールアルカン酸類 |
| EP1001764A4 (en) | 1997-05-29 | 2005-08-24 | Merck & Co Inc | HETEROCYCLIC AMIDE COMPOUNDS AS INHIBITORS OF CELL ADHESION |
| AU8678698A (en) | 1997-07-31 | 1999-02-22 | American Home Products Corporation | Compounds which inhibit leukocyte adhesion mediated by vla-4 |
| IL133639A0 (en) | 1997-07-31 | 2001-04-30 | Elan Pharm Inc | Dipeptide and related compounds which inhibit leukocyte adhesion mediated by vla-4 |
| AR016133A1 (es) | 1997-07-31 | 2001-06-20 | Wyeth Corp | Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria |
| KR20010022411A (ko) | 1997-07-31 | 2001-03-15 | 진 엠. 듀발 | Ｖｌａ-4에 의해 매개되는 백혈구 부착을 억제하는 치환된페닐알라닌계의 화합물 |
| EP1005445B1 (en) | 1997-08-22 | 2004-05-26 | F. Hoffmann-La Roche Ag | N-alkanoylphenylalanine derivatives |
| CN1276785A (zh) | 1997-08-22 | 2000-12-13 | 霍夫曼-拉罗奇有限公司 | N－烷酰基苯丙氨酸衍生物 |
| KR20010034317A (ko) | 1998-01-23 | 2001-04-25 | 한스 루돌프 하우스 | Ｖｌａ-4 길항제 |
| US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
| PL343770A1 (en) | 1998-04-16 | 2001-09-10 | Texas Biotechnology Corp | N,n-disubstituted amides that inhibit the binding of integrins to their receptors |
| GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
| ATE455106T1 (de) * | 1999-01-22 | 2010-01-15 | Elan Pharm Inc | Acyl derivate zur behandlung von krankheiten die in zusammenhang mit vla-4 stehen |
| AU2623900A (en) * | 1999-01-22 | 2000-08-07 | American Home Products Corporation | Compounds which inhibit leukocyte adhesion mediated by vla-4 |
| PE20020384A1 (es) | 2000-07-21 | 2002-05-28 | Schering Corp | PEPTIDOS COMO INHIBIDORES DE LA PROTEASA SERINA NS3/NS4a DEL VIRUS DE LA HEPATITIS C |
| TWI281470B (en) * | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
-
2003
- 2003-05-26 TW TW092114183A patent/TWI281470B/zh not_active IP Right Cessation
- 2003-05-27 US US10/447,308 patent/US7026328B2/en not_active Expired - Fee Related
- 2003-05-27 KR KR1020047018173A patent/KR100978832B1/ko not_active Expired - Fee Related
- 2003-05-27 AU AU2003240823A patent/AU2003240823C1/en not_active Ceased
- 2003-05-27 CA CA2481926A patent/CA2481926C/en not_active Expired - Fee Related
- 2003-05-27 ZA ZA200407590A patent/ZA200407590B/en unknown
- 2003-05-27 AT AT03731419T patent/ATE419243T1/de not_active IP Right Cessation
- 2003-05-27 EA EA200401562A patent/EA008256B1/ru not_active IP Right Cessation
- 2003-05-27 CN CNB038115484A patent/CN1314682C/zh not_active Expired - Fee Related
- 2003-05-27 ES ES03731419T patent/ES2320436T3/es not_active Expired - Lifetime
- 2003-05-27 DE DE60325583T patent/DE60325583D1/de not_active Expired - Lifetime
- 2003-05-27 DK DK03731419T patent/DK1507775T3/da active
- 2003-05-27 WO PCT/US2003/016804 patent/WO2003099809A1/en not_active Ceased
- 2003-05-27 EP EP03731419A patent/EP1507775B1/en not_active Expired - Lifetime
- 2003-05-27 MX MXPA04010995A patent/MXPA04010995A/es active IP Right Grant
- 2003-05-27 JP JP2004507466A patent/JP4469715B2/ja not_active Expired - Fee Related
- 2003-05-27 UA UA20041008397A patent/UA76339C2/uk unknown
- 2003-05-27 US US10/494,790 patent/US7135477B2/en not_active Expired - Fee Related
- 2003-05-27 NZ NZ535504A patent/NZ535504A/en not_active IP Right Cessation
- 2003-05-27 BR BR0308881-2A patent/BR0308881A/pt active Search and Examination
- 2003-05-27 IL IL16422503A patent/IL164225A0/xx unknown
-
2004
- 2004-09-17 NO NO20043900A patent/NO329933B1/no not_active IP Right Cessation
- 2004-09-22 IL IL164225A patent/IL164225A/en not_active IP Right Cessation
- 2004-10-11 EC EC2004005425A patent/ECSP045425A/es unknown
-
2006
- 2006-09-26 US US11/527,901 patent/US7427628B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005527628A5 (https=) | ||
| JP2023527575A5 (https=) | ||
| RU2472509C2 (ru) | Способ лечения артрита | |
| CA2481926A1 (en) | Heterocyclic compounds which inhibit leukocyte adhesion mediated by .alpha.4 integrins | |
| US20080182845A1 (en) | Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection | |
| JP2021534124A5 (https=) | ||
| JP2004115534A5 (https=) | ||
| JP2004525179A5 (https=) | ||
| JP2009504763A5 (https=) | ||
| JP2010500415A5 (https=) | ||
| JP2005529155A5 (https=) | ||
| JP2015512860A5 (https=) | ||
| JP2011510080A5 (https=) | ||
| JP2003508388A5 (https=) | ||
| JP2020507589A5 (https=) | ||
| JP2005524609A5 (https=) | ||
| JP2006515585A5 (https=) | ||
| JP2007522135A5 (https=) | ||
| RU2003133924A (ru) | Дейтерированные 3-пиперидиноэтилфенилкетоны, а также лекарственные средства, содержащие эти соединения | |
| JP2022537140A5 (https=) | ||
| JP2011518168A5 (https=) | ||
| JP2008519824A5 (https=) | ||
| RU2007102274A (ru) | Пиперазиндионы как антагонисты рецептора окситоцина | |
| JP2009040767A5 (https=) | ||
| JP2001270839A5 (https=) |