JP2019214626A5 - - Google Patents
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- Publication number
- JP2019214626A5 JP2019214626A5 JP2019176572A JP2019176572A JP2019214626A5 JP 2019214626 A5 JP2019214626 A5 JP 2019214626A5 JP 2019176572 A JP2019176572 A JP 2019176572A JP 2019176572 A JP2019176572 A JP 2019176572A JP 2019214626 A5 JP2019214626 A5 JP 2019214626A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- reaction mixture
- forming
- under conditions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 19
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 12
- 239000011541 reaction mixture Substances 0.000 claims 10
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 7
- OISVCGZHLKNMSJ-UHFFFAOYSA-N 2,6-dimethylpyridine Chemical compound CC1=CC=CC(C)=N1 OISVCGZHLKNMSJ-UHFFFAOYSA-N 0.000 claims 6
- 239000003638 chemical reducing agent Substances 0.000 claims 6
- 230000000269 nucleophilic effect Effects 0.000 claims 6
- 239000011734 sodium Substances 0.000 claims 6
- BWZVCCNYKMEVEX-UHFFFAOYSA-N 2,4,6-Trimethylpyridine Chemical compound CC1=CC(C)=NC(C)=C1 BWZVCCNYKMEVEX-UHFFFAOYSA-N 0.000 claims 4
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 claims 4
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims 4
- GGSUCNLOZRCGPQ-UHFFFAOYSA-N diethylaniline Chemical compound CCN(CC)C1=CC=CC=C1 GGSUCNLOZRCGPQ-UHFFFAOYSA-N 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 3
- AUHZEENZYGFFBQ-UHFFFAOYSA-N 1,3,5-Me3C6H3 Natural products CC1=CC(C)=CC(C)=C1 AUHZEENZYGFFBQ-UHFFFAOYSA-N 0.000 claims 2
- XWKFPIODWVPXLX-UHFFFAOYSA-N 2-methyl-5-methylpyridine Natural products CC1=CC=C(C)N=C1 XWKFPIODWVPXLX-UHFFFAOYSA-N 0.000 claims 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims 2
- 238000010276 construction Methods 0.000 claims 2
- SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical compound C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 claims 2
- GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 claims 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- -1 comprising BH Substances 0.000 claims 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims 1
- 235000019341 magnesium sulphate Nutrition 0.000 claims 1
- 235000006408 oxalic acid Nutrition 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229910052938 sodium sulfate Inorganic materials 0.000 claims 1
- 235000011152 sodium sulphate Nutrition 0.000 claims 1
- GJTOKYAWIFLYOK-UHFFFAOYSA-N CCOC(CNCc1cc(CN2CCCC2)ccc1)=O Chemical compound CCOC(CNCc1cc(CN2CCCC2)ccc1)=O GJTOKYAWIFLYOK-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022016438A JP7333843B2 (ja) | 2014-09-16 | 2022-02-04 | Ｔｏｌｌ様受容体モジュレーターを調製する方法 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051044P | 2014-09-16 | 2014-09-16 | |
| US62/051,044 | 2014-09-16 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018134200A Division JP6596127B2 (ja) | 2014-09-16 | 2018-07-17 | Ｔｏｌｌ様受容体モジュレーターを調製する方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022016438A Division JP7333843B2 (ja) | 2014-09-16 | 2022-02-04 | Ｔｏｌｌ様受容体モジュレーターを調製する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019214626A JP2019214626A (ja) | 2019-12-19 |
| JP2019214626A5 true JP2019214626A5 (enExample) | 2020-02-06 |
| JP7063865B2 JP7063865B2 (ja) | 2022-05-09 |
Family
ID=54291584
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017514494A Active JP6373490B2 (ja) | 2014-09-16 | 2015-09-14 | Ｔｏｌｌ様受容体モジュレーターを調製する方法 |
| JP2018134200A Active JP6596127B2 (ja) | 2014-09-16 | 2018-07-17 | Ｔｏｌｌ様受容体モジュレーターを調製する方法 |
| JP2019176572A Active JP7063865B2 (ja) | 2014-09-16 | 2019-09-27 | Ｔｏｌｌ様受容体モジュレーターを調製する方法 |
| JP2022016438A Active JP7333843B2 (ja) | 2014-09-16 | 2022-02-04 | Ｔｏｌｌ様受容体モジュレーターを調製する方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017514494A Active JP6373490B2 (ja) | 2014-09-16 | 2015-09-14 | Ｔｏｌｌ様受容体モジュレーターを調製する方法 |
| JP2018134200A Active JP6596127B2 (ja) | 2014-09-16 | 2018-07-17 | Ｔｏｌｌ様受容体モジュレーターを調製する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022016438A Active JP7333843B2 (ja) | 2014-09-16 | 2022-02-04 | Ｔｏｌｌ様受容体モジュレーターを調製する方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9573952B2 (enExample) |
| EP (3) | EP3194402B1 (enExample) |
| JP (4) | JP6373490B2 (enExample) |
| KR (3) | KR101978809B1 (enExample) |
| CN (2) | CN107074860B (enExample) |
| AR (1) | AR101882A1 (enExample) |
| AU (2) | AU2015318062B2 (enExample) |
| BR (1) | BR112017005100A2 (enExample) |
| CA (1) | CA2960384C (enExample) |
| EA (1) | EA201790373A1 (enExample) |
| ES (3) | ES2975520T3 (enExample) |
| IL (1) | IL250849A0 (enExample) |
| MX (1) | MX2017003288A (enExample) |
| NZ (1) | NZ729526A (enExample) |
| PL (2) | PL3461828T3 (enExample) |
| PT (2) | PT3194402T (enExample) |
| SG (1) | SG11201701472VA (enExample) |
| SI (1) | SI3461828T1 (enExample) |
| TW (2) | TWI692468B (enExample) |
| WO (1) | WO2016044183A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY32306A (es) | 2008-12-09 | 2010-07-30 | Gilead Sciences Inc | Derivados de pteridinona y pirimidinodiazepinona y composiciones farmacéuticas que modulan en forma selectiva los receptores tipo toll, métodos y usos |
| SI3166607T1 (sl) | 2014-07-11 | 2023-01-31 | Gilead Sciences, Inc. | Modulatorji toličnih receptorjev za zdravljenje HIV-a |
| CN110305133A (zh) | 2014-09-16 | 2019-10-08 | 吉利德科学公司 | Toll样受体调节剂的固体形式 |
| CN111065636B (zh) * | 2017-09-22 | 2022-08-23 | 江苏恒瑞医药股份有限公司 | 稠合杂芳基衍生物、其制备方法及其在医药上的应用 |
| CN113924114A (zh) | 2019-05-22 | 2022-01-11 | 吉利德科学公司 | Tlr7调节化合物和hiv疫苗的组合 |
| PE20251874A1 (es) * | 2022-04-26 | 2025-07-22 | Bigelow Laboratory For Ocean Sciences | Metodos para producir compuestos halogenados |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| WO1990014837A1 (en) | 1989-05-25 | 1990-12-13 | Chiron Corporation | Adjuvant formulation comprising a submicron oil droplet emulsion |
| JP2886570B2 (ja) | 1989-09-29 | 1999-04-26 | エーザイ株式会社 | 縮合ヘテロ環を有する化合物 |
| JPH05320143A (ja) * | 1992-03-18 | 1993-12-03 | Mochida Pharmaceut Co Ltd | 新規ピリミジン誘導体 |
| TW274550B (enExample) | 1992-09-26 | 1996-04-21 | Hoechst Ag | |
| IL112235A (en) | 1994-01-03 | 2000-06-29 | Acea Pharm Inc | 1,4-dihydro-pyrido¬2,3-b¾pyrazine-2,3-dione (5 or 8) oxide derivatives and pharmaceutical compositions containing them |
| ZA973884B (en) | 1996-05-23 | 1998-11-06 | Du Pont Merck Pharma | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
| DK0920429T3 (da) | 1996-08-06 | 2003-05-12 | Pfizer | Substituerede pyrido- eller pyrimidoholdige, 6,6- eller 6,7-bicykliske derivater |
| US5693641A (en) | 1996-08-16 | 1997-12-02 | Berlex Laboratories Inc. | Bicyclic pyrimidine derivatives and their use as anti-coagulants |
| WO2000000478A1 (en) | 1998-06-26 | 2000-01-06 | Bristol-Myers Squibb Pharma Company | Substituted quinoxalin-2(1h)-ones useful as hiv reverse transcriptase inhibitors |
| JP2003509425A (ja) | 1999-09-15 | 2003-03-11 | ワーナー−ランバート・カンパニー | キナーゼ阻害剤としてのプテリジノン |
| US6452325B1 (en) | 2000-07-24 | 2002-09-17 | Thermoplastic Processes, Inc. | Shatterproofing of fluorescent lamps |
| WO2002076954A1 (en) | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
| UY27427A1 (es) | 2001-09-04 | 2003-03-31 | Boehringer Ingelheim Pharma | Nuevas dihidro-pteridinonas, procedimientos para su preparación y su utilización como medicamentos |
| US6806272B2 (en) | 2001-09-04 | 2004-10-19 | Boehringer Ingelheim Pharma Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
| DE50307267D1 (de) | 2003-02-26 | 2007-06-21 | Boehringer Ingelheim Pharma | Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| EP2269638A3 (en) | 2004-05-28 | 2012-06-13 | GlaxoSmithKline Biologicals S.A. | Vaccine compositions comprising virosomes and a saponin adjuvant |
| DE102004029784A1 (de) | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
| EA200702235A1 (ru) | 2005-05-04 | 2008-04-28 | Пфайзер Лимитед | Производные 2-амидо-6-амино-8-оксопурина в качестве модуляторов toll-подобных рецепторов для лечения рака и вирусных инфекций, таких как гепатит с |
| WO2007014838A1 (en) | 2005-08-03 | 2007-02-08 | Boehringer Ingelheim International Gmbh | Dihydropteridinones in the treatment of respiratory diseases |
| WO2007034917A1 (ja) | 2005-09-22 | 2007-03-29 | Dainippon Sumitomo Pharma Co., Ltd. | 新規なアデニン化合物 |
| WO2007049771A1 (ja) * | 2005-10-28 | 2007-05-03 | Ono Pharmaceutical Co., Ltd. | 塩基性基を含有する化合物およびその用途 |
| CA2644850A1 (en) * | 2006-03-08 | 2007-09-13 | Amgen Inc. | Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors |
| WO2007108968A2 (en) | 2006-03-13 | 2007-09-27 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
| CN101479269A (zh) | 2006-06-23 | 2009-07-08 | 阿斯利康(瑞典)有限公司 | 蝶啶衍生物及其作为组织蛋白酶抑制剂的用途 |
| ES2627352T3 (es) | 2006-10-19 | 2017-07-27 | Signal Pharmaceuticals, Llc | Compuestos heteroarilo, sus composiciones y su uso como inhibidores de proteínas quinasas |
| JP2010519186A (ja) | 2007-02-19 | 2010-06-03 | スミスクライン ビーチャム コーポレーション | 免疫調節物質としてのプリン誘導体 |
| CN101636399B (zh) | 2007-03-22 | 2012-04-18 | 武田药品工业株式会社 | 可用作plk1抑制剂的取代的嘧啶并二氮杂* |
| WO2008124575A1 (en) * | 2007-04-05 | 2008-10-16 | Smithkline Beecham Corporation | Renin inhibitors |
| JP2010523599A (ja) * | 2007-04-05 | 2010-07-15 | シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド | クリックケミストリーを使用した炭酸脱水酵素−ｉｘのための分子イメージングプローブの開発 |
| KR101524817B1 (ko) * | 2007-04-18 | 2015-06-01 | 깃세이 야쿠힌 고교 가부시키가이샤 | 질소 함유 축합환 유도체, 그것을 함유하는 의약 조성물 및 그 의약 용도 |
| AU2008287339A1 (en) | 2007-08-15 | 2009-02-19 | Vertex Pharmaceuticals Incorporated | 4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5H-pyrimido [4, 5-b][1, 4] diazepin-2-ylamino)-3-methoxybenzamide Derivatives as Inhibitors of the Human Protein Kinases PLK1 to PLK4 for the Treatment of Proliferative Diseases |
| WO2009022185A2 (en) | 2007-08-16 | 2009-02-19 | Astrazeneca Ab | 6, 6-fused heterocycles, their pharmaceutical compositions and methos of use |
| WO2009067547A1 (en) | 2007-11-19 | 2009-05-28 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
| CN101284810A (zh) * | 2008-06-02 | 2008-10-15 | 秦引林 | 氰基吡咯烷和氰基噻唑烷衍生物 |
| UY32306A (es) * | 2008-12-09 | 2010-07-30 | Gilead Sciences Inc | Derivados de pteridinona y pirimidinodiazepinona y composiciones farmacéuticas que modulan en forma selectiva los receptores tipo toll, métodos y usos |
| WO2011031965A1 (en) * | 2009-09-14 | 2011-03-17 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
| TW201306841A (zh) | 2010-12-20 | 2013-02-16 | Gilead Sciences Inc | 治療ｃ型肝炎病毒（ｈｃｖ）之方法 |
-
2015
- 2015-09-14 CN CN201580050126.2A patent/CN107074860B/zh active Active
- 2015-09-14 EA EA201790373A patent/EA201790373A1/ru unknown
- 2015-09-14 AU AU2015318062A patent/AU2015318062B2/en active Active
- 2015-09-14 US US14/853,883 patent/US9573952B2/en active Active
- 2015-09-14 JP JP2017514494A patent/JP6373490B2/ja active Active
- 2015-09-14 ES ES20207453T patent/ES2975520T3/es active Active
- 2015-09-14 PL PL18205728T patent/PL3461828T3/pl unknown
- 2015-09-14 KR KR1020177009930A patent/KR101978809B1/ko active Active
- 2015-09-14 TW TW104130275A patent/TWI692468B/zh active
- 2015-09-14 EP EP15778411.7A patent/EP3194402B1/en active Active
- 2015-09-14 SI SI201531451T patent/SI3461828T1/sl unknown
- 2015-09-14 TW TW109111477A patent/TWI780423B/zh active
- 2015-09-14 ES ES15778411T patent/ES2706527T3/es active Active
- 2015-09-14 CN CN202210865358.5A patent/CN115043840A/zh active Pending
- 2015-09-14 NZ NZ729526A patent/NZ729526A/en not_active IP Right Cessation
- 2015-09-14 SG SG11201701472VA patent/SG11201701472VA/en unknown
- 2015-09-14 EP EP20207453.0A patent/EP3848375B1/en active Active
- 2015-09-14 EP EP18205728.1A patent/EP3461828B1/en active Active
- 2015-09-14 BR BR112017005100A patent/BR112017005100A2/pt active Search and Examination
- 2015-09-14 KR KR1020217030537A patent/KR102457426B1/ko active Active
- 2015-09-14 PL PL20207453.0T patent/PL3848375T3/pl unknown
- 2015-09-14 KR KR1020197013364A patent/KR102306860B1/ko active Active
- 2015-09-14 ES ES18205728T patent/ES2845205T3/es active Active
- 2015-09-14 PT PT15778411T patent/PT3194402T/pt unknown
- 2015-09-14 PT PT182057281T patent/PT3461828T/pt unknown
- 2015-09-14 WO PCT/US2015/050039 patent/WO2016044183A1/en not_active Ceased
- 2015-09-14 CA CA2960384A patent/CA2960384C/en active Active
- 2015-09-14 MX MX2017003288A patent/MX2017003288A/es unknown
- 2015-09-16 AR ARP150102954A patent/AR101882A1/es unknown
-
2017
- 2017-02-28 IL IL250849A patent/IL250849A0/en unknown
-
2018
- 2018-07-17 JP JP2018134200A patent/JP6596127B2/ja active Active
- 2018-09-27 AU AU2018236824A patent/AU2018236824B2/en active Active
-
2019
- 2019-09-27 JP JP2019176572A patent/JP7063865B2/ja active Active
-
2022
- 2022-02-04 JP JP2022016438A patent/JP7333843B2/ja active Active
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