JP2005525358A - ヌクレオチド模倣体およびそのプロドラッグ - Google Patents

ヌクレオチド模倣体およびそのプロドラッグ Download PDF

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Publication number
JP2005525358A
JP2005525358A JP2003571445A JP2003571445A JP2005525358A JP 2005525358 A JP2005525358 A JP 2005525358A JP 2003571445 A JP2003571445 A JP 2003571445A JP 2003571445 A JP2003571445 A JP 2003571445A JP 2005525358 A JP2005525358 A JP 2005525358A
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Prior art keywords
deoxy
dideoxy
methyl
group
arabinofuranosyl
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Japanese (ja)
Inventor
フィリップ ダン クック
グワンギ ワン
トーマス ダブリュ． ブルース
ニコラス エー． ボイル
ジャネット エム． リーズ
ジェニファー エル． ブルックス
マハール プラハビック
マーユージニア アリザ
パトリック シー． フェイガン
イー． ジン
ヴィヴェク ケイ． ラジャワンシ
キャサリン ディー． タッカー
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ビオタ インコーポレーティッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
JP2003571445A 2002-02-28 2003-02-28 ヌクレオチド模倣体およびそのプロドラッグ Pending JP2005525358A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36091502P 2002-02-28 2002-02-28
US36069902P 2002-02-28 2002-02-28
PCT/US2003/006368 WO2003072757A2 (en) 2002-02-28 2003-02-28 Nucleotide mimics and their prodrugs

Publications (1)

Publication Number Publication Date
JP2005525358A true JP2005525358A (ja) 2005-08-25

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JP2003571445A Pending JP2005525358A (ja) 2002-02-28 2003-02-28 ヌクレオチド模倣体およびそのプロドラッグ

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US (3) US7285658B2 (US20070265224A1-20071115-C00015.png)
EP (1) EP1485395A4 (US20070265224A1-20071115-C00015.png)
JP (1) JP2005525358A (US20070265224A1-20071115-C00015.png)
AU (1) AU2003217863B9 (US20070265224A1-20071115-C00015.png)
CA (1) CA2477741A1 (US20070265224A1-20071115-C00015.png)
RU (1) RU2004128943A (US20070265224A1-20071115-C00015.png)
WO (1) WO2003072757A2 (US20070265224A1-20071115-C00015.png)

Cited By (5)

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JP2010524874A (ja) * 2007-04-18 2010-07-22 エフ．ホフマン−ラ ロシュ アーゲー α−リン酸擬似体を有するヌクレオチド
JP2016514710A (ja) * 2013-03-19 2016-05-23 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． ヤヌスキナーゼ阻害剤としてのｎ−（２−シアノヘテロシクリル）ピラゾロピリドン
JP2018188468A (ja) * 2011-12-22 2018-11-29 アリオス バイオファーマ インク． 置換されたヌクレオシド、ヌクレオチドおよびそのアナログ
US10485815B2 (en) 2012-03-21 2019-11-26 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

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