JP2005514024A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005514024A5 JP2005514024A5 JP2003557493A JP2003557493A JP2005514024A5 JP 2005514024 A5 JP2005514024 A5 JP 2005514024A5 JP 2003557493 A JP2003557493 A JP 2003557493A JP 2003557493 A JP2003557493 A JP 2003557493A JP 2005514024 A5 JP2005514024 A5 JP 2005514024A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid residue
- polypeptide
- seq
- neutral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000007935 neutral effect Effects 0.000 claims description 93
- 125000000539 amino acid group Chemical group 0.000 claims description 92
- 229920001184 polypeptide Polymers 0.000 claims description 86
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 86
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 86
- 150000003839 salts Chemical class 0.000 claims description 49
- 230000002209 hydrophobic effect Effects 0.000 claims description 44
- 239000000203 mixture Substances 0.000 claims description 36
- 210000004027 cell Anatomy 0.000 claims description 33
- 229910052698 phosphorus Inorganic materials 0.000 claims description 16
- 206010028980 Neoplasm Diseases 0.000 claims description 15
- 229910052700 potassium Inorganic materials 0.000 claims description 10
- 201000011510 cancer Diseases 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 201000011066 hemangioma Diseases 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 2
- 230000002378 acidificating effect Effects 0.000 claims 28
- 125000003275 alpha amino acid group Chemical group 0.000 claims 23
- 229910052727 yttrium Inorganic materials 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 230000033115 angiogenesis Effects 0.000 claims 8
- 239000013604 expression vector Substances 0.000 claims 8
- 230000004927 fusion Effects 0.000 claims 8
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 241000588724 Escherichia coli Species 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 150000001720 carbohydrates Chemical class 0.000 claims 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol group Chemical group [C@@H]1(CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)[C@H](C)CCCC(C)C HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 239000000539 dimer Substances 0.000 claims 4
- 210000003527 eukaryotic cell Anatomy 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 150000002632 lipids Chemical class 0.000 claims 4
- 229920001542 oligosaccharide Polymers 0.000 claims 4
- 150000002482 oligosaccharides Chemical class 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 210000001236 prokaryotic cell Anatomy 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 230000002939 deleterious effect Effects 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 206010003210 Arteriosclerosis Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 201000009273 Endometriosis Diseases 0.000 claims 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 229940063683 taxotere Drugs 0.000 claims 2
- 230000004614 tumor growth Effects 0.000 claims 2
- 230000008728 vascular permeability Effects 0.000 claims 2
- 210000003566 hemangioblast Anatomy 0.000 claims 1
- 201000002222 hemangioblastoma Diseases 0.000 claims 1
- 208000018142 Leiomyosarcoma Diseases 0.000 description 3
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 3
- 208000003200 Adenoma Diseases 0.000 description 2
- 206010001233 Adenoma benign Diseases 0.000 description 2
- 201000003076 Angiosarcoma Diseases 0.000 description 2
- 206010061692 Benign muscle neoplasm Diseases 0.000 description 2
- 208000001258 Hemangiosarcoma Diseases 0.000 description 2
- 201000004458 Myoma Diseases 0.000 description 2
- 206010061332 Paraganglion neoplasm Diseases 0.000 description 2
- 206010039491 Sarcoma Diseases 0.000 description 2
- 206010041067 Small cell lung cancer Diseases 0.000 description 2
- 208000009956 adenocarcinoma Diseases 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 206010024627 liposarcoma Diseases 0.000 description 2
- 208000012804 lymphangiosarcoma Diseases 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 208000003154 papilloma Diseases 0.000 description 2
- 208000007312 paraganglioma Diseases 0.000 description 2
- 208000003609 Bile Duct Adenoma Diseases 0.000 description 1
- 206010007270 Carcinoid syndrome Diseases 0.000 description 1
- 201000000274 Carcinosarcoma Diseases 0.000 description 1
- 206010008263 Cervical dysplasia Diseases 0.000 description 1
- 206010008642 Cholesteatoma Diseases 0.000 description 1
- 201000009047 Chordoma Diseases 0.000 description 1
- 208000009798 Craniopharyngioma Diseases 0.000 description 1
- 201000005171 Cystadenoma Diseases 0.000 description 1
- 206010014967 Ependymoma Diseases 0.000 description 1
- 201000008808 Fibrosarcoma Diseases 0.000 description 1
- 208000021309 Germ cell tumor Diseases 0.000 description 1
- 208000007569 Giant Cell Tumors Diseases 0.000 description 1
- 208000032612 Glial tumor Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 241000235503 Glomus Species 0.000 description 1
- 208000005234 Granulosa Cell Tumor Diseases 0.000 description 1
- 208000002927 Hamartoma Diseases 0.000 description 1
- 208000002125 Hemangioendothelioma Diseases 0.000 description 1
- 208000002291 Histiocytic Sarcoma Diseases 0.000 description 1
- 208000017604 Hodgkin disease Diseases 0.000 description 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
- 206010024612 Lipoma Diseases 0.000 description 1
- 206010025219 Lymphangioma Diseases 0.000 description 1
- 208000004138 Lymphangiomyoma Diseases 0.000 description 1
- 208000008095 Malignant Carcinoid Syndrome Diseases 0.000 description 1
- 208000000172 Medulloblastoma Diseases 0.000 description 1
- 208000002030 Merkel cell carcinoma Diseases 0.000 description 1
- 206010027406 Mesothelioma Diseases 0.000 description 1
- 208000007727 Muscle Tissue Neoplasms Diseases 0.000 description 1
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 description 1
- 201000004404 Neurofibroma Diseases 0.000 description 1
- 208000009905 Neurofibromatoses Diseases 0.000 description 1
- 208000005890 Neuroma Diseases 0.000 description 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 208000007641 Pinealoma Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 208000034541 Rare lymphatic malformation Diseases 0.000 description 1
- 206010038802 Reticuloendothelial system stimulated Diseases 0.000 description 1
- 208000003274 Sertoli cell tumor Diseases 0.000 description 1
- 206010043276 Teratoma Diseases 0.000 description 1
- 208000010029 ameloblastoma Diseases 0.000 description 1
- 208000021592 benign granular cell tumor Diseases 0.000 description 1
- 201000008274 breast adenocarcinoma Diseases 0.000 description 1
- 208000003362 bronchogenic carcinoma Diseases 0.000 description 1
- 208000005761 carcinoid heart disease Diseases 0.000 description 1
- 201000005217 chondroblastoma Diseases 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 description 1
- 208000002445 cystadenocarcinoma Diseases 0.000 description 1
- 201000008825 fibrosarcoma of bone Diseases 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 201000010260 leiomyoma Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000000966 lung oat cell carcinoma Diseases 0.000 description 1
- 201000006812 malignant histiocytosis Diseases 0.000 description 1
- 206010027191 meningioma Diseases 0.000 description 1
- 201000010879 mucinous adenocarcinoma Diseases 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 201000004130 myoblastoma Diseases 0.000 description 1
- 208000009091 myxoma Diseases 0.000 description 1
- 208000001611 myxosarcoma Diseases 0.000 description 1
- 208000007538 neurilemmoma Diseases 0.000 description 1
- 210000003757 neuroblast Anatomy 0.000 description 1
- 208000029986 neuroepithelioma Diseases 0.000 description 1
- 201000004931 neurofibromatosis Diseases 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 208000004128 odontoma Diseases 0.000 description 1
- 208000008798 osteoma Diseases 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 201000010198 papillary carcinoma Diseases 0.000 description 1
- 210000004786 perivascular cell Anatomy 0.000 description 1
- 208000024724 pineal body neoplasm Diseases 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 201000005825 prostate adenocarcinoma Diseases 0.000 description 1
- 206010039667 schwannoma Diseases 0.000 description 1
- 208000000649 small cell carcinoma Diseases 0.000 description 1
- 208000000587 small cell lung carcinoma Diseases 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 208000008732 thymoma Diseases 0.000 description 1
- 206010044412 transitional cell carcinoma Diseases 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
Images
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32862401P | 2001-10-11 | 2001-10-11 | |
| US41415502P | 2002-09-27 | 2002-09-27 | |
| US10/269,695 US7138370B2 (en) | 2001-10-11 | 2002-10-10 | Specific binding agents of human angiopoietin-2 |
| PCT/US2002/032657 WO2003057134A2 (en) | 2001-10-11 | 2002-10-11 | Specific binding agents of human angiopoietin-2 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009016351A Division JP2009273457A (ja) | 2001-10-11 | 2009-01-28 | ヒトアンギオポエチン−２の特異的結合物質 |
| JP2010052612A Division JP5432777B2 (ja) | 2001-10-11 | 2010-03-10 | ヒトアンギオポエチン−２の特異的結合物質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005514024A JP2005514024A (ja) | 2005-05-19 |
| JP2005514024A5 true JP2005514024A5 (enExample) | 2006-01-12 |
| JP4573238B2 JP4573238B2 (ja) | 2010-11-04 |
Family
ID=27402210
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003557493A Expired - Lifetime JP4573238B2 (ja) | 2001-10-11 | 2002-10-11 | ヒトアンギオポエチン−２の特異的結合物質 |
| JP2009016351A Pending JP2009273457A (ja) | 2001-10-11 | 2009-01-28 | ヒトアンギオポエチン−２の特異的結合物質 |
| JP2010052612A Expired - Lifetime JP5432777B2 (ja) | 2001-10-11 | 2010-03-10 | ヒトアンギオポエチン−２の特異的結合物質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009016351A Pending JP2009273457A (ja) | 2001-10-11 | 2009-01-28 | ヒトアンギオポエチン−２の特異的結合物質 |
| JP2010052612A Expired - Lifetime JP5432777B2 (ja) | 2001-10-11 | 2010-03-10 | ヒトアンギオポエチン−２の特異的結合物質 |
Country Status (25)
| Country | Link |
|---|---|
| US (7) | US7138370B2 (enExample) |
| EP (5) | EP1434791B1 (enExample) |
| JP (3) | JP4573238B2 (enExample) |
| KR (2) | KR20100038238A (enExample) |
| CN (3) | CN101787072B (enExample) |
| AT (1) | ATE444967T1 (enExample) |
| AU (2) | AU2002365179B2 (enExample) |
| BR (1) | BRPI0213223B8 (enExample) |
| CA (2) | CA2767061C (enExample) |
| CY (1) | CY1110571T1 (enExample) |
| DE (1) | DE60233955D1 (enExample) |
| DK (1) | DK1434791T3 (enExample) |
| EA (1) | EA008248B1 (enExample) |
| ES (3) | ES2402918T3 (enExample) |
| HU (1) | HUP0402162A3 (enExample) |
| IL (2) | IL161016A0 (enExample) |
| ME (2) | ME00185B (enExample) |
| MX (1) | MXPA04003342A (enExample) |
| NO (1) | NO336004B1 (enExample) |
| NZ (4) | NZ554021A (enExample) |
| PL (1) | PL224701B1 (enExample) |
| PT (1) | PT1434791E (enExample) |
| RS (1) | RS51898B (enExample) |
| SI (1) | SI1434791T1 (enExample) |
| WO (1) | WO2003057134A2 (enExample) |
Families Citing this family (210)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| WO2000024770A2 (en) | 1998-10-23 | 2000-05-04 | Amgen Inc. | Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity |
| US7205275B2 (en) * | 2001-10-11 | 2007-04-17 | Amgen Inc. | Methods of treatment using specific binding agents of human angiopoietin-2 |
| US7138370B2 (en) * | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
| US7432331B2 (en) | 2002-12-31 | 2008-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
| KR101025143B1 (ko) | 2002-12-31 | 2011-04-01 | 넥타르 테라퓨틱스 | 가수분해상으로 안정한 말레이미드－종결 중합체 |
| TW201319088A (zh) | 2003-07-18 | 2013-05-16 | Amgen Inc | 對肝細胞生長因子具專一性之結合劑 |
| US7605120B2 (en) * | 2003-10-22 | 2009-10-20 | Amgen Inc. | Antagonists of the brandykinin B1 receptor |
| US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
| JP4762904B2 (ja) | 2003-11-13 | 2011-08-31 | ハンミ ホールディングス カンパニー リミテッド | 免疫グロブリン不変領域の量産方法 |
| US20060080092A1 (en) * | 2004-07-28 | 2006-04-13 | Sherman Edward S | Telecommunication device and method |
| AU2005289685B2 (en) | 2004-09-24 | 2009-07-16 | Amgen Inc. | Modified Fc molecules |
| WO2006138181A2 (en) | 2005-06-14 | 2006-12-28 | Amgen Inc. | Self-buffering protein formulations |
| WO2008020827A2 (en) * | 2005-08-01 | 2008-02-21 | Biogen Idec Ma Inc. | Altered polypeptides, immunoconjugates thereof, and methods related thereto |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| PL2481756T3 (pl) | 2005-10-31 | 2018-02-28 | Oncomed Pharmaceuticals, Inc. | Kompozycje i sposoby diagnozowania i leczenia nowotworu |
| EP3168234A1 (en) * | 2005-12-15 | 2017-05-17 | Medimmune Limited | Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or fltl antagonist for treating cancer |
| AR059066A1 (es) | 2006-01-27 | 2008-03-12 | Amgen Inc | Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf) |
| TW200738752A (en) * | 2006-01-31 | 2007-10-16 | Bayer Schering Pharma Ag | Modulation of MDL-1 activity for treatment of inflammatory disease |
| US7873029B2 (en) | 2006-03-06 | 2011-01-18 | At&T Intellectual Property I, L.P. | System and method of providing multimedia communication services |
| JO3324B1 (ar) | 2006-04-21 | 2019-03-13 | Amgen Inc | مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية |
| US7981425B2 (en) | 2006-06-19 | 2011-07-19 | Amgen Inc. | Thrombopoietic compounds |
| WO2008051383A2 (en) * | 2006-10-19 | 2008-05-02 | Amgen Inc. | Use of alcohol co-solvents to improve pegylation reaction yields |
| US8288349B2 (en) * | 2006-11-10 | 2012-10-16 | Covx Technology Ireland, Ltd. | Anti-angiogenic compounds |
| EP2738257A1 (en) | 2007-05-22 | 2014-06-04 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
| CN101802008B (zh) | 2007-08-21 | 2015-04-01 | 安美基公司 | 人类c-fms抗原结合蛋白 |
| US20110097318A1 (en) * | 2007-08-31 | 2011-04-28 | Amgen Inc. | Solid-State Protein Formulation |
| EP2205280B1 (en) * | 2007-09-27 | 2019-09-04 | Amgen Inc. | Pharmaceutical formulations |
| EP2219602A1 (en) | 2007-11-15 | 2010-08-25 | Amgen, Inc | Aqueous formulation of erythropoiesis stimulating protein stablised by antioxidants for parenteral administration |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US8557242B2 (en) * | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
| US8454960B2 (en) * | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
| NZ586701A (en) * | 2008-01-03 | 2013-07-26 | Scripps Research Inst | Antibody targeting through a modular recognition domain (MRD) wherein the MRD targets angiopoietin-2 (ANG-2) |
| US8557243B2 (en) * | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
| US8574577B2 (en) * | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| CA2729012A1 (en) | 2008-06-27 | 2009-12-30 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| NZ592338A (en) | 2008-09-26 | 2012-11-30 | Oncomed Pharm Inc | Frizzled-binding agents and uses thereof |
| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| US8133979B2 (en) | 2008-12-16 | 2012-03-13 | Hoffmann-La Roche Inc. | Antibodies against human angiopoietin 2 |
| CA2755133A1 (en) | 2009-03-20 | 2010-09-23 | Amgen Inc. | Selective and potent peptide inhibitors of kv1.3 |
| CN102369215B (zh) | 2009-04-02 | 2015-01-21 | 罗切格利卡特公司 | 包含全长抗体和单链Fab片段的多特异性抗体 |
| DK2417156T3 (en) | 2009-04-07 | 2015-03-02 | Roche Glycart Ag | Trivalent, bispecific antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| EA020621B1 (ru) | 2009-06-22 | 2014-12-30 | Амген Инк. | Рефолдинг белков с использованием химически контролируемого окислительно-восстановительного состояния |
| TWI513465B (zh) | 2009-06-25 | 2015-12-21 | Regeneron Pharma | 以ｄｌｌ４拮抗劑與化學治療劑治療癌症之方法 |
| JP2012531428A (ja) * | 2009-06-25 | 2012-12-10 | アムジエン・インコーポレーテツド | 哺乳類以外の系で発現されるタンパク質の捕獲精製プロセス |
| JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| US8980268B2 (en) | 2009-07-29 | 2015-03-17 | Regeneron Pharamceuticals, Inc. | Methods for treating cancer by administering an anti-Ang-2 antibody |
| US20120189635A1 (en) | 2009-07-29 | 2012-07-26 | Regeneron Pharmaceuticals, Inc. | Methods for Treating or Preventing Malaria by Administering an Antibody that Specifically Binds Angiopoietin-2 (Ang-2) |
| JP6091894B2 (ja) | 2009-09-16 | 2017-03-15 | ジェネンテック， インコーポレイテッド | コイルドコイルおよび／またはテザー含有タンパク質複合体およびその使用 |
| US20120183546A1 (en) * | 2009-09-23 | 2012-07-19 | Amgen Inc. | Treatment of ovarian cancer using a specific binding agent of human angiopoietin-2 in combination with a taxane |
| CA2778105C (en) | 2009-10-23 | 2019-04-02 | Amgen Inc. | Vial adapter and system |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| JO3183B1 (ar) | 2010-01-29 | 2018-03-08 | Regeneron Pharma | طرق لمعالجة أمراض المناعة الذاتية مضادات dll4 |
| AR080794A1 (es) | 2010-03-26 | 2012-05-09 | Hoffmann La Roche | Anticuerpos bivalentes biespecificos anti- vegf/ anti-ang-2 |
| TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
| AU2011235904B2 (en) | 2010-04-01 | 2015-10-08 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| KR101860963B1 (ko) | 2010-04-23 | 2018-05-24 | 제넨테크, 인크. | 이종다량체 단백질의 생산 |
| CA2800919C (en) | 2010-06-07 | 2019-01-15 | Amgen Inc. | Drug delivery device |
| US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
| RU2013110844A (ru) | 2010-08-13 | 2014-09-20 | Дженентек, Инк. | АНТИТЕЛА ПРОТИВ IL-1β И IL-18, ИСПОЛЬЗУЕМЫЕ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ |
| WO2012025530A1 (en) | 2010-08-24 | 2012-03-01 | F. Hoffmann-La Roche Ag | Bispecific antibodies comprising a disulfide stabilized - fv fragment |
| EP2725034B1 (en) | 2010-09-22 | 2019-04-03 | Amgen Inc. | Carrier immunoglobulins with no specificity for human tissues and uses thereof |
| EP2655413B1 (en) | 2010-12-23 | 2019-01-16 | F.Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| US10689447B2 (en) | 2011-02-04 | 2020-06-23 | Genentech, Inc. | Fc variants and methods for their production |
| CN103649117B (zh) | 2011-02-04 | 2016-09-14 | 霍夫曼-拉罗奇有限公司 | Fc变体及其生成方法 |
| CA2827170A1 (en) | 2011-02-11 | 2012-08-16 | David M. Hilbert | Monovalent and multivalent multispecific complexes and uses thereof |
| BR112013019975A2 (pt) | 2011-02-28 | 2017-08-01 | Hoffmann La Roche | proteínas de ligação de antígeno, composição farmacêutica, uso de uma proteína de ligação de antígeno, método para o tratamento de um paciente e método para a preparação de uma proteína de ligação de antígeno, ácido nucleico, vetor e célula hospedeira" |
| CN103403025B (zh) | 2011-02-28 | 2016-10-12 | 弗·哈夫曼-拉罗切有限公司 | 单价抗原结合蛋白 |
| WO2012135315A1 (en) | 2011-03-31 | 2012-10-04 | Amgen Inc. | Vial adapter and system |
| AU2012245231B2 (en) | 2011-04-20 | 2016-10-13 | Amgen Inc. | Autoinjector apparatus |
| DK2714738T3 (en) | 2011-05-24 | 2019-01-28 | Zyngenia Inc | MULTIVALENT AND MONOVALENT MULTISPECIFIC COMPLEXES AND THEIR APPLICATIONS |
| US9938353B2 (en) | 2011-06-24 | 2018-04-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| JP6069312B2 (ja) | 2011-06-29 | 2017-02-01 | アムジェン インコーポレイテッド | 腎細胞癌の治療における生存の予測バイオマーカー |
| WO2013025479A1 (en) | 2011-08-16 | 2013-02-21 | Emory University | Jaml specific binding agents, antibodies, and uses related thereto |
| JP6216321B2 (ja) | 2011-10-11 | 2017-10-18 | ジェネンテック， インコーポレイテッド | 二重特異性抗体の構築の改善 |
| EA030868B1 (ru) | 2011-10-14 | 2018-10-31 | Эмджен Инк. | Инжектор и способ его сборки |
| KR102091294B1 (ko) | 2011-10-26 | 2020-04-16 | 암젠 인크 | Uv 광으로의 노출로 인한 단백질 변형 및 분해의 감소 또는 제거 방법 |
| KR20140137347A (ko) | 2012-01-10 | 2014-12-02 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 |
| NZ627859A (en) * | 2012-01-23 | 2015-09-25 | Regeneron Pharma | Stabilized formulations containing anti-ang2 antibodies |
| JP6486686B2 (ja) | 2012-02-10 | 2019-03-20 | ジェネンテック， インコーポレイテッド | 単鎖抗体及び他のヘテロ多量体 |
| AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
| CN104395339A (zh) | 2012-06-27 | 2015-03-04 | 弗·哈夫曼-拉罗切有限公司 | 用于选择并产生含有至少两种不同结合实体的定制高度选择性和多特异性靶向实体的方法及其用途 |
| MX2014014804A (es) | 2012-06-27 | 2015-02-12 | Hoffmann La Roche | Metodo para la elaboracion de conjugados de la region fc de anticuerpos que comprenden por lo menos una entidad de union que se une especificamente a un objetivo y usos del mismo. |
| MX361337B (es) | 2012-07-13 | 2018-12-04 | Roche Glycart Ag | Anticuerpos biespecificos anti-factor de crecimiento endotelial vascular humano (vegf) / anti-angiopoyetina-2 humana (ang-2) y su uso en el tratamiento de enfermedades vasculares oculares. |
| BR112015004734A2 (pt) * | 2012-09-07 | 2017-11-21 | Sanofi Sa | proteínas de fusão para tratar uma síndrome metabólica |
| KR101967345B1 (ko) | 2012-10-18 | 2019-04-09 | 삼성전자주식회사 | 안지오포이에틴-2와 인테그린 간의 결합을 저해하는 펩타이드 및 그 용도 |
| US9266959B2 (en) | 2012-10-23 | 2016-02-23 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using frizzled-binding agents |
| AR093445A1 (es) | 2012-11-14 | 2015-06-10 | Regeneron Pharma | Metodos para tratar el cancer de ovario con antagonistas de dll4 |
| EP3072548B1 (en) | 2012-11-21 | 2019-03-06 | Amgen, Inc | Drug delivery device |
| WO2014108854A1 (en) | 2013-01-09 | 2014-07-17 | Fusimab Ltd. | Monospecific anti-hgf and anti-ang2 antibodies and bispecific anti-hgf/anti-ang2 antibodies |
| US9359444B2 (en) | 2013-02-04 | 2016-06-07 | Oncomed Pharmaceuticals Inc. | Methods and monitoring of treatment with a Wnt pathway inhibitor |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| CN105142695B (zh) | 2013-03-15 | 2020-06-02 | 安进公司 | 身体轮廓可调适的自动注射器装置 |
| CA2907181C (en) | 2013-03-15 | 2023-10-17 | Viktor Roschke | Multivalent and monovalent multispecific complexes and their uses |
| ES2973257T3 (es) | 2013-03-15 | 2024-06-19 | Amgen Inc | Casete de fármaco, autoinyector y sistema de autoinyector |
| EP3593839A1 (en) | 2013-03-15 | 2020-01-15 | Amgen Inc. | Drug cassette |
| CA2897825C (en) | 2013-03-22 | 2022-05-24 | Scott R. Gibson | Injector and method of assembly |
| KR102131371B1 (ko) | 2013-07-02 | 2020-07-08 | 삼성전자주식회사 | Ang-2 특이적 항체 및 그의 용도 |
| US9902767B2 (en) | 2013-07-29 | 2018-02-27 | Samsung Electronics Co., Ltd. | Method of blocking vascular leakage using an anti-ANG2 antibody |
| KR102196450B1 (ko) | 2013-09-17 | 2020-12-30 | 삼성전자주식회사 | Tie2와 결합을 유도하는 항 Ang2 항체를 포함하는 항암제 |
| JP6422956B2 (ja) | 2013-10-11 | 2018-11-14 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 多重特異性ドメイン交換共通可変軽鎖抗体 |
| AU2014340174B2 (en) | 2013-10-24 | 2019-09-12 | Amgen Inc. | Drug delivery system with temperature-sensitive control |
| US11097055B2 (en) | 2013-10-24 | 2021-08-24 | Amgen Inc. | Injector and method of assembly |
| WO2015090234A1 (en) * | 2013-12-19 | 2015-06-25 | Beijing Anxinhuaide Biotech. Co., Ltd | Improving pharmacokinetic profile for angiopoietin-2 inhibiting polypeptide or thymalfasin |
| KR102206029B1 (ko) | 2014-01-27 | 2021-01-20 | 삼성전자주식회사 | Ang-2에 특이적으로 결합하는 항체 및 그의 용도 |
| US10994112B2 (en) | 2014-02-05 | 2021-05-04 | Amgen Inc. | Drug delivery system with electromagnetic field generator |
| KR20230164192A (ko) | 2014-05-06 | 2023-12-01 | 제넨테크, 인크. | 포유동물 세포를 사용한 이종다량체 단백질의 생산 |
| CA3193070A1 (en) | 2014-05-07 | 2015-11-12 | Amgen Inc. | Autoinjector with shock reducing elements |
| AR100270A1 (es) * | 2014-05-19 | 2016-09-21 | Lilly Co Eli | Anticuerpos ang2 |
| JP6817074B2 (ja) | 2014-06-03 | 2021-01-20 | アムジエン・インコーポレーテツド | 制御可能な薬物送達システム及び使用方法 |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| JP6766040B2 (ja) | 2014-10-14 | 2020-10-07 | アムジエン・インコーポレーテツド | 視覚および可聴インジケータを備える薬剤注射装置 |
| PL3227332T3 (pl) | 2014-12-03 | 2020-06-15 | F. Hoffmann-La Roche Ag | Wielospecyficzne przeciwciała |
| JP2017538512A (ja) | 2014-12-19 | 2017-12-28 | アムジエン・インコーポレーテツド | ライブボタンまたはユーザインタフェースフィールドを含む薬物送達装置 |
| EP3848072A1 (en) | 2014-12-19 | 2021-07-14 | Amgen Inc. | Drug delivery device with proximity sensor |
| WO2016133947A1 (en) | 2015-02-17 | 2016-08-25 | Amgen Inc. | Drug delivery device with vacuum assisted securement and/or feedback |
| ES2905870T3 (es) | 2015-02-27 | 2022-04-12 | Amgen Inc | Dispositivo de suministro de fármacos que tiene un mecanismo de protección de aguja con un umbral de resistencia ajustable al movimiento de la protección de aguja |
| US10857229B2 (en) | 2015-04-30 | 2020-12-08 | Amgen Inc. | Treatment of ovarian cancer in patients with ascites using a specific binding agent of human angiopoietin-2 in combination with a taxane |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US20190004048A1 (en) | 2015-06-26 | 2019-01-03 | Amgen Inc. | Biomarker of Survival in the Treatment of Renal Cell Carcinoma with a VEGFR Inhibitor and an Ang2 Inhibitor |
| WO2017027861A1 (en) | 2015-08-13 | 2017-02-16 | Amgen Inc. | Charged depth filtration of antigen-binding proteins |
| WO2017039786A1 (en) | 2015-09-02 | 2017-03-09 | Amgen Inc. | Syringe assembly adapter for a syringe |
| EP3386573B1 (en) | 2015-12-09 | 2019-10-02 | Amgen Inc. | Auto-injector with signaling cap |
| US11154661B2 (en) | 2016-01-06 | 2021-10-26 | Amgen Inc. | Auto-injector with signaling electronics |
| EP3423078A4 (en) * | 2016-03-03 | 2019-11-06 | Cue Biopharma, Inc. | T CELL MODULATING MULTIPLE POLYPEPTIDES AND METHOD OF USE THEREOF |
| US11200298B2 (en) | 2016-03-15 | 2021-12-14 | Amgen Inc. | Reducing probability of glass breakage in drug delivery devices |
| CA3017424A1 (en) * | 2016-03-15 | 2017-09-21 | Idp Discovery Pharma, S.L. | Peptides with anti-cancer activity |
| WO2017189089A1 (en) | 2016-04-29 | 2017-11-02 | Amgen Inc. | Drug delivery device with messaging label |
| US11389588B2 (en) | 2016-05-02 | 2022-07-19 | Amgen Inc. | Syringe adapter and guide for filling an on-body injector |
| EP3455142B1 (en) | 2016-05-13 | 2023-08-09 | Amgen Inc. | Vial sleeve assembly |
| US10654922B2 (en) * | 2016-05-13 | 2020-05-19 | Askgene Pharma Inc. | Angiopoietin 2, VEGF dual antagonists |
| US11059885B2 (en) * | 2016-05-13 | 2021-07-13 | Askgene Pharma Inc. | Angiopoietin 2, VEGF dual antagonists |
| US11238150B2 (en) | 2016-05-16 | 2022-02-01 | Amgen Inc. | Data encryption in medical devices with limited computational capability |
| WO2017209899A1 (en) | 2016-06-03 | 2017-12-07 | Amgen Inc. | Impact testing apparatuses and methods for drug delivery devices |
| WO2018004842A1 (en) | 2016-07-01 | 2018-01-04 | Amgen Inc. | Drug delivery device having minimized risk of component fracture upon impact events |
| US20190328965A1 (en) | 2016-08-17 | 2019-10-31 | Amgen Inc. | Drug delivery device with placement detection |
| WO2018081234A1 (en) | 2016-10-25 | 2018-05-03 | Amgen Inc. | On-body injector |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| JP7250677B2 (ja) | 2016-12-22 | 2023-04-03 | キュー バイオファーマ， インコーポレイテッド | Ｔ細胞調節多量体ポリペプチド及びその使用方法 |
| WO2018128939A1 (en) | 2017-01-05 | 2018-07-12 | Gensun Biopharma Inc. | Checkpoint regulator antagonists |
| MX2019008432A (es) | 2017-01-17 | 2019-11-18 | Amgen Inc | Dispositivos de inyeccion y metodos relacionados de uso y ensamblaje. |
| EP3582825A1 (en) | 2017-02-17 | 2019-12-25 | Amgen Inc. | Drug delivery device with sterile fluid flowpath and related method of assembly |
| CA3052204A1 (en) | 2017-02-17 | 2018-08-23 | Amgen Inc. | Insertion mechanism for drug delivery device |
| JP2020508803A (ja) | 2017-03-06 | 2020-03-26 | アムジエン・インコーポレーテツド | 作動防止特徴部を備える薬物送達デバイス |
| AU2018230546B2 (en) | 2017-03-07 | 2024-03-21 | Amgen Inc. | Needle insertion by overpressure |
| CA3052310A1 (en) | 2017-03-09 | 2018-09-13 | Amgen Inc. | Insertion mechanism for drug delivery device |
| KR20240042212A (ko) | 2017-03-28 | 2024-04-01 | 암겐 인코포레이티드 | 플런저 로드 및 주사기 조립 시스템 및 방법 |
| AU2018282077B2 (en) | 2017-06-08 | 2023-11-23 | Amgen Inc. | Torque driven drug delivery device |
| WO2018226515A1 (en) | 2017-06-08 | 2018-12-13 | Amgen Inc. | Syringe assembly for a drug delivery device and method of assembly |
| JP7195276B2 (ja) | 2017-06-22 | 2022-12-23 | アムジエン・インコーポレーテツド | デバイス起動による衝突／衝撃の低減 |
| EP3641861A1 (en) | 2017-06-23 | 2020-04-29 | Amgen Inc. | Electronic drug delivery device comprising a cap activated by a switch assembly |
| WO2019014014A1 (en) | 2017-07-14 | 2019-01-17 | Amgen Inc. | NEEDLE INSERTION-RETRACTING SYSTEM HAVING DOUBLE TORSION SPRING SYSTEM |
| IL271173B2 (en) | 2017-07-21 | 2024-04-01 | Amgen Inc | Gas permeable sealing member for drug container and methods of assembly |
| EP4085942A1 (en) | 2017-07-25 | 2022-11-09 | Amgen Inc. | Drug delivery device with gear module and related method of assembly |
| MA49676A (fr) | 2017-07-25 | 2020-06-03 | Amgen Inc | Dispositif d'administration de médicament doté d'un système d'accès à un récipient et procédé d'assemblage associé |
| WO2019032482A2 (en) | 2017-08-09 | 2019-02-14 | Amgen Inc. | HYDRAULIC-PNEUMATIC PRESSURE CHAMBER DELIVERY SYSTEM |
| WO2019036181A1 (en) | 2017-08-18 | 2019-02-21 | Amgen Inc. | BODY INJECTOR WITH STERILE ADHESIVE PATCH |
| US11103636B2 (en) | 2017-08-22 | 2021-08-31 | Amgen Inc. | Needle insertion mechanism for drug delivery device |
| EP3691717B1 (en) | 2017-10-04 | 2023-02-08 | Amgen Inc. | Flow adapter for drug delivery device |
| EP3691716B1 (en) | 2017-10-06 | 2023-11-29 | Amgen Inc. | Drug delivery device with interlock assembly and related method of assembly |
| EP3694578B1 (en) | 2017-10-09 | 2025-09-24 | Amgen Inc. | Drug delivery device with drive assembly and related method of assembly |
| EP3703779A1 (en) | 2017-11-03 | 2020-09-09 | Amgen Inc. | Systems and approaches for sterilizing a drug delivery device |
| US20200261648A1 (en) | 2017-11-06 | 2020-08-20 | Amgen Inc. | Drug delivery device with placement and flow sensing |
| MA50569A (fr) | 2017-11-06 | 2020-09-16 | Amgen Inc | Ensembles de remplissage-finition et procédés associés |
| EP3706826A1 (en) | 2017-11-10 | 2020-09-16 | Amgen Inc. | Plungers for drug delivery devices |
| SG11202003004RA (en) | 2017-11-16 | 2020-04-29 | Amgen Inc | Door latch mechanism for drug delivery device |
| MA50903A (fr) | 2017-11-16 | 2021-05-12 | Amgen Inc | Auto-injecteur avec détection de décrochage et de point d'extrémité |
| US10835685B2 (en) | 2018-05-30 | 2020-11-17 | Amgen Inc. | Thermal spring release mechanism for a drug delivery device |
| US11083840B2 (en) | 2018-06-01 | 2021-08-10 | Amgen Inc. | Modular fluid path assemblies for drug delivery devices |
| US11001635B2 (en) | 2018-06-29 | 2021-05-11 | Gensun Biopharma Inc. | Antitumor antagonists |
| CA3103681A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Delivery devices for administering drugs |
| US12303677B2 (en) | 2018-07-24 | 2025-05-20 | Amgen Inc. | Hybrid drug delivery devices with optional grip portion and related method of preparation |
| WO2020023451A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Delivery devices for administering drugs |
| WO2020023336A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Hybrid drug delivery devices with grip portion |
| CA3103105A1 (en) | 2018-07-31 | 2020-02-06 | Amgen Inc. | Fluid path assembly for a drug delivery device |
| WO2020068623A1 (en) | 2018-09-24 | 2020-04-02 | Amgen Inc. | Interventional dosing systems and methods |
| IL281469B2 (en) | 2018-09-28 | 2024-08-01 | Amgen Inc | Muscle wire escapement activation assembly for a drug delivery device |
| JP2022503983A (ja) | 2018-10-02 | 2022-01-12 | アムジエン・インコーポレーテツド | 内力伝達を伴う薬物送達用の注入システム |
| EP3860686A1 (en) | 2018-10-05 | 2021-08-11 | Amgen Inc. | Drug delivery device having dose indicator |
| KR102848295B1 (ko) | 2018-10-15 | 2025-08-20 | 암젠 인크 | 댐핑 메커니즘을 갖는 약물 전달 장치 |
| EA202191038A1 (ru) | 2018-10-15 | 2021-07-06 | Эмджен Инк. | Способ платформенной сборки для устройства доставки лекарственного средства |
| SG11202103232WA (en) | 2018-10-23 | 2021-05-28 | Amgen Inc | Automatic calibration and automatic maintenance of raman spectroscopic models for real-time predictions |
| EP3873566B1 (en) | 2018-11-01 | 2024-11-27 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
| TWI831847B (zh) | 2018-11-01 | 2024-02-11 | 美商安進公司 | 部分針頭縮回之藥物遞送裝置及其操作方法 |
| MA54057A (fr) | 2018-11-01 | 2022-02-09 | Amgen Inc | Dispositifs d'administration de médicament à rétraction partielle d'élément d'administration de médicament |
| MX2021012557A (es) | 2019-04-24 | 2021-11-12 | Amgen Inc | Conjuntos y metodos de verificacion de esterilizacion de jeringuillas. |
| KR102400401B1 (ko) * | 2019-05-22 | 2022-05-24 | (주)셀인바이오 | 항염증 펩타이드 및 항염증 조성물 |
| EP3990116A1 (en) | 2019-06-28 | 2022-05-04 | Gensun Biopharma Inc. | ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD |
| EP4017560A2 (en) | 2019-08-23 | 2022-06-29 | Amgen, Inc | Drug delivery device with configurable needle shield engagement components and related methods |
| KR102195957B1 (ko) * | 2019-11-19 | 2020-12-28 | 삼성전자주식회사 | Tie2와 결합을 유도하는 항 Ang2 항체 |
| KR102312922B1 (ko) * | 2019-11-19 | 2021-10-13 | 삼성전자주식회사 | Tie2와 결합을 유도하는 항 Ang2 항체 |
| WO2021158469A1 (en) | 2020-02-03 | 2021-08-12 | Amgen Inc. | Multivariate bracketing approach for sterile filter validation |
| CN115996946A (zh) * | 2020-04-30 | 2023-04-21 | 免疫靶向有限公司 | 可活化il2组合物和使用方法 |
| CA3169949A1 (en) | 2020-05-12 | 2021-11-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| CN112126671B (zh) * | 2020-08-18 | 2021-08-31 | 中山大学附属第五医院 | 无乳链球菌Streptococus agalactiae治疗子宫内膜异位症的应用 |
| CA3192239A1 (en) * | 2020-08-19 | 2022-02-24 | Pharmabcine Inc. | Modified antibody and method for manufacturing same |
| CN116981470A (zh) * | 2021-03-19 | 2023-10-31 | Cue生物制药股份有限公司 | T细胞调节多肽和其使用方法 |
| CN120904344A (zh) * | 2021-03-31 | 2025-11-07 | 杭州嘉因生物科技有限公司 | 靶向vegf和血管生成素的融合分子及其用途 |
| BR112023024278A2 (pt) | 2021-05-21 | 2024-01-30 | Amgen Inc | Método de otimizar uma receita de enchimento para um recipiente de fármacos |
| WO2022256820A1 (en) | 2021-06-03 | 2022-12-08 | Gensun Biopharma Inc. | Multispecific antagonists |
| CA3236194A1 (en) | 2021-10-27 | 2023-05-04 | Amgen Inc. | Deep learning-based prediction for monitoring of pharmaceuticals using spectroscopy |
| WO2023173084A1 (en) | 2022-03-11 | 2023-09-14 | University Of Rochester | Cyclopeptibodies and uses thereof |
| WO2024085632A1 (ko) * | 2022-10-18 | 2024-04-25 | 고려대학교 산학협력단 | 인간 항체 fc 도메인 변이체 및 그 용도 |
| WO2025037108A2 (en) | 2023-08-15 | 2025-02-20 | Board Of Trustees Of The Leland Stanford Junior University | Modified thrombopoietin |
| WO2025237264A1 (en) * | 2024-05-14 | 2025-11-20 | Shanghai Affamed Therapeutics Limited | A method for treating retinal and choroidal vascular diseases with a chimeric molecule |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3691016A (en) | 1970-04-17 | 1972-09-12 | Monsanto Co | Process for the preparation of insoluble enzymes |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| CA1023287A (en) | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4195128A (en) | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
| US4330440A (en) | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
| CA1093991A (en) | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
| US4229537A (en) | 1978-02-09 | 1980-10-21 | New York University | Preparation of trichloro-s-triazine activated supports for coupling ligands |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4289872A (en) | 1979-04-06 | 1981-09-15 | Allied Corporation | Macromolecular highly branched homogeneous compound based on lysine units |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| EP0088046B1 (de) | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipide in wässriger Phase |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| US4710473A (en) | 1983-08-10 | 1987-12-01 | Amgen, Inc. | DNA plasmids |
| EP0143949B1 (en) | 1983-11-01 | 1988-10-12 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Pharmaceutical composition containing urokinase |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US5229490A (en) | 1987-05-06 | 1993-07-20 | The Rockefeller University | Multiple antigen peptide system |
| EP0315456B1 (en) | 1987-11-05 | 1994-06-01 | Hybritech Incorporated | Polysaccharide-modified immunoglobulins having reduced immunogenic potential or improved pharmacokinetics |
| US6018026A (en) | 1988-01-22 | 2000-01-25 | Zymogenetics, Inc. | Biologically active dimerized and multimerized polypeptide fusions |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| DE10399023I2 (de) | 1989-09-12 | 2006-11-23 | Ahp Mfg B V | TFN-bindende Proteine |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| US5733731A (en) | 1991-10-16 | 1998-03-31 | Affymax Technologies N.V. | Peptide library and screening method |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5955291A (en) | 1992-01-09 | 1999-09-21 | Alitalo; Kari | Antibodies recognizing tie receptor tyrosine kinase and uses thereof |
| WO1993015722A1 (en) | 1992-02-07 | 1993-08-19 | Syntex (Usa) Inc. | Controlled delivery of pharmaceuticals from preformed porous microparticles |
| US6004555A (en) | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for the specific coagulation of vasculature |
| US5877289A (en) | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
| ATE222291T1 (de) | 1992-03-13 | 2002-08-15 | Organon Teknika Bv | Epstein-barr-virus verwandte peptide und nukleinsäuresegmenten |
| JPH07505915A (ja) | 1992-04-14 | 1995-06-29 | コーネル リサーチ ファウンデーション、インコーポレーテッド | 樹枝状巨大分子およびその製造法 |
| DK0615451T3 (da) | 1992-05-26 | 2006-04-24 | Immunex Corp | Hidtil ukendt cytokin der binder til CD30 |
| AU4651893A (en) | 1992-06-26 | 1994-01-24 | Immunex Corporation | Novel tyrosine kinase |
| US5922545A (en) | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| AU8143094A (en) | 1993-11-12 | 1995-05-29 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | (tie-2), a novel receptor tyrosine kinase |
| US5643755A (en) | 1994-10-07 | 1997-07-01 | Regeneron Pharmaceuticals Inc. | Nucleic acid encoding tie-2 ligand |
| US5879672A (en) | 1994-10-07 | 1999-03-09 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 1 |
| AU689214B2 (en) | 1994-02-01 | 1998-03-26 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Fusion proteins that include antibody and nonantibody portions |
| AUPM379494A0 (en) | 1994-02-10 | 1994-03-03 | Ludwig Institute For Cancer Research | Immunointeractive molecules - ii |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US5650490A (en) | 1994-10-07 | 1997-07-22 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 2 |
| US5814464A (en) | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US5854202A (en) | 1995-01-24 | 1998-12-29 | Dedhar; Shoukat | Peptide fragments of calreticulin, peptide mimetics thereof, and pharmaceutical compostions comprising same |
| ATE273384T1 (de) * | 1995-04-06 | 2004-08-15 | Regeneron Pharma | Tie-2 liganden, herstellungsverfahren und verwendung |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| US5670110A (en) | 1995-12-21 | 1997-09-23 | The Procter & Gamble Company | Method for making three-dimensional macroscopically-expanded webs having improved functional surfaces |
| US6369027B1 (en) | 1995-12-22 | 2002-04-09 | Amgen Inc. | Osteoprotegerin |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| US6265564B1 (en) | 1996-08-02 | 2001-07-24 | Regeneron Pharmaceuticals, Inc. | Expressed ligand-vascular intercellular signalling molecule |
| DK0934526T3 (da) | 1996-10-08 | 2003-05-05 | Bisys B V U | Fremgangsmåder og midler til udvælgelse af peptider og proteiner, der har specifik affinitet til et mål |
| KR100565883B1 (ko) | 1997-01-22 | 2006-03-31 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 응고 및 종양 치료용 조직 인자 방법 및 조성물 |
| US6133426A (en) | 1997-02-21 | 2000-10-17 | Genentech, Inc. | Humanized anti-IL-8 monoclonal antibodies |
| WO1998039027A2 (en) | 1997-03-05 | 1998-09-11 | John Wayne Cancer Institute | Sialyl lewis antigens as targets for immunotherapy |
| WO2001062891A2 (en) | 2000-02-24 | 2001-08-30 | Human Genome Sciences, Inc. | 207 human secreted proteins |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| US5972338A (en) | 1997-09-19 | 1999-10-26 | Genentech, Inc. | Tie ligands homologues |
| US6030831A (en) | 1997-09-19 | 2000-02-29 | Genetech, Inc. | Tie ligand homologues |
| US6077934A (en) | 1997-12-24 | 2000-06-20 | University Of Utah Research Foundation | Contryphan peptides |
| GB9804121D0 (en) | 1998-02-26 | 1998-04-22 | Cancer Res Campaign Tech | Anti-angiogenic vaccines: materials and methods relating thereto |
| US6387663B1 (en) | 1998-07-31 | 2002-05-14 | University Of Southern California | Targeting pharmaceutical agents to injured tissues |
| EP1150688A4 (en) | 1998-10-19 | 2004-06-16 | Yeda Res & Dev | TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS BY NEGATIVE REGULATION OF THE AUTO-IMMUNE RESPONSE TO AUTOANTIGENS |
| US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| WO2001064835A2 (en) * | 2000-02-28 | 2001-09-07 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| US6521593B1 (en) * | 1999-02-01 | 2003-02-18 | Childrens Hospital Los Angeles | Methods for inhibiting brain tumor growth |
| US6455035B1 (en) | 1999-03-26 | 2002-09-24 | Regeneron Pharmaceuticals, Inc. | Angiopoietins and methods of use thereof |
| JP2002540165A (ja) | 1999-03-26 | 2002-11-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｔｉｅ２レセプターアクチベーターによる血管透過性の調節 |
| CA2383592A1 (en) * | 1999-03-31 | 2000-10-05 | Curagen Corporation | 2384891 acids including open reading frames encoding polypeptides; orfx |
| PT1187918E (pt) | 1999-06-07 | 2006-08-31 | Immunex Corp | Antagonistas de tek |
| ATE449109T1 (de) | 1999-06-15 | 2009-12-15 | Genentech Inc | Sekretierte und transmembran-polypeptide sowie nukleinsäuren zu deren kodierung |
| AU4347701A (en) * | 2000-03-01 | 2001-09-12 | Corixa Corp | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
| AU2001245945A1 (en) | 2000-03-23 | 2001-10-03 | Pe Corporation (Ny) | Detection kits, such as nucleic acid arrays, for detecting the expression of 10,000 or more drosophila genes and uses thereof |
| EP1160321A1 (en) | 2000-05-31 | 2001-12-05 | Sanofi-Synthelabo | Kidney Injury Novel Gene-1: Isolation and therapeutic applications |
| US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
| US7521053B2 (en) | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7205275B2 (en) | 2001-10-11 | 2007-04-17 | Amgen Inc. | Methods of treatment using specific binding agents of human angiopoietin-2 |
| WO2013180295A1 (ja) | 2012-06-01 | 2013-12-05 | 日本電信電話株式会社 | パケット転送処理方法およびパケット転送処理装置 |
| US9300829B2 (en) | 2014-04-04 | 2016-03-29 | Canon Kabushiki Kaisha | Image reading apparatus and correction method thereof |
| EP3035305B1 (en) | 2014-12-18 | 2016-11-16 | Axis AB | Enclosure and arrangement for recess mounting of a camera or camera head |
-
2002
- 2002-10-10 US US10/269,695 patent/US7138370B2/en not_active Expired - Lifetime
- 2002-10-11 IL IL16101602A patent/IL161016A0/xx unknown
- 2002-10-11 DK DK02804105.1T patent/DK1434791T3/da active
- 2002-10-11 HU HU0402162A patent/HUP0402162A3/hu unknown
- 2002-10-11 NZ NZ554021A patent/NZ554021A/en not_active IP Right Cessation
- 2002-10-11 WO PCT/US2002/032657 patent/WO2003057134A2/en not_active Ceased
- 2002-10-11 EP EP02804105A patent/EP1434791B1/en not_active Expired - Lifetime
- 2002-10-11 NZ NZ554022A patent/NZ554022A/en not_active IP Right Cessation
- 2002-10-11 DE DE60233955T patent/DE60233955D1/de not_active Expired - Lifetime
- 2002-10-11 EA EA200400526A patent/EA008248B1/ru unknown
- 2002-10-11 CA CA2767061A patent/CA2767061C/en not_active Expired - Lifetime
- 2002-10-11 NZ NZ543687A patent/NZ543687A/en not_active IP Right Cessation
- 2002-10-11 ES ES10075639T patent/ES2402918T3/es not_active Expired - Lifetime
- 2002-10-11 CN CN200910159451.9A patent/CN101787072B/zh not_active Expired - Lifetime
- 2002-10-11 CN CN028246519A patent/CN1596266B/zh not_active Expired - Lifetime
- 2002-10-11 ES ES02804105T patent/ES2334118T3/es not_active Expired - Lifetime
- 2002-10-11 CA CA2462610A patent/CA2462610C/en not_active Expired - Lifetime
- 2002-10-11 ES ES09004305T patent/ES2396272T3/es not_active Expired - Lifetime
- 2002-10-11 AT AT02804105T patent/ATE444967T1/de active
- 2002-10-11 KR KR1020107006456A patent/KR20100038238A/ko not_active Ceased
- 2002-10-11 EP EP09004305A patent/EP2070944B1/en not_active Expired - Lifetime
- 2002-10-11 ME MEP-2008-320A patent/ME00185B/me unknown
- 2002-10-11 SI SI200230859T patent/SI1434791T1/sl unknown
- 2002-10-11 KR KR1020047005380A patent/KR100976915B1/ko not_active Expired - Lifetime
- 2002-10-11 AU AU2002365179A patent/AU2002365179B2/en not_active Expired
- 2002-10-11 PL PL372671A patent/PL224701B1/pl unknown
- 2002-10-11 RS YU37304A patent/RS51898B/sr unknown
- 2002-10-11 EP EP10075639A patent/EP2316845B1/en not_active Expired - Lifetime
- 2002-10-11 PT PT02804105T patent/PT1434791E/pt unknown
- 2002-10-11 EP EP09011712A patent/EP2157097A1/en not_active Withdrawn
- 2002-10-11 EP EP10075643.6A patent/EP2311849B1/en not_active Expired - Lifetime
- 2002-10-11 BR BRPI0213223A patent/BRPI0213223B8/pt not_active IP Right Cessation
- 2002-10-11 JP JP2003557493A patent/JP4573238B2/ja not_active Expired - Lifetime
- 2002-10-11 CN CN201010130022A patent/CN101812118A/zh active Pending
- 2002-10-11 NZ NZ554023A patent/NZ554023A/en not_active IP Right Cessation
- 2002-10-11 ME MEP-320/08A patent/MEP32008A/xx unknown
- 2002-10-11 MX MXPA04003342A patent/MXPA04003342A/es active IP Right Grant
-
2004
- 2004-03-22 IL IL161016A patent/IL161016A/en active IP Right Grant
- 2004-05-10 NO NO20041917A patent/NO336004B1/no not_active IP Right Cessation
-
2006
- 2006-01-30 US US11/343,583 patent/US7723499B2/en not_active Expired - Lifetime
-
2007
- 2007-12-07 US US11/952,738 patent/US8129331B2/en not_active Expired - Lifetime
-
2009
- 2009-01-28 JP JP2009016351A patent/JP2009273457A/ja active Pending
- 2009-06-23 AU AU2009202513A patent/AU2009202513C1/en not_active Expired
-
2010
- 2010-01-07 CY CY20101100021T patent/CY1110571T1/el unknown
- 2010-03-10 JP JP2010052612A patent/JP5432777B2/ja not_active Expired - Lifetime
- 2010-03-23 US US12/729,498 patent/US20100286060A1/en not_active Abandoned
-
2012
- 2012-01-12 US US13/348,845 patent/US9200040B2/en not_active Expired - Fee Related
- 2012-03-30 US US13/435,810 patent/US20130158234A1/en not_active Abandoned
-
2014
- 2014-05-29 US US14/290,531 patent/US20140275479A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005514024A5 (enExample) | ||
| KR101893010B1 (ko) | ＴＮＦα를 저해하는 안정한 가용성 항체 | |
| EP4032892A1 (en) | Camptothecin derivative and conjugate thereof | |
| KR102342934B1 (ko) | 항체-약물 접합체 및 면역독소 | |
| KR20120008078A (ko) | 튜불린 저해제 | |
| KR20090122439A (ko) | 단일 아미노산을 갖는 화학적 링커 및 이의 접합체 | |
| JP2015500287A (ja) | 抗体−薬物のコンジュゲート、ならびに関連する化合物、組成物および方法 | |
| JP2016520618A5 (enExample) | ||
| BRPI0617546A2 (pt) | conjugado de fÁrmaco-anticorpo, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula de tumor, mÉtodo para retardar ou interromper o crescimento de um tumor em um sujeito mamÍfero e composto | |
| EA200702641A1 (ru) | Препараты наночастиц мезилата иматиниба | |
| EA019938B1 (ru) | Цитотоксические средства, включающие новые соединения томаймицина, и их терапевтическое применение | |
| JP2009523777A5 (enExample) | ||
| CN112601522A (zh) | 抗体-alk5抑制剂偶联物及其用途 | |
| WO2003027068A3 (en) | Substituted amines for the treatment of neurological disorders | |
| JP2010530478A (ja) | 青銅の腐食保護 | |
| KR20230084163A (ko) | 항체-약물 접합체와 parp1 선택적 억제제의 조합 | |
| ES2202453T3 (es) | Agentes antifungicos de triazol. | |
| US20250325689A1 (en) | Antibody-multidrug conjugate | |
| US20130338110A1 (en) | Mitochondria targeted cationic anti-oxidant compounds for prevention, therapy or treatment of hyper-proliferative disease, neoplasias and cancers | |
| CN109641911B (zh) | seco-环丙吡咯并吲哚化合物和其抗体-药物缀合物以及制备和使用方法 | |
| CN119013024A (zh) | 喜树碱类似物的配体-药物缀合物、中间体、制备方法、药物组合物及其应用 | |
| JP2009505973A5 (enExample) | ||
| CN109922802A (zh) | 三唑苯甲酰胺衍生物及其相关组合物和治疗方法 | |
| EP4534106A1 (en) | Antibody-multidrug conjugate precursor and synthetic intermediate thereof | |
| JP2010520915A5 (enExample) |