CA2554771A1 - Nitroxyl progenitor compounds and methods of use - Google Patents
Nitroxyl progenitor compounds and methods of use Download PDFInfo
- Publication number
- CA2554771A1 CA2554771A1 CA002554771A CA2554771A CA2554771A1 CA 2554771 A1 CA2554771 A1 CA 2554771A1 CA 002554771 A CA002554771 A CA 002554771A CA 2554771 A CA2554771 A CA 2554771A CA 2554771 A1 CA2554771 A1 CA 2554771A1
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- Prior art keywords
- compound
- subject
- independently
- electron
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 167
- 238000000034 method Methods 0.000 title claims abstract description 79
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 71
- 201000010099 disease Diseases 0.000 claims abstract description 37
- 208000024891 symptom Diseases 0.000 claims abstract description 33
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- 125000006575 electron-withdrawing group Chemical group 0.000 claims description 39
- 208000035475 disorder Diseases 0.000 claims description 34
- 125000003118 aryl group Chemical group 0.000 claims description 33
- 239000003550 marker Substances 0.000 claims description 31
- 125000001072 heteroaryl group Chemical group 0.000 claims description 30
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 29
- 125000000623 heterocyclic group Chemical group 0.000 claims description 26
- 125000004122 cyclic group Chemical group 0.000 claims description 25
- 238000011282 treatment Methods 0.000 claims description 24
- 206010019280 Heart failures Diseases 0.000 claims description 23
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 22
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 20
- 125000005843 halogen group Chemical group 0.000 claims description 19
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 17
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C247/18—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
- C07C291/08—Azoxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/50—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US54068804P | 2004-01-30 | 2004-01-30 | |
| US60/540,688 | 2004-01-30 | ||
| US63245604P | 2004-12-02 | 2004-12-02 | |
| US60/632,456 | 2004-12-02 | ||
| PCT/US2005/003183 WO2005074598A2 (en) | 2004-01-30 | 2005-01-28 | Nitroxyl progenitor compounds and methods of use |
Publications (1)
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|---|---|
| CA2554771A1 true CA2554771A1 (en) | 2005-08-18 |
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Family Applications (1)
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|---|---|---|---|
| CA002554771A Abandoned CA2554771A1 (en) | 2004-01-30 | 2005-01-28 | Nitroxyl progenitor compounds and methods of use |
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| Country | Link |
|---|---|
| US (2) | US20090281067A1 (https=) |
| EP (1) | EP1718621A4 (https=) |
| JP (1) | JP2007522135A (https=) |
| AU (1) | AU2005209843B2 (https=) |
| CA (1) | CA2554771A1 (https=) |
| WO (1) | WO2005074598A2 (https=) |
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| US20040038947A1 (en) | 2002-06-14 | 2004-02-26 | The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services | Method of treating ischemia/reperfusion injury with nitroxyl donors |
| US6936639B2 (en) | 2002-08-21 | 2005-08-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroxyl progenitors in the treatment of heart failure |
| CA2554771A1 (en) | 2004-01-30 | 2005-08-18 | Johns Hopkins University | Nitroxyl progenitor compounds and methods of use |
| EP1909779A1 (en) * | 2005-06-23 | 2008-04-16 | Johns Hopkins University | Thiol-sensitive positive inotropes |
| BRPI0708804B8 (pt) * | 2006-03-17 | 2021-05-25 | Cardioxyl Pharmaceuticals Inc | compostos derivados de n-hidroxilsulfonamida como doadores de nitroxil, composição farmacêutica e kit |
| NZ584036A (en) | 2007-09-26 | 2012-06-29 | Univ Johns Hopkins | N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors |
| JP2011511079A (ja) * | 2008-02-08 | 2011-04-07 | メルク・シャープ・エンド・ドーム・コーポレイション | アンジオテンシンｉｉ受容体アンタゴニスト |
| WO2011063339A1 (en) | 2009-11-23 | 2011-05-26 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl donors for the treatment of pulmonary hypertension |
| WO2011071947A2 (en) | 2009-12-07 | 2011-06-16 | Johns Hopkins University | Bis-acylated hydroxylamine derivatives |
| US20110144067A1 (en) * | 2009-12-07 | 2011-06-16 | Toscano John P | N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives |
| RU2013138391A (ru) * | 2011-01-19 | 2015-02-27 | Мерк Шарп Энд Домэ Корп. | Производные диазенийдиолата |
| AU2013201929B2 (en) | 2011-10-17 | 2015-07-23 | The Johns Hopkins University | N-substituted hydroxylamine derivatives with carbon-based leaving groups |
| HRP20180121T1 (hr) | 2013-01-18 | 2018-02-23 | Cardioxyl Pharmaceuticals Inc. | Donori nitroksila s poboljšanim terapijskim indeksom |
| EP3126329B1 (en) | 2014-01-17 | 2019-05-29 | Cardioxyl Pharmaceuticals Inc. | N-hydroxymethanesulfonamide nitroxyl donors |
| US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
| EP3148972B1 (en) | 2014-05-27 | 2019-08-21 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
| EP3148983A1 (en) | 2014-05-27 | 2017-04-05 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives as nitroxyl donors |
| KR20180063326A (ko) | 2015-10-19 | 2018-06-11 | 카르디옥실 파마슈티칼스 인코포레이티드 | 니트록실 공여자로서의 피라졸론 유도체 |
| US10730828B2 (en) | 2015-10-19 | 2020-08-04 | Cardioxyl Pharmaceuticals, Inc. | N-hydroxylsulfonamide derivatives as nitroxyl donors |
| US10913728B2 (en) | 2016-07-28 | 2021-02-09 | The Johns Hopkins University | O-substituted hydroxamic acids |
| US11083704B2 (en) | 2017-01-03 | 2021-08-10 | Bristol-Myers Squibb Company | Method of administering nitroxyl donating compounds |
| CA3189027A1 (en) | 2020-07-11 | 2022-01-20 | Pfizer Inc. | Antiviral heteroaryl ketone derivatives |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
| WO2025043108A1 (en) | 2023-08-23 | 2025-02-27 | Bristol -Myers S Quibb Company | Co-crystals of nitroxyl donating compounds |
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| US4369172A (en) | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| DE3583799D1 (de) | 1985-01-11 | 1991-09-19 | Abbott Lab Ltd | Feste zubereitung mit langsamer freisetzung. |
| US4954526A (en) | 1989-02-28 | 1990-09-04 | The United States Of America As Represented By The Department Of Health And Human Services | Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents |
| US5039705A (en) * | 1989-09-15 | 1991-08-13 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof |
| JP2773959B2 (ja) | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
| AU668107B2 (en) * | 1991-09-24 | 1996-04-26 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs |
| US6200558B1 (en) * | 1993-09-14 | 2001-03-13 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US5632981A (en) * | 1992-08-24 | 1997-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US5700830A (en) * | 1994-11-22 | 1997-12-23 | The United States Of America As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents for reducing metastasis risk |
| EP2292630B1 (en) * | 1996-09-27 | 2015-11-25 | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | O2-substituted 1- (2-carboxylato)pyrrolidin-1-yl diazen-1-ium-1,2-diolates |
| US5958427A (en) | 1996-11-08 | 1999-09-28 | Salzman; Andrew L. | Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications |
| JP4856295B2 (ja) * | 1997-07-03 | 2012-01-18 | アメリカ合衆国政府 | 新規な一酸化窒素放出アミジン誘導ジアゼニウムジオレート及びその組成物 |
| UA73092C2 (uk) | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| DE69924735T2 (de) | 1998-07-28 | 2006-01-19 | Tanabe Seiyaku Co., Ltd. | Zur wirkstoffabgabe an zielorten im darm fähige zubereitung |
| DE50202121D1 (de) * | 2001-06-05 | 2005-03-03 | Basf Ag | Metallsalze als antimykotika |
| WO2003006427A1 (en) * | 2001-07-12 | 2003-01-23 | Johns Hopkins University | Compounds that release nitric oxide at controlled rates upon photolysis |
| MXPA04008821A (es) * | 2002-03-15 | 2004-11-26 | Btg Int Ltd | Formulaciones de derivados de antraquinona. |
| AU2003230715A1 (en) * | 2002-03-21 | 2003-10-08 | The University Of Utah Research Foundation | In vivo use of glutathionone s-transferase activated nitric oxide donors |
| US20040038947A1 (en) * | 2002-06-14 | 2004-02-26 | The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services | Method of treating ischemia/reperfusion injury with nitroxyl donors |
| US6936639B2 (en) * | 2002-08-21 | 2005-08-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroxyl progenitors in the treatment of heart failure |
| US20050009789A1 (en) | 2003-05-13 | 2005-01-13 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Service | Cyclooxygenase inhibition with nitroxyl |
| CA2554771A1 (en) | 2004-01-30 | 2005-08-18 | Johns Hopkins University | Nitroxyl progenitor compounds and methods of use |
-
2005
- 2005-01-28 CA CA002554771A patent/CA2554771A1/en not_active Abandoned
- 2005-01-28 US US10/587,644 patent/US20090281067A1/en not_active Abandoned
- 2005-01-28 WO PCT/US2005/003183 patent/WO2005074598A2/en not_active Ceased
- 2005-01-28 JP JP2006551595A patent/JP2007522135A/ja active Pending
- 2005-01-28 EP EP05726388A patent/EP1718621A4/en not_active Withdrawn
- 2005-01-28 AU AU2005209843A patent/AU2005209843B2/en not_active Ceased
-
2014
- 2014-09-22 US US14/492,741 patent/US10273202B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1718621A4 (en) | 2009-08-19 |
| US10273202B2 (en) | 2019-04-30 |
| AU2005209843A1 (en) | 2005-08-18 |
| AU2005209843B2 (en) | 2012-02-16 |
| US20150141378A1 (en) | 2015-05-21 |
| JP2007522135A (ja) | 2007-08-09 |
| US20090281067A1 (en) | 2009-11-12 |
| EP1718621A2 (en) | 2006-11-08 |
| WO2005074598A3 (en) | 2005-12-15 |
| WO2005074598A2 (en) | 2005-08-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20141118 |