JP2006518731A5 - - Google Patents
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- Publication number
- JP2006518731A5 JP2006518731A5 JP2006502681A JP2006502681A JP2006518731A5 JP 2006518731 A5 JP2006518731 A5 JP 2006518731A5 JP 2006502681 A JP2006502681 A JP 2006502681A JP 2006502681 A JP2006502681 A JP 2006502681A JP 2006518731 A5 JP2006518731 A5 JP 2006518731A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- heart failure
- acceptable salt
- benzazepine
- severe heart
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 benzoazepine compound Chemical class 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 14
- 206010019280 Heart failures Diseases 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000005843 halogen group Chemical group 0.000 claims 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- 229940124597 therapeutic agent Drugs 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- WRNXUQJJCIZICJ-UHFFFAOYSA-N mozavaptan Chemical compound C12=CC=CC=C2C(N(C)C)CCCN1C(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C WRNXUQJJCIZICJ-UHFFFAOYSA-N 0.000 claims 3
- GYHCTFXIZSNGJT-UHFFFAOYSA-N tolvaptan Chemical compound CC1=CC=CC=C1C(=O)NC(C=C1C)=CC=C1C(=O)N1C2=CC=C(Cl)C=C2C(O)CCC1 GYHCTFXIZSNGJT-UHFFFAOYSA-N 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 206010007556 Cardiac failure acute Diseases 0.000 claims 1
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- 230000009798 acute exacerbation Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44887803P | 2003-02-24 | 2003-02-24 | |
| US60/448,878 | 2003-02-24 | ||
| PCT/JP2004/002085 WO2004073716A1 (en) | 2003-02-24 | 2004-02-23 | Method for treating severe heart failure and medicament therefor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011049403A Division JP2011148806A (ja) | 2003-02-24 | 2011-03-07 | 重症心不全の治療方法およびその薬剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006518731A JP2006518731A (ja) | 2006-08-17 |
| JP2006518731A5 true JP2006518731A5 (https=) | 2006-11-24 |
| JP4771937B2 JP4771937B2 (ja) | 2011-09-14 |
Family
ID=32908667
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006502681A Expired - Lifetime JP4771937B2 (ja) | 2003-02-24 | 2004-02-23 | 重症心不全の治療方法およびその薬剤 |
| JP2011049403A Pending JP2011148806A (ja) | 2003-02-24 | 2011-03-07 | 重症心不全の治療方法およびその薬剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011049403A Pending JP2011148806A (ja) | 2003-02-24 | 2011-03-07 | 重症心不全の治療方法およびその薬剤 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7423032B2 (https=) |
| EP (2) | EP2000142A1 (https=) |
| JP (2) | JP4771937B2 (https=) |
| KR (1) | KR100706727B1 (https=) |
| CN (1) | CN100577171C (https=) |
| AR (1) | AR043259A1 (https=) |
| AT (1) | ATE411803T1 (https=) |
| AU (2) | AU2004212842B9 (https=) |
| BR (1) | BRPI0405657A (https=) |
| CA (1) | CA2493475A1 (https=) |
| CY (1) | CY1108583T1 (https=) |
| DE (1) | DE602004017283D1 (https=) |
| DK (1) | DK1596868T3 (https=) |
| ES (1) | ES2315640T3 (https=) |
| MX (1) | MXPA05001623A (https=) |
| MY (1) | MY143740A (https=) |
| NO (1) | NO335369B1 (https=) |
| PL (2) | PL404315A1 (https=) |
| PT (1) | PT1596868E (https=) |
| RU (2) | RU2346689C2 (https=) |
| SI (1) | SI1596868T1 (https=) |
| TW (1) | TWI322689B (https=) |
| WO (1) | WO2004073716A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7468390B2 (en) * | 2002-01-17 | 2008-12-23 | Novartis Ag | Methods of treatment and pharmaceutical composition |
| TWI322689B (en) * | 2003-02-24 | 2010-04-01 | Otsuka Pharma Co Ltd | Method for treating severe heart failure and medicament therefor |
| DE102005003632A1 (de) | 2005-01-20 | 2006-08-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Katheter für die transvaskuläre Implantation von Herzklappenprothesen |
| US20070213813A1 (en) | 2005-12-22 | 2007-09-13 | Symetis Sa | Stent-valves for valve replacement and associated methods and systems for surgery |
| DK1968990T3 (da) | 2005-12-27 | 2015-04-27 | Otsuka Pharma Co Ltd | Vandopløselig benzoazepinforbindelse og farmaceutisk sammensætning deraf |
| JP5076327B2 (ja) * | 2006-02-01 | 2012-11-21 | 味の素株式会社 | 分岐鎖アミノ酸の心不全適応 |
| US7896915B2 (en) | 2007-04-13 | 2011-03-01 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
| PT2146721E (pt) * | 2007-05-15 | 2013-07-18 | Otsuka Pharma Co Ltd | Métodos de utilização de antagonistas da vasopressina com agentes quimioterapeuticos de antraciclina para reduzir a cardiotoxicidade e/ou melhorar a sobrevivência |
| TWI405574B (zh) * | 2007-06-21 | 2013-08-21 | Otsuka Pharma Co Ltd | 藥學固體製劑及其製造方法 |
| US9044318B2 (en) | 2008-02-26 | 2015-06-02 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis |
| WO2011104269A1 (en) | 2008-02-26 | 2011-09-01 | Jenavalve Technology Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
| US10856978B2 (en) | 2010-05-20 | 2020-12-08 | Jenavalve Technology, Inc. | Catheter system |
| CN103002833B (zh) | 2010-05-25 | 2016-05-11 | 耶拿阀门科技公司 | 人工心脏瓣及包括人工心脏瓣和支架的经导管输送的内假体 |
| JP5477413B2 (ja) * | 2012-04-24 | 2014-04-23 | 味の素株式会社 | 分岐鎖アミノ酸の心不全適応 |
| WO2015028209A1 (en) | 2013-08-30 | 2015-03-05 | Jenavalve Technology Gmbh | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
| WO2016150806A1 (en) | 2015-03-20 | 2016-09-29 | Jenavalve Technology, Inc. | Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath |
| CN107530168B (zh) | 2015-05-01 | 2020-06-09 | 耶拿阀门科技股份有限公司 | 在心脏瓣膜替换中具有降低的起搏器比例的装置和方法 |
| CN109475419B (zh) | 2016-05-13 | 2021-11-09 | 耶拿阀门科技股份有限公司 | 用于通过引导鞘和装载系统来递送心脏瓣膜假体的心脏瓣膜假体递送系统和方法 |
| CN110392557A (zh) | 2017-01-27 | 2019-10-29 | 耶拿阀门科技股份有限公司 | 心脏瓣膜模拟 |
| CN110174474B (zh) * | 2019-05-24 | 2022-02-18 | 石家庄四药有限公司 | 复方电解质注射液(ⅱ)中l-苹果酸异构体的检测方法 |
| CN112121051B (zh) * | 2020-09-30 | 2021-06-18 | 郑州大学 | 莫扎伐坦在制备抗消化道肿瘤药物中的应用 |
| CN120152682A (zh) | 2022-11-09 | 2025-06-13 | 耶拿阀门科技公司 | 用于顺序地部署可扩张植入物的导管系统 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01102124A (ja) | 1987-10-14 | 1989-04-19 | Kubota Ltd | コンクリート構造体支持構造 |
| US5753677A (en) * | 1989-10-20 | 1998-05-19 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds |
| US5258510A (en) | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
| DK0450097T3 (da) | 1989-10-20 | 1996-05-20 | Otsuka Pharma Co Ltd | Benzoheterocykliske forbindelser |
| AU657424B2 (en) | 1992-07-02 | 1995-03-09 | Otsuka Pharmaceutical Co., Ltd. | Oxytocin antagonist |
| JPH0680641A (ja) | 1992-09-01 | 1994-03-22 | Otsuka Pharmaceut Co Ltd | 光学活性な５−ヒドロキシベンゾアゼピン誘導体の製造法 |
| TW354762B (en) | 1993-02-23 | 1999-03-21 | Otsuka Pharma Co Ltd | Agent for prophylaxis or treatment of cataract |
| JP2694319B2 (ja) | 1993-12-24 | 1997-12-24 | 大塚製薬株式会社 | 抗潰瘍剤 |
| JP3002766B2 (ja) | 1994-12-09 | 2000-01-24 | 大塚製薬株式会社 | 脳浮腫治療剤 |
| JPH10120592A (ja) | 1996-10-22 | 1998-05-12 | Otsuka Pharmaceut Co Ltd | メニエール病乃至メニエール症候群治療剤 |
| JP4210355B2 (ja) | 1997-07-03 | 2009-01-14 | 大塚製薬株式会社 | 固形製剤組成物 |
| EP1253945B1 (en) | 2000-01-26 | 2006-10-04 | Astellas Pharma Inc. | Ace inhibitor-vasopressin antagonist combinations |
| US20030103983A1 (en) * | 2002-05-09 | 2003-06-05 | Pressler Milton Lethan | Ace inhibitor-vasopressin antagonist combinations |
| US20030008860A1 (en) | 2002-05-09 | 2003-01-09 | Bakker-Arkema Rebecca Guggemos | Treatment of congestive heart failure |
| ES2288899T3 (es) * | 2000-10-04 | 2008-02-01 | Astellas Pharma Inc. | Uso de un antagonista de vasopresina tal como conivaptan en la fabricacion de un medicamento para el tratamiento de la hipertension pulmonar. |
| TWI322689B (en) * | 2003-02-24 | 2010-04-01 | Otsuka Pharma Co Ltd | Method for treating severe heart failure and medicament therefor |
-
2004
- 2004-02-05 TW TW093102582A patent/TWI322689B/zh not_active IP Right Cessation
- 2004-02-17 MY MYPI20040510A patent/MY143740A/en unknown
- 2004-02-23 PT PT04713672T patent/PT1596868E/pt unknown
- 2004-02-23 AR ARP040100557A patent/AR043259A1/es unknown
- 2004-02-23 PL PL404315A patent/PL404315A1/pl unknown
- 2004-02-23 DK DK04713672T patent/DK1596868T3/da active
- 2004-02-23 JP JP2006502681A patent/JP4771937B2/ja not_active Expired - Lifetime
- 2004-02-23 ES ES04713672T patent/ES2315640T3/es not_active Expired - Lifetime
- 2004-02-23 AT AT04713672T patent/ATE411803T1/de active
- 2004-02-23 CN CN200480000735A patent/CN100577171C/zh not_active Expired - Lifetime
- 2004-02-23 US US10/523,020 patent/US7423032B2/en not_active Expired - Lifetime
- 2004-02-23 DE DE602004017283T patent/DE602004017283D1/de not_active Expired - Lifetime
- 2004-02-23 SI SI200430894T patent/SI1596868T1/sl unknown
- 2004-02-23 EP EP08162362A patent/EP2000142A1/en not_active Withdrawn
- 2004-02-23 BR BR0405657-4A patent/BRPI0405657A/pt not_active Application Discontinuation
- 2004-02-23 CA CA002493475A patent/CA2493475A1/en not_active Abandoned
- 2004-02-23 EP EP04713672A patent/EP1596868B1/en not_active Expired - Lifetime
- 2004-02-23 PL PL373432A patent/PL218069B1/pl unknown
- 2004-02-23 AU AU2004212842A patent/AU2004212842B9/en not_active Expired
- 2004-02-23 RU RU2005102110/14A patent/RU2346689C2/ru active
- 2004-02-23 KR KR1020057002579A patent/KR100706727B1/ko not_active Expired - Lifetime
- 2004-02-23 WO PCT/JP2004/002085 patent/WO2004073716A1/en not_active Ceased
- 2004-02-23 MX MXPA05001623A patent/MXPA05001623A/es active IP Right Grant
-
2005
- 2005-02-02 NO NO20050569A patent/NO335369B1/no unknown
-
2008
- 2008-05-05 US US12/149,578 patent/US7749993B2/en not_active Expired - Lifetime
- 2008-08-15 RU RU2008133654/14A patent/RU2008133654A/ru not_active Application Discontinuation
- 2008-11-20 CY CY20081101341T patent/CY1108583T1/el unknown
-
2009
- 2009-03-19 AU AU2009201109A patent/AU2009201109A1/en not_active Abandoned
-
2011
- 2011-03-07 JP JP2011049403A patent/JP2011148806A/ja active Pending