KR101168451B1 - 아밀로이드 병 및 시뉴클레인 병의 치료를 위한 치환된 ｎ-아릴 벤즈아미드 및 관련 화합물 - Google Patents
아밀로이드 병 및 시뉴클레인 병의 치료를 위한 치환된 ｎ-아릴 벤즈아미드 및 관련 화합물 Download PDFInfo
- Publication number
- KR101168451B1 KR101168451B1 KR1020067026028A KR20067026028A KR101168451B1 KR 101168451 B1 KR101168451 B1 KR 101168451B1 KR 1020067026028 A KR1020067026028 A KR 1020067026028A KR 20067026028 A KR20067026028 A KR 20067026028A KR 101168451 B1 KR101168451 B1 KR 101168451B1
- Authority
- KR
- South Korea
- Prior art keywords
- delete delete
- disease
- amyloidosis
- amyloid
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *c(c(*)c1)ccc1NC(c(cc1)cc(N2)c1NS2(=O)=O)=O Chemical compound *c(c(*)c1)ccc1NC(c(cc1)cc(N2)c1NS2(=O)=O)=O 0.000 description 18
- FREOXOJLJUTUTF-UHFFFAOYSA-N CN(c1ccc(CCc(cc2)cc(NS=O)c2N)cc1N1)S1(O)=O Chemical compound CN(c1ccc(CCc(cc2)cc(NS=O)c2N)cc1N1)S1(O)=O FREOXOJLJUTUTF-UHFFFAOYSA-N 0.000 description 1
- DQJPMTGLPCJMML-UHFFFAOYSA-N CNc(ccc(C(Nc(cc1)cc(O)c1O)=O)c1)c1NC Chemical compound CNc(ccc(C(Nc(cc1)cc(O)c1O)=O)c1)c1NC DQJPMTGLPCJMML-UHFFFAOYSA-N 0.000 description 1
- IOPLHGOSNCJOOO-UHFFFAOYSA-N COC(c(cc1)cc(N)c1N)=O Chemical compound COC(c(cc1)cc(N)c1N)=O IOPLHGOSNCJOOO-UHFFFAOYSA-N 0.000 description 1
- RGNZFNMSDFVMLW-UHFFFAOYSA-N COC1C=CC(C(Cl)=O)=CC1[N+]([O-])=O Chemical compound COC1C=CC(C(Cl)=O)=CC1[N+]([O-])=O RGNZFNMSDFVMLW-UHFFFAOYSA-N 0.000 description 1
- ANXBDAFDZSXOPQ-UHFFFAOYSA-N COc(ccc(C(O)=O)c1)c1[N+]([O-])=O Chemical compound COc(ccc(C(O)=O)c1)c1[N+]([O-])=O ANXBDAFDZSXOPQ-UHFFFAOYSA-N 0.000 description 1
- HEMGYNNCNNODNX-UHFFFAOYSA-N Nc(ccc(C(O)=O)c1)c1N Chemical compound Nc(ccc(C(O)=O)c1)c1N HEMGYNNCNNODNX-UHFFFAOYSA-N 0.000 description 1
- RAUWPNXIALNKQM-UHFFFAOYSA-N Nc(ccc([N+]([O-])=O)c1)c1N Chemical compound Nc(ccc([N+]([O-])=O)c1)c1N RAUWPNXIALNKQM-UHFFFAOYSA-N 0.000 description 1
- SLAQPZAHSPAAOP-UHFFFAOYSA-N Nc1cc(NC(c(cc2)cc(N3)c2NS3(=O)=O)=O)ccc1NS=O Chemical compound Nc1cc(NC(c(cc2)cc(N3)c2NS3(=O)=O)=O)ccc1NS=O SLAQPZAHSPAAOP-UHFFFAOYSA-N 0.000 description 1
- NVNGYYDUVUVVMK-UHFFFAOYSA-N OC(c(cc1O)cc2c1[nH]cc2)Nc(cc1O)ccc1O Chemical compound OC(c(cc1O)cc2c1[nH]cc2)Nc(cc1O)ccc1O NVNGYYDUVUVVMK-UHFFFAOYSA-N 0.000 description 1
- PTDCIPZJAPKFCR-UHFFFAOYSA-N Oc(cc1)c2[nH]ccc2c1NC(c(cc1)cc(O)c1O)=O Chemical compound Oc(cc1)c2[nH]ccc2c1NC(c(cc1)cc(O)c1O)=O PTDCIPZJAPKFCR-UHFFFAOYSA-N 0.000 description 1
- MXCTXRDCGTUZOZ-UHFFFAOYSA-N Oc(ccc(C(Nc(cc1N2)ccc1NS2(=O)=O)=O)c1)c1O Chemical compound Oc(ccc(C(Nc(cc1N2)ccc1NS2(=O)=O)=O)c1)c1O MXCTXRDCGTUZOZ-UHFFFAOYSA-N 0.000 description 1
- YWCDEWBESQKUAW-UHFFFAOYSA-N Oc1c2[nH]ccc2cc(NC(c(cc2)cc(O)c2O)=O)c1 Chemical compound Oc1c2[nH]ccc2cc(NC(c(cc2)cc(O)c2O)=O)c1 YWCDEWBESQKUAW-UHFFFAOYSA-N 0.000 description 1
- CRZBRWCTTHEILE-UHFFFAOYSA-N Oc1ccc(CCc(cc2N3)ccc2NS3=O)cc1O Chemical compound Oc1ccc(CCc(cc2N3)ccc2NS3=O)cc1O CRZBRWCTTHEILE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57066904P | 2004-05-12 | 2004-05-12 | |
| US60/570,669 | 2004-05-12 | ||
| US62952504P | 2004-11-18 | 2004-11-18 | |
| US60/629,525 | 2004-11-18 | ||
| PCT/US2005/016677 WO2005113489A1 (en) | 2004-05-12 | 2005-05-12 | Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20070015612A KR20070015612A (ko) | 2007-02-05 |
| KR101168451B1 true KR101168451B1 (ko) | 2012-07-25 |
Family
ID=34969702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067026028A Expired - Fee Related KR101168451B1 (ko) | 2004-05-12 | 2005-05-12 | 아밀로이드 병 및 시뉴클레인 병의 치료를 위한 치환된 ｎ-아릴 벤즈아미드 및 관련 화합물 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7745490B2 (https=) |
| EP (1) | EP1751097B1 (https=) |
| JP (1) | JP5203701B2 (https=) |
| KR (1) | KR101168451B1 (https=) |
| AT (1) | ATE453617T1 (https=) |
| AU (1) | AU2005245412B2 (https=) |
| BR (1) | BRPI0510803A (https=) |
| CA (1) | CA2566090C (https=) |
| DE (1) | DE602005018634D1 (https=) |
| DK (1) | DK1751097T3 (https=) |
| ES (1) | ES2337162T3 (https=) |
| IL (1) | IL179160A (https=) |
| MX (1) | MXPA06012603A (https=) |
| NO (1) | NO20065717L (https=) |
| NZ (1) | NZ551589A (https=) |
| RU (1) | RU2381213C2 (https=) |
| SG (1) | SG137850A1 (https=) |
| WO (1) | WO2005113489A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090124690A1 (en) * | 2000-04-03 | 2009-05-14 | Alberte Randall S | Generation of Combinatorial Synthetic Libraries and Screening for Novel Proadhesins and Nonadhesins |
| US20070208087A1 (en) * | 2001-11-02 | 2007-09-06 | Sanders Virginia J | Compounds, compositions and methods for the treatment of inflammatory diseases |
| CA2647543A1 (en) * | 2006-03-29 | 2007-11-08 | Foldrx Pharmaceuticals, Inc. | Inhibition of alpha-synuclein toxicity |
| WO2009111611A2 (en) * | 2008-03-05 | 2009-09-11 | Proteotech Inc. | Compounds, compositions and methods for the treatment of islet amyloid polypeptide (iapp) accumulation in diabetes |
| EP2098226A1 (de) * | 2008-03-06 | 2009-09-09 | Forschungsverbund Berlin e.V. | AKAP-PKA-Interaktionshemmer zur Anwendung in der Behandlung von Herzkrankheiten |
| EP2554163A4 (en) * | 2010-03-26 | 2013-07-17 | Univ Hokkaido Nat Univ Corp | THERAPEUTIC ACTIVE FOR NEURODEGENERATIVE DISEASES |
| US20120251448A1 (en) * | 2011-03-03 | 2012-10-04 | Hefti Franz F | Compounds for Use in the Detection of Neurodegenerative Diseases |
| CN118206529A (zh) | 2017-09-04 | 2024-06-18 | C4医药公司 | 二氢苯并咪唑酮 |
| US10799551B2 (en) | 2017-09-25 | 2020-10-13 | Amorepacific Corporation | Composition for enhancing cognitive function comprising green tea extract which has modified amounts of ingredients |
| KR102011033B1 (ko) * | 2017-09-25 | 2019-08-14 | (주)아모레퍼시픽 | 성분 함량이 변화된 녹차 추출물을 포함하는 인지기능 개선용 조성물 |
| US20220041591A1 (en) * | 2018-10-19 | 2022-02-10 | Auckland Uniservices Limited | Compounds for treating diabetes and/or related conditions |
| WO2020181232A1 (en) | 2019-03-06 | 2020-09-10 | C4 Therapeutics, Inc. | Heterocyclic compounds for medical treatment |
| WO2023224893A1 (en) * | 2022-05-20 | 2023-11-23 | Merck Sharp & Dohme Llc | Inhibitors of msba as antibiotics, pharmaceutical compositions, and uses thereof |
| CN117682973B (zh) * | 2022-09-26 | 2026-03-20 | 中国药科大学 | 磺酰胺类化合物及其医药用途 |
| EP4686725A1 (en) | 2024-08-02 | 2026-02-04 | Technische Universität München, in Vertretung des Freistaats Bayern | Amyloid inhibitory peptides |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5916871A (ja) * | 1982-07-20 | 1984-01-28 | Shionogi & Co Ltd | スルホンアミド系ベンズアミド類 |
| JPS63132237A (ja) * | 1986-11-21 | 1988-06-04 | Konica Corp | 迅速処理を行なつても優れた発色性を有するハロゲン化銀写真感光材料 |
| MX9203460A (es) * | 1988-09-12 | 1992-09-01 | Upjohn Co | Nuevos analogos cc-1065 que tienen dos subunidades cpi. |
| GB8914660D0 (en) * | 1989-06-26 | 1989-08-16 | Fujisawa Pharmaceutical Co | Aniline derivatives,processes for production thereof and pharmaceutical compositions comprising the same |
| JPH04285955A (ja) * | 1991-03-14 | 1992-10-12 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| RU2236220C2 (ru) * | 1998-05-22 | 2004-09-20 | Аванир Фармасьютикэлз | Аналоги бензимидазола в качестве понижающих регуляторов ige |
| OA11665A (en) * | 1998-10-22 | 2004-12-08 | Neurosearch As | Substituted phenyl derivatives, their preparation and use. |
| JP4623453B2 (ja) * | 1999-10-14 | 2011-02-02 | 旭化成イーマテリアルズ株式会社 | アミドフェノール化合物 |
| MXPA03011201A (es) * | 2001-06-07 | 2004-02-26 | Lilly Co Eli | Moduladores de receptores activados por proliferadores de persoxisomas. |
| PT2527315E (pt) * | 2002-05-31 | 2014-06-24 | Proteotech Inc | Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson |
| WO2004026264A2 (en) * | 2002-09-20 | 2004-04-01 | Genelabs Technologies, Inc. | Novel aromatic compounds possessing antifungal or antibacterial activity |
-
2005
- 2005-05-12 BR BRPI0510803-9A patent/BRPI0510803A/pt not_active IP Right Cessation
- 2005-05-12 SG SG200717673-8A patent/SG137850A1/en unknown
- 2005-05-12 NZ NZ551589A patent/NZ551589A/en not_active IP Right Cessation
- 2005-05-12 ES ES05749770T patent/ES2337162T3/es not_active Expired - Lifetime
- 2005-05-12 RU RU2006143761/04A patent/RU2381213C2/ru not_active IP Right Cessation
- 2005-05-12 JP JP2007513368A patent/JP5203701B2/ja not_active Expired - Fee Related
- 2005-05-12 AT AT05749770T patent/ATE453617T1/de active
- 2005-05-12 KR KR1020067026028A patent/KR101168451B1/ko not_active Expired - Fee Related
- 2005-05-12 WO PCT/US2005/016677 patent/WO2005113489A1/en not_active Ceased
- 2005-05-12 MX MXPA06012603A patent/MXPA06012603A/es active IP Right Grant
- 2005-05-12 CA CA2566090A patent/CA2566090C/en not_active Expired - Fee Related
- 2005-05-12 EP EP05749770A patent/EP1751097B1/en not_active Expired - Lifetime
- 2005-05-12 DK DK05749770.3T patent/DK1751097T3/da active
- 2005-05-12 AU AU2005245412A patent/AU2005245412B2/en not_active Ceased
- 2005-05-12 DE DE602005018634T patent/DE602005018634D1/de not_active Expired - Lifetime
-
2006
- 2006-01-09 US US11/328,748 patent/US7745490B2/en not_active Expired - Fee Related
- 2006-11-09 IL IL179160A patent/IL179160A/en not_active IP Right Cessation
- 2006-12-12 NO NO20065717A patent/NO20065717L/no not_active Application Discontinuation
-
2008
- 2008-08-29 US US12/201,183 patent/US20090060838A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO20065717L (no) | 2007-02-08 |
| RU2381213C2 (ru) | 2010-02-10 |
| ATE453617T1 (de) | 2010-01-15 |
| EP1751097B1 (en) | 2009-12-30 |
| JP2007537287A (ja) | 2007-12-20 |
| US7745490B2 (en) | 2010-06-29 |
| SG137850A1 (en) | 2007-12-28 |
| RU2006143761A (ru) | 2008-06-20 |
| MXPA06012603A (es) | 2007-04-12 |
| EP1751097A1 (en) | 2007-02-14 |
| NZ551589A (en) | 2009-10-30 |
| US20060199838A1 (en) | 2006-09-07 |
| WO2005113489A1 (en) | 2005-12-01 |
| JP5203701B2 (ja) | 2013-06-05 |
| BRPI0510803A (pt) | 2007-11-06 |
| IL179160A (en) | 2011-04-28 |
| ES2337162T3 (es) | 2010-04-21 |
| DE602005018634D1 (de) | 2010-02-11 |
| US20090060838A1 (en) | 2009-03-05 |
| CA2566090C (en) | 2013-07-23 |
| DK1751097T3 (da) | 2010-05-10 |
| AU2005245412B2 (en) | 2011-08-04 |
| IL179160A0 (en) | 2007-03-08 |
| CA2566090A1 (en) | 2005-12-01 |
| KR20070015612A (ko) | 2007-02-05 |
| AU2005245412A1 (en) | 2005-12-01 |
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| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
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St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
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| A201 | Request for examination | ||
| E13-X000 | Pre-grant limitation requested |
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| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
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| P13-X000 | Application amended |
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| R18-X000 | Changes to party contact information recorded |
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| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
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St.27 status event code: A-2-3-E10-E13-lim-X000 |
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| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
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