HUP0401125A2 - Eljárás fexofenadine, egy piperidinszármazék és új közbenső termékei előállítására - Google Patents

Eljárás fexofenadine, egy piperidinszármazék és új közbenső termékei előállítására

Info

Publication number
HUP0401125A2
HUP0401125A2 HU0401125A HUP0401125A HUP0401125A2 HU P0401125 A2 HUP0401125 A2 HU P0401125A2 HU 0401125 A HU0401125 A HU 0401125A HU P0401125 A HUP0401125 A HU P0401125A HU P0401125 A2 HUP0401125 A2 HU P0401125A2
Authority
HU
Hungary
Prior art keywords
alkyl
formula
compound
carbon atoms
general formula
Prior art date
Application number
HU0401125A
Other languages
English (en)
Hungarian (hu)
Inventor
Collin Schroeder
Ryan Huddleston
Richard Charles
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of HUP0401125A2 publication Critical patent/HUP0401125A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU0401125A 2001-06-15 2002-06-12 Eljárás fexofenadine, egy piperidinszármazék és új közbenső termékei előállítására HUP0401125A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29839701P 2001-06-15 2001-06-15
PCT/EP2002/006424 WO2002102776A1 (en) 2001-06-15 2002-06-12 Process for the production of the piperidine derivative fexofenadine

Publications (1)

Publication Number Publication Date
HUP0401125A2 true HUP0401125A2 (hu) 2004-09-28

Family

ID=23150325

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401125A HUP0401125A2 (hu) 2001-06-15 2002-06-12 Eljárás fexofenadine, egy piperidinszármazék és új közbenső termékei előállítására

Country Status (22)

Country Link
US (2) US6743941B2 (enExample)
EP (1) EP1401816B1 (enExample)
JP (1) JP4344230B2 (enExample)
KR (1) KR100903285B1 (enExample)
CN (1) CN1229347C (enExample)
AR (1) AR037005A1 (enExample)
AT (1) ATE386021T1 (enExample)
AU (1) AU2002320847B2 (enExample)
BR (1) BR0210410A (enExample)
CA (1) CA2450313C (enExample)
DE (1) DE60225008T2 (enExample)
DK (1) DK1401816T3 (enExample)
ES (1) ES2298384T3 (enExample)
HU (1) HUP0401125A2 (enExample)
IL (2) IL159304A0 (enExample)
MX (1) MXPA03010960A (enExample)
NO (1) NO20035572L (enExample)
NZ (1) NZ530153A (enExample)
PL (1) PL364369A1 (enExample)
PT (1) PT1401816E (enExample)
WO (1) WO2002102776A1 (enExample)
ZA (1) ZA200308697B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7498443B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
CN100453522C (zh) * 2005-01-26 2009-01-21 中国科学技术大学 4-[4-(1-乙氧基酰基-1-甲基乙基苯)]-4-氧代丁酸的制备方法
WO2007135693A2 (en) * 2006-05-18 2007-11-29 Ind-Swift Laboratories Limited Intermediates useful for the preparation of antihistaminic piperidine derivative
ITMI20061491A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
ITMI20061492A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
CN102070490B (zh) * 2009-11-21 2014-07-30 浙江华海药业股份有限公司 一种非索非那定中间体2-(4-(4-羟基丁酰基)苯基)-2-甲基丙氰的制备方法
CN102070570A (zh) * 2009-11-21 2011-05-25 浙江华海药业股份有限公司 一种非索非那定中间体2-甲基-2(4-(2-氧代四氢呋喃-3-羰基)苯基)丙氰及其盐的制备方法
CN107922387B (zh) 2015-06-15 2024-11-22 阿沙纳生物科学公司 Erk1与erk2的杂环抑制剂及其在癌症治疗中的应用
CN104876853B (zh) * 2015-06-17 2017-06-16 苏州卫生职业技术学院 盐酸非索非那定的合成方法
RS59874B1 (sr) 2015-10-22 2020-03-31 Sanofi Aventis Deutschland Proces za pripremu feksofenadina i njegovih intermedijara
WO2018183762A1 (en) 2017-03-29 2018-10-04 United States Government As Represented By The Department Of Veterans Affairs Methods and compositions for treating cancer
US20230027072A1 (en) 2019-10-28 2023-01-26 Asana Biosciences, Llc Improved methods, kits, compositions and dosing regimens for the use of heterocyclic inhibitors of erk1 and erk2

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2946809A1 (de) * 1979-11-20 1981-06-11 A. Nattermann & Cie GmbH, 5000 Köln 4-phenyl-4-oxo-buttersaeuren, deren salze und ester, verfahren zu deren herstellung und diese enthaltende arzneimittel
IT1200123B (it) 1985-09-27 1989-01-05 Ind Chimica Srl Procedimento per la preparazione di alfa-(p-terbutilfenil)-4-(idrossidifenilmetil)-1-piperidinobutanolo
EP0347123A3 (en) 1988-06-17 1991-07-03 Fisons Corporation Dibenzo-cycloheptenyl, -cycloheptyl and -oxepinyl amines having antihistaminic properties
IT1249684B (it) 1991-07-19 1995-03-09 Sorin Biomedica Spa Epitopi della proteina env del virus dell'epatite c.
JP3686950B2 (ja) * 1992-04-10 2005-08-24 メレル ファーマスーティカルズ インコーポレイテッド ピペリジン誘導体類の新規な方法
DK1026147T3 (da) 1993-06-24 2004-03-22 Albany Molecular Res Inc Forbindelser, der er anvendelige som mellemprodukter i fremstillingen af piperidinderivater

Also Published As

Publication number Publication date
CA2450313A1 (en) 2002-12-27
CN1516689A (zh) 2004-07-28
US7235665B2 (en) 2007-06-26
MXPA03010960A (es) 2004-02-27
US20030105329A1 (en) 2003-06-05
IL159304A (en) 2010-02-17
PL364369A1 (en) 2004-12-13
DE60225008D1 (de) 2008-03-27
EP1401816B1 (en) 2008-02-13
WO2002102776A1 (en) 2002-12-27
DK1401816T3 (da) 2008-06-09
CA2450313C (en) 2010-08-10
ES2298384T3 (es) 2008-05-16
AR037005A1 (es) 2004-10-20
JP4344230B2 (ja) 2009-10-14
KR100903285B1 (ko) 2009-06-17
JP2005502603A (ja) 2005-01-27
ATE386021T1 (de) 2008-03-15
HK1063795A1 (en) 2005-01-14
IL159304A0 (en) 2004-06-01
BR0210410A (pt) 2004-08-17
US6743941B2 (en) 2004-06-01
KR20040010720A (ko) 2004-01-31
NO20035572L (no) 2004-02-16
ZA200308697B (en) 2004-09-03
NZ530153A (en) 2005-07-29
US20040198983A1 (en) 2004-10-07
EP1401816A1 (en) 2004-03-31
PT1401816E (pt) 2008-04-08
DE60225008T2 (de) 2009-01-29
CN1229347C (zh) 2005-11-30
AU2002320847B2 (en) 2007-09-20
NO20035572D0 (no) 2003-12-12

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Legal Events

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