JP2007522135A5 - - Google Patents

Download PDF

Info

Publication number
JP2007522135A5
JP2007522135A5 JP2006551595A JP2006551595A JP2007522135A5 JP 2007522135 A5 JP2007522135 A5 JP 2007522135A5 JP 2006551595 A JP2006551595 A JP 2006551595A JP 2006551595 A JP2006551595 A JP 2006551595A JP 2007522135 A5 JP2007522135 A5 JP 2007522135A5
Authority
JP
Japan
Prior art keywords
compound
independently
subject
electron withdrawing
withdrawing group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006551595A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007522135A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2005/003183 external-priority patent/WO2005074598A2/en
Publication of JP2007522135A publication Critical patent/JP2007522135A/ja
Publication of JP2007522135A5 publication Critical patent/JP2007522135A5/ja
Pending legal-status Critical Current

Links

JP2006551595A 2004-01-30 2005-01-28 ニトロキシル前駆化合物および使用方法 Pending JP2007522135A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54068804P 2004-01-30 2004-01-30
US63245604P 2004-12-02 2004-12-02
PCT/US2005/003183 WO2005074598A2 (en) 2004-01-30 2005-01-28 Nitroxyl progenitor compounds and methods of use

Publications (2)

Publication Number Publication Date
JP2007522135A JP2007522135A (ja) 2007-08-09
JP2007522135A5 true JP2007522135A5 (https=) 2008-11-27

Family

ID=34841107

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006551595A Pending JP2007522135A (ja) 2004-01-30 2005-01-28 ニトロキシル前駆化合物および使用方法

Country Status (6)

Country Link
US (2) US20090281067A1 (https=)
EP (1) EP1718621A4 (https=)
JP (1) JP2007522135A (https=)
AU (1) AU2005209843B2 (https=)
CA (1) CA2554771A1 (https=)
WO (1) WO2005074598A2 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040038947A1 (en) 2002-06-14 2004-02-26 The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services Method of treating ischemia/reperfusion injury with nitroxyl donors
US6936639B2 (en) 2002-08-21 2005-08-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroxyl progenitors in the treatment of heart failure
WO2005074598A2 (en) 2004-01-30 2005-08-18 Johns Hopkins University Nitroxyl progenitor compounds and methods of use
US20090298795A1 (en) * 2005-06-23 2009-12-03 The Johns Hopins University Thiol-Sensitive Positive Inotropes
US8030356B2 (en) * 2006-03-17 2011-10-04 Cardioxyl Pharmaceuticals, Inc. N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
CN104119310B (zh) 2007-09-26 2017-04-12 约翰斯霍普金斯大学 作为新的在生理学上可用于硝酰基供体的n‑羟基磺酰胺衍生物及包含其的医药组合物
AU2009210484A1 (en) * 2008-02-08 2009-08-13 Merck Sharp & Dohme Corp. Angiotensin II receptor antagonists
US20110160200A1 (en) * 2009-11-23 2011-06-30 Cardioxyl Pharmaceuticals, Inc. Nitroxyl Progenitors for the Treatment of Pulmonary Hypertension
CN105130855B (zh) * 2009-12-07 2018-05-25 约翰斯霍普金斯大学 二酰基化的羟基胺衍生物及其用途
AU2010328234B2 (en) 2009-12-07 2016-05-12 Cardioxyl Pharmaceuticals, Inc. N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivatives
CN103476744A (zh) * 2011-01-19 2013-12-25 默沙东公司 二醇二氮烯鎓衍生物
JP6177246B2 (ja) 2011-10-17 2017-08-09 ザ・ジョンズ・ホプキンス・ユニバーシティ ヒドロキシルアミンで置換された、ｈｎｏ供与体としてのメルドラム酸、バルビツール酸、及びピラゾロンの誘導体
SG10201802862WA (en) 2013-01-18 2018-05-30 Cardioxyl Pharmaceuticals Inc Pharmaceutical compositions comprising nitroxyl donors
ES2734060T3 (es) 2014-01-17 2019-12-04 Cardioxyl Pharmaceuticals Inc Donadores de nitroxilo de N-hidroximetanosulfonamida
WO2015183838A1 (en) 2014-05-27 2015-12-03 The Johns Hopkins University N-hydroxylamino-barbituric acid derivatives as nitroxyl donors
EP3148972B1 (en) 2014-05-27 2019-08-21 Cardioxyl Pharmaceuticals, Inc. Pyrazolone derivatives as nitroxyl donors
US9464061B2 (en) 2014-05-27 2016-10-11 The Johns Hopkins University N-hydroxylamino-barbituric acid derivatives
KR20180070672A (ko) 2015-10-19 2018-06-26 카르디옥실 파마슈티칼스 인코포레이티드 니트록실 공여자로서의 n-히드록실술폰아미드 유도체
US10723704B2 (en) 2015-10-19 2020-07-28 Cardioxyl Pharmaceuticals, Inc. Pyrazolone derivatives as nitroxyl donors
EP3490975B1 (en) 2016-07-28 2021-05-05 The Johns Hopkins University O-substituted hydroxamic acids
WO2018128999A1 (en) 2017-01-03 2018-07-12 Cardioxyl Pharmaceuticals, Inc. Method of administering nitroxyl donating compounds
JP2023533016A (ja) 2020-07-11 2023-08-01 ファイザー・インク 抗ウイルス性ヘテロアリールケトン誘導体
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
WO2025043108A1 (en) 2023-08-23 2025-02-27 Bristol -Myers S Quibb Company Co-crystals of nitroxyl donating compounds

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4369172A (en) 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
DE3583799D1 (de) 1985-01-11 1991-09-19 Abbott Lab Ltd Feste zubereitung mit langsamer freisetzung.
US4954526A (en) * 1989-02-28 1990-09-04 The United States Of America As Represented By The Department Of Health And Human Services Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
US5039705A (en) * 1989-09-15 1991-08-13 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
JP2773959B2 (ja) 1990-07-10 1998-07-09 信越化学工業株式会社 大腸内放出性固形製剤
WO1993007114A1 (en) * 1991-09-24 1993-04-15 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs
US5632981A (en) 1992-08-24 1997-05-27 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US6200558B1 (en) * 1993-09-14 2001-03-13 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5700830A (en) * 1994-11-22 1997-12-23 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents for reducing metastasis risk
CA2266908C (en) * 1996-09-27 2010-07-20 Joseph E. Saavedra O2-arylated or o2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and o2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates
US5958427A (en) 1996-11-08 1999-09-28 Salzman; Andrew L. Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications
JP4856295B2 (ja) * 1997-07-03 2012-01-18 アメリカ合衆国政府 新規な一酸化窒素放出アミジン誘導ジアゼニウムジオレート及びその組成物
UA73092C2 (uk) 1998-07-17 2005-06-15 Брістол-Майерс Сквібб Компані Таблетка з ентеросолюбільним покриттям і спосіб її приготування
DE69924735T2 (de) 1998-07-28 2006-01-19 Tanabe Seiyaku Co., Ltd. Zur wirkstoffabgabe an zielorten im darm fähige zubereitung
WO2002098430A1 (de) * 2001-06-05 2002-12-12 Basf Aktiengesellschaft Antimykotikum
WO2003006427A1 (en) * 2001-07-12 2003-01-23 Johns Hopkins University Compounds that release nitric oxide at controlled rates upon photolysis
MXPA04008821A (es) * 2002-03-15 2004-11-26 Btg Int Ltd Formulaciones de derivados de antraquinona.
EP1490045B1 (en) * 2002-03-21 2013-03-13 University of Utah Research Foundation In vivo use of glutathionone s-transferase activated nitric oxide donors
US20040038947A1 (en) * 2002-06-14 2004-02-26 The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services Method of treating ischemia/reperfusion injury with nitroxyl donors
US6936639B2 (en) * 2002-08-21 2005-08-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroxyl progenitors in the treatment of heart failure
US20050009789A1 (en) * 2003-05-13 2005-01-13 The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Service Cyclooxygenase inhibition with nitroxyl
WO2005074598A2 (en) 2004-01-30 2005-08-18 Johns Hopkins University Nitroxyl progenitor compounds and methods of use

Similar Documents

Publication Publication Date Title
JP2007522135A5 (https=)
JP2019094345A5 (https=)
JP2005528393A5 (https=)
JP2019524883A5 (https=)
JP2012529486A5 (https=)
JP2006501295A5 (https=)
JP2005521713A5 (https=)
JP2010077141A5 (https=)
JP2005539088A5 (https=)
JP2009537559A5 (https=)
JP2010527985A5 (https=)
JP2005508337A5 (https=)
JP2012512186A (ja) アミドチアゾール誘導体、その製造方法および使用
JP2010248215A (ja) 筋弛緩促進剤及び筋弛緩不全等の筋組織に係る疾病の治療薬
JP2010506919A5 (https=)
JP2005526696A5 (https=)
WO2003002554A1 (en) Piperazine compounds
JP2006524252A5 (https=)
JP2020111571A5 (https=)
CN101134745A (zh) 一氧化氮供体型替米沙坦衍生物、制备方法及其医药用途
JP2010504321A5 (https=)
JP2009040767A5 (https=)
JP2007537287A5 (https=)
JP2009537532A5 (https=)
US11746090B2 (en) Crystal forms of 2-[4-[(2,3,4- trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate