JP2005521741A5 - - Google Patents
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- Publication number
- JP2005521741A5 JP2005521741A5 JP2003582115A JP2003582115A JP2005521741A5 JP 2005521741 A5 JP2005521741 A5 JP 2005521741A5 JP 2003582115 A JP2003582115 A JP 2003582115A JP 2003582115 A JP2003582115 A JP 2003582115A JP 2005521741 A5 JP2005521741 A5 JP 2005521741A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- hydrogen
- acetic acid
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 41
- 125000003118 aryl group Chemical group 0.000 claims 24
- 229910052739 hydrogen Inorganic materials 0.000 claims 23
- 239000001257 hydrogen Substances 0.000 claims 23
- 150000002431 hydrogen Chemical class 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000003545 alkoxy group Chemical group 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 125000003342 alkenyl group Chemical group 0.000 claims 9
- 125000000304 alkynyl group Chemical group 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 9
- 125000001188 haloalkyl group Chemical group 0.000 claims 9
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 9
- 125000004429 atom Chemical group 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 claims 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000001054 5 membered carbocyclic group Chemical group 0.000 claims 2
- -1 5-trifluoromethyl - pyridin-2-yl Chemical group 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 2
- 230000002152 alkylating effect Effects 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 229930195733 hydrocarbon Natural products 0.000 claims 2
- 150000002430 hydrocarbons Chemical class 0.000 claims 2
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 claims 2
- 150000003573 thiols Chemical class 0.000 claims 2
- VFQRJNOXLNYYTE-UHFFFAOYSA-N 2-[3-methoxy-4-[[4-[4-(trifluoromethyl)phenyl]phenyl]methylsulfanyl]phenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=CC=C1SCC1=CC=C(C=2C=CC(=CC=2)C(F)(F)F)C=C1 VFQRJNOXLNYYTE-UHFFFAOYSA-N 0.000 claims 1
- QZCOZWYSOAUBJR-UHFFFAOYSA-N 2-[4-[[4-(2,4-dichlorophenyl)phenyl]methylsulfanyl]-5-methoxy-2-methylphenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCC1=CC=C(C=2C(=CC(Cl)=CC=2)Cl)C=C1 QZCOZWYSOAUBJR-UHFFFAOYSA-N 0.000 claims 1
- UXBLXTMVLIEOGI-UHFFFAOYSA-N 2-[4-[[4-(4-fluorophenyl)phenyl]methylsulfanyl]-5-methoxy-2-methylphenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCC1=CC=C(C=2C=CC(F)=CC=2)C=C1 UXBLXTMVLIEOGI-UHFFFAOYSA-N 0.000 claims 1
- QPQVDUHBPMLTTD-UHFFFAOYSA-N 2-[4-[[4-[2-(3-fluorophenyl)ethenyl]phenyl]methylsulfanyl]-5-methoxy-2-methylphenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCC(C=C1)=CC=C1C=CC1=CC=CC(F)=C1 QPQVDUHBPMLTTD-UHFFFAOYSA-N 0.000 claims 1
- JLQGDIDQGNXZJJ-UHFFFAOYSA-N 2-[4-[[5-(4-chlorophenyl)-1,2-oxazol-3-yl]methylsulfanyl]-5-methoxy-2-methylphenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCC1=NOC(C=2C=CC(Cl)=CC=2)=C1 JLQGDIDQGNXZJJ-UHFFFAOYSA-N 0.000 claims 1
- COOMMSHFMOKEKM-UHFFFAOYSA-N 2-[5-methoxy-2-methyl-4-[(4-phenylphenyl)methylsulfanyl]phenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCC1=CC=C(C=2C=CC=CC=2)C=C1 COOMMSHFMOKEKM-UHFFFAOYSA-N 0.000 claims 1
- AJQNSRYZFLLBOI-UHFFFAOYSA-N 2-[5-methoxy-2-methyl-4-[2-[4-[4-(trifluoromethyl)phenyl]phenyl]ethylsulfanyl]phenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCCC1=CC=C(C=2C=CC(=CC=2)C(F)(F)F)C=C1 AJQNSRYZFLLBOI-UHFFFAOYSA-N 0.000 claims 1
- HXCKESKWJSVFAR-UHFFFAOYSA-N 2-[5-methoxy-2-methyl-4-[[2-methyl-4-[4-(trifluoromethyl)phenyl]phenyl]methylsulfanyl]phenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCC1=CC=C(C=2C=CC(=CC=2)C(F)(F)F)C=C1C HXCKESKWJSVFAR-UHFFFAOYSA-N 0.000 claims 1
- VVUWGDAIOYKXPE-UHFFFAOYSA-N 2-[5-methoxy-2-methyl-4-[[3-[3-(trifluoromethoxy)phenyl]phenyl]methylsulfanyl]phenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCC1=CC=CC(C=2C=C(OC(F)(F)F)C=CC=2)=C1 VVUWGDAIOYKXPE-UHFFFAOYSA-N 0.000 claims 1
- GSPKTIOMMLSIHT-UHFFFAOYSA-N 2-[5-methoxy-2-methyl-4-[[3-[4-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methylsulfanyl]phenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCC1=CC(C=2C=CC(=CC=2)C(F)(F)F)=NO1 GSPKTIOMMLSIHT-UHFFFAOYSA-N 0.000 claims 1
- MANTXHYUNLPBHE-UHFFFAOYSA-N 2-[5-methoxy-2-methyl-4-[[3-[4-(trifluoromethyl)phenyl]phenyl]methylsulfanyl]phenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCC1=CC=CC(C=2C=CC(=CC=2)C(F)(F)F)=C1 MANTXHYUNLPBHE-UHFFFAOYSA-N 0.000 claims 1
- WPLMYOVJSNXPMK-UHFFFAOYSA-N 2-[5-methoxy-2-methyl-4-[[4-[3-(trifluoromethyl)phenyl]phenyl]methylsulfanyl]phenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCC1=CC=C(C=2C=C(C=CC=2)C(F)(F)F)C=C1 WPLMYOVJSNXPMK-UHFFFAOYSA-N 0.000 claims 1
- YBYRUZQLTYRCRF-UHFFFAOYSA-N 2-[5-methoxy-2-methyl-4-[[4-[4-(trifluoromethyl)phenyl]phenyl]methylsulfanyl]phenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCC1=CC=C(C=2C=CC(=CC=2)C(F)(F)F)C=C1 YBYRUZQLTYRCRF-UHFFFAOYSA-N 0.000 claims 1
- NWEHHVVXCHVPFQ-UHFFFAOYSA-N 2-[5-methoxy-2-methyl-4-[[4-[5-(trifluoromethyl)pyridin-2-yl]phenyl]methylsulfanyl]phenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCC1=CC=C(C=2N=CC(=CC=2)C(F)(F)F)C=C1 NWEHHVVXCHVPFQ-UHFFFAOYSA-N 0.000 claims 1
- ONKOHQZZVMTPOM-UHFFFAOYSA-N 2-[5-methoxy-2-methyl-4-[[4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylsulfanyl]phenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCC(C=C1)=CC=C1OCC1=CC=C(C(F)(F)F)C=C1 ONKOHQZZVMTPOM-UHFFFAOYSA-N 0.000 claims 1
- WIOTZGHDAYUCBC-UHFFFAOYSA-N 2-[5-methoxy-2-methyl-4-[[5-[4-(trifluoromethyl)phenyl]-1,2-oxazol-3-yl]methylsulfanyl]phenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCC1=NOC(C=2C=CC(=CC=2)C(F)(F)F)=C1 WIOTZGHDAYUCBC-UHFFFAOYSA-N 0.000 claims 1
- HEMOEZGWSUFMTR-UHFFFAOYSA-N 2-[5-methoxy-2-methyl-4-[[6-[4-(trifluoromethyl)phenyl]pyridin-3-yl]methylsulfanyl]phenoxy]acetic acid Chemical compound COC1=CC(OCC(O)=O)=C(C)C=C1SCC1=CC=C(C=2C=CC(=CC=2)C(F)(F)F)N=C1 HEMOEZGWSUFMTR-UHFFFAOYSA-N 0.000 claims 1
- UUBMLUGVHDOXPD-UHFFFAOYSA-N 2-[[7-[[4-[4-(trifluoromethyl)phenyl]phenyl]methylsulfanyl]-2,3-dihydro-1h-inden-4-yl]oxy]acetic acid Chemical compound C1=2CCCC=2C(OCC(=O)O)=CC=C1SCC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 UUBMLUGVHDOXPD-UHFFFAOYSA-N 0.000 claims 1
- IVINVXPMKZERSK-UHFFFAOYSA-N 2-[[7-[[4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methylsulfanyl]-2,3-dihydro-1h-inden-4-yl]oxy]acetic acid Chemical compound C1=2CCCC=2C(OCC(=O)O)=CC=C1SCC(C=C1)=CC=C1OCC1=CC=C(C(F)(F)F)C=C1 IVINVXPMKZERSK-UHFFFAOYSA-N 0.000 claims 1
- 125000004199 4-trifluoromethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C(F)(F)F 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 102000016267 Leptin Human genes 0.000 claims 1
- 108010092277 Leptin Proteins 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 150000002148 esters Chemical group 0.000 claims 1
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 1
- 229940039781 leptin Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37050802P | 2002-04-05 | 2002-04-05 | |
| US38602602P | 2002-06-05 | 2002-06-05 | |
| PCT/IB2003/001121 WO2003084916A2 (en) | 2002-04-05 | 2003-03-24 | Compounds that modulate ppar activity and methods for their preparation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005360431A Division JP2006151985A (ja) | 2002-04-05 | 2005-12-14 | Ｐｐａｒ活性を調節する化合物、及び該化合物の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005521741A JP2005521741A (ja) | 2005-07-21 |
| JP2005521741A5 true JP2005521741A5 (https=) | 2005-12-22 |
| JP3816922B2 JP3816922B2 (ja) | 2006-08-30 |
Family
ID=28794388
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003582115A Expired - Fee Related JP3816922B2 (ja) | 2002-04-05 | 2003-03-24 | Ｐｐａｒ活性を調節する化合物、及び該化合物の製造方法 |
| JP2005360431A Withdrawn JP2006151985A (ja) | 2002-04-05 | 2005-12-14 | Ｐｐａｒ活性を調節する化合物、及び該化合物の製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005360431A Withdrawn JP2006151985A (ja) | 2002-04-05 | 2005-12-14 | Ｐｐａｒ活性を調節する化合物、及び該化合物の製造方法 |
Country Status (35)
| Country | Link |
|---|---|
| US (4) | US6875780B2 (https=) |
| EP (1) | EP1494989A2 (https=) |
| JP (2) | JP3816922B2 (https=) |
| KR (1) | KR100687166B1 (https=) |
| CN (1) | CN1649820A (https=) |
| AP (1) | AP1772A (https=) |
| AR (1) | AR039239A1 (https=) |
| AU (1) | AU2003212578A1 (https=) |
| BR (1) | BR0309169A (https=) |
| CA (1) | CA2481246C (https=) |
| CO (1) | CO5640080A2 (https=) |
| DO (1) | DOP2003000620A (https=) |
| EA (2) | EA200700969A1 (https=) |
| GE (1) | GEP20074244B (https=) |
| GT (3) | GT200300075BA (https=) |
| HN (1) | HN2003000113A (https=) |
| HR (1) | HRP20040916A2 (https=) |
| IL (1) | IL164015A0 (https=) |
| IS (1) | IS7429A (https=) |
| MA (1) | MA27189A1 (https=) |
| MX (1) | MXPA04009727A (https=) |
| MY (1) | MY134199A (https=) |
| NI (1) | NI200300042A (https=) |
| NO (1) | NO20044795L (https=) |
| NZ (1) | NZ554477A (https=) |
| OA (1) | OA12859A (https=) |
| PA (1) | PA8570701A1 (https=) |
| PE (1) | PE20040307A1 (https=) |
| PL (1) | PL373651A1 (https=) |
| RS (1) | RS82904A (https=) |
| TN (1) | TNSN04191A1 (https=) |
| TW (1) | TWI249522B (https=) |
| UA (1) | UA76838C2 (https=) |
| UY (1) | UY27749A1 (https=) |
| WO (1) | WO2003084916A2 (https=) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7517884B2 (en) * | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| GB0029974D0 (en) * | 2000-12-08 | 2001-01-24 | Glaxo Group Ltd | Chemical compounds |
| EP1435946B8 (en) | 2001-09-14 | 2013-12-18 | Amgen Inc. | Linked biaryl compounds |
| US6833380B2 (en) | 2002-03-07 | 2004-12-21 | Warner-Lambert Company, Llc | Compounds that modulate PPAR activity and methods of preparation |
| US20050205505A1 (en) * | 2002-06-24 | 2005-09-22 | Sugatsune Kogyo Co. Ltd | Umbrella storage device and umbrella holding lock |
| US7396850B2 (en) * | 2003-01-06 | 2008-07-08 | Eli Lilly And Company | Pyrazole derivative as PPAR modulator |
| US7244763B2 (en) * | 2003-04-17 | 2007-07-17 | Warner Lambert Company Llc | Compounds that modulate PPAR activity and methods of preparation |
| EP1630152A4 (en) * | 2003-05-30 | 2009-09-23 | Takeda Pharmaceutical | CONDENSED CYCLIC COMPOUND |
| EP1667964B1 (en) | 2003-09-19 | 2009-07-22 | Janssen Pharmaceutica N.V. | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| AU2004283147A1 (en) * | 2003-10-28 | 2005-05-06 | Dr. Reddy's Laboratories Ltd. | Novel compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them |
| CN1897939A (zh) | 2003-10-31 | 2007-01-17 | 詹森药业有限公司 | 适用作过氧化物酶体增生物激活受体（ppar）双重激动剂的苯氧基乙酸衍生物 |
| EP1682507A1 (en) * | 2003-11-05 | 2006-07-26 | F. Hoffmann-La Roche Ag | Benzannelated compounds as ppar activators |
| RU2367659C2 (ru) * | 2003-11-05 | 2009-09-20 | Ф.Хоффманн-Ля Рош Аг | Гетероарильные производные в качестве активаторов рецепторов, активируемых пролифераторами пероксисом (ppar) |
| CN1875002B (zh) * | 2003-11-05 | 2011-08-03 | 霍夫曼-拉罗奇有限公司 | 作为ppar激动剂的苯基衍生物 |
| EP1690538A4 (en) * | 2003-12-02 | 2009-02-25 | Shionogi & Co | ISOXAZOLE DERIVATIVE AGONISTIC ACTION AGAINST PEROXISOM PROLIFERATOR ACTIVATED RECEPTOR |
| WO2005066136A1 (en) * | 2003-12-22 | 2005-07-21 | Eli Lilly And Company | Bicyclic derivatives as ppar modulators |
| US7507832B2 (en) | 2003-12-22 | 2009-03-24 | Eli Lilly And Company | Triazole PPAR modulators |
| AU2004309271A1 (en) | 2003-12-25 | 2005-07-14 | Takeda Pharmaceutical Company Limited | 3-(4-benzyloxyphenyl)propanoic acid derivatives |
| GB0403148D0 (en) * | 2004-02-12 | 2004-03-17 | Smithkline Beecham Corp | Chemical compounds |
| JP5299810B2 (ja) * | 2004-02-27 | 2013-09-25 | アムジエン・インコーポレーテツド | 代謝疾患の治療に使用するための、化合物、薬学的組成物及び方法 |
| CA2557789C (en) * | 2004-03-09 | 2012-12-11 | F.Hoffmann-La Roche Ag | Pyrazolyl indolyl derivatives as ppar activators |
| US7119214B2 (en) * | 2004-04-13 | 2006-10-10 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
| DE602005024384D1 (de) * | 2004-05-05 | 2010-12-09 | High Point Pharmaceuticals Llc | Neue verbindungen, ihre herstellung und verwendung |
| ES2347578T3 (es) * | 2004-05-05 | 2010-11-02 | High Point Pharmaceuticals, Llc | Derivados del acido fenoxiacetico como agonistas de ppar. |
| US8053598B2 (en) * | 2004-05-05 | 2011-11-08 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
| BRPI0510024A (pt) | 2004-05-14 | 2007-09-25 | Irm Llc | compostos e composições como modulares de ppar |
| BRPI0511099A (pt) * | 2004-05-14 | 2007-12-26 | Irm Llc | compostos e composições como moduladores de ppar |
| AU2005247473A1 (en) * | 2004-05-25 | 2005-12-08 | Metabolex, Inc. | Substituted triazoles as modulators of PPAR and methods of their preparation |
| CN101123956A (zh) * | 2004-05-25 | 2008-02-13 | 辉瑞产品有限公司 | Ppar激动剂治疗反刍动物的用途 |
| US20060014785A1 (en) * | 2004-05-25 | 2006-01-19 | Metabolex, Inc. | Bicyclic, substituted triazoles as modulators of ppar and methods of their preparation |
| JP4568329B2 (ja) * | 2004-07-01 | 2010-10-27 | エフ．ホフマン−ラ ロシュ アーゲー | アセチレン基を含むフェニル誘導体 |
| US7622491B2 (en) * | 2004-08-13 | 2009-11-24 | Metabolex Inc. | Modulators of PPAR and methods of their preparation |
| MY145712A (en) * | 2004-09-15 | 2012-03-30 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| MX2007005205A (es) * | 2004-10-29 | 2007-05-11 | Kalypsys Inc | Compuestos biciclicos sulfonilo-sustituidos como moduladores de receptores activados por el proliferador de la peroxisoma. |
| US20070190079A1 (en) * | 2004-10-29 | 2007-08-16 | Kalypsys, Inc. | Methods for the selective modulation of ppar |
| WO2006056845A1 (en) * | 2004-11-23 | 2006-06-01 | Warner-Lambert Company Llc | 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia |
| US7465804B2 (en) * | 2005-05-20 | 2008-12-16 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders |
| ES2372617T3 (es) * | 2005-06-30 | 2012-01-24 | High Point Pharmaceuticals, Llc | Ácidos fenoxiacéticos como activadores de ppar-delta. |
| KR20080042170A (ko) * | 2005-09-07 | 2008-05-14 | 플렉시콘, 인코퍼레이티드 | Ｐｐａｒ 활성 화합물 |
| JO3006B1 (ar) * | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| WO2007033002A1 (en) * | 2005-09-14 | 2007-03-22 | Amgen Inc. | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| EP1940815B1 (en) * | 2005-10-25 | 2018-08-15 | Kalypsys, Inc. | Salts of modulators of ppar and methods of treating metabolic disorders |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| CN103224477A (zh) | 2005-12-22 | 2013-07-31 | 高点制药有限责任公司 | 作为PPAR-δ活化剂的苯氧基乙酸 |
| CN101007798B (zh) * | 2006-01-24 | 2011-01-26 | 中国人民解放军军事医学科学院毒物药物研究所 | 苯并间二氧杂环戊烯衍生物及其制备方法和医药用途 |
| US7943612B2 (en) * | 2006-03-09 | 2011-05-17 | High Point Pharmaceuticals, Llc | Compounds that modulate PPAR activity, their preparation and use |
| US8383660B2 (en) | 2006-03-10 | 2013-02-26 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| CA2646430A1 (en) * | 2006-03-14 | 2007-09-20 | Amgen Inc. | Bicyclic carboxylic acid derivatives useful for treating metabolic disorders |
| UY30288A1 (es) * | 2006-04-18 | 2007-08-31 | Janssen Pharmaceutica Nv | Derivados del ácido benzoazepin-oxi-acético como agonistas de ppar-delta usados para aumentar hdl-c. reducir ldl-c y reducir colesterol |
| US20070249519A1 (en) * | 2006-04-20 | 2007-10-25 | Kalypsys, Inc. | Methods for the upregulation of glut4 via modulation of ppar delta in adipose tissue and for the treatment of disease |
| TW200745059A (en) * | 2006-05-16 | 2007-12-16 | Kalypsys Inc | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| AU2007292816B2 (en) * | 2006-09-07 | 2011-11-17 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
| CA2662305C (en) | 2006-09-07 | 2012-04-17 | Amgen Inc. | Heterocyclic gpr40 modulators |
| CN101663262B (zh) | 2006-12-01 | 2014-03-26 | 百时美施贵宝公司 | 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物 |
| US8519145B2 (en) | 2006-12-02 | 2013-08-27 | Seoul National University Industry Foundation | Aryl compounds as PPAR ligands and their use |
| WO2008091863A1 (en) * | 2007-01-23 | 2008-07-31 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
| CA2678846A1 (en) * | 2007-02-23 | 2008-08-28 | Eli Lilly And Company | Peroxisome proliferator activated receptor modulators |
| CA2679694A1 (en) * | 2007-03-13 | 2008-09-18 | Merck & Co., Inc. | Inhibitors of janus kinases and/or 3-phosphoinositide-dependent protein kinase-1 |
| EP2139843B1 (en) * | 2007-04-16 | 2013-12-25 | Amgen, Inc | Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators |
| JP5291708B2 (ja) * | 2007-07-25 | 2013-09-18 | 中国人民解放軍軍事医学科学院毒物薬物研究所 | アリールピリミジン誘導体、その製造方法、及び、その使用 |
| CN102083783A (zh) | 2007-10-10 | 2011-06-01 | 安姆根有限公司 | 取代的联苯gpr40调节剂 |
| US20090163481A1 (en) * | 2007-12-13 | 2009-06-25 | Murphy Brian J | Ppar-delta ligands and methods of their use |
| WO2009111056A1 (en) * | 2008-03-06 | 2009-09-11 | Amgen Inc. | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders |
| EP2310371B1 (fr) | 2008-05-26 | 2013-05-15 | Genfit | Composés agonistes ppar, préparation et utilisations pour le traitement du diabète et/ou des dyslipidémies |
| WO2010018547A1 (en) * | 2008-08-13 | 2010-02-18 | Pfizer Inc. | Aminoquinoline compounds |
| AU2009303475B2 (en) * | 2008-10-15 | 2012-09-13 | Amgen Inc. | Spirocyclic GPR40 modulators |
| WO2012178142A1 (en) * | 2011-06-23 | 2012-12-27 | Metabolic Solutions Development Company, Llc | Ppar-sparing compounds and combinations fort the treatment of diabetes and other metabolic diseases |
| US20150203756A1 (en) * | 2012-07-06 | 2015-07-23 | Merck Patent Gmbh | Bimesogenic compounds and mesogenic media |
| MX2015014666A (es) | 2013-04-17 | 2016-03-01 | Pfizer | Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares. |
| EP3756661A1 (en) | 2013-09-09 | 2020-12-30 | vTv Therapeutics LLC | Use of a ppar-delta agonist for treating muscle atrophy |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| CN106831437B (zh) * | 2016-02-03 | 2019-06-21 | 华中师范大学 | 含硝基乙烯基的酯类化合物及其制备方法和应用 |
| SG11202000230VA (en) | 2017-07-11 | 2020-02-27 | Vertex Pharma | Carboxamides as modulators of sodium channels |
| MX2020003242A (es) | 2017-09-22 | 2020-09-18 | Jubilant Epipad LLC | Compuestos heterociclicos como inhibidores de pad. |
| AU2018352142B2 (en) | 2017-10-18 | 2022-08-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as PAD inhibitors |
| KR20200085836A (ko) | 2017-11-06 | 2020-07-15 | 주빌런트 프로델 엘엘씨 | Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체 |
| BR112020010322A2 (pt) | 2017-11-24 | 2020-11-17 | Jubilant Episcribe Llc | composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer |
| SG11202008950PA (en) | 2018-03-13 | 2020-10-29 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
| WO2020146612A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| US12441703B2 (en) | 2019-01-10 | 2025-10-14 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| SG11202107614PA (en) | 2019-01-18 | 2021-08-30 | Astrazeneca Ab | Pcsk9 inhibitors and methods of use thereof |
| CN114026060A (zh) * | 2019-06-28 | 2022-02-08 | 住友化学株式会社 | 丙烯酸酯衍生物、其用途及其制造中间体 |
| CN112824394B (zh) * | 2019-11-21 | 2024-08-13 | 中国科学院上海药物研究所 | PPARs-FXR多靶点小分子激动剂及其制备方法和用途 |
| AU2021312855A1 (en) | 2020-07-22 | 2023-03-09 | Reneo Pharmaceuticals, Inc. | Crystalline PPAR-delta agonist |
| WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3526235A1 (de) | 1984-11-16 | 1986-05-22 | Bayer Ag, 5090 Leverkusen | Fluessigkristallzusammensetzungen |
| DE4002374C2 (de) | 1990-01-27 | 1999-04-15 | Merck Patent Gmbh | Partiell fluorierte Verbindungen und deren Verwendung als Komponente flüssig kristalliner Medien |
| DE4222565A1 (de) | 1992-07-09 | 1994-01-13 | Hoechst Ag | Meta-substituierte Sechsringaromaten zur Verwendung in Flüssigkristallmischungen |
| JP3187611B2 (ja) | 1993-05-17 | 2001-07-11 | キヤノン株式会社 | 液晶性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法および表示装置 |
| BR9506309A (pt) | 1994-08-04 | 1997-08-05 | Sumitomo Chemical Co | Compostos de dihalopropeno agentes inseticidas/acaricidas contendo os mesmos e intermediários para a sua produção |
| JPH09194418A (ja) | 1996-01-18 | 1997-07-29 | Sumitomo Chem Co Ltd | ジハロプロペン化合物、その用途およびその製造中間体 |
| DE69720429T9 (de) | 1996-02-02 | 2004-09-23 | Merck & Co., Inc. | Heterocyclische verbindungen als antidiabetische mittel und für die behandlung von fettleibigkeit |
| AU1856997A (en) | 1996-02-02 | 1997-08-22 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
| US6204277B1 (en) | 1996-08-19 | 2001-03-20 | Japan Tobacco Inc. | Propionic acid derivatives and applications thereof |
| ATE451346T1 (de) | 1998-03-10 | 2009-12-15 | Ono Pharmaceutical Co | Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten |
| GB9914977D0 (en) | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| DE60005973T2 (de) | 1999-08-27 | 2004-05-13 | Eli Lilly And Co., Indianapolis | Biaryl-oxa(thia)zolderivate und ihre verwendung als ppars modulatoren |
| AU7962200A (en) * | 1999-10-29 | 2001-05-14 | Wakunaga Pharmaceutical Co., Ltd | Novel indole derivatives and drugs containing the same as the active ingredient |
| GB0031109D0 (en) | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
| GB0031107D0 (en) | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
| GB0111523D0 (en) | 2001-05-11 | 2001-07-04 | Glaxo Group Ltd | Chemical compounds |
| EA200400011A1 (ru) | 2001-06-07 | 2004-06-24 | Эли Лилли Энд Компани | Модуляторы рецепторов, активируемых пролифераторами пероксисом (prar) |
| EP1435946B8 (en) | 2001-09-14 | 2013-12-18 | Amgen Inc. | Linked biaryl compounds |
| US20030207924A1 (en) * | 2002-03-07 | 2003-11-06 | Xue-Min Cheng | Compounds that modulate PPAR activity and methods of preparation |
| US6833380B2 (en) * | 2002-03-07 | 2004-12-21 | Warner-Lambert Company, Llc | Compounds that modulate PPAR activity and methods of preparation |
| US6867224B2 (en) * | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
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