JP2012521428A5 - - Google Patents

Download PDF

Info

Publication number
JP2012521428A5
JP2012521428A5 JP2012502097A JP2012502097A JP2012521428A5 JP 2012521428 A5 JP2012521428 A5 JP 2012521428A5 JP 2012502097 A JP2012502097 A JP 2012502097A JP 2012502097 A JP2012502097 A JP 2012502097A JP 2012521428 A5 JP2012521428 A5 JP 2012521428A5
Authority
JP
Japan
Prior art keywords
chr
alkyl
heterocyclyl
cycloalkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012502097A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012521428A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/027286 external-priority patent/WO2010111058A1/en
Publication of JP2012521428A publication Critical patent/JP2012521428A/ja
Publication of JP2012521428A5 publication Critical patent/JP2012521428A5/ja
Pending legal-status Critical Current

Links

JP2012502097A 2009-03-23 2010-03-15 疼痛治療用のｐ２ｘ３受容体アンタゴニスト Pending JP2012521428A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21084509P 2009-03-23 2009-03-23
US61/210,845 2009-03-23
PCT/US2010/027286 WO2010111058A1 (en) 2009-03-23 2010-03-15 P2x3, receptor antagonists for treatment of pain

Publications (2)

Publication Number Publication Date
JP2012521428A JP2012521428A (ja) 2012-09-13
JP2012521428A5 true JP2012521428A5 (https=) 2013-05-02

Family

ID=42781385

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012502097A Pending JP2012521428A (ja) 2009-03-23 2010-03-15 疼痛治療用のｐ２ｘ３受容体アンタゴニスト

Country Status (6)

Country Link
US (1) US9238647B2 (https=)
EP (1) EP2410857B1 (https=)
JP (1) JP2012521428A (https=)
AU (1) AU2010229142A1 (https=)
CA (1) CA2755680A1 (https=)
WO (1) WO2010111058A1 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2715835C (en) 2008-02-29 2017-03-21 Renovis, Inc. Amide compounds, compositions and uses thereof
JP5608655B2 (ja) 2008-09-18 2014-10-15 エヴォテック アーゲー Ｐ２ｘ３受容体活性のモジュレーター
US20100273805A1 (en) * 2009-04-23 2010-10-28 Astrazeneca Ab Sulphide bridged derivatives as modulators of mglur5 733
US8476457B2 (en) * 2009-06-22 2013-07-02 Roche Palo Alto Llc Indole, indazole and benzimidazole arylamides as P2X3 and P2X2/3 antagonists
US9271967B2 (en) * 2010-11-08 2016-03-01 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
ES2536433T3 (es) * 2010-11-08 2015-05-25 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
BR112013021675A2 (pt) * 2011-02-25 2016-11-01 Array Biopharma Inc compostos de triazolopiridina como inibidores de pim cinase
DK3381917T3 (da) * 2013-01-31 2021-10-18 Bellus Health Cough Inc Imidazopyridinforbindelser og anvendelser deraf
CA2933811C (en) * 2013-12-16 2021-02-09 Asana Biosciences, Llc P2x3 and/or p2x2/3 compounds and methods
EP2905282A1 (en) * 2014-02-05 2015-08-12 AXXAM S.p.A. Substituted thiazole or oxazole as P2X7 receptor antagonists
WO2016036638A1 (en) 2014-09-05 2016-03-10 Merck Sharp & Dohme Corp. Isoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
EP3188730B1 (en) 2014-09-05 2019-05-01 Merck Sharp & Dohme Corp. Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
US10568876B2 (en) 2014-09-05 2020-02-25 Merck Sharp & Dohme Corp. Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
WO2016088838A1 (ja) * 2014-12-04 2016-06-09 塩野義製薬株式会社 プリン誘導体およびその医薬組成物
JO3637B1 (ar) 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv
WO2017209267A1 (ja) * 2016-06-03 2017-12-07 塩野義製薬株式会社 プリン誘導体
AU2017360939B2 (en) 2016-11-18 2022-03-03 Merck Sharp & Dohme Corp. Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
EP3541376B1 (en) 2016-11-18 2023-04-19 Merck Sharp & Dohme LLC Indole derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
KR102606737B1 (ko) * 2017-03-15 2023-11-24 스미토모 파마 가부시키가이샤 신규 벤즈이미다졸론 화합물 및 그의 의약 용도
TW201932470A (zh) 2017-11-29 2019-08-16 愛爾蘭商健生科學愛爾蘭無限公司 具有抗ｒｓｖ活性之吡唑并嘧啶
SG11202006141RA (en) 2018-01-31 2020-07-29 Janssen Sciences Ireland Unlimited Co Cycloalkyl substituted pyrazolopyrimidines having activity against rsv
US11708369B2 (en) 2018-04-23 2023-07-25 Janssen Sciences Ireland Unlimited Company Heteroaromatic compounds having activity against RSV
WO2020256430A1 (ko) * 2019-06-19 2020-12-24 주식회사 엘지화학 인돌 또는 인다졸 화합물의 제조방법
CN115427419B (zh) * 2020-02-14 2026-04-21 葛兰素史密斯克莱知识产权(第3号)有限公司 P2x3拮抗剂的制备
WO2022063205A1 (zh) * 2020-09-24 2022-03-31 中国医药研究开发中心有限公司 芳基甲酰胺类化合物及其制备方法和医药用途
CN115322143B (zh) * 2022-07-21 2023-07-14 安徽德诺医药股份有限公司 一种4-哌啶甲酸叔丁酯盐酸盐的制备方法
EP4638420A1 (en) * 2022-12-20 2025-10-29 Exelixis, Inc. Compounds that inhibit pkmyt1

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4373497B2 (ja) * 1996-06-19 2009-11-25 ローン−プーラン・ロレ・リミテツド 置換されたアザビシクロ化合物、ならびにｔｎｆおよびサイクリックａｍｐホスホジエステラーゼ産生の阻害剤としてのそれらの使用
MXPA01002173A (es) * 1998-08-28 2003-07-14 Scios Inc Inhibidores de p38-alfa cinasa.
KR100875222B1 (ko) 1999-08-19 2008-12-19 아스트라제네카 아베 헤테로폴리사이클릭 화합물 및 간접 글루타메이트 수용체길항제로서의 그들의 용도
WO2003000682A1 (en) * 2001-06-25 2003-01-03 Merck & Co., Inc. (pyrimidyl)(phenyl)substituted fused heteroaryl p38 inhibiting and pkg kinase inhibiting compounds
EP1711498A2 (en) 2004-01-26 2006-10-18 Altana Pharma AG 1,2,4-triazolo¬1,5-a|pyridines as gastric acid secretion inhibitors
ZA200709177B (en) 2005-03-24 2009-06-24 Arrow Coated Products Ltd Combined multi-layered water soluble film and process for producing the same
MX2007013595A (es) 2005-05-04 2008-01-24 Renovis Inc Compuestos heterociclicos fusionados y composiciones y usos de estos.
MY147756A (en) * 2005-05-25 2013-01-15 Theravance Inc Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists
CN101203220A (zh) 2005-06-28 2008-06-18 阿斯利康(瑞典)有限公司 新用途
MX2008002014A (es) * 2005-08-15 2008-03-27 Hoffmann La Roche Derivados de piperidina y piperazina como antagonistas de p2x3.
CN101300012B (zh) 2005-09-01 2011-09-14 弗·哈夫曼-拉罗切有限公司 作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物在制备治疗呼吸系统疾病的药物中的应用
WO2007041087A2 (en) 2005-09-30 2007-04-12 Merck & Co., Inc. Nucleic acids encoding a functional mammalian purinoreceptor, p2x3, methods of production and use thereof
JP2009514894A (ja) * 2005-11-07 2009-04-09 バーテックス ファーマシューティカルズ インコーポレイテッド ジャイレース阻害剤としてのベンズイミダゾール誘導体
WO2007069053A1 (en) * 2005-12-14 2007-06-21 Pfizer Products Inc. Benzimidazole antagonists of the h-3 receptor
WO2007086080A2 (en) * 2006-01-30 2007-08-02 Glenmark Pharmaceuticals Limited NOVEL IMIDAZO[1,2-a]PYRIDINE CANNABINOID RECEPTOR LIGANDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP2038264B1 (en) 2006-06-29 2016-10-26 F.Hoffmann-La Roche Ag Tetrazole-substituted arylamides
FR2903107B1 (fr) * 2006-07-03 2008-08-22 Sanofi Aventis Sa Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique
WO2008027812A2 (en) * 2006-08-28 2008-03-06 Forest Laboratories Holdings Limited Imidazopyridine and imidazopyrimidine derivatives
WO2008085302A1 (en) * 2006-12-20 2008-07-17 Merck & Co., Inc. Imidazopyridine analogs as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases
CN101631786A (zh) * 2006-12-20 2010-01-20 先灵公司 新颖的jnk抑制剂
CA2703915C (en) 2007-10-31 2015-02-24 Merck Sharp & Dohme Corp. P2x3 receptor antagonists for treatment of pain
JP2011502148A (ja) 2007-10-31 2011-01-20 メルク・シャープ・エンド・ドーム・コーポレイション 疼痛の治療用としてのｐ２ｘ３受容体アンタゴニスト
MX2011004570A (es) 2008-10-31 2011-06-17 Merck Sharp & Dohme Antagonistas del receptor p2x3 para el tratamiento del dolor.
WO2010059836A1 (en) * 2008-11-20 2010-05-27 Decode Genetics Ehf Substituted aza-bridged bicyclics for cardiovascular and cns disease
US8476457B2 (en) * 2009-06-22 2013-07-02 Roche Palo Alto Llc Indole, indazole and benzimidazole arylamides as P2X3 and P2X2/3 antagonists

Similar Documents

Publication Publication Date Title
JP2012521428A5 (https=)
JP2012521429A5 (https=)
RU2012142180A (ru) Ингибиторы катехол-о-метилтрансферазы и их применение для лечения психотических расстройств
JP2024153782A (ja) 多動性運動障害を処置するためのｖｍａｔ２インヒビター
JP2013521288A5 (https=)
RU2012142171A (ru) Ингибиторы катехол-о-метилтрансферазы и их применение в лечении психических расстройств
JP2015503507A5 (https=)
RU2014102362A (ru) Антитромботические соединения
WO2007093624A2 (en) Pharmaceutical compositions for the treatment of attention deficit hyperactivity disorder comprising flibanserin
RU2006142521A (ru) Средство для улучшения когнитивных функций и памяти на основе гидрированных пиридо(4,3-b)индолов (варианты), фармакологическое средство на его основе и способ его применения
EP1858516A1 (en) Pharmaceutical compositions for the treatment and/or prevention of depression
JP2009541223A5 (https=)
JP2007530694A5 (https=)
JP2010535790A5 (https=)
RU2011137131A (ru) Производные 1-аминоалкилциклогексана для лечения тиннитуса, связанного с потерей слуха или незначительной потерей слуха
RU2011129229A (ru) Новые соли
SI3004106T1 (en) Dual selective PI3 delta and gamma inhibitors
JP2013522368A5 (https=)
RU2009136592A (ru) Терапевтические агенты
JP2009541443A5 (https=)
JP2021505575A5 (https=)
RU2019141734A (ru) Терапевтические соединения и композиции и способы их применения
RU2012108423A (ru) Ацилгуанидиновые производные с азотсодержащим циклом
JP2017500321A5 (https=)
RU2011146032A (ru) Соединения-агонисты рецептора 5-ht4 для лечения расстройств познавательной способности