SG137850A1 - Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies - Google Patents
Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathiesInfo
- Publication number
- SG137850A1 SG137850A1 SG200717673-8A SG2007176738A SG137850A1 SG 137850 A1 SG137850 A1 SG 137850A1 SG 2007176738 A SG2007176738 A SG 2007176738A SG 137850 A1 SG137850 A1 SG 137850A1
- Authority
- SG
- Singapore
- Prior art keywords
- treatment
- synucleinopathies
- substituted
- related compounds
- amyloid diseases
- Prior art date
Links
- 206010002022 amyloidosis Diseases 0.000 title abstract 4
- 208000032859 Synucleinopathies Diseases 0.000 title abstract 2
- 229940054066 benzamide antipsychotics Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000036770 Islet Amyloid Polypeptide Human genes 0.000 abstract 1
- 108010041872 Islet Amyloid Polypeptide Proteins 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- PLOPBXQQPZYQFA-AXPWDRQUSA-N amlintide Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)CSSC1)[C@@H](C)O)C(C)C)C1=CC=CC=C1 PLOPBXQQPZYQFA-AXPWDRQUSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57066904P | 2004-05-12 | 2004-05-12 | |
| US62952504P | 2004-11-18 | 2004-11-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG137850A1 true SG137850A1 (en) | 2007-12-28 |
Family
ID=34969702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG200717673-8A SG137850A1 (en) | 2004-05-12 | 2005-05-12 | Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7745490B2 (https=) |
| EP (1) | EP1751097B1 (https=) |
| JP (1) | JP5203701B2 (https=) |
| KR (1) | KR101168451B1 (https=) |
| AT (1) | ATE453617T1 (https=) |
| AU (1) | AU2005245412B2 (https=) |
| BR (1) | BRPI0510803A (https=) |
| CA (1) | CA2566090C (https=) |
| DE (1) | DE602005018634D1 (https=) |
| DK (1) | DK1751097T3 (https=) |
| ES (1) | ES2337162T3 (https=) |
| IL (1) | IL179160A (https=) |
| MX (1) | MXPA06012603A (https=) |
| NO (1) | NO20065717L (https=) |
| NZ (1) | NZ551589A (https=) |
| RU (1) | RU2381213C2 (https=) |
| SG (1) | SG137850A1 (https=) |
| WO (1) | WO2005113489A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090124690A1 (en) * | 2000-04-03 | 2009-05-14 | Alberte Randall S | Generation of Combinatorial Synthetic Libraries and Screening for Novel Proadhesins and Nonadhesins |
| US20070208087A1 (en) * | 2001-11-02 | 2007-09-06 | Sanders Virginia J | Compounds, compositions and methods for the treatment of inflammatory diseases |
| US20100273776A1 (en) * | 2006-03-29 | 2010-10-28 | FOLDRx PHARMACEUTICALS, INC | Inhibition of alpha-synuclein toxicity |
| WO2009111611A2 (en) * | 2008-03-05 | 2009-09-11 | Proteotech Inc. | Compounds, compositions and methods for the treatment of islet amyloid polypeptide (iapp) accumulation in diabetes |
| EP2098226A1 (de) * | 2008-03-06 | 2009-09-09 | Forschungsverbund Berlin e.V. | AKAP-PKA-Interaktionshemmer zur Anwendung in der Behandlung von Herzkrankheiten |
| EP2554163A4 (en) * | 2010-03-26 | 2013-07-17 | Univ Hokkaido Nat Univ Corp | THERAPEUTIC ACTIVE FOR NEURODEGENERATIVE DISEASES |
| US20120251448A1 (en) * | 2011-03-03 | 2012-10-04 | Hefti Franz F | Compounds for Use in the Detection of Neurodegenerative Diseases |
| WO2019043217A1 (en) | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | DIHYDROBENZIMIDAZOLONES |
| KR102011033B1 (ko) * | 2017-09-25 | 2019-08-14 | (주)아모레퍼시픽 | 성분 함량이 변화된 녹차 추출물을 포함하는 인지기능 개선용 조성물 |
| US10799551B2 (en) | 2017-09-25 | 2020-10-13 | Amorepacific Corporation | Composition for enhancing cognitive function comprising green tea extract which has modified amounts of ingredients |
| EP3867227A4 (en) * | 2018-10-19 | 2022-08-03 | Auckland Uniservices Limited | COMPOUNDS FOR THE TREATMENT OF DIABETES AND/OR RELATED DISEASES |
| ES2995214T3 (en) | 2019-03-06 | 2025-02-07 | C4 Therapeutics Inc | Heterocyclic compounds for medical treatment |
| EP4525852A1 (en) * | 2022-05-20 | 2025-03-26 | Merck Sharp & Dohme LLC | Inhibitors of msba as antibiotics, pharmaceutical compositions, and uses thereof |
| CN117682973B (zh) * | 2022-09-26 | 2026-03-20 | 中国药科大学 | 磺酰胺类化合物及其医药用途 |
| EP4686725A1 (en) | 2024-08-02 | 2026-02-04 | Technische Universität München, in Vertretung des Freistaats Bayern | Amyloid inhibitory peptides |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5916871A (ja) * | 1982-07-20 | 1984-01-28 | Shionogi & Co Ltd | スルホンアミド系ベンズアミド類 |
| JPS63132237A (ja) * | 1986-11-21 | 1988-06-04 | Konica Corp | 迅速処理を行なつても優れた発色性を有するハロゲン化銀写真感光材料 |
| MX9203460A (es) * | 1988-09-12 | 1992-09-01 | Upjohn Co | Nuevos analogos cc-1065 que tienen dos subunidades cpi. |
| GB8914660D0 (en) * | 1989-06-26 | 1989-08-16 | Fujisawa Pharmaceutical Co | Aniline derivatives,processes for production thereof and pharmaceutical compositions comprising the same |
| JPH04285955A (ja) * | 1991-03-14 | 1992-10-12 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| BR9910642A (pt) * | 1998-05-22 | 2001-10-09 | Avanir Pharmaceuticals | Análogos de benzimidazol como reguladores descendentes de ige |
| PL198852B1 (pl) * | 1998-10-22 | 2008-07-31 | Neurosearch As | Podstawione pochodne fenylu, kompozycja farmaceutyczna je zawierająca oraz ich zastosowanie |
| JP4623453B2 (ja) * | 1999-10-14 | 2011-02-02 | 旭化成イーマテリアルズ株式会社 | アミドフェノール化合物 |
| CZ20033309A3 (cs) * | 2001-06-07 | 2004-05-12 | Eliálillyáandácompany | Modulátory receptorů aktivovaných peroxizomálními proliferátory }PPARB |
| WO2003101927A1 (en) * | 2002-05-31 | 2003-12-11 | Proteotech, Inc. | Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's disease |
| AU2003275225A1 (en) * | 2002-09-20 | 2004-04-08 | Genelabs Technologies, Inc. | Novel aromatic compounds possessing antifungal or antibacterial activity |
-
2005
- 2005-05-12 AT AT05749770T patent/ATE453617T1/de active
- 2005-05-12 CA CA2566090A patent/CA2566090C/en not_active Expired - Fee Related
- 2005-05-12 KR KR1020067026028A patent/KR101168451B1/ko not_active Expired - Fee Related
- 2005-05-12 WO PCT/US2005/016677 patent/WO2005113489A1/en not_active Ceased
- 2005-05-12 DK DK05749770.3T patent/DK1751097T3/da active
- 2005-05-12 SG SG200717673-8A patent/SG137850A1/en unknown
- 2005-05-12 MX MXPA06012603A patent/MXPA06012603A/es active IP Right Grant
- 2005-05-12 NZ NZ551589A patent/NZ551589A/en not_active IP Right Cessation
- 2005-05-12 ES ES05749770T patent/ES2337162T3/es not_active Expired - Lifetime
- 2005-05-12 JP JP2007513368A patent/JP5203701B2/ja not_active Expired - Fee Related
- 2005-05-12 AU AU2005245412A patent/AU2005245412B2/en not_active Ceased
- 2005-05-12 RU RU2006143761/04A patent/RU2381213C2/ru not_active IP Right Cessation
- 2005-05-12 EP EP05749770A patent/EP1751097B1/en not_active Expired - Lifetime
- 2005-05-12 DE DE602005018634T patent/DE602005018634D1/de not_active Expired - Lifetime
- 2005-05-12 BR BRPI0510803-9A patent/BRPI0510803A/pt not_active IP Right Cessation
-
2006
- 2006-01-09 US US11/328,748 patent/US7745490B2/en not_active Expired - Fee Related
- 2006-11-09 IL IL179160A patent/IL179160A/en not_active IP Right Cessation
- 2006-12-12 NO NO20065717A patent/NO20065717L/no not_active Application Discontinuation
-
2008
- 2008-08-29 US US12/201,183 patent/US20090060838A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005113489A1 (en) | 2005-12-01 |
| US20090060838A1 (en) | 2009-03-05 |
| IL179160A (en) | 2011-04-28 |
| EP1751097A1 (en) | 2007-02-14 |
| CA2566090C (en) | 2013-07-23 |
| DK1751097T3 (da) | 2010-05-10 |
| ES2337162T3 (es) | 2010-04-21 |
| RU2381213C2 (ru) | 2010-02-10 |
| CA2566090A1 (en) | 2005-12-01 |
| ATE453617T1 (de) | 2010-01-15 |
| KR20070015612A (ko) | 2007-02-05 |
| DE602005018634D1 (de) | 2010-02-11 |
| KR101168451B1 (ko) | 2012-07-25 |
| JP2007537287A (ja) | 2007-12-20 |
| NZ551589A (en) | 2009-10-30 |
| IL179160A0 (en) | 2007-03-08 |
| US7745490B2 (en) | 2010-06-29 |
| BRPI0510803A (pt) | 2007-11-06 |
| EP1751097B1 (en) | 2009-12-30 |
| NO20065717L (no) | 2007-02-08 |
| JP5203701B2 (ja) | 2013-06-05 |
| US20060199838A1 (en) | 2006-09-07 |
| AU2005245412A1 (en) | 2005-12-01 |
| RU2006143761A (ru) | 2008-06-20 |
| MXPA06012603A (es) | 2007-04-12 |
| AU2005245412B2 (en) | 2011-08-04 |
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