JP2006515585A5 - - Google Patents
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- Publication number
- JP2006515585A5 JP2006515585A5 JP2004559375A JP2004559375A JP2006515585A5 JP 2006515585 A5 JP2006515585 A5 JP 2006515585A5 JP 2004559375 A JP2004559375 A JP 2004559375A JP 2004559375 A JP2004559375 A JP 2004559375A JP 2006515585 A5 JP2006515585 A5 JP 2006515585A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridyl
- group
- alkyl
- compound
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*c1c(*)c(N(*)*C)c(*)c(*)n1 Chemical compound C*c1c(*)c(N(*)*C)c(*)c(*)n1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43163702P | 2002-12-06 | 2002-12-06 | |
| US60/431,637 | 2002-12-06 | ||
| PCT/US2003/038834 WO2004052291A2 (en) | 2002-12-06 | 2003-12-05 | Pyridines for treating injured mammalian nerve tissue |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006515585A JP2006515585A (ja) | 2006-06-01 |
| JP2006515585A5 true JP2006515585A5 (https=) | 2007-02-01 |
| JP4903385B2 JP4903385B2 (ja) | 2012-03-28 |
Family
ID=32507771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004559375A Expired - Fee Related JP4903385B2 (ja) | 2002-12-06 | 2003-12-05 | 損傷した哺乳類神経組織を治療するためのピリジン類 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7244748B2 (https=) |
| EP (1) | EP1567497B1 (https=) |
| JP (1) | JP4903385B2 (https=) |
| CN (1) | CN1745064A (https=) |
| AT (1) | ATE443699T1 (https=) |
| AU (1) | AU2003298034B2 (https=) |
| CA (1) | CA2508165C (https=) |
| DE (1) | DE60329415D1 (https=) |
| WO (1) | WO2004052291A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8729107B2 (en) * | 2002-12-06 | 2014-05-20 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| FR2849029B1 (fr) | 2002-12-20 | 2005-03-18 | Lafon Labor | Procede de preparation et formes cristallines des enantiomeres optiques du modafinil. |
| WO2007061554A2 (en) * | 2005-10-21 | 2007-05-31 | Purdue Research Foundation | Dosage of 4-aminopyridine derivatives for treatment of central nervous system injuries |
| US8181994B1 (en) | 2008-07-18 | 2012-05-22 | Chicago Tag & Label, Inc. | Sheet with wristband |
| US8066306B1 (en) | 2008-07-18 | 2011-11-29 | Chicago Tag & Label, Inc. | Label sheet with wristband |
| WO2012009204A1 (en) * | 2010-07-15 | 2012-01-19 | The Trustees Of Columbia University In The City Of New York | Methods for diagnosing and treating concussive disorders |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| US9617215B2 (en) | 2012-05-17 | 2017-04-11 | The University Of Chicago | Use of fluorinated derivatives of 4-aminopyridine in therapeutics and medical imaging |
| AU2013262578B2 (en) * | 2012-05-17 | 2017-07-13 | The University Of Chicago | Fluorinated derivatives of 4-aminopyridine |
| CN102702261A (zh) * | 2012-05-29 | 2012-10-03 | 南京信息工程大学 | 制备1-取代苯基-4-乙氧羰基-5-( 二苯基膦氧)氨基-1 ,2 ,3-三唑的方法 |
| ES2704744T3 (es) | 2012-06-13 | 2019-03-19 | Incyte Holdings Corp | Compuestos tricíclicos sustituidos como inhibidores de FGFR |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| EA035095B1 (ru) | 2013-04-19 | 2020-04-27 | Инсайт Холдингс Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| MX373169B (es) | 2015-02-20 | 2020-04-24 | Incyte Holdings Corp | Heterociclos bicíclicos como inhibidores de receptores del factor de crecimiento fibroblástico (fgfr). |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| CR20200590A (es) | 2018-05-04 | 2021-04-26 | Incyte Corp | Formas sólidas de un inhibidor de fgfr y procesos para prepararlas |
| MA52493A (fr) | 2018-05-04 | 2021-03-10 | Incyte Corp | Sels d'un inhibiteur de fgfr |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| TWI891666B (zh) | 2019-10-14 | 2025-08-01 | 美商英塞特公司 | 作為fgfr抑制劑之雙環雜環 |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
| EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| TW202304459A (zh) | 2021-04-12 | 2023-02-01 | 美商英塞特公司 | 包含fgfr抑制劑及nectin-4靶向劑之組合療法 |
| EP4352059A1 (en) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2022261159A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1071035A (en) * | 1964-09-02 | 1967-06-07 | Rech Et Pharmacologie | Improvements in and relating to new carbamates and thiocarbamates and the process of preparation and therapeutic applications thereof |
| US3433873A (en) | 1966-04-05 | 1969-03-18 | Phillips Petroleum Co | Compositions and methods for controlling birds |
| US3804844A (en) * | 1970-12-02 | 1974-04-16 | Dow Chemical Co | Process for preparing pyridylcarbamates |
| GB1339764A (en) * | 1971-03-29 | 1973-12-05 | Ici Ltd | Pyridine derivatives |
| IL39094A (en) * | 1971-04-21 | 1976-05-31 | Ciba Geigy Ag | 7-(aminopyridiniumacetyl)-3-heterocyclylthiomethyl-cephalosporanic acid derivatives,their manufacture and pharmaceutical compositions containing them |
| SU464177A1 (ru) * | 1973-01-08 | 1978-03-25 | Донецкое Отделение Физико-Органической Химии Института Физической Химии Ан Украинской Сср | Способ получени 4-галоидзамещенных имидазо- (4,5-с)-пиридин -2-она |
| US3995042A (en) | 1973-09-07 | 1976-11-30 | E. R. Squibb & Sons, Inc. | Pyridine containing compounds |
| US4304911A (en) | 1980-11-19 | 1981-12-08 | Sterling Drug Inc. | Benzoylphenyl lower alkanoyl piperidines |
| FR2624699B1 (fr) * | 1987-12-18 | 1990-04-13 | Bernard Lyon I Universite Clau | Derives heterocycliques de n-carbamoyl-, n-thiocarbamoyl- ou n-amidino-glycine ou beta-alanine utiles comme agents edulcorants |
| JPH03181462A (ja) * | 1989-12-08 | 1991-08-07 | Nippon Kayaku Co Ltd | N―(4―ピリジル)カーバメート誘導体およびそれを有効成分とする開花促進剤 |
| IE82916B1 (en) | 1990-11-02 | 2003-06-11 | Elan Corp Plc | Formulations and their use in the treatment of neurological diseases |
| AU677968B2 (en) | 1992-09-25 | 1997-05-15 | H. Lundbeck A/S | DNA encoding human alpha 1 adrenergic receptors and uses thereof |
| CA2085785C (en) * | 1992-12-18 | 2005-03-15 | Robert R. Hansebout | The use of 4-aminopyridine in the treatment of a neurological condition |
| US5502498A (en) | 1993-03-10 | 1996-03-26 | Samsung Electronics Co., Ltd. | Clamp signal generation-control circuit and a method therefor |
| US5849772A (en) | 1994-09-22 | 1998-12-15 | Yukong Limited | Carbamate compounds and processes for preparing the same |
| JP3583489B2 (ja) | 1994-12-22 | 2004-11-04 | 日清紡績株式会社 | カルボジイミド誘導体 |
| US5763463A (en) * | 1995-04-28 | 1998-06-09 | Kumiai Chemical Industry Co., Ltd. | Pyridine compounds which are useful as pesticides |
| US5880128A (en) * | 1996-05-08 | 1999-03-09 | Schering Corporation | Carbonyl piperazinyl and piperidinyl compounds |
| PT935598E (pt) | 1996-10-07 | 2004-03-31 | Ortho Mcneil Pharm Inc | Derivados de 3-oxo-pirido (1,2-a)benzimidazole-4-carboxamida alquilo substituidos contendo 5 heteroatomos uteis no tratamento de disturbios do sistema nervoso central |
| US5961309A (en) * | 1997-04-24 | 1999-10-05 | Trw Inc. | Gear pump with noise attenuation |
| US6200984B1 (en) | 1997-10-07 | 2001-03-13 | Ortho-Mcneil Pharmaceutical, Inc. | Naphtho-imidazo pyridine derivatives useful in treating central nervous system disorders |
| US6632823B1 (en) | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
| AUPP150098A0 (en) * | 1998-01-27 | 1998-02-19 | Fujisawa Pharmaceutical Co., Ltd. | Benzamide derivatives |
| ATE430149T1 (de) * | 1998-03-04 | 2009-05-15 | Bristol Myers Squibb Co | Heterocyclen substituierte imidazopyrazine als protein- tyrosin-kinase-inhibitoren |
| ES2213984T3 (es) * | 1998-10-30 | 2004-09-01 | Eli Lilly And Company | Derivados de azaindol y su uso como agentes antitrombicos. |
| EP1394150B1 (en) | 1999-02-24 | 2011-01-19 | F. Hoffmann-La Roche AG | 4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists |
| TR200102481T2 (tr) | 1999-02-25 | 2002-01-21 | Pfizer Products Inc. | Fazlı zincir muadili içeren 2-aminopiridinler. |
| JP2002540206A (ja) * | 1999-03-11 | 2002-11-26 | ニューロゲン コーポレイション | アリールの縮合した2,4−二置換ピリジン:nk3受容体リガンド |
| SK1182002A3 (en) * | 1999-07-28 | 2002-11-06 | Aventis Pharm Prod Inc | Substituted oxoazaheterocyclyl compounds |
| US6495550B2 (en) | 1999-08-04 | 2002-12-17 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
| WO2001034567A1 (en) * | 1999-11-10 | 2001-05-17 | Aventis Pharma Deutschland Gmbh | N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor xa |
| FR2806722B1 (fr) * | 2000-03-23 | 2002-05-17 | Sanofi Synthelabo | Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique |
| US20020045613A1 (en) * | 2000-04-27 | 2002-04-18 | Heinz Pauls | 1-aroyl-piperidinyl benzamidines |
| DE10063294A1 (de) | 2000-12-19 | 2002-07-04 | Aventis Pharma Gmbh | Substituierte Heterocyclo-Norbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| KR100745307B1 (ko) | 2001-05-31 | 2007-08-01 | 사노피-아벤티스 | 아미노퀴놀린 유도체 및 아데노신 a3 리간드로서의 이의 용도 |
| JP2003073357A (ja) * | 2001-09-03 | 2003-03-12 | Mitsubishi Pharma Corp | アミド化合物を含有するRhoキナーゼ阻害剤 |
| TWI317360B (en) * | 2001-11-07 | 2009-11-21 | Schering Corp | Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1 |
-
2003
- 2003-12-05 EP EP03796756A patent/EP1567497B1/en not_active Expired - Lifetime
- 2003-12-05 DE DE60329415T patent/DE60329415D1/de not_active Expired - Lifetime
- 2003-12-05 AT AT03796756T patent/ATE443699T1/de not_active IP Right Cessation
- 2003-12-05 AU AU2003298034A patent/AU2003298034B2/en not_active Ceased
- 2003-12-05 JP JP2004559375A patent/JP4903385B2/ja not_active Expired - Fee Related
- 2003-12-05 CA CA2508165A patent/CA2508165C/en not_active Expired - Fee Related
- 2003-12-05 US US10/730,495 patent/US7244748B2/en not_active Expired - Fee Related
- 2003-12-05 CN CNA2003801094006A patent/CN1745064A/zh active Pending
- 2003-12-05 WO PCT/US2003/038834 patent/WO2004052291A2/en not_active Ceased
-
2007
- 2007-07-16 US US11/778,524 patent/US8097638B2/en active Active
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