AR037005A1 - Derivados de acidos dimetilfenilaceticos, derivados de piperidina, y proceso para la produccion de derivados de piperidina. - Google Patents
Derivados de acidos dimetilfenilaceticos, derivados de piperidina, y proceso para la produccion de derivados de piperidina.Info
- Publication number
- AR037005A1 AR037005A1 ARP020102261A ARP020102261A AR037005A1 AR 037005 A1 AR037005 A1 AR 037005A1 AR P020102261 A ARP020102261 A AR P020102261A AR P020102261 A ARP020102261 A AR P020102261A AR 037005 A1 AR037005 A1 AR 037005A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- alkyl
- carbon atoms
- piperidine
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 6
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 15
- 125000000217 alkyl group Chemical group 0.000 abstract 13
- 125000004432 carbon atom Chemical group C* 0.000 abstract 13
- 239000000203 mixture Substances 0.000 abstract 6
- 150000003053 piperidines Chemical class 0.000 abstract 3
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 abstract 2
- -1 fexofenadine (F) Chemical class 0.000 abstract 2
- YYEROYLAYAVZNW-UHFFFAOYSA-N 2-methyl-2-phenylpropanoic acid Chemical class OC(=O)C(C)(C)C1=CC=CC=C1 YYEROYLAYAVZNW-UHFFFAOYSA-N 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940008201 allegra Drugs 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- MCQRPQCQMGVWIQ-UHFFFAOYSA-N boron;methylsulfanylmethane Chemical compound [B].CSC MCQRPQCQMGVWIQ-UHFFFAOYSA-N 0.000 abstract 1
- 229960003592 fexofenadine Drugs 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29839701P | 2001-06-15 | 2001-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037005A1 true AR037005A1 (es) | 2004-10-20 |
Family
ID=23150325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102261A AR037005A1 (es) | 2001-06-15 | 2002-06-14 | Derivados de acidos dimetilfenilaceticos, derivados de piperidina, y proceso para la produccion de derivados de piperidina. |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6743941B2 (enExample) |
| EP (1) | EP1401816B1 (enExample) |
| JP (1) | JP4344230B2 (enExample) |
| KR (1) | KR100903285B1 (enExample) |
| CN (1) | CN1229347C (enExample) |
| AR (1) | AR037005A1 (enExample) |
| AT (1) | ATE386021T1 (enExample) |
| AU (1) | AU2002320847B2 (enExample) |
| BR (1) | BR0210410A (enExample) |
| CA (1) | CA2450313C (enExample) |
| DE (1) | DE60225008T2 (enExample) |
| DK (1) | DK1401816T3 (enExample) |
| ES (1) | ES2298384T3 (enExample) |
| HU (1) | HUP0401125A2 (enExample) |
| IL (2) | IL159304A0 (enExample) |
| MX (1) | MXPA03010960A (enExample) |
| NO (1) | NO20035572L (enExample) |
| NZ (1) | NZ530153A (enExample) |
| PL (1) | PL364369A1 (enExample) |
| PT (1) | PT1401816E (enExample) |
| WO (1) | WO2002102776A1 (enExample) |
| ZA (1) | ZA200308697B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7498443B2 (en) * | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of carebastine |
| US7498345B2 (en) * | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| CN100453522C (zh) * | 2005-01-26 | 2009-01-21 | 中国科学技术大学 | 4-[4-(1-乙氧基酰基-1-甲基乙基苯)]-4-氧代丁酸的制备方法 |
| WO2007135693A2 (en) * | 2006-05-18 | 2007-11-29 | Ind-Swift Laboratories Limited | Intermediates useful for the preparation of antihistaminic piperidine derivative |
| ITMI20061491A1 (it) * | 2006-07-27 | 2008-01-28 | Archimica Srl | Processo per la preparazione di fexofenadina. |
| ITMI20061492A1 (it) * | 2006-07-27 | 2008-01-28 | Archimica Srl | Processo per la preparazione di fexofenadina. |
| CN102070490B (zh) * | 2009-11-21 | 2014-07-30 | 浙江华海药业股份有限公司 | 一种非索非那定中间体2-(4-(4-羟基丁酰基)苯基)-2-甲基丙氰的制备方法 |
| CN102070570A (zh) * | 2009-11-21 | 2011-05-25 | 浙江华海药业股份有限公司 | 一种非索非那定中间体2-甲基-2(4-(2-氧代四氢呋喃-3-羰基)苯基)丙氰及其盐的制备方法 |
| CA2986587C (en) | 2015-06-15 | 2024-03-12 | Asana Biosciences, Llc | Heterocyclic inhibitors of erk1 and erk2 and their use in the treatment of cancer |
| CN104876853B (zh) * | 2015-06-17 | 2017-06-16 | 苏州卫生职业技术学院 | 盐酸非索非那定的合成方法 |
| CN109071438B (zh) | 2015-10-22 | 2023-02-21 | 赛诺菲-安万特德国有限公司 | 用于制备非索非那定和其中使用的中间体的方法 |
| EP3600302A4 (en) | 2017-03-29 | 2020-12-30 | United States Government as Represented by The Department of Veterans Affairs | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER |
| US20230027072A1 (en) | 2019-10-28 | 2023-01-26 | Asana Biosciences, Llc | Improved methods, kits, compositions and dosing regimens for the use of heterocyclic inhibitors of erk1 and erk2 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2946809A1 (de) * | 1979-11-20 | 1981-06-11 | A. Nattermann & Cie GmbH, 5000 Köln | 4-phenyl-4-oxo-buttersaeuren, deren salze und ester, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| IT1200123B (it) | 1985-09-27 | 1989-01-05 | Ind Chimica Srl | Procedimento per la preparazione di alfa-(p-terbutilfenil)-4-(idrossidifenilmetil)-1-piperidinobutanolo |
| EP0347123A3 (en) | 1988-06-17 | 1991-07-03 | Fisons Corporation | Dibenzo-cycloheptenyl, -cycloheptyl and -oxepinyl amines having antihistaminic properties |
| IT1249684B (it) | 1991-07-19 | 1995-03-09 | Sorin Biomedica Spa | Epitopi della proteina env del virus dell'epatite c. |
| MX9302076A (es) * | 1992-04-10 | 1994-03-31 | Merrell Dow Pharma | Proceso novedoso para preparar derivados de piperidina. |
| DK0703902T3 (da) | 1993-06-24 | 1999-08-23 | Albany Molecular Res Inc | Fremgangsmåde til fremstilling af piperidinderivater |
-
2002
- 2002-06-11 US US10/166,893 patent/US6743941B2/en not_active Expired - Lifetime
- 2002-06-12 DE DE60225008T patent/DE60225008T2/de not_active Expired - Lifetime
- 2002-06-12 BR BR0210410-5A patent/BR0210410A/pt not_active IP Right Cessation
- 2002-06-12 EP EP02754657A patent/EP1401816B1/en not_active Expired - Lifetime
- 2002-06-12 JP JP2003505319A patent/JP4344230B2/ja not_active Expired - Fee Related
- 2002-06-12 MX MXPA03010960A patent/MXPA03010960A/es active IP Right Grant
- 2002-06-12 CN CNB028119312A patent/CN1229347C/zh not_active Expired - Fee Related
- 2002-06-12 AU AU2002320847A patent/AU2002320847B2/en not_active Ceased
- 2002-06-12 CA CA2450313A patent/CA2450313C/en not_active Expired - Fee Related
- 2002-06-12 NZ NZ530153A patent/NZ530153A/en not_active IP Right Cessation
- 2002-06-12 IL IL15930402A patent/IL159304A0/xx unknown
- 2002-06-12 PT PT02754657T patent/PT1401816E/pt unknown
- 2002-06-12 KR KR1020037016429A patent/KR100903285B1/ko not_active Expired - Fee Related
- 2002-06-12 DK DK02754657T patent/DK1401816T3/da active
- 2002-06-12 PL PL02364369A patent/PL364369A1/xx not_active Application Discontinuation
- 2002-06-12 WO PCT/EP2002/006424 patent/WO2002102776A1/en not_active Ceased
- 2002-06-12 AT AT02754657T patent/ATE386021T1/de active
- 2002-06-12 ES ES02754657T patent/ES2298384T3/es not_active Expired - Lifetime
- 2002-06-12 HU HU0401125A patent/HUP0401125A2/hu unknown
- 2002-06-14 AR ARP020102261A patent/AR037005A1/es unknown
-
2003
- 2003-11-07 ZA ZA200308697A patent/ZA200308697B/en unknown
- 2003-12-10 IL IL159304A patent/IL159304A/en not_active IP Right Cessation
- 2003-12-12 NO NO20035572A patent/NO20035572L/no unknown
-
2004
- 2004-04-22 US US10/829,803 patent/US7235665B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040010720A (ko) | 2004-01-31 |
| HK1063795A1 (en) | 2005-01-14 |
| DE60225008D1 (de) | 2008-03-27 |
| US20030105329A1 (en) | 2003-06-05 |
| BR0210410A (pt) | 2004-08-17 |
| IL159304A0 (en) | 2004-06-01 |
| NO20035572L (no) | 2004-02-16 |
| MXPA03010960A (es) | 2004-02-27 |
| EP1401816A1 (en) | 2004-03-31 |
| ATE386021T1 (de) | 2008-03-15 |
| US20040198983A1 (en) | 2004-10-07 |
| ZA200308697B (en) | 2004-09-03 |
| JP2005502603A (ja) | 2005-01-27 |
| JP4344230B2 (ja) | 2009-10-14 |
| CN1229347C (zh) | 2005-11-30 |
| PL364369A1 (en) | 2004-12-13 |
| CA2450313A1 (en) | 2002-12-27 |
| IL159304A (en) | 2010-02-17 |
| CN1516689A (zh) | 2004-07-28 |
| HUP0401125A2 (hu) | 2004-09-28 |
| PT1401816E (pt) | 2008-04-08 |
| US7235665B2 (en) | 2007-06-26 |
| EP1401816B1 (en) | 2008-02-13 |
| CA2450313C (en) | 2010-08-10 |
| US6743941B2 (en) | 2004-06-01 |
| NZ530153A (en) | 2005-07-29 |
| ES2298384T3 (es) | 2008-05-16 |
| WO2002102776A1 (en) | 2002-12-27 |
| DK1401816T3 (da) | 2008-06-09 |
| NO20035572D0 (no) | 2003-12-12 |
| DE60225008T2 (de) | 2009-01-29 |
| AU2002320847B2 (en) | 2007-09-20 |
| KR100903285B1 (ko) | 2009-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |