JP2013522368A5 - - Google Patents
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- JP2013522368A5 JP2013522368A5 JP2013501397A JP2013501397A JP2013522368A5 JP 2013522368 A5 JP2013522368 A5 JP 2013522368A5 JP 2013501397 A JP2013501397 A JP 2013501397A JP 2013501397 A JP2013501397 A JP 2013501397A JP 2013522368 A5 JP2013522368 A5 JP 2013522368A5
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 **(C=C(*)C=C1)C=C1c1ccc(*)cc1 Chemical compound **(C=C(*)C=C1)C=C1c1ccc(*)cc1 0.000 description 3
- DREJORWPJIOPST-UHFFFAOYSA-N CC(C)C1N(C)NNNN1 Chemical compound CC(C)C1N(C)NNNN1 DREJORWPJIOPST-UHFFFAOYSA-N 0.000 description 1
- DRYSRBROYABEJA-UHFFFAOYSA-N CC(NN)NN(C)NC Chemical compound CC(NN)NN(C)NC DRYSRBROYABEJA-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31617510P | 2010-03-22 | 2010-03-22 | |
| US61/316,175 | 2010-03-22 | ||
| US39414810P | 2010-10-18 | 2010-10-18 | |
| US61/394,148 | 2010-10-18 | ||
| US42191510P | 2010-12-10 | 2010-12-10 | |
| US61/421,915 | 2010-12-10 | ||
| PCT/US2011/029425 WO2011119605A2 (en) | 2010-03-22 | 2011-03-22 | Carboxamide biosiosteres of opiates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016078368A Division JP2016175910A (ja) | 2010-03-22 | 2016-04-08 | オピオイド受容体リガンドとしてのカルボキサミド基を含有するモルヒネ誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013522368A JP2013522368A (ja) | 2013-06-13 |
| JP2013522368A5 true JP2013522368A5 (https=) | 2014-05-08 |
| JP5964809B2 JP5964809B2 (ja) | 2016-08-03 |
Family
ID=44072680
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013501397A Expired - Fee Related JP5964809B2 (ja) | 2010-03-22 | 2011-03-22 | オピオイド受容体リガンドとしてのカルボキサミド基を含有するモルヒネ誘導体 |
| JP2016078368A Pending JP2016175910A (ja) | 2010-03-22 | 2016-04-08 | オピオイド受容体リガンドとしてのカルボキサミド基を含有するモルヒネ誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016078368A Pending JP2016175910A (ja) | 2010-03-22 | 2016-04-08 | オピオイド受容体リガンドとしてのカルボキサミド基を含有するモルヒネ誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US8436175B2 (https=) |
| EP (1) | EP2550253B9 (https=) |
| JP (2) | JP5964809B2 (https=) |
| AU (1) | AU2011232628B2 (https=) |
| CA (1) | CA2793725C (https=) |
| ES (1) | ES2582306T3 (https=) |
| WO (1) | WO2011119605A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5266051B2 (ja) | 2005-07-21 | 2013-08-21 | レンセラール ポリテクニック インスティチュート | 大きい置換基を有する非フェノール性オピオイド |
| TR201908514T4 (tr) | 2009-12-04 | 2019-07-22 | Alkermes Pharma Ireland Ltd | İlaç doz aşimi tedavi̇si̇ i̇çi̇n morfi̇nan türevleri̇ |
| US8436175B2 (en) | 2010-03-22 | 2013-05-07 | Rensselaer Polytechnic Institute | Carboxamide bioisosteres of opiates |
| US8778960B2 (en) | 2010-08-23 | 2014-07-15 | Alkermes Pharma Ireland Limited | Methods for treating antipsychotic-induced weight gain |
| WO2013003720A1 (en) * | 2011-06-29 | 2013-01-03 | Alkermes, Inc. | Peripherally acting opioid compounds |
| US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
| ES2770978T3 (es) | 2013-05-24 | 2020-07-06 | Alkermes Pharma Ireland Ltd | Análogos de morfanos y morfinanos y métodos de uso |
| EP3003311A2 (en) * | 2013-05-24 | 2016-04-13 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
| CN103992272B (zh) * | 2014-06-09 | 2016-05-11 | 安徽省逸欣铭医药科技有限公司 | 一种盐酸喷他佐辛酯、其制备方法及其用途 |
| EP4243768A1 (en) | 2020-11-12 | 2023-09-20 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES252980A1 (es) | 1958-10-30 | 1960-11-01 | Boehringer Sohn Ingelheim | Procedimiento para la obtencion de nuevas sales cuaternarias, terapéuticamente valiosas, de la normorfina y de sus derivados |
| CH581624A5 (https=) | 1970-08-14 | 1976-11-15 | Sumitomo Chemical Co | |
| US3856795A (en) | 1972-04-25 | 1974-12-24 | American Home Prod | Process for preparation of secondary amines from tertiary amines |
| DE2254298A1 (de) | 1972-11-06 | 1974-05-16 | Boehringer Sohn Ingelheim | Neue (heteroarylmethyl)-normorphine, deren saeureadditionssalze, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| US4032529A (en) | 1974-09-20 | 1977-06-28 | Sterling Drug Inc. | Aminomethanobenzazocine intermediates |
| US3957793A (en) | 1974-09-20 | 1976-05-18 | Sterling Drug Inc. | Hydroxyiminobenzazocines |
| US4205171A (en) | 1976-01-12 | 1980-05-27 | Sterling Drug Inc. | Aminomethanobenzazocines and nitromethanobenzazocines |
| US4176186A (en) | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
| US4373139A (en) | 1979-04-30 | 1983-02-08 | Motorola, Inc. | Detectors |
| FR2514644A1 (fr) | 1981-10-19 | 1983-04-22 | Sanofi Sa | Composition pharmaceutique a action antagoniste peripherique des opiaces |
| US4374139A (en) | 1981-11-09 | 1983-02-15 | Hoffmann-La Roche Inc. | Levorotatory N-substituted acylmorphinans useful as analgesic agents |
| US4649200A (en) | 1986-05-08 | 1987-03-10 | Regents Of The University Of Minnesota | Substituted pyrroles with opioid receptor activity |
| US4939264A (en) | 1986-07-14 | 1990-07-03 | Abbott Laboratories | Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies |
| US4929622A (en) | 1987-09-24 | 1990-05-29 | Hoechst-Roussel Pharmaceuticals, Inc. | 2,6-Methanopyrrolo-3-benzazocines |
| US5258386A (en) | 1991-06-05 | 1993-11-02 | The United States Of America As Represented By The Secretary Of The Army | (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents |
| US5607941A (en) | 1992-06-26 | 1997-03-04 | Boehringer Ingelheim Kg | Useful for treating neurodegenerative diseases |
| SE9103745D0 (sv) | 1991-12-18 | 1991-12-18 | Wikstroem Haakan | Aryl-triflates and related compounds |
| EP0632041A1 (en) | 1993-07-01 | 1995-01-04 | Katholieke Universiteit Nijmegen | New morphine derivatives having improved analgesic and narcotic properties |
| ATE229958T1 (de) | 1996-01-10 | 2003-01-15 | Glaxosmithkline Spa | Heterocyclische kondensierte morphin-derivate |
| ES2121553B1 (es) | 1996-12-23 | 1999-06-16 | Univ Santiago Compostela | Nuevos endoperoxidos morfinicos funcionalizados en posiciones c-6 y c-14 del anillo c y procedimiento para su obtencion. |
| GB9709972D0 (en) | 1997-05-19 | 1997-07-09 | Pfizer Ltd | Tetrazoles |
| GB9912411D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| EP1210084A4 (en) | 1999-08-13 | 2002-11-13 | Southern Res Inst | PYRIDOMORPHINANS, THIENOMORPHINANS AND THEIR USE |
| NZ518562A (en) | 1999-11-29 | 2005-04-29 | Adolor Corp | Novel methods and compositions involving opioids and antagonists thereof |
| AU2002227135B2 (en) | 2000-10-31 | 2008-01-03 | Rensselaer Polytechnic Institute | 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents |
| US7375082B2 (en) | 2002-02-22 | 2008-05-20 | Shire Llc | Abuse-resistant hydrocodone compounds |
| US20050222204A1 (en) | 2002-05-30 | 2005-10-06 | Mitch Charles H | Opioid receptor antagonists |
| DE10228103A1 (de) | 2002-06-24 | 2004-01-15 | Bayer Cropscience Ag | Fungizide Wirkstoffkombinationen |
| DE10229842A1 (de) | 2002-07-03 | 2004-02-05 | Helmut Prof. Dr. Schmidhammer | Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung |
| WO2004007449A1 (en) | 2002-07-16 | 2004-01-22 | Rensselaer Polytechnic Institute | Process for conversion of phenols to carboxamides via the succinimide esters |
| AU2003298691A1 (en) | 2002-11-18 | 2004-06-15 | The Mclean Hospital Corporation | Mixed kappa/mu opioids and uses thereof |
| RU2346996C2 (ru) | 2004-06-29 | 2009-02-20 | ЮРОПИЭН НИКЕЛЬ ПиЭлСи | Усовершенствованное выщелачивание основных металлов |
| ES2387737T3 (es) | 2004-11-05 | 2012-10-01 | Rensselaer Polytechnic Institute | 4-Hidroxibenzomorfanos |
| EP1820795A4 (en) * | 2004-12-07 | 2010-10-20 | Toyama Chemical Co Ltd | NEW ANTHRANILIC ACID DERIVATIVE OR SALT FROM IT |
| ES2714198T3 (es) | 2005-03-07 | 2019-05-27 | Univ Chicago | Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales |
| KR101280096B1 (ko) | 2005-06-29 | 2013-06-28 | 컴퓨메딕스 리미티드 | 전도성 브리지를 포함하는 센서 어셈블리 |
| JP5266051B2 (ja) | 2005-07-21 | 2013-08-21 | レンセラール ポリテクニック インスティチュート | 大きい置換基を有する非フェノール性オピオイド |
| EP1928881A2 (en) | 2005-08-19 | 2008-06-11 | Pharmacofore, Inc. | Prodrugs of active agents |
| TW200801513A (en) | 2006-06-29 | 2008-01-01 | Fermiscan Australia Pty Ltd | Improved process |
| EP2148864A2 (en) | 2007-05-16 | 2010-02-03 | Rensselaer Polytechnic Institute | Fused-ring heterocycle opioids |
| CN101827819B (zh) * | 2007-08-09 | 2013-06-12 | 伦斯勒理工学院 | 阿片样物质酰胺季铵盐 |
| WO2010000020A1 (en) | 2008-06-30 | 2010-01-07 | Cathrx Ltd | A catheter |
| JP5727374B2 (ja) | 2008-07-21 | 2015-06-03 | レンセラール ポリテクニック インスティチュート | 大型置換基を有する非フェノール性アミンオピオイド |
| WO2011000020A1 (en) | 2009-06-12 | 2011-01-06 | Sbc Research Pty Ltd | Enhanced method of detection |
| US8436175B2 (en) | 2010-03-22 | 2013-05-07 | Rensselaer Polytechnic Institute | Carboxamide bioisosteres of opiates |
-
2011
- 2011-03-22 US US13/069,104 patent/US8436175B2/en active Active
- 2011-03-22 CA CA2793725A patent/CA2793725C/en active Active
- 2011-03-22 JP JP2013501397A patent/JP5964809B2/ja not_active Expired - Fee Related
- 2011-03-22 EP EP11715100.1A patent/EP2550253B9/en active Active
- 2011-03-22 AU AU2011232628A patent/AU2011232628B2/en active Active
- 2011-03-22 ES ES11715100.1T patent/ES2582306T3/es active Active
- 2011-03-22 WO PCT/US2011/029425 patent/WO2011119605A2/en not_active Ceased
-
2013
- 2013-04-05 US US13/857,588 patent/US8716306B2/en active Active
-
2014
- 2014-03-12 US US14/206,170 patent/US8957085B2/en active Active
-
2015
- 2015-01-05 US US14/589,164 patent/US9422301B2/en active Active
-
2016
- 2016-04-08 JP JP2016078368A patent/JP2016175910A/ja active Pending
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