CA2567223A1 - Treatment of diseases associated with altered level of amyloid beta peptides - Google Patents
Treatment of diseases associated with altered level of amyloid beta peptides Download PDFInfo
- Publication number
- CA2567223A1 CA2567223A1 CA002567223A CA2567223A CA2567223A1 CA 2567223 A1 CA2567223 A1 CA 2567223A1 CA 002567223 A CA002567223 A CA 002567223A CA 2567223 A CA2567223 A CA 2567223A CA 2567223 A1 CA2567223 A1 CA 2567223A1
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- alkyl
- phenyl
- beta
- compound
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04011894 | 2004-05-19 | ||
| EP04011894.5 | 2004-05-19 | ||
| PCT/EP2005/005229 WO2005110422A2 (en) | 2004-05-19 | 2005-05-13 | Treatment of diseases associated with altered level of amyloid beta peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2567223A1 true CA2567223A1 (en) | 2005-11-24 |
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ID=34979633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002567223A Abandoned CA2567223A1 (en) | 2004-05-19 | 2005-05-13 | Treatment of diseases associated with altered level of amyloid beta peptides |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US7393843B2 (https=) |
| EP (1) | EP1750719A2 (https=) |
| JP (1) | JP2007538024A (https=) |
| CA (1) | CA2567223A1 (https=) |
| WO (1) | WO2005110422A2 (https=) |
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| JP2008534541A (ja) * | 2005-03-30 | 2008-08-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換１，２−エチレンジアミン、前記化合物を含む薬物、それらの使用及びそれらの製造方法 |
| EP1913017A1 (en) * | 2005-08-03 | 2008-04-23 | Boehringer Ingelheim International GmbH | Substituted ethane-1,2-diamines for the treatment of alzheimer's disease ii |
| EP1915339A1 (de) * | 2005-08-11 | 2008-04-30 | Boehringer Ingelheim International GmbH | Inhibitoren der beta-sekretase zur behandlung der alzheimer- erkrankung |
| US20090042867A1 (en) * | 2005-08-11 | 2009-02-12 | Klaus Fuchs | Compounds for the treatment of alzheimer's disease |
| US20100168070A1 (en) * | 2005-08-11 | 2010-07-01 | Niklas Heine | Compounds for the treatment of alzheimer's disease |
| US20100144681A1 (en) * | 2005-08-11 | 2010-06-10 | Klaus Fuchs | Compounds for the treatment of alzheimer's disease |
| US20110105602A2 (en) * | 2007-03-08 | 2011-05-05 | Daria Mochly-Rosen | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof |
| RU2009144998A (ru) | 2007-05-07 | 2011-06-20 | Шеринг Корпорейшн (US) | Модуляторы гамма-секретазы |
| CA2689930A1 (en) | 2007-06-01 | 2008-12-18 | Schering Corporation | Gamma secretase modulators |
| CA2689948A1 (en) | 2007-06-01 | 2008-12-18 | Schering Corporation | Gamma secretase modulators |
| CA2695543A1 (en) * | 2007-08-06 | 2009-02-12 | Schering Corporation | Gamma secretase modulators |
| US8518975B2 (en) | 2007-09-06 | 2013-08-27 | Merck Sharp + Dohme Corp. | Gamma secretase modulators |
| MX2010005028A (es) | 2007-11-05 | 2010-05-27 | Schering Corp | Moduladores de gamma secretasa. |
| EP2227471A1 (en) | 2007-12-11 | 2010-09-15 | Schering Corporation | Gamma secretase modulators |
| US8354435B2 (en) | 2008-09-08 | 2013-01-15 | The Board Of Trustees Of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
| CN102202669A (zh) | 2008-10-28 | 2011-09-28 | 利兰·斯坦福青年大学托管委员会 | 醛脱氢酶调节剂及其使用方法 |
| JP2012508748A (ja) | 2008-11-13 | 2012-04-12 | シェーリング コーポレイション | γ−セクレターゼ調節剤 |
| MX2011005046A (es) | 2008-11-13 | 2011-06-01 | Schering Corp | Moduladores de gamma secretasa. |
| US20100159485A1 (en) * | 2008-12-19 | 2010-06-24 | Centre For Dna Fingerprinting And Diagnostics | Detection of mycobacterium tuberculosis |
| EP2379563B1 (en) | 2008-12-22 | 2014-07-16 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
| WO2010075204A2 (en) | 2008-12-22 | 2010-07-01 | Schering Corporation | Gamma secretase modulators |
| US20100233156A1 (en) * | 2009-03-09 | 2010-09-16 | Georgetown University | Treating Central Nervous System Injury with Beta and Gamma Secretase Inhibitors |
| CN102438622A (zh) * | 2009-03-19 | 2012-05-02 | 百时美施贵宝公司 | 作为β淀粉样肽产生抑制剂的新颖α-(N-磺酰氨基)乙酰胺化合物 |
| WO2010147975A1 (en) | 2009-06-16 | 2010-12-23 | Schering Corporation | Gamma secretase modulators |
| WO2010147973A1 (en) | 2009-06-16 | 2010-12-23 | Schering Corporation | Gamma secretase modulators |
| WO2010147969A2 (en) | 2009-06-16 | 2010-12-23 | Schering Corporation | Gamma secretase modulators |
| US10160789B2 (en) | 2011-03-14 | 2018-12-25 | University Of Louisville Research Foundation, Inc. | Polypeptides having immunoactivating activity and methods of producing the same |
| US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| WO2014160185A2 (en) | 2013-03-14 | 2014-10-02 | The Board Of Trustees Of The Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
| EP3313866B1 (en) | 2015-06-29 | 2024-11-20 | University Of Louisville Research Foundation, Inc. | Compositions and methods for treating cancer and promoting wound healing |
| US12343375B2 (en) | 2021-02-09 | 2025-07-01 | University Of Louisville Research Foundation, Inc. | Spray dried formulation of a cholera toxin B subunit variant |
| CN118791377B (zh) * | 2024-09-10 | 2025-02-07 | 山东国邦药业有限公司 | 一种2,4,5-三氟苯乙酸的制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3674876A (en) | 1969-06-09 | 1972-07-04 | Pfizer | Benzothiazine dioxides as lipid regulating agents |
| US3998954A (en) * | 1971-02-05 | 1976-12-21 | Pfizer Inc. | 1,3(2H,4H)-Dioxoisoquinoline-4-carboxamides used as anti-inflammatory agents |
| US3891637A (en) | 1974-10-01 | 1975-06-24 | Pfizer | Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides |
| MC1135A1 (fr) | 1976-02-23 | 1977-11-18 | Hoffmann La Roche | Derives de thiazine |
| US4175085A (en) | 1976-02-23 | 1979-11-20 | Hoffmann-La Roche Inc. | Thienothiazine derivatives |
| LU78009A1 (de) | 1977-08-22 | 1979-05-23 | Hoffmann La Roche | Verfahren zur herstellung von thiazinderivaten |
| US4683306A (en) | 1984-07-13 | 1987-07-28 | Yuhan Corporation Co., Ltd. | Process for the preparation of 3,4-dihydro-2-substituted-2H-1,2-thiazine-carboxylic acid 1,1-dioxide derivatives |
| ES2217250T3 (es) * | 1990-06-15 | 2004-11-01 | Scios Inc. | Mamifero transgenico, no humano que muestra la patologia de formacion amiloides de la enfermedad de alzheimer. |
| ES2236682T5 (es) * | 1991-01-21 | 2011-03-31 | Elan Pharmaceuticals, Inc. | Ensayo y modelo para la enfermedad de alzheimer. |
| JPH05286941A (ja) * | 1991-09-30 | 1993-11-02 | Nippon Zeon Co Ltd | ピリジン−２，６−ジオン誘導体 |
| AU671093B2 (en) | 1992-01-07 | 1996-08-15 | Elan Pharmaceuticals, Inc. | Transgenic animal models for alzheimer's disease |
| US5604102A (en) * | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
| AU702293B2 (en) * | 1993-10-27 | 1999-02-18 | Athena Neurosciences, Inc. | Transgenic animals harboring APP allele having Swedish mutation |
| US5877399A (en) | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
| ES2239801T3 (es) * | 1997-04-02 | 2005-10-01 | The Brigham And Women's Hospital, Inc. | Uso de un agente para disminuir el riesgo de enfermedad cardiovascular. |
| KR20020013961A (ko) | 1999-07-16 | 2002-02-21 | 룬딩 에른스트 | 신규한 아미노벤조페논 |
| EP1212101A1 (en) * | 1999-08-31 | 2002-06-12 | The Brigham And Women's Hospital, Inc. | Systemic inflammatory markers as diagnostic tools in the prevention of atherosclerotic diseases |
| JP2003530437A (ja) | 2000-04-13 | 2003-10-14 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ | Ａβ４２低下物質 |
| WO2003040691A2 (en) * | 2001-11-05 | 2003-05-15 | The Brigham And Women's Hospital, Inc. | Soluble cd40l(cd154) as a prognostic marker of atherosclerotic diseases |
| WO2003088811A2 (en) * | 2002-04-16 | 2003-10-30 | The Brigham And Women's Hospital, Inc. | Gelsolin as a prognostic marker of artherosclerotic diseases |
-
2005
- 2005-05-13 WO PCT/EP2005/005229 patent/WO2005110422A2/en not_active Ceased
- 2005-05-13 CA CA002567223A patent/CA2567223A1/en not_active Abandoned
- 2005-05-13 EP EP05744035A patent/EP1750719A2/en not_active Withdrawn
- 2005-05-13 JP JP2007517041A patent/JP2007538024A/ja active Pending
- 2005-05-19 US US11/132,482 patent/US7393843B2/en active Active
- 2005-05-19 US US11/132,815 patent/US7375220B2/en not_active Expired - Lifetime
-
2008
- 2008-01-17 US US12/015,735 patent/US7534787B2/en not_active Expired - Lifetime
- 2008-12-17 US US12/337,242 patent/US20090099159A1/en not_active Abandoned
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| WO2005110422A3 (en) | 2006-05-18 |
| WO2005110422A2 (en) | 2005-11-24 |
| US20060040928A1 (en) | 2006-02-23 |
| US20050277635A1 (en) | 2005-12-15 |
| EP1750719A2 (en) | 2007-02-14 |
| US7375220B2 (en) | 2008-05-20 |
| JP2007538024A (ja) | 2007-12-27 |
| US20090099159A1 (en) | 2009-04-16 |
| US20080139541A1 (en) | 2008-06-12 |
| US7393843B2 (en) | 2008-07-01 |
| US7534787B2 (en) | 2009-05-19 |
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