CN100577171C - 治疗重度心力衰竭的药物 - Google Patents

治疗重度心力衰竭的药物 Download PDF

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Publication number
CN100577171C
CN100577171C CN200480000735A CN200480000735A CN100577171C CN 100577171 C CN100577171 C CN 100577171C CN 200480000735 A CN200480000735 A CN 200480000735A CN 200480000735 A CN200480000735 A CN 200480000735A CN 100577171 C CN100577171 C CN 100577171C
Authority
CN
China
Prior art keywords
heart failure
sub
present
compound
benzazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN200480000735A
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English (en)
Chinese (zh)
Other versions
CN1700919A (zh
Inventor
尾崎敦
真木洋介
佐藤修
山村由孝
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32908667&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN100577171(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of CN1700919A publication Critical patent/CN1700919A/zh
Application granted granted Critical
Publication of CN100577171C publication Critical patent/CN100577171C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200480000735A 2003-02-24 2004-02-23 治疗重度心力衰竭的药物 Expired - Lifetime CN100577171C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44887803P 2003-02-24 2003-02-24
US60/448,878 2003-02-24

Publications (2)

Publication Number Publication Date
CN1700919A CN1700919A (zh) 2005-11-23
CN100577171C true CN100577171C (zh) 2010-01-06

Family

ID=32908667

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200480000735A Expired - Lifetime CN100577171C (zh) 2003-02-24 2004-02-23 治疗重度心力衰竭的药物

Country Status (23)

Country Link
US (2) US7423032B2 (https=)
EP (2) EP2000142A1 (https=)
JP (2) JP4771937B2 (https=)
KR (1) KR100706727B1 (https=)
CN (1) CN100577171C (https=)
AR (1) AR043259A1 (https=)
AT (1) ATE411803T1 (https=)
AU (2) AU2004212842B9 (https=)
BR (1) BRPI0405657A (https=)
CA (1) CA2493475A1 (https=)
CY (1) CY1108583T1 (https=)
DE (1) DE602004017283D1 (https=)
DK (1) DK1596868T3 (https=)
ES (1) ES2315640T3 (https=)
MX (1) MXPA05001623A (https=)
MY (1) MY143740A (https=)
NO (1) NO335369B1 (https=)
PL (2) PL218069B1 (https=)
PT (1) PT1596868E (https=)
RU (2) RU2346689C2 (https=)
SI (1) SI1596868T1 (https=)
TW (1) TWI322689B (https=)
WO (1) WO2004073716A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7468390B2 (en) * 2002-01-17 2008-12-23 Novartis Ag Methods of treatment and pharmaceutical composition
TWI322689B (en) * 2003-02-24 2010-04-01 Otsuka Pharma Co Ltd Method for treating severe heart failure and medicament therefor
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
PL1968990T3 (pl) 2005-12-27 2015-06-30 Otsuka Pharma Co Ltd Rozpuszczalny w wodzie związek benzoazepinowy i jego kompozycja farmaceutyczna
JP5076327B2 (ja) * 2006-02-01 2012-11-21 味の素株式会社 分岐鎖アミノ酸の心不全適応
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
AU2008254273B2 (en) * 2007-05-15 2013-03-28 Otsuka Pharmaceutical Co., Ltd. Methods for using vasopressin antagonists with anthracycline chemotherapy agents to reduce cardiotoxicity and/or improve survival
TWI405574B (zh) * 2007-06-21 2013-08-21 Otsuka Pharma Co Ltd 藥學固體製劑及其製造方法
WO2011104269A1 (en) 2008-02-26 2011-09-01 Jenavalve Technology Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
WO2011147849A1 (en) 2010-05-25 2011-12-01 Jenavalve Technology Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
JP5477413B2 (ja) * 2012-04-24 2014-04-23 味の素株式会社 分岐鎖アミノ酸の心不全適応
WO2015028209A1 (en) 2013-08-30 2015-03-05 Jenavalve Technology Gmbh Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
EP3270825B1 (en) 2015-03-20 2020-04-22 JenaValve Technology, Inc. Heart valve prosthesis delivery system
EP3288495B1 (en) 2015-05-01 2019-09-25 JenaValve Technology, Inc. Device with reduced pacemaker rate in heart valve replacement
WO2017195125A1 (en) 2016-05-13 2017-11-16 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
US11197754B2 (en) 2017-01-27 2021-12-14 Jenavalve Technology, Inc. Heart valve mimicry
CN110174474B (zh) * 2019-05-24 2022-02-18 石家庄四药有限公司 复方电解质注射液(ⅱ)中l-苹果酸异构体的检测方法
CN112121051B (zh) * 2020-09-30 2021-06-18 郑州大学 莫扎伐坦在制备抗消化道肿瘤药物中的应用
US12171658B2 (en) 2022-11-09 2024-12-24 Jenavalve Technology, Inc. Catheter system for sequential deployment of an expandable implant

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01102124A (ja) 1987-10-14 1989-04-19 Kubota Ltd コンクリート構造体支持構造

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258510A (en) 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
US5753677A (en) 1989-10-20 1998-05-19 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
DK0450097T3 (da) 1989-10-20 1996-05-20 Otsuka Pharma Co Ltd Benzoheterocykliske forbindelser
EP0602209A1 (en) 1992-07-02 1994-06-22 Otsuka Pharmaceutical Co., Ltd. Oxytocin antagonist
JPH0680641A (ja) 1992-09-01 1994-03-22 Otsuka Pharmaceut Co Ltd 光学活性な５−ヒドロキシベンゾアゼピン誘導体の製造法
TW354762B (en) 1993-02-23 1999-03-21 Otsuka Pharma Co Ltd Agent for prophylaxis or treatment of cataract
JP2694319B2 (ja) 1993-12-24 1997-12-24 大塚製薬株式会社 抗潰瘍剤
JP3002766B2 (ja) * 1994-12-09 2000-01-24 大塚製薬株式会社 脳浮腫治療剤
JPH10120592A (ja) 1996-10-22 1998-05-12 Otsuka Pharmaceut Co Ltd メニエール病乃至メニエール症候群治療剤
JP4210355B2 (ja) 1997-07-03 2009-01-14 大塚製薬株式会社 固形製剤組成物
US20030103983A1 (en) * 2002-05-09 2003-06-05 Pressler Milton Lethan Ace inhibitor-vasopressin antagonist combinations
JP2003521496A (ja) 2000-01-26 2003-07-15 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー Ａｃｅ阻害剤−バソプレッシンアンタゴニストの組み合わせ
US20030008860A1 (en) 2002-05-09 2003-01-09 Bakker-Arkema Rebecca Guggemos Treatment of congestive heart failure
ATE367815T1 (de) 2000-10-04 2007-08-15 Astellas Pharma Inc Verwendung von einem vasopressin-antagonisten wie conivaptan zur herstellung eines medikaments für die behandlung der pulmonalen hypertension
TWI322689B (en) * 2003-02-24 2010-04-01 Otsuka Pharma Co Ltd Method for treating severe heart failure and medicament therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01102124A (ja) 1987-10-14 1989-04-19 Kubota Ltd コンクリート構造体支持構造

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
effect of long-term treatment with selective vasopressin v1and v2 receptor antagonist on the development of heartfailurein rats. Nishikimi等.journal of cardiovascular pharmacology,Vol.27 No.2. 1996 *
OPC-31260 otsuka,current opinion in cardiovascular. Martinez-castelao.pulmonary &renal investigational drugs,Vol.1 No.3. 1999 *

Also Published As

Publication number Publication date
CN1700919A (zh) 2005-11-23
ATE411803T1 (de) 2008-11-15
US7423032B2 (en) 2008-09-09
AU2004212842B2 (en) 2009-01-08
EP1596868B1 (en) 2008-10-22
MY143740A (en) 2011-07-15
AU2004212842B9 (en) 2009-03-05
US20050187210A1 (en) 2005-08-25
PL218069B1 (pl) 2014-10-31
WO2004073716A1 (en) 2004-09-02
TW200418489A (en) 2004-10-01
NO20050569L (no) 2005-11-22
US7749993B2 (en) 2010-07-06
RU2005102110A (ru) 2005-09-20
PL404315A1 (pl) 2013-08-05
JP2011148806A (ja) 2011-08-04
JP4771937B2 (ja) 2011-09-14
RU2346689C2 (ru) 2009-02-20
DK1596868T3 (da) 2008-12-08
AU2009201109A1 (en) 2009-04-09
CY1108583T1 (el) 2014-04-09
NO20050569D0 (no) 2005-02-02
ES2315640T3 (es) 2009-04-01
KR100706727B1 (ko) 2007-04-12
PT1596868E (pt) 2009-01-14
RU2008133654A (ru) 2010-02-20
EP1596868A4 (en) 2006-03-29
NO335369B1 (no) 2014-12-01
JP2006518731A (ja) 2006-08-17
EP2000142A1 (en) 2008-12-10
BRPI0405657A (pt) 2005-07-19
PL373432A1 (en) 2005-08-22
AR043259A1 (es) 2005-07-20
MXPA05001623A (es) 2005-04-25
AU2004212842A1 (en) 2004-09-02
TWI322689B (en) 2010-04-01
US20080214523A1 (en) 2008-09-04
CA2493475A1 (en) 2004-09-02
HK1084037A1 (zh) 2006-07-21
DE602004017283D1 (de) 2008-12-04
KR20050105972A (ko) 2005-11-08
EP1596868A1 (en) 2005-11-23
SI1596868T1 (sl) 2008-12-31

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