JP2007530694A5 - - Google Patents
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- Publication number
- JP2007530694A5 JP2007530694A5 JP2007506398A JP2007506398A JP2007530694A5 JP 2007530694 A5 JP2007530694 A5 JP 2007530694A5 JP 2007506398 A JP2007506398 A JP 2007506398A JP 2007506398 A JP2007506398 A JP 2007506398A JP 2007530694 A5 JP2007530694 A5 JP 2007530694A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutical composition
- composition according
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 30
- 150000003839 salts Chemical class 0.000 claims 24
- 125000001424 substituent group Chemical group 0.000 claims 13
- 208000002193 Pain Diseases 0.000 claims 10
- 230000001684 chronic effect Effects 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 230000036407 pain Effects 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000004076 pyridyl group Chemical group 0.000 claims 7
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 4
- 208000004296 neuralgia Diseases 0.000 claims 4
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims 4
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 claims 4
- 208000011580 syndromic disease Diseases 0.000 claims 4
- 125000000842 isoxazolyl group Chemical group 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 3
- 125000002971 oxazolyl group Chemical group 0.000 claims 3
- 125000004193 piperazinyl group Chemical group 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000003373 pyrazinyl group Chemical group 0.000 claims 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims 3
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
- 125000003831 tetrazolyl group Chemical group 0.000 claims 3
- 125000000335 thiazolyl group Chemical group 0.000 claims 3
- 125000001425 triazolyl group Chemical group 0.000 claims 3
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims 2
- 229940127239 5 Hydroxytryptamine receptor antagonist Drugs 0.000 claims 2
- 208000006820 Arthralgia Diseases 0.000 claims 2
- 206010003497 Asphyxia Diseases 0.000 claims 2
- 208000008035 Back Pain Diseases 0.000 claims 2
- 208000020925 Bipolar disease Diseases 0.000 claims 2
- 229940127291 Calcium channel antagonist Drugs 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 206010010904 Convulsion Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 2
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims 2
- 206010065390 Inflammatory pain Diseases 0.000 claims 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 2
- 208000008930 Low Back Pain Diseases 0.000 claims 2
- 229940099433 NMDA receptor antagonist Drugs 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010029174 Nerve compression Diseases 0.000 claims 2
- 208000028389 Nerve injury Diseases 0.000 claims 2
- 208000005890 Neuroma Diseases 0.000 claims 2
- 208000000450 Pelvic Pain Diseases 0.000 claims 2
- 208000004983 Phantom Limb Diseases 0.000 claims 2
- 206010056238 Phantom pain Diseases 0.000 claims 2
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 2
- 229940089973 Sodium channel antagonist Drugs 0.000 claims 2
- 206010049447 Tachyarrhythmia Diseases 0.000 claims 2
- 208000001871 Tachycardia Diseases 0.000 claims 2
- 206010043994 Tonic convulsion Diseases 0.000 claims 2
- 230000001430 anti-depressive effect Effects 0.000 claims 2
- 239000000935 antidepressant agent Substances 0.000 claims 2
- 229940005513 antidepressants Drugs 0.000 claims 2
- 239000003420 antiserotonin agent Substances 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000000480 calcium channel blocker Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 229940111134 coxibs Drugs 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 230000000302 ischemic effect Effects 0.000 claims 2
- 229910052744 lithium Inorganic materials 0.000 claims 2
- 238000002690 local anesthesia Methods 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 claims 2
- 239000003706 n methyl dextro aspartic acid receptor stimulating agent Substances 0.000 claims 2
- 210000005036 nerve Anatomy 0.000 claims 2
- 230000008764 nerve damage Effects 0.000 claims 2
- 239000002742 neurokinin 1 receptor antagonist Substances 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 230000004112 neuroprotection Effects 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- 239000002767 noradrenalin uptake inhibitor Substances 0.000 claims 2
- 229960002748 norepinephrine Drugs 0.000 claims 2
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 claims 2
- 229940127221 norepinephrine reuptake inhibitor Drugs 0.000 claims 2
- 238000011275 oncology therapy Methods 0.000 claims 2
- 239000003402 opiate agonist Substances 0.000 claims 2
- 239000003401 opiate antagonist Substances 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 239000000952 serotonin receptor agonist Substances 0.000 claims 2
- 239000003195 sodium channel blocking agent Substances 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- 230000000472 traumatic effect Effects 0.000 claims 2
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 2
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 claims 2
- 229960000604 valproic acid Drugs 0.000 claims 2
- 230000009278 visceral effect Effects 0.000 claims 2
- 208000009935 visceral pain Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- URCAPVFQXOZSHU-UHFFFAOYSA-N CN(C=C(C(N)=O)N=C1c2cc(-c(cccc3)c3OC(F)(F)F)ccc2)C1=O Chemical compound CN(C=C(C(N)=O)N=C1c2cc(-c(cccc3)c3OC(F)(F)F)ccc2)C1=O URCAPVFQXOZSHU-UHFFFAOYSA-N 0.000 description 1
- BBSDMELJSOYPSO-UHFFFAOYSA-N CN(C=C(C(N)=O)N=C1c2cc(-c3c(C(F)(F)F)cccc3)ccc2)C1=O Chemical compound CN(C=C(C(N)=O)N=C1c2cc(-c3c(C(F)(F)F)cccc3)ccc2)C1=O BBSDMELJSOYPSO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55735504P | 2004-03-29 | 2004-03-29 | |
| PCT/US2005/010153 WO2005097136A1 (en) | 2004-03-29 | 2005-03-25 | Biaryl substituted pyrazinones as sodium channel blockers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007530694A JP2007530694A (ja) | 2007-11-01 |
| JP2007530694A5 true JP2007530694A5 (https=) | 2008-02-21 |
Family
ID=35124829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007506398A Withdrawn JP2007530694A (ja) | 2004-03-29 | 2005-03-25 | ナトリウムチャネル遮断薬としてのビアリール置換ピラジノン |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20080280873A1 (https=) |
| EP (1) | EP1732564A1 (https=) |
| JP (1) | JP2007530694A (https=) |
| CN (1) | CN1938031A (https=) |
| AU (1) | AU2005231332A1 (https=) |
| CA (1) | CA2560796A1 (https=) |
| WO (1) | WO2005097136A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| WO2008124092A2 (en) * | 2007-04-03 | 2008-10-16 | E. I. Du Pont De Nemours And Company | Substituted benzene fungicides |
| HRP20130992T1 (hr) * | 2008-04-29 | 2013-11-22 | Merck Patent Gmbh | Derivati arilpirazinona kao stimulatori luäśenja inzulina, postupci za njihovo dobivanje i njihova uporaba za lijeäśenje dijabetesa |
| CN105218565A (zh) | 2008-10-17 | 2016-01-06 | 泽农医药公司 | 螺羟吲哚化合物及其作为治疗剂的用途 |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| AR077252A1 (es) * | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| MX2012004373A (es) | 2009-10-14 | 2012-06-28 | Xenon Pharmaceuticals Inc | Metodos sinteticos para compuestos espiro-oxoindol. |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| WO2011092290A1 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists |
| EP2531490B1 (en) | 2010-02-02 | 2014-10-15 | Novartis AG | Cyclohexyl amide derivatives as crf receptor antagonists |
| CA2788440A1 (en) | 2010-02-26 | 2011-09-01 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
| AR086554A1 (es) | 2011-05-27 | 2014-01-08 | Novartis Ag | Derivados de la piperidina 3-espirociclica como agonistas de receptores de la ghrelina |
| FR2985202A1 (fr) * | 2012-01-03 | 2013-07-05 | Oreal | Tete de distribution |
| DE102012201178B3 (de) * | 2012-01-27 | 2013-02-14 | Aptar Radolfzell Gmbh | Düseneinheit und Spender mit einer solchen |
| JP2015525202A (ja) | 2012-05-03 | 2015-09-03 | ノバルティス アーゲー | グレリン受容体アゴニストとしての２，７−ジアザ−スピロ［４，５］デカ−７−イル誘導体のｌ−リンゴ酸塩およびその結晶形態 |
| FR3004901B1 (fr) * | 2013-04-30 | 2016-02-12 | Oreal | Dispositif aerosol a diffusion a multi-orifices pour le lavage a sec des cheveux |
| FR3004902A1 (fr) | 2013-04-30 | 2014-10-31 | Oreal | Dispositif aerosol a diffusion a multi-orifices pour la mise en forme des cheveux et/ou le maintien de la coiffure |
| FR3022770B1 (fr) | 2014-06-30 | 2016-07-29 | Oreal | Dispositif aerosol a base de sel de calcium, de polymere fixant, de tensioactif et d'eau |
| US9999895B2 (en) | 2014-08-06 | 2018-06-19 | S. C. Johnson & Son, Inc. | Spray inserts |
| TW201636017A (zh) | 2015-02-05 | 2016-10-16 | 梯瓦製藥國際有限責任公司 | 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法 |
| US10174884B2 (en) * | 2015-06-25 | 2019-01-08 | The Gillette Company Llc | Valve stem for a compressible valve |
| ES2800067T3 (es) * | 2015-09-04 | 2020-12-23 | Oreal | Dispositivo de pulverización para un producto |
| US11033531B2 (en) | 2016-12-14 | 2021-06-15 | Sk Biopharmaceuticals Co., Ltd. | Use of carbamate compound for preventing, alleviating, or treating tremors or tremor syndrome |
| CN106674264A (zh) * | 2016-12-20 | 2017-05-17 | 苏州汉德创宏生化科技有限公司 | (2,2,2‑三氟乙氧基)苯硼酸类化合物的合成方法 |
| FR3063605B1 (fr) * | 2017-03-09 | 2021-07-23 | Oreal | Dispositif aerosol pour la mise en forme des cheveux et/ou le maintien de la coiffure |
| FR3063607B1 (fr) | 2017-03-09 | 2021-07-23 | Oreal | Dispositif aerosol pour le lavage a sec et le traitement des cheveux |
| FR3063606B1 (fr) | 2017-03-09 | 2021-07-23 | Oreal | Dispositif aerosol pour la mise en forme des cheveux et/ou le maintien de la coiffure |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| EP3513880B1 (en) | 2018-01-23 | 2021-08-25 | The Procter & Gamble Company | Dispensing device suitable for a foamable product |
| TWI707849B (zh) * | 2018-02-13 | 2020-10-21 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| EP3820572B1 (en) | 2018-07-13 | 2023-08-16 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| US11267644B2 (en) * | 2018-11-08 | 2022-03-08 | The Procter And Gamble Company | Aerosol foam dispenser and methods for delivering a textured foam product |
| CN114230552B (zh) * | 2021-12-29 | 2023-11-03 | 江苏广域化学有限公司 | 三氟甲氧基二苯并噻吩、其制备方法及相关中间体的制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3401888A (en) * | 1965-10-22 | 1968-09-17 | Sutter Arthur | Snow nozzle |
| US3342382A (en) * | 1965-10-22 | 1967-09-19 | Clayton Corp Of Delaware | Pressured dispenser spout having plurality of decorator orifices |
| US3415426A (en) * | 1966-05-16 | 1968-12-10 | Eaton Yale & Towne | Dispensing valve |
| US3406913A (en) * | 1966-09-01 | 1968-10-22 | Revlon | Mechanical break-up actuator for fluid dispensers |
| US3504862A (en) | 1968-01-05 | 1970-04-07 | Gillette Co | Dispensing device |
| US3628733A (en) * | 1969-05-01 | 1971-12-21 | Associated Products Inc | Two-hole aerosol button |
| US3767125A (en) * | 1971-05-28 | 1973-10-23 | Union Carbide Corp | Multiple orifice aerosol actuator |
| FR2367681A1 (fr) * | 1976-08-06 | 1978-05-12 | Oreal | Recipient pressurise du type " bombe aerosol " a debit de distribution sensiblement constant |
| US4239407A (en) * | 1979-02-22 | 1980-12-16 | Knight Hester L | Hard to reach places spray can |
| DE2925435A1 (de) | 1979-06-23 | 1981-01-22 | Hans Ing Grad Grothoff | Spruehkopf |
| IT8112656A0 (it) | 1981-10-21 | 1981-10-21 | Orlando Morchio | Pettine irroratore avente lo scopo di irrorare qualsiasi sostanza |
| US4690312A (en) | 1986-05-15 | 1987-09-01 | S. C. Johnson & Son, Inc. | Dual function cap |
| US5249747A (en) * | 1990-07-12 | 1993-10-05 | Par-Way Group | Sprayable dispensing system for viscous vegetable oils and apparatus therefor |
| FR2691383B1 (fr) * | 1992-05-21 | 1994-08-19 | Oreal | Bouton-poussoir destiné à être monté sur une valve ou une pompe équipant un distributeur, et distributeur comportant un tel bouton-poussoir. |
| DE9390268U1 (de) * | 1993-05-24 | 1995-01-12 | Deutsche Präzisions-Ventil GmbH, 65795 Hattersheim | Betätigungsteil für einen Aerosol-Behälter |
| FR2737198B1 (fr) * | 1995-07-24 | 1997-09-26 | Oreal | Tete de distribution d'un produit liquide sous forme d'aerosol et distributeur muni d'une telle tete |
| FR2744104B1 (fr) * | 1996-01-29 | 1998-03-20 | Oreal | Dispositif de conditionnement, de distribution et d'application d'un gel ou mousse |
| US5890661A (en) * | 1996-11-27 | 1999-04-06 | Par-Way Group | Colliding stream spray dispensing system with a moldable nozzle |
| US6158674A (en) * | 1999-04-28 | 2000-12-12 | Humphreys; Ronald O. | Liquid dispenser with multiple nozzles |
| US6820823B2 (en) | 2003-02-25 | 2004-11-23 | S. C. Johnson & Son, Inc. | Aerosol dispensing nozzle |
| US6971557B2 (en) * | 2003-06-19 | 2005-12-06 | S. C. Johnson & Son, Inc. | Actuator for a pressurized material dispenser |
| US6817493B1 (en) * | 2003-08-22 | 2004-11-16 | S. C. Johnson & Son, Inc. | Spray nozzle |
-
2005
- 2005-03-25 CN CNA2005800101317A patent/CN1938031A/zh active Pending
- 2005-03-25 JP JP2007506398A patent/JP2007530694A/ja not_active Withdrawn
- 2005-03-25 EP EP05730103A patent/EP1732564A1/en not_active Withdrawn
- 2005-03-25 US US10/594,367 patent/US20080280873A1/en not_active Abandoned
- 2005-03-25 CA CA002560796A patent/CA2560796A1/en not_active Abandoned
- 2005-03-25 AU AU2005231332A patent/AU2005231332A1/en not_active Abandoned
- 2005-03-25 WO PCT/US2005/010153 patent/WO2005097136A1/en not_active Ceased
- 2005-03-29 US US11/092,088 patent/US8191802B2/en active Active
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