JP2005502603A5 - - Google Patents
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- Publication number
- JP2005502603A5 JP2005502603A5 JP2003505319A JP2003505319A JP2005502603A5 JP 2005502603 A5 JP2005502603 A5 JP 2005502603A5 JP 2003505319 A JP2003505319 A JP 2003505319A JP 2003505319 A JP2003505319 A JP 2003505319A JP 2005502603 A5 JP2005502603 A5 JP 2005502603A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- compound
- carbon atoms
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 47
- 125000004432 carbon atom Chemical group C* 0.000 claims 31
- 150000001875 compounds Chemical class 0.000 claims 29
- 238000000034 method Methods 0.000 claims 27
- -1 piperidine derivative compound Chemical class 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 8
- 238000011084 recovery Methods 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 239000002841 Lewis acid Substances 0.000 claims 5
- 150000007517 lewis acids Chemical class 0.000 claims 5
- 239000007858 starting material Substances 0.000 claims 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- MCQRPQCQMGVWIQ-UHFFFAOYSA-N boron;methylsulfanylmethane Chemical compound [B].CSC MCQRPQCQMGVWIQ-UHFFFAOYSA-N 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 150000003053 piperidines Chemical class 0.000 claims 1
- 0 CC(c1ccc(C(C)(C)*)cc1)O Chemical compound CC(c1ccc(C(C)(C)*)cc1)O 0.000 description 2
- ZAKPZGUPZCQKEP-UHFFFAOYSA-N CN(CC1)CCC1C(c1ccccc1)(c1ccccc1)O Chemical compound CN(CC1)CCC1C(c1ccccc1)(c1ccccc1)O ZAKPZGUPZCQKEP-UHFFFAOYSA-N 0.000 description 2
- RINCXYDBBGOEEQ-UHFFFAOYSA-N O=C(CC1)OC1=O Chemical compound O=C(CC1)OC1=O RINCXYDBBGOEEQ-UHFFFAOYSA-N 0.000 description 2
- ZMISODWVFHHWNR-UHFFFAOYSA-N OC(C1CCNCC1)(c1ccccc1)c1ccccc1 Chemical compound OC(C1CCNCC1)(c1ccccc1)c1ccccc1 ZMISODWVFHHWNR-UHFFFAOYSA-N 0.000 description 2
- MWRBCODVEAQUAD-UHFFFAOYSA-N CC(c1ccc(C(C)(C)C(O)=O)cc1)O Chemical compound CC(c1ccc(C(C)(C)C(O)=O)cc1)O MWRBCODVEAQUAD-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29839701P | 2001-06-15 | 2001-06-15 | |
| PCT/EP2002/006424 WO2002102776A1 (en) | 2001-06-15 | 2002-06-12 | Process for the production of the piperidine derivative fexofenadine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005502603A JP2005502603A (ja) | 2005-01-27 |
| JP2005502603A5 true JP2005502603A5 (enExample) | 2006-01-05 |
| JP4344230B2 JP4344230B2 (ja) | 2009-10-14 |
Family
ID=23150325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003505319A Expired - Fee Related JP4344230B2 (ja) | 2001-06-15 | 2002-06-12 | ピペリジン誘導体フェキソフェナジンの製造方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6743941B2 (enExample) |
| EP (1) | EP1401816B1 (enExample) |
| JP (1) | JP4344230B2 (enExample) |
| KR (1) | KR100903285B1 (enExample) |
| CN (1) | CN1229347C (enExample) |
| AR (1) | AR037005A1 (enExample) |
| AT (1) | ATE386021T1 (enExample) |
| AU (1) | AU2002320847B2 (enExample) |
| BR (1) | BR0210410A (enExample) |
| CA (1) | CA2450313C (enExample) |
| DE (1) | DE60225008T2 (enExample) |
| DK (1) | DK1401816T3 (enExample) |
| ES (1) | ES2298384T3 (enExample) |
| HU (1) | HUP0401125A2 (enExample) |
| IL (2) | IL159304A0 (enExample) |
| MX (1) | MXPA03010960A (enExample) |
| NO (1) | NO20035572L (enExample) |
| NZ (1) | NZ530153A (enExample) |
| PL (1) | PL364369A1 (enExample) |
| PT (1) | PT1401816E (enExample) |
| WO (1) | WO2002102776A1 (enExample) |
| ZA (1) | ZA200308697B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7498443B2 (en) * | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of carebastine |
| US7498345B2 (en) * | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| CN100453522C (zh) * | 2005-01-26 | 2009-01-21 | 中国科学技术大学 | 4-[4-(1-乙氧基酰基-1-甲基乙基苯)]-4-氧代丁酸的制备方法 |
| WO2007135693A2 (en) * | 2006-05-18 | 2007-11-29 | Ind-Swift Laboratories Limited | Intermediates useful for the preparation of antihistaminic piperidine derivative |
| ITMI20061491A1 (it) * | 2006-07-27 | 2008-01-28 | Archimica Srl | Processo per la preparazione di fexofenadina. |
| ITMI20061492A1 (it) * | 2006-07-27 | 2008-01-28 | Archimica Srl | Processo per la preparazione di fexofenadina. |
| CN102070490B (zh) * | 2009-11-21 | 2014-07-30 | 浙江华海药业股份有限公司 | 一种非索非那定中间体2-(4-(4-羟基丁酰基)苯基)-2-甲基丙氰的制备方法 |
| CN102070570A (zh) * | 2009-11-21 | 2011-05-25 | 浙江华海药业股份有限公司 | 一种非索非那定中间体2-甲基-2(4-(2-氧代四氢呋喃-3-羰基)苯基)丙氰及其盐的制备方法 |
| CA2986587C (en) | 2015-06-15 | 2024-03-12 | Asana Biosciences, Llc | Heterocyclic inhibitors of erk1 and erk2 and their use in the treatment of cancer |
| CN104876853B (zh) * | 2015-06-17 | 2017-06-16 | 苏州卫生职业技术学院 | 盐酸非索非那定的合成方法 |
| CN109071438B (zh) | 2015-10-22 | 2023-02-21 | 赛诺菲-安万特德国有限公司 | 用于制备非索非那定和其中使用的中间体的方法 |
| EP3600302A4 (en) | 2017-03-29 | 2020-12-30 | United States Government as Represented by The Department of Veterans Affairs | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER |
| US20230027072A1 (en) | 2019-10-28 | 2023-01-26 | Asana Biosciences, Llc | Improved methods, kits, compositions and dosing regimens for the use of heterocyclic inhibitors of erk1 and erk2 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2946809A1 (de) * | 1979-11-20 | 1981-06-11 | A. Nattermann & Cie GmbH, 5000 Köln | 4-phenyl-4-oxo-buttersaeuren, deren salze und ester, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| IT1200123B (it) | 1985-09-27 | 1989-01-05 | Ind Chimica Srl | Procedimento per la preparazione di alfa-(p-terbutilfenil)-4-(idrossidifenilmetil)-1-piperidinobutanolo |
| EP0347123A3 (en) | 1988-06-17 | 1991-07-03 | Fisons Corporation | Dibenzo-cycloheptenyl, -cycloheptyl and -oxepinyl amines having antihistaminic properties |
| IT1249684B (it) | 1991-07-19 | 1995-03-09 | Sorin Biomedica Spa | Epitopi della proteina env del virus dell'epatite c. |
| MX9302076A (es) * | 1992-04-10 | 1994-03-31 | Merrell Dow Pharma | Proceso novedoso para preparar derivados de piperidina. |
| DK0703902T3 (da) | 1993-06-24 | 1999-08-23 | Albany Molecular Res Inc | Fremgangsmåde til fremstilling af piperidinderivater |
-
2002
- 2002-06-11 US US10/166,893 patent/US6743941B2/en not_active Expired - Lifetime
- 2002-06-12 DE DE60225008T patent/DE60225008T2/de not_active Expired - Lifetime
- 2002-06-12 BR BR0210410-5A patent/BR0210410A/pt not_active IP Right Cessation
- 2002-06-12 EP EP02754657A patent/EP1401816B1/en not_active Expired - Lifetime
- 2002-06-12 JP JP2003505319A patent/JP4344230B2/ja not_active Expired - Fee Related
- 2002-06-12 MX MXPA03010960A patent/MXPA03010960A/es active IP Right Grant
- 2002-06-12 CN CNB028119312A patent/CN1229347C/zh not_active Expired - Fee Related
- 2002-06-12 AU AU2002320847A patent/AU2002320847B2/en not_active Ceased
- 2002-06-12 CA CA2450313A patent/CA2450313C/en not_active Expired - Fee Related
- 2002-06-12 NZ NZ530153A patent/NZ530153A/en not_active IP Right Cessation
- 2002-06-12 IL IL15930402A patent/IL159304A0/xx unknown
- 2002-06-12 PT PT02754657T patent/PT1401816E/pt unknown
- 2002-06-12 KR KR1020037016429A patent/KR100903285B1/ko not_active Expired - Fee Related
- 2002-06-12 DK DK02754657T patent/DK1401816T3/da active
- 2002-06-12 PL PL02364369A patent/PL364369A1/xx not_active Application Discontinuation
- 2002-06-12 WO PCT/EP2002/006424 patent/WO2002102776A1/en not_active Ceased
- 2002-06-12 AT AT02754657T patent/ATE386021T1/de active
- 2002-06-12 ES ES02754657T patent/ES2298384T3/es not_active Expired - Lifetime
- 2002-06-12 HU HU0401125A patent/HUP0401125A2/hu unknown
- 2002-06-14 AR ARP020102261A patent/AR037005A1/es unknown
-
2003
- 2003-11-07 ZA ZA200308697A patent/ZA200308697B/en unknown
- 2003-12-10 IL IL159304A patent/IL159304A/en not_active IP Right Cessation
- 2003-12-12 NO NO20035572A patent/NO20035572L/no unknown
-
2004
- 2004-04-22 US US10/829,803 patent/US7235665B2/en not_active Expired - Lifetime
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