JP2007538024A5 - - Google Patents
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- Publication number
- JP2007538024A5 JP2007538024A5 JP2007517041A JP2007517041A JP2007538024A5 JP 2007538024 A5 JP2007538024 A5 JP 2007538024A5 JP 2007517041 A JP2007517041 A JP 2007517041A JP 2007517041 A JP2007517041 A JP 2007517041A JP 2007538024 A5 JP2007538024 A5 JP 2007538024A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- phenyl
- cycloalkyl
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 23
- 125000001424 substituent group Chemical group 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 102000001708 Protein Isoforms Human genes 0.000 claims 3
- 108010029485 Protein Isoforms Proteins 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000003884 phenylalkyl group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04011894 | 2004-05-19 | ||
| PCT/EP2005/005229 WO2005110422A2 (en) | 2004-05-19 | 2005-05-13 | Treatment of diseases associated with altered level of amyloid beta peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007538024A JP2007538024A (ja) | 2007-12-27 |
| JP2007538024A5 true JP2007538024A5 (https=) | 2008-07-03 |
Family
ID=34979633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007517041A Pending JP2007538024A (ja) | 2004-05-19 | 2005-05-13 | アミロイドベータペプチドのレベル変化に関連する疾患及び状態の治療方法及び新規エノールカルボキサミド化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US7393843B2 (https=) |
| EP (1) | EP1750719A2 (https=) |
| JP (1) | JP2007538024A (https=) |
| CA (1) | CA2567223A1 (https=) |
| WO (1) | WO2005110422A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008534541A (ja) * | 2005-03-30 | 2008-08-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換１，２−エチレンジアミン、前記化合物を含む薬物、それらの使用及びそれらの製造方法 |
| EP1913017A1 (en) * | 2005-08-03 | 2008-04-23 | Boehringer Ingelheim International GmbH | Substituted ethane-1,2-diamines for the treatment of alzheimer's disease ii |
| EP1915339A1 (de) * | 2005-08-11 | 2008-04-30 | Boehringer Ingelheim International GmbH | Inhibitoren der beta-sekretase zur behandlung der alzheimer- erkrankung |
| US20090042867A1 (en) * | 2005-08-11 | 2009-02-12 | Klaus Fuchs | Compounds for the treatment of alzheimer's disease |
| US20100168070A1 (en) * | 2005-08-11 | 2010-07-01 | Niklas Heine | Compounds for the treatment of alzheimer's disease |
| US20100144681A1 (en) * | 2005-08-11 | 2010-06-10 | Klaus Fuchs | Compounds for the treatment of alzheimer's disease |
| US20110105602A2 (en) * | 2007-03-08 | 2011-05-05 | Daria Mochly-Rosen | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof |
| RU2009144998A (ru) | 2007-05-07 | 2011-06-20 | Шеринг Корпорейшн (US) | Модуляторы гамма-секретазы |
| CA2689930A1 (en) | 2007-06-01 | 2008-12-18 | Schering Corporation | Gamma secretase modulators |
| CA2689948A1 (en) | 2007-06-01 | 2008-12-18 | Schering Corporation | Gamma secretase modulators |
| CA2695543A1 (en) * | 2007-08-06 | 2009-02-12 | Schering Corporation | Gamma secretase modulators |
| US8518975B2 (en) | 2007-09-06 | 2013-08-27 | Merck Sharp + Dohme Corp. | Gamma secretase modulators |
| MX2010005028A (es) | 2007-11-05 | 2010-05-27 | Schering Corp | Moduladores de gamma secretasa. |
| EP2227471A1 (en) | 2007-12-11 | 2010-09-15 | Schering Corporation | Gamma secretase modulators |
| US8354435B2 (en) | 2008-09-08 | 2013-01-15 | The Board Of Trustees Of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
| CN102202669A (zh) | 2008-10-28 | 2011-09-28 | 利兰·斯坦福青年大学托管委员会 | 醛脱氢酶调节剂及其使用方法 |
| JP2012508748A (ja) | 2008-11-13 | 2012-04-12 | シェーリング コーポレイション | γ−セクレターゼ調節剤 |
| MX2011005046A (es) | 2008-11-13 | 2011-06-01 | Schering Corp | Moduladores de gamma secretasa. |
| US20100159485A1 (en) * | 2008-12-19 | 2010-06-24 | Centre For Dna Fingerprinting And Diagnostics | Detection of mycobacterium tuberculosis |
| EP2379563B1 (en) | 2008-12-22 | 2014-07-16 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
| WO2010075204A2 (en) | 2008-12-22 | 2010-07-01 | Schering Corporation | Gamma secretase modulators |
| US20100233156A1 (en) * | 2009-03-09 | 2010-09-16 | Georgetown University | Treating Central Nervous System Injury with Beta and Gamma Secretase Inhibitors |
| CN102438622A (zh) * | 2009-03-19 | 2012-05-02 | 百时美施贵宝公司 | 作为β淀粉样肽产生抑制剂的新颖α-(N-磺酰氨基)乙酰胺化合物 |
| WO2010147975A1 (en) | 2009-06-16 | 2010-12-23 | Schering Corporation | Gamma secretase modulators |
| WO2010147973A1 (en) | 2009-06-16 | 2010-12-23 | Schering Corporation | Gamma secretase modulators |
| WO2010147969A2 (en) | 2009-06-16 | 2010-12-23 | Schering Corporation | Gamma secretase modulators |
| US10160789B2 (en) | 2011-03-14 | 2018-12-25 | University Of Louisville Research Foundation, Inc. | Polypeptides having immunoactivating activity and methods of producing the same |
| US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| WO2014160185A2 (en) | 2013-03-14 | 2014-10-02 | The Board Of Trustees Of The Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
| EP3313866B1 (en) | 2015-06-29 | 2024-11-20 | University Of Louisville Research Foundation, Inc. | Compositions and methods for treating cancer and promoting wound healing |
| US12343375B2 (en) | 2021-02-09 | 2025-07-01 | University Of Louisville Research Foundation, Inc. | Spray dried formulation of a cholera toxin B subunit variant |
| CN118791377B (zh) * | 2024-09-10 | 2025-02-07 | 山东国邦药业有限公司 | 一种2,4,5-三氟苯乙酸的制备方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3674876A (en) | 1969-06-09 | 1972-07-04 | Pfizer | Benzothiazine dioxides as lipid regulating agents |
| US3998954A (en) * | 1971-02-05 | 1976-12-21 | Pfizer Inc. | 1,3(2H,4H)-Dioxoisoquinoline-4-carboxamides used as anti-inflammatory agents |
| US3891637A (en) | 1974-10-01 | 1975-06-24 | Pfizer | Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides |
| MC1135A1 (fr) | 1976-02-23 | 1977-11-18 | Hoffmann La Roche | Derives de thiazine |
| US4175085A (en) | 1976-02-23 | 1979-11-20 | Hoffmann-La Roche Inc. | Thienothiazine derivatives |
| LU78009A1 (de) | 1977-08-22 | 1979-05-23 | Hoffmann La Roche | Verfahren zur herstellung von thiazinderivaten |
| US4683306A (en) | 1984-07-13 | 1987-07-28 | Yuhan Corporation Co., Ltd. | Process for the preparation of 3,4-dihydro-2-substituted-2H-1,2-thiazine-carboxylic acid 1,1-dioxide derivatives |
| ES2217250T3 (es) * | 1990-06-15 | 2004-11-01 | Scios Inc. | Mamifero transgenico, no humano que muestra la patologia de formacion amiloides de la enfermedad de alzheimer. |
| ES2236682T5 (es) * | 1991-01-21 | 2011-03-31 | Elan Pharmaceuticals, Inc. | Ensayo y modelo para la enfermedad de alzheimer. |
| JPH05286941A (ja) * | 1991-09-30 | 1993-11-02 | Nippon Zeon Co Ltd | ピリジン−２，６−ジオン誘導体 |
| AU671093B2 (en) | 1992-01-07 | 1996-08-15 | Elan Pharmaceuticals, Inc. | Transgenic animal models for alzheimer's disease |
| US5604102A (en) * | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
| AU702293B2 (en) * | 1993-10-27 | 1999-02-18 | Athena Neurosciences, Inc. | Transgenic animals harboring APP allele having Swedish mutation |
| US5877399A (en) | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
| ES2239801T3 (es) * | 1997-04-02 | 2005-10-01 | The Brigham And Women's Hospital, Inc. | Uso de un agente para disminuir el riesgo de enfermedad cardiovascular. |
| KR20020013961A (ko) | 1999-07-16 | 2002-02-21 | 룬딩 에른스트 | 신규한 아미노벤조페논 |
| EP1212101A1 (en) * | 1999-08-31 | 2002-06-12 | The Brigham And Women's Hospital, Inc. | Systemic inflammatory markers as diagnostic tools in the prevention of atherosclerotic diseases |
| JP2003530437A (ja) | 2000-04-13 | 2003-10-14 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ | Ａβ４２低下物質 |
| WO2003040691A2 (en) * | 2001-11-05 | 2003-05-15 | The Brigham And Women's Hospital, Inc. | Soluble cd40l(cd154) as a prognostic marker of atherosclerotic diseases |
| WO2003088811A2 (en) * | 2002-04-16 | 2003-10-30 | The Brigham And Women's Hospital, Inc. | Gelsolin as a prognostic marker of artherosclerotic diseases |
-
2005
- 2005-05-13 WO PCT/EP2005/005229 patent/WO2005110422A2/en not_active Ceased
- 2005-05-13 CA CA002567223A patent/CA2567223A1/en not_active Abandoned
- 2005-05-13 EP EP05744035A patent/EP1750719A2/en not_active Withdrawn
- 2005-05-13 JP JP2007517041A patent/JP2007538024A/ja active Pending
- 2005-05-19 US US11/132,482 patent/US7393843B2/en active Active
- 2005-05-19 US US11/132,815 patent/US7375220B2/en not_active Expired - Lifetime
-
2008
- 2008-01-17 US US12/015,735 patent/US7534787B2/en not_active Expired - Lifetime
- 2008-12-17 US US12/337,242 patent/US20090099159A1/en not_active Abandoned