JP2022537140A5 - - Google Patents
Info
- Publication number
- JP2022537140A5 JP2022537140A5 JP2021573446A JP2021573446A JP2022537140A5 JP 2022537140 A5 JP2022537140 A5 JP 2022537140A5 JP 2021573446 A JP2021573446 A JP 2021573446A JP 2021573446 A JP2021573446 A JP 2021573446A JP 2022537140 A5 JP2022537140 A5 JP 2022537140A5
- Authority
- JP
- Japan
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962861902P | 2019-06-14 | 2019-06-14 | |
| US62/861,902 | 2019-06-14 | ||
| PCT/US2020/037591 WO2020252383A2 (en) | 2019-06-14 | 2020-06-12 | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (pcsk9) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022537140A JP2022537140A (ja) | 2022-08-24 |
| JP2022537140A5 true JP2022537140A5 (https=) | 2023-06-19 |
| JPWO2020252383A5 JPWO2020252383A5 (https=) | 2023-06-19 |
Family
ID=73780709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021573446A Pending JP2022537140A (ja) | 2019-06-14 | 2020-06-12 | プロタンパク質転換酵素サブチリシン／ケキシン９型（ｐｃｓｋ９）の調節のための化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220267269A1 (https=) |
| EP (1) | EP3983392A4 (https=) |
| JP (1) | JP2022537140A (https=) |
| CN (1) | CN114206843A (https=) |
| AU (1) | AU2020291468A1 (https=) |
| CA (1) | CA3142890A1 (https=) |
| IL (1) | IL288848A (https=) |
| WO (1) | WO2020252383A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1257102A1 (zh) | 2015-08-21 | 2019-10-11 | Portola Pharmaceuticals, Inc. | 苯基哌嗪前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)调节剂及其应用 |
| US10865185B2 (en) | 2015-08-21 | 2020-12-15 | Srx Cardio, Llc | Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate PCSK9 protein activity |
| US10821106B2 (en) | 2015-08-21 | 2020-11-03 | Srx Cardio, Llc | Composition and methods of use of novel phenylalanine small organic compounds to directly modulate PCSK9 protein activity |
| US20190119236A1 (en) | 2016-02-23 | 2019-04-25 | Portola Pharmaceuticals, Inc. | Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9) |
| US12115154B2 (en) | 2020-12-16 | 2024-10-15 | Srx Cardio, Llc | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) |
| CN121443616A (zh) * | 2023-07-27 | 2026-01-30 | 上海拓界生物医药科技有限公司 | 二氨基环戊基取代的杂芳基衍生物及其用途和制备方法 |
| WO2025034510A1 (en) | 2023-08-04 | 2025-02-13 | University Of Rochester | Adrenergic antagonists for use in a method for treating cerebral edema or a brain injury |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5556990A (en) * | 1994-12-16 | 1996-09-17 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Polyarylcarbamoylaza- and -carbamoylalkanedioic acids |
| HN1997000027A (es) * | 1996-12-06 | 1997-06-05 | Pfizer Prod Inc | Derivados de 6-fenil piridil - 2 amina |
| WO2000071107A2 (en) * | 1999-05-21 | 2000-11-30 | Pfizer Products Inc. | New pharmaceutical combinations for nos inhibitors |
| JP4866610B2 (ja) * | 2003-08-18 | 2012-02-01 | 富士フイルムファインケミカルズ株式会社 | ピリジルテトラヒドロピリジン類およびピリジルピペリジン類 |
| EP1957477B1 (en) * | 2005-09-29 | 2011-12-07 | Abbott Laboratories | 1h-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent parp inhibitors |
| US7834178B2 (en) * | 2006-03-01 | 2010-11-16 | Bristol-Myers Squibb Company | Triazine 11-beta hydroxysteroid dehydrogenase type 1 inhibitors |
| PT2057153E (pt) * | 2006-07-10 | 2012-11-14 | Lundbeck & Co As H | Derivados (3-aril-piperazin-1-il) de 6,7- dialcoxiquinazolina, 6,7-dialcoxiftalazina e 6,7-dialcoxiisoquinolina |
| HK1257102A1 (zh) * | 2015-08-21 | 2019-10-11 | Portola Pharmaceuticals, Inc. | 苯基哌嗪前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)调节剂及其应用 |
| CN106995413A (zh) * | 2016-01-25 | 2017-08-01 | 中国科学院大连化学物理研究所 | 一种铱催化氢化不对称合成哌嗪衍生物的方法 |
| WO2018165718A1 (en) * | 2017-03-17 | 2018-09-20 | Cardio Therapeutics Pty Ltd | Heterocyclic inhibitors of pcsk9 |
| CN110546149B (zh) * | 2017-04-21 | 2022-11-11 | 深圳信立泰药业股份有限公司 | 作为pcsk9抑制剂的哌啶类化合物 |
-
2020
- 2020-06-12 CA CA3142890A patent/CA3142890A1/en active Pending
- 2020-06-12 CN CN202080050808.4A patent/CN114206843A/zh active Pending
- 2020-06-12 WO PCT/US2020/037591 patent/WO2020252383A2/en not_active Ceased
- 2020-06-12 AU AU2020291468A patent/AU2020291468A1/en not_active Abandoned
- 2020-06-12 US US17/618,873 patent/US20220267269A1/en not_active Abandoned
- 2020-06-12 EP EP20823039.1A patent/EP3983392A4/en not_active Withdrawn
- 2020-06-12 JP JP2021573446A patent/JP2022537140A/ja active Pending
-
2021
- 2021-12-09 IL IL288848A patent/IL288848A/en unknown