JP5203701B2 - アミロイド疾患、及びシヌクレイノパチー治療用置換ｎ−アリールベンズアミド、及び関連化合物 - Google Patents

アミロイド疾患、及びシヌクレイノパチー治療用置換ｎ−アリールベンズアミド、及び関連化合物 Download PDF

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JP5203701B2
JP5203701B2 JP2007513368A JP2007513368A JP5203701B2 JP 5203701 B2 JP5203701 B2 JP 5203701B2 JP 2007513368 A JP2007513368 A JP 2007513368A JP 2007513368 A JP2007513368 A JP 2007513368A JP 5203701 B2 JP5203701 B2 JP 5203701B2
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amyloid
disease
compound
substituted
acid
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Japanese (ja)
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JP2007537287A (ja
JP2007537287A5 (https=
Inventor
ディー． スノウ アラン
ピー． ングイエン ベス
ピー． レイク トマス
エム． カスチルロ ゲラルド
ウェイゲレ マンフレド
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ProteoTech Inc
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ProteoTech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
JP2007513368A 2004-05-12 2005-05-12 アミロイド疾患、及びシヌクレイノパチー治療用置換ｎ−アリールベンズアミド、及び関連化合物 Expired - Fee Related JP5203701B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US57066904P 2004-05-12 2004-05-12
US60/570,669 2004-05-12
US62952504P 2004-11-18 2004-11-18
US60/629,525 2004-11-18
PCT/US2005/016677 WO2005113489A1 (en) 2004-05-12 2005-05-12 Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies

Publications (3)

Publication Number Publication Date
JP2007537287A JP2007537287A (ja) 2007-12-20
JP2007537287A5 JP2007537287A5 (https=) 2008-06-26
JP5203701B2 true JP5203701B2 (ja) 2013-06-05

Family

ID=34969702

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007513368A Expired - Fee Related JP5203701B2 (ja) 2004-05-12 2005-05-12 アミロイド疾患、及びシヌクレイノパチー治療用置換ｎ−アリールベンズアミド、及び関連化合物

Country Status (18)

Country Link
US (2) US7745490B2 (https=)
EP (1) EP1751097B1 (https=)
JP (1) JP5203701B2 (https=)
KR (1) KR101168451B1 (https=)
AT (1) ATE453617T1 (https=)
AU (1) AU2005245412B2 (https=)
BR (1) BRPI0510803A (https=)
CA (1) CA2566090C (https=)
DE (1) DE602005018634D1 (https=)
DK (1) DK1751097T3 (https=)
ES (1) ES2337162T3 (https=)
IL (1) IL179160A (https=)
MX (1) MXPA06012603A (https=)
NO (1) NO20065717L (https=)
NZ (1) NZ551589A (https=)
RU (1) RU2381213C2 (https=)
SG (1) SG137850A1 (https=)
WO (1) WO2005113489A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090124690A1 (en) * 2000-04-03 2009-05-14 Alberte Randall S Generation of Combinatorial Synthetic Libraries and Screening for Novel Proadhesins and Nonadhesins
US20070208087A1 (en) * 2001-11-02 2007-09-06 Sanders Virginia J Compounds, compositions and methods for the treatment of inflammatory diseases
CA2647543A1 (en) * 2006-03-29 2007-11-08 Foldrx Pharmaceuticals, Inc. Inhibition of alpha-synuclein toxicity
WO2009111611A2 (en) * 2008-03-05 2009-09-11 Proteotech Inc. Compounds, compositions and methods for the treatment of islet amyloid polypeptide (iapp) accumulation in diabetes
EP2098226A1 (de) * 2008-03-06 2009-09-09 Forschungsverbund Berlin e.V. AKAP-PKA-Interaktionshemmer zur Anwendung in der Behandlung von Herzkrankheiten
EP2554163A4 (en) * 2010-03-26 2013-07-17 Univ Hokkaido Nat Univ Corp THERAPEUTIC ACTIVE FOR NEURODEGENERATIVE DISEASES
US20120251448A1 (en) * 2011-03-03 2012-10-04 Hefti Franz F Compounds for Use in the Detection of Neurodegenerative Diseases
CN118206529A (zh) 2017-09-04 2024-06-18 C4医药公司 二氢苯并咪唑酮
US10799551B2 (en) 2017-09-25 2020-10-13 Amorepacific Corporation Composition for enhancing cognitive function comprising green tea extract which has modified amounts of ingredients
KR102011033B1 (ko) * 2017-09-25 2019-08-14 (주)아모레퍼시픽 성분 함량이 변화된 녹차 추출물을 포함하는 인지기능 개선용 조성물
US20220041591A1 (en) * 2018-10-19 2022-02-10 Auckland Uniservices Limited Compounds for treating diabetes and/or related conditions
WO2020181232A1 (en) 2019-03-06 2020-09-10 C4 Therapeutics, Inc. Heterocyclic compounds for medical treatment
WO2023224893A1 (en) * 2022-05-20 2023-11-23 Merck Sharp & Dohme Llc Inhibitors of msba as antibiotics, pharmaceutical compositions, and uses thereof
CN117682973B (zh) * 2022-09-26 2026-03-20 中国药科大学 磺酰胺类化合物及其医药用途
EP4686725A1 (en) 2024-08-02 2026-02-04 Technische Universität München, in Vertretung des Freistaats Bayern Amyloid inhibitory peptides

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5916871A (ja) * 1982-07-20 1984-01-28 Shionogi & Co Ltd スルホンアミド系ベンズアミド類
JPS63132237A (ja) * 1986-11-21 1988-06-04 Konica Corp 迅速処理を行なつても優れた発色性を有するハロゲン化銀写真感光材料
MX9203460A (es) * 1988-09-12 1992-09-01 Upjohn Co Nuevos analogos cc-1065 que tienen dos subunidades cpi.
GB8914660D0 (en) * 1989-06-26 1989-08-16 Fujisawa Pharmaceutical Co Aniline derivatives,processes for production thereof and pharmaceutical compositions comprising the same
JPH04285955A (ja) * 1991-03-14 1992-10-12 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
RU2236220C2 (ru) * 1998-05-22 2004-09-20 Аванир Фармасьютикэлз Аналоги бензимидазола в качестве понижающих регуляторов ige
OA11665A (en) * 1998-10-22 2004-12-08 Neurosearch As Substituted phenyl derivatives, their preparation and use.
JP4623453B2 (ja) * 1999-10-14 2011-02-02 旭化成イーマテリアルズ株式会社 アミドフェノール化合物
MXPA03011201A (es) * 2001-06-07 2004-02-26 Lilly Co Eli Moduladores de receptores activados por proliferadores de persoxisomas.
PT2527315E (pt) * 2002-05-31 2014-06-24 Proteotech Inc Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson
WO2004026264A2 (en) * 2002-09-20 2004-04-01 Genelabs Technologies, Inc. Novel aromatic compounds possessing antifungal or antibacterial activity

Also Published As

Publication number Publication date
NO20065717L (no) 2007-02-08
RU2381213C2 (ru) 2010-02-10
ATE453617T1 (de) 2010-01-15
EP1751097B1 (en) 2009-12-30
JP2007537287A (ja) 2007-12-20
US7745490B2 (en) 2010-06-29
SG137850A1 (en) 2007-12-28
RU2006143761A (ru) 2008-06-20
MXPA06012603A (es) 2007-04-12
EP1751097A1 (en) 2007-02-14
NZ551589A (en) 2009-10-30
US20060199838A1 (en) 2006-09-07
WO2005113489A1 (en) 2005-12-01
BRPI0510803A (pt) 2007-11-06
IL179160A (en) 2011-04-28
ES2337162T3 (es) 2010-04-21
DE602005018634D1 (de) 2010-02-11
US20090060838A1 (en) 2009-03-05
CA2566090C (en) 2013-07-23
DK1751097T3 (da) 2010-05-10
AU2005245412B2 (en) 2011-08-04
KR101168451B1 (ko) 2012-07-25
IL179160A0 (en) 2007-03-08
CA2566090A1 (en) 2005-12-01
KR20070015612A (ko) 2007-02-05
AU2005245412A1 (en) 2005-12-01

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