JP2007522135A - ニトロキシル前駆化合物および使用方法 - Google Patents

ニトロキシル前駆化合物および使用方法 Download PDF

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JP2007522135A
JP2007522135A JP2006551595A JP2006551595A JP2007522135A JP 2007522135 A JP2007522135 A JP 2007522135A JP 2006551595 A JP2006551595 A JP 2006551595A JP 2006551595 A JP2006551595 A JP 2006551595A JP 2007522135 A JP2007522135 A JP 2007522135A
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compound
subject
independently
alkyl
electron withdrawing
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Japanese (ja)
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JP2007522135A5 (https=
Inventor
トスカノ，ジョン，ピー．Ｉｉｉ
パヴロス，クリストファー，エム．
ボッパナ，プリーヤ，カプール
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Johns Hopkins University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C247/18—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/08—Azoxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
JP2006551595A 2004-01-30 2005-01-28 ニトロキシル前駆化合物および使用方法 Pending JP2007522135A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54068804P 2004-01-30 2004-01-30
US63245604P 2004-12-02 2004-12-02
PCT/US2005/003183 WO2005074598A2 (en) 2004-01-30 2005-01-28 Nitroxyl progenitor compounds and methods of use

Publications (2)

Publication Number Publication Date
JP2007522135A true JP2007522135A (ja) 2007-08-09
JP2007522135A5 JP2007522135A5 (https=) 2008-11-27

Family

ID=34841107

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006551595A Pending JP2007522135A (ja) 2004-01-30 2005-01-28 ニトロキシル前駆化合物および使用方法

Country Status (6)

Country Link
US (2) US20090281067A1 (https=)
EP (1) EP1718621A4 (https=)
JP (1) JP2007522135A (https=)
AU (1) AU2005209843B2 (https=)
CA (1) CA2554771A1 (https=)
WO (1) WO2005074598A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011511079A (ja) * 2008-02-08 2011-04-07 メルク・シャープ・エンド・ドーム・コーポレイション アンジオテンシンｉｉ受容体アンタゴニスト

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040038947A1 (en) 2002-06-14 2004-02-26 The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services Method of treating ischemia/reperfusion injury with nitroxyl donors
US6936639B2 (en) 2002-08-21 2005-08-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroxyl progenitors in the treatment of heart failure
CA2554771A1 (en) 2004-01-30 2005-08-18 Johns Hopkins University Nitroxyl progenitor compounds and methods of use
EP1909779A1 (en) * 2005-06-23 2008-04-16 Johns Hopkins University Thiol-sensitive positive inotropes
BRPI0708804B8 (pt) * 2006-03-17 2021-05-25 Cardioxyl Pharmaceuticals Inc compostos derivados de n-hidroxilsulfonamida como doadores de nitroxil, composição farmacêutica e kit
NZ584036A (en) 2007-09-26 2012-06-29 Univ Johns Hopkins N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
WO2011063339A1 (en) 2009-11-23 2011-05-26 Cardioxyl Pharmaceuticals, Inc. Nitroxyl donors for the treatment of pulmonary hypertension
WO2011071947A2 (en) 2009-12-07 2011-06-16 Johns Hopkins University Bis-acylated hydroxylamine derivatives
US20110144067A1 (en) * 2009-12-07 2011-06-16 Toscano John P N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives
RU2013138391A (ru) * 2011-01-19 2015-02-27 Мерк Шарп Энд Домэ Корп. Производные диазенийдиолата
AU2013201929B2 (en) 2011-10-17 2015-07-23 The Johns Hopkins University N-substituted hydroxylamine derivatives with carbon-based leaving groups
HRP20180121T1 (hr) 2013-01-18 2018-02-23 Cardioxyl Pharmaceuticals Inc. Donori nitroksila s poboljšanim terapijskim indeksom
EP3126329B1 (en) 2014-01-17 2019-05-29 Cardioxyl Pharmaceuticals Inc. N-hydroxymethanesulfonamide nitroxyl donors
US9464061B2 (en) 2014-05-27 2016-10-11 The Johns Hopkins University N-hydroxylamino-barbituric acid derivatives
EP3148972B1 (en) 2014-05-27 2019-08-21 Cardioxyl Pharmaceuticals, Inc. Pyrazolone derivatives as nitroxyl donors
EP3148983A1 (en) 2014-05-27 2017-04-05 The Johns Hopkins University N-hydroxylamino-barbituric acid derivatives as nitroxyl donors
KR20180063326A (ko) 2015-10-19 2018-06-11 카르디옥실 파마슈티칼스 인코포레이티드 니트록실 공여자로서의 피라졸론 유도체
US10730828B2 (en) 2015-10-19 2020-08-04 Cardioxyl Pharmaceuticals, Inc. N-hydroxylsulfonamide derivatives as nitroxyl donors
US10913728B2 (en) 2016-07-28 2021-02-09 The Johns Hopkins University O-substituted hydroxamic acids
US11083704B2 (en) 2017-01-03 2021-08-10 Bristol-Myers Squibb Company Method of administering nitroxyl donating compounds
CA3189027A1 (en) 2020-07-11 2022-01-20 Pfizer Inc. Antiviral heteroaryl ketone derivatives
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
WO2025043108A1 (en) 2023-08-23 2025-02-27 Bristol -Myers S Quibb Company Co-crystals of nitroxyl donating compounds

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10509181A (ja) * 1994-11-22 1998-09-08 アメリカ合衆国 転移リスクを減少させるための酸化窒素放出薬剤の使用
JPH10510249A (ja) * 1994-11-22 1998-10-06 アメリカ合衆国 酸化窒素放出生体高分子含有医薬組成物
JP2002510320A (ja) * 1997-07-03 2002-04-02 アメリカ合衆国政府 新規な一酸化窒素放出アミジンおよびエナミン誘導ジアゼニウムジオレート、組成物およびそれらの用途、ならびにその製造方法
JP2002511838A (ja) * 1996-11-08 2002-04-16 チルドレンズ ホスピタル メディカル センター 肺高血圧症およびその他の適応症用の一酸化窒素供与化合物および医薬組成物
WO2003006427A1 (en) * 2001-07-12 2003-01-23 Johns Hopkins University Compounds that release nitric oxide at controlled rates upon photolysis
WO2003080039A1 (en) * 2002-03-21 2003-10-02 The University Of Utah Research Foundation In vivo use of glutathionone s-transferase activated nitric oxide donors
JP2005501008A (ja) * 2001-06-05 2005-01-13 ビーエーエスエフ アクチェンゲゼルシャフト 抗真菌剤
JP2006501140A (ja) * 2002-03-15 2006-01-12 ビーティージー・インターナショナル・リミテッド アントラキノン誘導体の調製

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4369172A (en) 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
DE3583799D1 (de) 1985-01-11 1991-09-19 Abbott Lab Ltd Feste zubereitung mit langsamer freisetzung.
US4954526A (en) 1989-02-28 1990-09-04 The United States Of America As Represented By The Department Of Health And Human Services Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
US5039705A (en) * 1989-09-15 1991-08-13 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
JP2773959B2 (ja) 1990-07-10 1998-07-09 信越化学工業株式会社 大腸内放出性固形製剤
AU668107B2 (en) * 1991-09-24 1996-04-26 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs
US6200558B1 (en) * 1993-09-14 2001-03-13 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
EP2292630B1 (en) * 1996-09-27 2015-11-25 The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services O2-substituted 1- (2-carboxylato)pyrrolidin-1-yl diazen-1-ium-1,2-diolates
UA73092C2 (uk) 1998-07-17 2005-06-15 Брістол-Майерс Сквібб Компані Таблетка з ентеросолюбільним покриттям і спосіб її приготування
DE69924735T2 (de) 1998-07-28 2006-01-19 Tanabe Seiyaku Co., Ltd. Zur wirkstoffabgabe an zielorten im darm fähige zubereitung
US20040038947A1 (en) * 2002-06-14 2004-02-26 The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services Method of treating ischemia/reperfusion injury with nitroxyl donors
US6936639B2 (en) * 2002-08-21 2005-08-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroxyl progenitors in the treatment of heart failure
US20050009789A1 (en) 2003-05-13 2005-01-13 The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Service Cyclooxygenase inhibition with nitroxyl
CA2554771A1 (en) 2004-01-30 2005-08-18 Johns Hopkins University Nitroxyl progenitor compounds and methods of use

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10509181A (ja) * 1994-11-22 1998-09-08 アメリカ合衆国 転移リスクを減少させるための酸化窒素放出薬剤の使用
JPH10510249A (ja) * 1994-11-22 1998-10-06 アメリカ合衆国 酸化窒素放出生体高分子含有医薬組成物
JP2002511838A (ja) * 1996-11-08 2002-04-16 チルドレンズ ホスピタル メディカル センター 肺高血圧症およびその他の適応症用の一酸化窒素供与化合物および医薬組成物
JP2002510320A (ja) * 1997-07-03 2002-04-02 アメリカ合衆国政府 新規な一酸化窒素放出アミジンおよびエナミン誘導ジアゼニウムジオレート、組成物およびそれらの用途、ならびにその製造方法
JP2005501008A (ja) * 2001-06-05 2005-01-13 ビーエーエスエフ アクチェンゲゼルシャフト 抗真菌剤
WO2003006427A1 (en) * 2001-07-12 2003-01-23 Johns Hopkins University Compounds that release nitric oxide at controlled rates upon photolysis
JP2006501140A (ja) * 2002-03-15 2006-01-12 ビーティージー・インターナショナル・リミテッド アントラキノン誘導体の調製
WO2003080039A1 (en) * 2002-03-21 2003-10-02 The University Of Utah Research Foundation In vivo use of glutathionone s-transferase activated nitric oxide donors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6010059961; Ｎｉｔｒｉｃ　Ｏｘｉｄｅ ６（２）, 2002, ｐ．１３５-１４１ *
JPN6010059962; Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ ６６（９）, 2001, ｐ．３０９０-３０９８ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011511079A (ja) * 2008-02-08 2011-04-07 メルク・シャープ・エンド・ドーム・コーポレイション アンジオテンシンｉｉ受容体アンタゴニスト

Also Published As

Publication number Publication date
EP1718621A4 (en) 2009-08-19
US10273202B2 (en) 2019-04-30
AU2005209843A1 (en) 2005-08-18
AU2005209843B2 (en) 2012-02-16
US20150141378A1 (en) 2015-05-21
US20090281067A1 (en) 2009-11-12
EP1718621A2 (en) 2006-11-08
WO2005074598A3 (en) 2005-12-15
CA2554771A1 (en) 2005-08-18
WO2005074598A2 (en) 2005-08-18

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