JP2007537287A5 - - Google Patents
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- Publication number
- JP2007537287A5 JP2007537287A5 JP2007513368A JP2007513368A JP2007537287A5 JP 2007537287 A5 JP2007537287 A5 JP 2007537287A5 JP 2007513368 A JP2007513368 A JP 2007513368A JP 2007513368 A JP2007513368 A JP 2007513368A JP 2007537287 A5 JP2007537287 A5 JP 2007537287A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- day
- use according
- accumulation
- deposition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- 230000003941 amyloidogenesis Effects 0.000 claims 8
- 238000009825 accumulation Methods 0.000 claims 6
- 230000002265 prevention Effects 0.000 claims 6
- 230000007082 Aβ accumulation Effects 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 102000001049 Amyloid Human genes 0.000 claims 3
- 108010094108 Amyloid Proteins 0.000 claims 3
- 102000019355 Synuclein Human genes 0.000 claims 3
- 108050006783 Synuclein Proteins 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 230000035508 accumulation Effects 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 230000008021 deposition Effects 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 102000036770 Islet Amyloid Polypeptide Human genes 0.000 claims 1
- 108010041872 Islet Amyloid Polypeptide Proteins 0.000 claims 1
- 102000003802 alpha-Synuclein Human genes 0.000 claims 1
- 108090000185 alpha-Synuclein Proteins 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 239000005022 packaging material Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 0 *c(c(*)c1)ccc1NC(c1cc(*)c(*N*)cc1)=O Chemical compound *c(c(*)c1)ccc1NC(c1cc(*)c(*N*)cc1)=O 0.000 description 6
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57066904P | 2004-05-12 | 2004-05-12 | |
| US60/570,669 | 2004-05-12 | ||
| US62952504P | 2004-11-18 | 2004-11-18 | |
| US60/629,525 | 2004-11-18 | ||
| PCT/US2005/016677 WO2005113489A1 (en) | 2004-05-12 | 2005-05-12 | Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007537287A JP2007537287A (ja) | 2007-12-20 |
| JP2007537287A5 true JP2007537287A5 (https=) | 2008-06-26 |
| JP5203701B2 JP5203701B2 (ja) | 2013-06-05 |
Family
ID=34969702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007513368A Expired - Fee Related JP5203701B2 (ja) | 2004-05-12 | 2005-05-12 | アミロイド疾患、及びシヌクレイノパチー治療用置換ｎ−アリールベンズアミド、及び関連化合物 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7745490B2 (https=) |
| EP (1) | EP1751097B1 (https=) |
| JP (1) | JP5203701B2 (https=) |
| KR (1) | KR101168451B1 (https=) |
| AT (1) | ATE453617T1 (https=) |
| AU (1) | AU2005245412B2 (https=) |
| BR (1) | BRPI0510803A (https=) |
| CA (1) | CA2566090C (https=) |
| DE (1) | DE602005018634D1 (https=) |
| DK (1) | DK1751097T3 (https=) |
| ES (1) | ES2337162T3 (https=) |
| IL (1) | IL179160A (https=) |
| MX (1) | MXPA06012603A (https=) |
| NO (1) | NO20065717L (https=) |
| NZ (1) | NZ551589A (https=) |
| RU (1) | RU2381213C2 (https=) |
| SG (1) | SG137850A1 (https=) |
| WO (1) | WO2005113489A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090124690A1 (en) * | 2000-04-03 | 2009-05-14 | Alberte Randall S | Generation of Combinatorial Synthetic Libraries and Screening for Novel Proadhesins and Nonadhesins |
| US20070208087A1 (en) * | 2001-11-02 | 2007-09-06 | Sanders Virginia J | Compounds, compositions and methods for the treatment of inflammatory diseases |
| US20100273776A1 (en) * | 2006-03-29 | 2010-10-28 | FOLDRx PHARMACEUTICALS, INC | Inhibition of alpha-synuclein toxicity |
| WO2009111611A2 (en) * | 2008-03-05 | 2009-09-11 | Proteotech Inc. | Compounds, compositions and methods for the treatment of islet amyloid polypeptide (iapp) accumulation in diabetes |
| EP2098226A1 (de) * | 2008-03-06 | 2009-09-09 | Forschungsverbund Berlin e.V. | AKAP-PKA-Interaktionshemmer zur Anwendung in der Behandlung von Herzkrankheiten |
| EP2554163A4 (en) * | 2010-03-26 | 2013-07-17 | Univ Hokkaido Nat Univ Corp | THERAPEUTIC ACTIVE FOR NEURODEGENERATIVE DISEASES |
| US20120251448A1 (en) * | 2011-03-03 | 2012-10-04 | Hefti Franz F | Compounds for Use in the Detection of Neurodegenerative Diseases |
| WO2019043217A1 (en) | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | DIHYDROBENZIMIDAZOLONES |
| KR102011033B1 (ko) * | 2017-09-25 | 2019-08-14 | (주)아모레퍼시픽 | 성분 함량이 변화된 녹차 추출물을 포함하는 인지기능 개선용 조성물 |
| US10799551B2 (en) | 2017-09-25 | 2020-10-13 | Amorepacific Corporation | Composition for enhancing cognitive function comprising green tea extract which has modified amounts of ingredients |
| EP3867227A4 (en) * | 2018-10-19 | 2022-08-03 | Auckland Uniservices Limited | COMPOUNDS FOR THE TREATMENT OF DIABETES AND/OR RELATED DISEASES |
| ES2995214T3 (en) | 2019-03-06 | 2025-02-07 | C4 Therapeutics Inc | Heterocyclic compounds for medical treatment |
| EP4525852A1 (en) * | 2022-05-20 | 2025-03-26 | Merck Sharp & Dohme LLC | Inhibitors of msba as antibiotics, pharmaceutical compositions, and uses thereof |
| CN117682973B (zh) * | 2022-09-26 | 2026-03-20 | 中国药科大学 | 磺酰胺类化合物及其医药用途 |
| EP4686725A1 (en) | 2024-08-02 | 2026-02-04 | Technische Universität München, in Vertretung des Freistaats Bayern | Amyloid inhibitory peptides |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5916871A (ja) * | 1982-07-20 | 1984-01-28 | Shionogi & Co Ltd | スルホンアミド系ベンズアミド類 |
| JPS63132237A (ja) * | 1986-11-21 | 1988-06-04 | Konica Corp | 迅速処理を行なつても優れた発色性を有するハロゲン化銀写真感光材料 |
| MX9203460A (es) * | 1988-09-12 | 1992-09-01 | Upjohn Co | Nuevos analogos cc-1065 que tienen dos subunidades cpi. |
| GB8914660D0 (en) * | 1989-06-26 | 1989-08-16 | Fujisawa Pharmaceutical Co | Aniline derivatives,processes for production thereof and pharmaceutical compositions comprising the same |
| JPH04285955A (ja) * | 1991-03-14 | 1992-10-12 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| BR9910642A (pt) * | 1998-05-22 | 2001-10-09 | Avanir Pharmaceuticals | Análogos de benzimidazol como reguladores descendentes de ige |
| PL198852B1 (pl) * | 1998-10-22 | 2008-07-31 | Neurosearch As | Podstawione pochodne fenylu, kompozycja farmaceutyczna je zawierająca oraz ich zastosowanie |
| JP4623453B2 (ja) * | 1999-10-14 | 2011-02-02 | 旭化成イーマテリアルズ株式会社 | アミドフェノール化合物 |
| CZ20033309A3 (cs) * | 2001-06-07 | 2004-05-12 | Eliálillyáandácompany | Modulátory receptorů aktivovaných peroxizomálními proliferátory }PPARB |
| WO2003101927A1 (en) * | 2002-05-31 | 2003-12-11 | Proteotech, Inc. | Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's disease |
| AU2003275225A1 (en) * | 2002-09-20 | 2004-04-08 | Genelabs Technologies, Inc. | Novel aromatic compounds possessing antifungal or antibacterial activity |
-
2005
- 2005-05-12 AT AT05749770T patent/ATE453617T1/de active
- 2005-05-12 CA CA2566090A patent/CA2566090C/en not_active Expired - Fee Related
- 2005-05-12 KR KR1020067026028A patent/KR101168451B1/ko not_active Expired - Fee Related
- 2005-05-12 WO PCT/US2005/016677 patent/WO2005113489A1/en not_active Ceased
- 2005-05-12 DK DK05749770.3T patent/DK1751097T3/da active
- 2005-05-12 SG SG200717673-8A patent/SG137850A1/en unknown
- 2005-05-12 MX MXPA06012603A patent/MXPA06012603A/es active IP Right Grant
- 2005-05-12 NZ NZ551589A patent/NZ551589A/en not_active IP Right Cessation
- 2005-05-12 ES ES05749770T patent/ES2337162T3/es not_active Expired - Lifetime
- 2005-05-12 JP JP2007513368A patent/JP5203701B2/ja not_active Expired - Fee Related
- 2005-05-12 AU AU2005245412A patent/AU2005245412B2/en not_active Ceased
- 2005-05-12 RU RU2006143761/04A patent/RU2381213C2/ru not_active IP Right Cessation
- 2005-05-12 EP EP05749770A patent/EP1751097B1/en not_active Expired - Lifetime
- 2005-05-12 DE DE602005018634T patent/DE602005018634D1/de not_active Expired - Lifetime
- 2005-05-12 BR BRPI0510803-9A patent/BRPI0510803A/pt not_active IP Right Cessation
-
2006
- 2006-01-09 US US11/328,748 patent/US7745490B2/en not_active Expired - Fee Related
- 2006-11-09 IL IL179160A patent/IL179160A/en not_active IP Right Cessation
- 2006-12-12 NO NO20065717A patent/NO20065717L/no not_active Application Discontinuation
-
2008
- 2008-08-29 US US12/201,183 patent/US20090060838A1/en not_active Abandoned
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