|
US6395888B1
(en)
*
|
1996-02-01 |
2002-05-28 |
Gilead Sciences, Inc. |
High affinity nucleic acid ligands of complement system proteins
|
|
DE69534701T2
(de)
*
|
1994-09-23 |
2006-10-19 |
Alexion Pharmaceuticals, Inc., Cheshire |
Verfahren zur behandlung von entzündlichen gelenkerkrankungen
|
|
US7112327B2
(en)
|
1998-02-20 |
2006-09-26 |
Tanox, Inc. |
Inhibition of complement activation
|
|
WO1999042133A1
(en)
|
1998-02-20 |
1999-08-26 |
Tanox, Inc. |
Inhibitors of complement activation
|
|
US6956107B2
(en)
|
1998-02-20 |
2005-10-18 |
Tanox, Inc. |
Inhibitors of complement activation
|
|
DE19913707A1
(de)
*
|
1999-03-26 |
2000-10-05 |
Privates Inst Bioserv Gmbh |
Immunadsorber zur Sepsistherapie
|
|
IL147183A0
(en)
*
|
1999-06-29 |
2002-08-14 |
Autogen Res Pty Ltd |
Novel genes and their use in the modulation of obesity, diabetes and energy imbalance
|
|
JP4764590B2
(ja)
|
2000-04-29 |
2011-09-07 |
ユニバーシティー オブ アイオワ リサーチ ファウンデーション |
黄班変性関連疾患の診断および治療
|
|
ES2483991T3
(es)
*
|
2000-10-10 |
2014-08-08 |
Genentech, Inc. |
Anticuerpos contra C5 que inhibe la activación de las células endoteliales de tipo II
|
|
US20020094332A1
(en)
*
|
2001-01-18 |
2002-07-18 |
Alexion Pharmaceuticals |
Method of prophylaxis against large myocardial infractions
|
|
AU2002256624B2
(en)
|
2001-02-19 |
2007-12-06 |
Merck Patent Gmbh |
Method for identification of T-cell epitopes and use for preparing molecules with reduced immunogenicity
|
|
US20030109714A1
(en)
*
|
2001-03-22 |
2003-06-12 |
Neil Wishart |
Transition metal mediated process
|
|
JP2004536138A
(ja)
*
|
2001-07-26 |
2004-12-02 |
アレクシオン ファーマシューティカルズ， インコーポレイテッド |
認識機能を改善する方法
|
|
EP1878441B1
(en)
|
2001-08-17 |
2018-01-24 |
Genentech, Inc. |
Complement pathway inhibitors binding to C5 and C5a without preventing the formation of C5b
|
|
EP1425042B2
(en)
*
|
2001-08-17 |
2016-02-10 |
Genentech, Inc. |
Complement pathway inhibitors binding to c5 and c5a without preventing the formation of c5b
|
|
EP2298817A1
(en)
|
2001-12-03 |
2011-03-23 |
Alexion Pharmaceuticals, Inc. |
Hybrid antibodies
|
|
AU2003223288A1
(en)
*
|
2002-03-18 |
2003-10-08 |
Alexion Pharmaceuticals, Inc. |
Stratification of patient populations having or suspected of having rheumatoid arthritis
|
|
ITMI20021527A1
(it)
*
|
2002-07-11 |
2004-01-12 |
Consiglio Nazionale Ricerche |
Anticorpi anti componente c5 del complemento e loro uso
|
|
US20050271660A1
(en)
|
2002-09-06 |
2005-12-08 |
Alexion Pharmaceuticals, Inc. |
Nebulization of monoclonal antibodies for treating pulmonary diseases
|
|
US9415102B2
(en)
|
2002-09-06 |
2016-08-16 |
Alexion Pharmaceuticals, Inc. |
High concentration formulations of anti-C5 antibodies
|
|
NZ538384A
(en)
*
|
2002-09-06 |
2009-04-30 |
Alexion Pharma Inc |
Treatment for asthma using a compound which binds to or otherwise blocks the generation and/or activity of one or more complement components reptors, such as, C5a receptors
|
|
US7361339B2
(en)
*
|
2003-01-09 |
2008-04-22 |
Alexion Pharmaceuticals, Inc. |
Methods for reducing morality associated with acute myocardial infarction
|
|
EP1718674A4
(en)
*
|
2004-01-28 |
2008-05-07 |
Anil K Chauhan |
MEMBRANE ATTACK COMPLEXES ASSOCIATED WITH IMMUNE TRAFFIC COMPLEXES
|
|
US20050169921A1
(en)
|
2004-02-03 |
2005-08-04 |
Leonard Bell |
Method of treating hemolytic disease
|
|
US20070116710A1
(en)
*
|
2004-02-03 |
2007-05-24 |
Leonard Bell |
Methods of treating hemolytic anemia
|
|
US7803931B2
(en)
|
2004-02-12 |
2010-09-28 |
Archemix Corp. |
Aptamer therapeutics useful in the treatment of complement-related disorders
|
|
JP5161567B2
(ja)
|
2004-05-14 |
2013-03-13 |
アレクシオン ファーマシューティカルズ， インコーポレイテッド |
補体活性を阻害することによる同種移植片の生存の延長
|
|
US7973134B2
(en)
*
|
2004-07-07 |
2011-07-05 |
Cell Signaling Technology, Inc. |
Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways
|
|
US7935790B2
(en)
*
|
2004-10-04 |
2011-05-03 |
Cell Singaling Technology, Inc. |
Reagents for the detection of protein phosphorylation in T-cell receptor signaling pathways
|
|
US7807789B2
(en)
*
|
2004-12-21 |
2010-10-05 |
Cell Signaling Technology, Inc. |
Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
|
|
US20090099340A1
(en)
*
|
2007-10-12 |
2009-04-16 |
Cell Signaling Technology, Inc. |
Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
|
|
US20070292421A1
(en)
*
|
2005-07-28 |
2007-12-20 |
Feinberg Bruce B |
Method for treating preeclampsia
|
|
US20100151495A9
(en)
*
|
2005-08-31 |
2010-06-17 |
Cell Signaling Technolgy, Inc. |
Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
|
|
WO2007027906A2
(en)
|
2005-08-31 |
2007-03-08 |
Cell Signaling Technology, Inc. |
Reagents for the detection of protein phosphorylation in leukemia signaling pathways
|
|
KR20130137716A
(ko)
|
2005-11-04 |
2013-12-17 |
제넨테크, 인크. |
안질환 치료를 위한 보체 경로 억제제의 용도
|
|
US20120208824A1
(en)
|
2006-01-20 |
2012-08-16 |
Cell Signaling Technology, Inc. |
ROS Kinase in Lung Cancer
|
|
US20070196367A1
(en)
*
|
2006-02-22 |
2007-08-23 |
Valentin Dinu |
Methods of preventing and treating Alzheimer's disease, age related macular degeneration and other diseases involving extra-cellular debris through the inhibition of the complement system
|
|
ES2530637T3
(es)
*
|
2006-03-02 |
2015-03-04 |
Alexion Pharma Inc |
Prolongación de la supervivencia de un aloinjerto por inhibición de la actividad del complemento
|
|
EP3034094A1
(en)
|
2006-03-08 |
2016-06-22 |
Archemix LLC |
Complement binding aptamers and anti-c5 agents useful in the treatment of ocular disorders
|
|
EP4316465A3
(en)
|
2006-03-15 |
2024-04-24 |
Alexion Pharmaceuticals, Inc. |
Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement
|
|
IN2014DN10515A
(show.php)
|
2006-03-31 |
2015-08-21 |
Chugai Pharmaceutical Co Ltd |
|
|
US20090298093A1
(en)
*
|
2006-04-27 |
2009-12-03 |
Roberto Polakiewicz |
Reagents for the Detection of Protein Phosphorylation in ATM & ATR Kinase Signaling Pathways
|
|
AU2006343402A1
(en)
*
|
2006-05-01 |
2007-11-15 |
Alexion Pharmaceuticals, Inc. |
Methods for the treatment of muscular dystrophy associated with dysferlin-deficiency
|
|
EP2044111B1
(en)
|
2006-06-21 |
2014-08-13 |
MUSC Foundation For Research Development |
Targeting complement factor h for treatment of diseases
|
|
US7939636B2
(en)
*
|
2006-08-11 |
2011-05-10 |
Cell Signaling Technology, Inc. |
Reagents for the detection of protein phosphorylation in c-Src signaling pathways
|
|
US20090258442A1
(en)
*
|
2006-08-31 |
2009-10-15 |
Cell Signaling Technology, Inc. |
Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
|
|
NZ575018A
(en)
|
2006-09-05 |
2012-04-27 |
Alexion Pharma Inc |
Compositions for the treatment of antibody mediated neuropathies
|
|
EP2698166B1
(en)
|
2006-10-10 |
2015-09-30 |
Regenesance B.V. |
Complement inhibition for improved nerve regeneration
|
|
US20090041764A1
(en)
*
|
2006-10-20 |
2009-02-12 |
Alexion Pharmaceuticals, Inc. |
Methods for the treatment of muscular dystrophy associated with dysferlin-deficiency
|
|
MY157948A
(en)
|
2006-11-02 |
2016-08-30 |
Genentech Inc |
Humanized anti-factor d antibodies
|
|
RU2325651C1
(ru)
*
|
2006-12-22 |
2008-05-27 |
ФГУ "Российский научно-исследовательский институт геронтологии Росздрава" |
Способ диагностики гломерулонефрита
|
|
EP1972639A3
(en)
|
2007-03-07 |
2008-12-03 |
Cell Signaling Technology, Inc. |
Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
|
|
EP2129681A2
(en)
*
|
2007-03-22 |
2009-12-09 |
Novartis Ag |
C5 antigens and uses thereof
|
|
US20090068684A1
(en)
*
|
2007-03-26 |
2009-03-12 |
Cell Signaling Technology, Inc. |
Serine and threoninephosphorylation sites
|
|
US20080238709A1
(en)
*
|
2007-03-28 |
2008-10-02 |
Faramarz Vaziri |
One-way communication apparatus with dynamic key generation
|
|
US7977462B2
(en)
|
2007-04-19 |
2011-07-12 |
Cell Signaling Technology, Inc. |
Tyrosine phosphorylation sites
|
|
EP2145902A3
(en)
|
2007-04-19 |
2010-09-29 |
Peter Hornbeck |
Tyrosine phosphorylation sites and antibodies specific for them
|
|
EP1983003A3
(en)
|
2007-04-19 |
2009-03-11 |
Peter Hornbeck |
Tyrosine phosphorylation sites and antibodies specific for them
|
|
US20090053831A1
(en)
|
2007-05-01 |
2009-02-26 |
Cell Signaling Technology, Inc. |
Tyrosine phosphorylation sites
|
|
BRPI0815399A2
(pt)
*
|
2007-08-13 |
2019-09-24 |
Vasgene Therapeutics Inc |
tratamento de câncer usando anticorpos humanizados que se ligam ephb4
|
|
AU2008304778B9
(en)
|
2007-09-26 |
2014-05-08 |
Chugai Seiyaku Kabushiki Kaisha |
Method of modifying isoelectric point of antibody via amino acid substitution in CDR
|
|
JP5769968B2
(ja)
|
2007-10-18 |
2015-08-26 |
セル・シグナリング・テクノロジー・インコーポレイテツド |
ヒト非小細胞肺癌における転座および変異ｒｏｓキナーゼ
|
|
US20090203043A1
(en)
|
2007-11-21 |
2009-08-13 |
Peter Hornbeck |
Protein phosphorylation by basophilic serine/threonine kinases in insulin signaling pathways
|
|
US12492253B1
(en)
|
2008-02-25 |
2025-12-09 |
Xencor, Inc. |
Anti-human C5 antibodies
|
|
US20220281964A1
(en)
*
|
2008-02-25 |
2022-09-08 |
Xencor, Inc. |
Fc VARIANTS WITH ALTERED BINDING TO FcRn
|
|
US20090220991A1
(en)
*
|
2008-02-29 |
2009-09-03 |
Cell Signaling Technology, Inc. |
Reagents for the detection of protein phosphorylation in leukemia signaling pathways
|
|
EP3023502A1
(en)
|
2008-04-10 |
2016-05-25 |
Cell Signaling Technology, Inc. |
Compositions and methods for detecting egfr mutations in cancer
|
|
HRP20160209T1
(hr)
|
2008-04-11 |
2016-03-25 |
Chugai Pharmaceutical Co Ltd |
Antigenski vežuća molekula koja se može višekratno vezati na dva ili više antigena
|
|
CR20170001A
(es)
|
2008-04-28 |
2017-08-10 |
Genentech Inc |
Anticuerpos anti factor d humanizados
|
|
JP2011519373A
(ja)
*
|
2008-05-01 |
2011-07-07 |
コンプレクザ インコーポレイテッド |
ビニル置換脂肪酸
|
|
US8148088B2
(en)
*
|
2008-07-18 |
2012-04-03 |
Abgent |
Regulation of autophagy pathway phosphorylation and uses thereof
|
|
ES2643411T3
(es)
*
|
2008-08-05 |
2017-11-22 |
Novartis Ag |
Composiciones y métodos para anticuerpos dirigidos a la proteína del complemento C5
|
|
AU2014201433B2
(en)
*
|
2008-08-05 |
2016-05-26 |
Novartis Ag |
Compositions and methods for antibodies targeting complement protein C5
|
|
US20110165232A1
(en)
*
|
2008-09-16 |
2011-07-07 |
Ak Kimya Ithalat-Ihracat Ve Sanayii Anonim Sirketi |
Use of Opioid Antagonists for the Preparation of a Medicament in the Treatment of Retinal Degenerative Diseases
|
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
HRP20230167T1
(hr)
|
2008-11-10 |
2023-03-31 |
Alexion Pharmaceuticals, Inc. |
Postupci i pripravci za liječenje poremećaja povezanih s komplementom
|
|
DK2881402T3
(en)
|
2009-02-12 |
2017-08-28 |
Cell Signaling Technology Inc |
Mutant ROS expression in human liver cancer
|
|
ES2738700T3
(es)
|
2009-02-13 |
2020-01-24 |
Immunomedics Inc |
Inmunoconjugados con un enlace escindible intracelularmente
|
|
US9493551B2
(en)
|
2009-02-24 |
2016-11-15 |
Alexion Pharmaceuticals, Inc. |
Antibodies containing therapeutic TPO/EPO mimetic peptides
|
|
US20100248265A1
(en)
*
|
2009-02-27 |
2010-09-30 |
The Salk Institute For Biological Studies |
Compositions and methods for diagnosis and treatment of cancer
|
|
CA2766565A1
(en)
|
2009-06-23 |
2010-12-29 |
Alexion Pharmaceuticals, Inc. |
Bispecific antibodies that bind to complement proteins
|
|
EP2453906A4
(en)
|
2009-07-02 |
2014-01-15 |
Musc Found For Res Dev |
METHOD FOR STIMULATING THE LIVER REGENERATION
|
|
EP3009455A1
(en)
|
2009-09-16 |
2016-04-20 |
Immunomedics Inc. |
Class i anti-cea antibodies and uses thereof
|
|
US8323670B2
(en)
*
|
2009-10-01 |
2012-12-04 |
Ak Kimya Ithalat-Ihracat Ve Sanayii A.S. |
Topical compositions of opioid antagonists and methods for treating skin conditions therewith
|
|
WO2011057158A1
(en)
|
2009-11-05 |
2011-05-12 |
Taligen Therapeutics, Inc. |
Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis
|
|
ES2978177T3
(es)
|
2009-12-02 |
2024-09-06 |
Immunomedics Inc |
Combinación de radio inmunoterapia y conjugados anticuerpo-fármaco para mejorar la terapia contra el cáncer
|
|
EP2542255B1
(en)
*
|
2010-03-01 |
2016-11-16 |
Alexion Pharmaceuticals, Inc. |
Compositions for treating degos' disease
|
|
TWI667346B
(zh)
*
|
2010-03-30 |
2019-08-01 |
中外製藥股份有限公司 |
促進抗原消失之具有經修飾的FcRn親和力之抗體
|
|
TR201002473A2
(tr)
|
2010-03-31 |
2011-09-21 |
Mustafa Nevzat �La� Sanay�� A.�. |
Herpes zoster hastalığının bır opiat reseptör antagonist kullanılarak tedavi yöntemi.
|
|
CA2797856C
(en)
|
2010-04-30 |
2018-09-18 |
Alexion Pharmaceuticals, Inc. |
Anti-c5a antibodies and methods for using the antibodies
|
|
SG185107A1
(en)
*
|
2010-04-30 |
2012-12-28 |
Alexion Pharma Inc |
Antibodies having reduced immunogenicity in a human
|
|
US9650447B2
(en)
|
2010-05-14 |
2017-05-16 |
The Regents Of The University Of Colorado, A Body Corporate |
Complement receptor 2 (CR2) targeting groups
|
|
US9815890B2
(en)
|
2010-06-22 |
2017-11-14 |
The Regents Of The University Of Colorado, A Body Corporate |
Antibodies to the C3d fragment of complement component 3
|
|
US20120101108A1
(en)
|
2010-08-06 |
2012-04-26 |
Cell Signaling Technology, Inc. |
Anaplastic Lymphoma Kinase In Kidney Cancer
|
|
US8822663B2
(en)
|
2010-08-06 |
2014-09-02 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
EP2622064B1
(en)
|
2010-10-01 |
2019-05-29 |
Modernatx, Inc. |
Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
|
|
TW201241008A
(en)
*
|
2010-10-01 |
2012-10-16 |
Alexion Pharma Inc |
Polypeptides that bind to human complement component C5
|
|
TWI654203B
(zh)
|
2010-11-30 |
2019-03-21 |
中外製藥股份有限公司 |
具有鈣依存性的抗原結合能力之抗體
|
|
EP2468295A1
(en)
|
2010-12-21 |
2012-06-27 |
Affiris AG |
Vaccines based on peptides of the complement protein C5a
|
|
WO2012115241A1
(ja)
|
2011-02-25 |
2012-08-30 |
中外製薬株式会社 |
FcγRIIb特異的Fc抗体
|
|
US8710200B2
(en)
|
2011-03-31 |
2014-04-29 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids encoding a modified erythropoietin and their expression
|
|
KR101648960B1
(ko)
|
2011-04-15 |
2016-08-22 |
서울대학교산학협력단 |
접합 물질과 코티닌과의 접합체에 항-코티닌 항체가 결합된 복합체 및 이의 용도
|
|
JP6024025B2
(ja)
|
2011-05-02 |
2016-11-09 |
イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． |
少容量投与用のアロタイプ選択抗体の限外濾過濃縮
|
|
MX379206B
(es)
|
2011-06-22 |
2025-03-10 |
Apellis Pharmaceuticals Inc |
Uso de inhibidores del complemento en trastornos crónicos.
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
US20150050269A1
(en)
|
2011-09-30 |
2015-02-19 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
|
|
TW201326209A
(zh)
|
2011-09-30 |
2013-07-01 |
Chugai Pharmaceutical Co Ltd |
具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子
|
|
EP3492109B1
(en)
|
2011-10-03 |
2020-03-04 |
ModernaTX, Inc. |
Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
|
|
US20150056182A1
(en)
|
2011-11-30 |
2015-02-26 |
Chugai Seiyaku Kabushiki Kaisha |
Drug containing carrier into cell for forming immune complex
|
|
HRP20220717T1
(hr)
|
2011-12-16 |
2022-07-22 |
Modernatx, Inc. |
Modificirani pripravci mrna
|
|
KR102159843B1
(ko)
|
2011-12-21 |
2020-09-24 |
노파르티스 아게 |
인자 p를 표적화하는 항체에 대한 조성물 및 방법
|
|
WO2013118858A1
(ja)
|
2012-02-09 |
2013-08-15 |
中外製薬株式会社 |
抗体のFc領域改変体
|
|
SMT201900189T1
(it)
|
2012-02-20 |
2019-05-10 |
Swedish Orphan Biovitrum Ab Publ |
Polipeptidi che si legano al c5 del complemento umano
|
|
US10501512B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
WO2013151665A2
(en)
|
2012-04-02 |
2013-10-10 |
modeRNA Therapeutics |
Modified polynucleotides for the production of proteins associated with human disease
|
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
SMT201800253T1
(it)
|
2012-04-06 |
2018-07-17 |
Omeros Corp |
Composizioni e metodi per inibire masp-1 e/o masp-3 per il trattamento di emoglobinuria parossistica notturna
|
|
DK2838998T3
(en)
|
2012-04-18 |
2018-01-15 |
Cell Signaling Technology Inc |
EGFR AND ROS1 IN CANCER
|
|
RU2019140356A
(ru)
|
2012-06-18 |
2020-01-27 |
Омерос Корпорейшн |
Композиции и способы ингибирования masp-1, и/или masp-2, и/или masp-3 для лечения различных заболеваний и нарушений
|
|
US9315567B2
(en)
|
2012-08-14 |
2016-04-19 |
Ibc Pharmaceuticals, Inc. |
T-cell redirecting bispecific antibodies for treatment of disease
|
|
US10413620B2
(en)
|
2012-08-17 |
2019-09-17 |
The Regents Of The University Of Colorado, A Body Corporate |
Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging
|
|
WO2014028865A1
(en)
|
2012-08-17 |
2014-02-20 |
The Regents Of The University Of Colorado, A Body Corporate |
Compositions and methods for detecting complement activation
|
|
DK2889377T3
(da)
|
2012-08-24 |
2020-03-30 |
Chugai Pharmaceutical Co Ltd |
Fc?RIIb-Specifik Fc-regionsvariant
|
|
TW201418707A
(zh)
*
|
2012-09-21 |
2014-05-16 |
Alexion Pharma Inc |
補體組分ｃ５拮抗劑之篩選分析
|
|
US9597380B2
(en)
|
2012-11-26 |
2017-03-21 |
Modernatx, Inc. |
Terminally modified RNA
|
|
CA3177936A1
(en)
|
2012-12-13 |
2014-06-19 |
Immunomedics, Inc. |
Dosages of immunoconjugates of antibodies and sn-38 for improved efficacy and decreased toxicity
|
|
BR112015018438A2
(pt)
*
|
2013-01-31 |
2017-07-18 |
Seoul Nat Univ R&Db Foundation |
anticorpo contra c5 e método para prevenir e tratar doenças relacionadas a complemento
|
|
KR20160043927A
(ko)
|
2013-03-14 |
2016-04-22 |
파카쉬 길 |
세포 표면 grp78에 결합하는 항체를 사용하는 암 치료
|
|
AU2014244116B9
(en)
|
2013-03-14 |
2020-08-13 |
Alnylam Pharmaceuticals, Inc. |
Complement component C5 iRNA compositions and methods of use thereof
|
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
|
JP6505079B2
(ja)
|
2013-03-29 |
2019-04-24 |
アレクシオン ファーマシューティカルズ， インコーポレイテッド |
補体ｃ５を標的とする治療薬の血清半減期を増加させるための組成物及び方法
|
|
SG11201508170TA
(en)
|
2013-04-02 |
2015-11-27 |
Chugai Pharmaceutical Co Ltd |
Fc REGION VARIANT
|
|
US10208125B2
(en)
|
2013-07-15 |
2019-02-19 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Anti-mucin 1 binding agents and uses thereof
|
|
KR102448976B1
(ko)
|
2013-08-07 |
2022-09-29 |
알렉시온 파마슈티칼스, 인코포레이티드 |
비정형적 용혈성 요독증후군 (ahus) 바이오마커 단백질
|
|
AU2014306867B2
(en)
|
2013-08-12 |
2017-10-26 |
Genentech, Inc. |
Compositions and method for treating complement-associated conditions
|
|
US20160184391A1
(en)
*
|
2013-08-16 |
2016-06-30 |
Alexion Pharmaceuticals, Inc. |
Treatment of graft rejection by administering a complement inhibitor to an organ prior to transplant
|
|
UA117933C2
(uk)
|
2013-08-28 |
2018-10-25 |
Сведіш Орфан Біовітрум Аб (Пабл) |
Поліпептид, здатний зв'язувати с5-компонент комплементу людини
|
|
PT3039033T
(pt)
|
2013-08-28 |
2019-09-06 |
Affibody Ab |
Polipéptidos de ligação com um scaffold mutado
|
|
WO2015048744A2
(en)
|
2013-09-30 |
2015-04-02 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding immune modulating polypeptides
|
|
SG11201602503TA
(en)
|
2013-10-03 |
2016-04-28 |
Moderna Therapeutics Inc |
Polynucleotides encoding low density lipoprotein receptor
|
|
US20150104445A1
(en)
|
2013-10-10 |
2015-04-16 |
Viropharma Holdings Limited |
Methods of inhibiting the alternative pathway of complement immune system activation and compositions used therein
|
|
JP6710638B2
(ja)
|
2013-12-12 |
2020-06-17 |
アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． |
補体成分ｉＲＮＡ組成物及びその使用方法
|
|
US10238700B2
(en)
|
2014-01-02 |
2019-03-26 |
Genelux Corporation |
Oncolytic virus adjunct therapy with agents that increase virus infectivity
|
|
US20170073754A1
(en)
|
2014-02-07 |
2017-03-16 |
Novartis Ag |
Impact of genetic factors on disease progression and response to anti-c5 antibody in geographic atrophy
|
|
CA3177696A1
(en)
|
2014-02-20 |
2015-08-27 |
Allergan, Inc. |
Complement component c5 antibodies
|
|
JP6447933B2
(ja)
|
2014-02-21 |
2019-01-09 |
アイビーシー ファーマスーティカルズ，インコーポレイテッド |
Ｔｒｏｐ−２発現細胞に対する免疫応答を誘発することによる疾患治療
|
|
WO2015130416A1
(en)
|
2014-02-25 |
2015-09-03 |
Immunomedics, Inc. |
Humanized rfb4 anti-cd22 antibody
|
|
CA2940772C
(en)
|
2014-02-25 |
2024-06-11 |
Achillion Pharmaceuticals, Inc. |
Aryl, heteroaryl, and heterocyclic compounds for treatment of complement mediated disorders
|
|
BR112016019286B1
(pt)
*
|
2014-02-26 |
2024-02-20 |
Allergan, Inc. |
Anticorpo anti-c5
|
|
NZ711451A
(en)
|
2014-03-07 |
2016-05-27 |
Alexion Pharma Inc |
Anti-c5 antibodies having improved pharmacokinetics
|
|
US10179821B2
(en)
|
2014-05-01 |
2019-01-15 |
Genentech, Inc. |
Anti-factor D antibodies
|
|
SG11201608696RA
(en)
|
2014-05-05 |
2016-11-29 |
Regeneron Pharma |
Humanized c5 and c3 animals
|
|
CN119236050A
(zh)
|
2014-06-12 |
2025-01-03 |
Ra制药公司 |
补体活性的调节
|
|
EP3160504B1
(en)
|
2014-06-24 |
2020-09-16 |
Immunomedics, Inc. |
Anti-histone therapy for vascular necrosis in severe glomerulonephritis
|
|
WO2016033382A1
(en)
*
|
2014-08-27 |
2016-03-03 |
Capnia, Inc. |
Methods for immune globulin administration
|
|
EP3191591A1
(en)
|
2014-09-12 |
2017-07-19 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting complement component c5 and methods of use thereof
|
|
EP3954373A1
(en)
|
2014-10-07 |
2022-02-16 |
Immunomedics, Inc. |
Neoadjuvant use of antibody-drug conjugates
|
|
JP6948942B2
(ja)
|
2014-10-15 |
2021-10-13 |
アレクシオン ファーマシューティカルズ， インコーポレイテッド |
タンパク質産物の等電性プロファイルをシフトさせる方法およびその使用
|
|
WO2016061165A1
(en)
|
2014-10-15 |
2016-04-21 |
Alexion Pharmaceuticals, Inc. |
Methods of culturing a cell
|
|
US10544209B2
(en)
|
2014-10-15 |
2020-01-28 |
Alexion Pharmaceuticals, Inc. |
Methods of replicating a large scale eculizumab production cell culture
|
|
WO2016094834A2
(en)
|
2014-12-12 |
2016-06-16 |
Alexion Pharmaceuticals, Inc. |
A method for treating a complement mediated disorder caused by an infectious agent in a patient
|
|
MX2017005774A
(es)
|
2014-12-19 |
2017-07-28 |
Chugai Pharmaceutical Co Ltd |
Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso.
|
|
TWI725847B
(zh)
|
2014-12-19 |
2021-04-21 |
日商中外製藥股份有限公司 |
抗c5抗體及使用方法
|
|
WO2016117346A1
(en)
|
2015-01-22 |
2016-07-28 |
Chugai Seiyaku Kabushiki Kaisha |
A combination of two or more anti-c5 antibodies and methods of use
|
|
EP3988110A1
(en)
|
2015-01-28 |
2022-04-27 |
RA Pharmaceuticals, Inc. |
Modulators of complement activity
|
|
EP3274724A1
(en)
|
2015-03-25 |
2018-01-31 |
Alexion Pharmaceuticals, Inc. |
A method for measuring the protease activity of factor d of the alternative complement pathway
|
|
TR201904903T4
(tr)
|
2015-03-25 |
2019-05-21 |
Alexion Pharma Inc |
Alternatif tamamlama yolağının C3 ve C5 konvertazının proteaz aktivitesinin ölçülmesine yönelik bir yöntem.
|
|
EP3286224A4
(en)
|
2015-04-22 |
2018-11-14 |
Immunomedics, Inc. |
Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells
|
|
WO2016178980A1
(en)
|
2015-05-01 |
2016-11-10 |
Alexion Pharmaceuticals, Inc. |
Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of kindney thansplant
|
|
CA2986957A1
(en)
|
2015-06-03 |
2016-12-08 |
Children's Hospital Medical Center |
Compositions and methods for treating neonatal biliary atresia
|
|
WO2016200627A1
(en)
|
2015-06-09 |
2016-12-15 |
Children's Hospital Medical Center |
Dosing algorithm for complement inhibitor
|
|
WO2016201301A1
(en)
|
2015-06-12 |
2016-12-15 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions and methods of use thereof
|
|
CN114796500A
(zh)
|
2015-06-25 |
2022-07-29 |
免疫医疗公司 |
组合抗trop-2抗体与微管抑制剂、parp抑制剂使癌症治疗结果显著改善
|
|
EP3313437A1
(en)
*
|
2015-06-26 |
2018-05-02 |
Alexion Pharmaceuticals, Inc. |
A method for treating a patient in compliance with vaccination with eculizumab or an eculizumab variant
|
|
PL3316885T3
(pl)
|
2015-07-01 |
2021-12-06 |
Immunomedics, Inc. |
Immunokoniugaty przeciwciało-sn-38 z linkerem cl2a
|
|
WO2017035409A1
(en)
|
2015-08-26 |
2017-03-02 |
Achillion Pharmaceuticals, Inc. |
Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
|
|
WO2017035361A1
(en)
|
2015-08-26 |
2017-03-02 |
Achillion Pharmaceuticals, Inc. |
Disubstituted compounds for the treatment of medical disorders
|
|
AR105808A1
(es)
|
2015-08-26 |
2017-11-08 |
Achillion Pharmaceuticals Inc |
Compuestos de amida para el tratamiento de trastornos médicos
|
|
WO2017035405A1
(en)
|
2015-08-26 |
2017-03-02 |
Achillion Pharmaceuticals, Inc. |
Amino compounds for treatment of immune and inflammatory disorders
|
|
ES2908479T3
(es)
|
2015-08-26 |
2022-04-29 |
Achillion Pharmaceuticals Inc |
Compuestos para el tratamiento de trastornos inmunitarios e inflamatorios
|
|
WO2017035351A1
(en)
|
2015-08-26 |
2017-03-02 |
Achillion Pharmaceuticals, Inc. |
Amino compounds for treatment of medical disorders
|
|
AR105809A1
(es)
|
2015-08-26 |
2017-11-08 |
Achillion Pharmaceuticals Inc |
Compuestos para el tratamiento de trastornos médicos
|
|
WO2017035401A1
(en)
|
2015-08-26 |
2017-03-02 |
Achillion Pharmaceuticals, Inc. |
Amide compounds for treatment of immune and inflammatory disorders
|
|
US10385097B2
(en)
|
2015-08-26 |
2019-08-20 |
Achillion Pharmaceuticals, Inc. |
Ether compounds for treatment of medical disorders
|
|
US10000516B2
(en)
|
2015-08-26 |
2018-06-19 |
Achillion Pharmaceuticals, Inc. |
Phosphonate compounds for treatment of medical disorders
|
|
AR106018A1
(es)
|
2015-08-26 |
2017-12-06 |
Achillion Pharmaceuticals Inc |
Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
|
|
EP3328885A1
(en)
|
2015-09-11 |
2018-06-06 |
Bruce Andrien |
Recombinant glycosylated eculizumab and eculizumab variants
|
|
EP3349773A4
(en)
|
2015-09-14 |
2019-05-01 |
Cincinnati Children's Hospital Medical Center |
METHOD AND COMPOSITIONS FOR TREATING GAUCHER DISEASE BY MODULATION OF THE C5A RECEPTOR
|
|
US11203634B2
(en)
|
2015-10-07 |
2021-12-21 |
Alexion Pharmaceuticals, Inc. |
Methods of treating age-related macular degeneration in a patient comprising administering an anti-C5a antibody
|
|
TW201718014A
(zh)
|
2015-10-12 |
2017-06-01 |
諾華公司 |
C5抑制劑於移植相關微血管病之用途
|
|
JP7221691B2
(ja)
|
2015-10-30 |
2023-02-14 |
アレクシオン ファーマシューティカルズ， インコーポレイテッド |
Ｔ細胞媒介性同種移植片血管障害の増悪を抑制する方法
|
|
TW201730211A
(zh)
|
2015-10-30 |
2017-09-01 |
建南德克公司 |
抗因子d抗體及結合物
|
|
US10654932B2
(en)
|
2015-10-30 |
2020-05-19 |
Genentech, Inc. |
Anti-factor D antibody variant conjugates and uses thereof
|
|
MX2018007352A
(es)
|
2015-12-16 |
2019-05-16 |
Ra Pharmaceuticals Inc |
Moduladores de la actividad del complemento.
|
|
FI3390442T3
(fi)
|
2015-12-18 |
2023-11-10 |
Chugai Pharmaceutical Co Ltd |
Anti-C5-vasta-aineita ja käyttömenetelmiä
|
|
AU2017269839A1
(en)
|
2016-05-27 |
2018-11-22 |
Alexion Pharmaceuticals, Inc. |
Methods for treatment of refractory generalized myasthenia gravis
|
|
CN109310760A
(zh)
|
2016-06-07 |
2019-02-05 |
诺华股份有限公司 |
抗c5抗体给药方案
|
|
WO2017214518A1
(en)
|
2016-06-10 |
2017-12-14 |
Alnylam Pharmaceuticals, Inc. |
COMPLETMENT COMPONENT C5 iRNA COMPOSTIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
|
|
KR102534895B1
(ko)
|
2016-06-14 |
2023-05-24 |
리제너론 파아마슈티컬스, 인크. |
항-c5 항체 및 이의 용도
|
|
CN115960223A
(zh)
|
2016-06-17 |
2023-04-14 |
中外制药株式会社 |
抗-c5抗体及使用方法
|
|
MX2018016046A
(es)
|
2016-06-27 |
2019-05-02 |
Achillion Pharmaceuticals Inc |
Quinazolina y compuestos indol para tratar trastornos medicos.
|
|
JOP20170154B1
(ar)
|
2016-08-01 |
2023-03-28 |
Omeros Corp |
تركيبات وطرق لتثبيط masp-3 لعلاج أمراض واضطرابات مختلفة
|
|
AU2017305073B2
(en)
|
2016-08-05 |
2024-02-01 |
Chugai Seiyaku Kabushiki Kaisha |
Composition for prevention or treatment of IL-8 related diseases
|
|
WO2018071624A1
(en)
|
2016-10-12 |
2018-04-19 |
Alexion Pharmaceuticals, Inc. |
Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of a kidney transplant
|
|
EP3526248A4
(en)
|
2016-10-17 |
2020-07-08 |
Musc Foundation for Research Development |
COMPOSITIONS AND METHODS FOR TREATING CENTRAL NERVOUS SYSTEM DAMAGE
|
|
US11828683B2
(en)
|
2016-10-19 |
2023-11-28 |
Alexion Pharmaceuticals, Inc. |
Method of quantitating unbound C5a in a sample
|
|
JP7096240B2
(ja)
|
2016-10-19 |
2022-07-05 |
アレクシオン ファーマシューティカルズ， インコーポレイテッド |
試料中の非結合ｃ５の定量化方法
|
|
WO2018081400A1
(en)
|
2016-10-27 |
2018-05-03 |
Alexion Pharmaceuticals Inc. |
Assay for c5b-9 deposition in complement-associated disorders
|
|
WO2018106859A1
(en)
|
2016-12-07 |
2018-06-14 |
Ra Pharmaceuticals, Inc. |
Modulators of complement activity
|
|
CA3051389A1
(en)
|
2017-01-31 |
2018-08-09 |
Kenji SHINOMIYA |
A pharmaceutical composition for use in the treatment or prevention of a c5-related disease and a method for treating or preventing a c5-related disease
|
|
EP3589287B1
(en)
|
2017-03-01 |
2022-09-14 |
Achillion Pharmaceuticals, Inc. |
Macrocyclic compounds for treatment of medical disorders
|
|
FI3985002T3
(fi)
|
2017-03-01 |
2025-07-30 |
Achillion Pharmaceuticals Inc |
Aryyli-, heteroaryyli- ja heterosyklisiä lääkeyhdisteitä sairauksien hoitoon
|
|
WO2018160891A1
(en)
|
2017-03-01 |
2018-09-07 |
Achillion Pharmaceutical, Inc. |
Pharmaceutical compounds for treatment of medical disorders
|
|
EP3600421A4
(en)
|
2017-03-23 |
2021-01-06 |
The Trustees of The University of Pennsylvania |
ANTI-C5A ANTIBODIES AND USES OF THEM
|
|
US11112411B2
(en)
|
2017-03-31 |
2021-09-07 |
Alexion Pharmaceuticals, Inc. |
Method for simultaneous quantification of ALXN1210 and eculizumab in human serum or urine
|
|
US10376595B2
(en)
|
2017-04-03 |
2019-08-13 |
Inflarx Gmbh |
Treatment of inflammatory diseases with inhibitors of C5a activity
|
|
TWI826364B
(zh)
|
2017-04-03 |
2023-12-21 |
德商因夫萊亞斯有限公司 |
活性抑制劑於發炎性疾病之治療
|
|
JP2020517605A
(ja)
|
2017-04-19 |
2020-06-18 |
アレクシオン ファーマシューティカルズ， インコーポレイテッド |
腎臓移植の感作されたレシピエントにおける抗体媒介性拒絶の予防における抗ｃ５抗体の有効性
|
|
JP7209637B2
(ja)
*
|
2017-04-21 |
2023-01-20 |
ヴォリューション イミュノ ファーマシューティカルズ エスエイ |
自己免疫性水疱症の治療のためのコバーシン
|
|
WO2018203545A1
(ja)
|
2017-05-02 |
2018-11-08 |
国立研究開発法人国立精神・神経医療研究センター |
Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法
|
|
WO2018217638A1
(en)
|
2017-05-22 |
2018-11-29 |
Alexion Pharmaceuticals Inc. |
Dosage and administration of anti-c5 antibodies for treatment of protein-losing enteropathy in patients
|
|
EP3658184B1
(en)
|
2017-07-27 |
2023-09-06 |
Alexion Pharmaceuticals, Inc. |
High concentration anti-c5 antibody formulations
|
|
US20190038623A1
(en)
|
2017-08-02 |
2019-02-07 |
Achillion Pharmaceuticals, Inc. |
Therapeutic regimens for treatment of paroxysmal nocturnal hemoglobinuria
|
|
CN111278857A
(zh)
|
2017-10-04 |
2020-06-12 |
亚力兄制药公司 |
抗c5抗体治疗患有膜增生性肾小球肾炎的患者的剂量和施用
|
|
KR20200070355A
(ko)
|
2017-10-26 |
2020-06-17 |
알렉시온 파마슈티칼스, 인코포레이티드 |
발작성 야간 혈색소뇨 (pnh) 및 비정형 용혈성 요독 증후군 (ahus)의 치료를 위한 항-c5 항체의 투여량 및 투여
|
|
US11866701B2
(en)
|
2017-11-01 |
2024-01-09 |
Alnylam Pharmaceuticals, Inc. |
Complement component C3 iRNA compositions and methods of use thereof
|
|
EP4528277A3
(en)
|
2017-11-29 |
2025-06-18 |
F. Hoffmann-La Roche AG |
Target interference suppressed anti-drug antibody assay
|
|
EP3717004A4
(en)
|
2017-12-01 |
2021-12-01 |
Children's Hospital Medical Center |
COMPOSITIONS FOR BLOCKING INTERERONS AND THEIR METHODS OF USE
|
|
SG11202004662RA
(en)
|
2017-12-13 |
2020-06-29 |
Regeneron Pharma |
Anti-c5 antibody combinations and uses thereof
|
|
US20190247560A1
(en)
|
2018-02-13 |
2019-08-15 |
Gambro Lundia Ab |
Extracorporeal devices and methods of treating complement factor related diseases
|
|
EP3802593B1
(en)
|
2018-05-31 |
2024-09-11 |
Alexion Pharmaceuticals, Inc. |
Dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) in pediatric patients
|
|
WO2019236345A1
(en)
|
2018-06-04 |
2019-12-12 |
Alexion Pharmaceuticals, Inc. |
DOSAGE AND ADMINISTRATION OF ANTI-C5 ANTIBODIES FOR TREATMENT OF ATYPICAL HEMOLYTIC UREMIC SYNDROME (aHUS) IN PEDIATRIC PATIENTS
|
|
WO2019246293A2
(en)
*
|
2018-06-19 |
2019-12-26 |
Atarga, Llc |
Antibody molecules to complement component 5 and uses thereof
|
|
US12312394B2
(en)
|
2018-06-28 |
2025-05-27 |
Alexion Pharmaceuticals, Inc. |
Methods of producing anti-C5 antibodies
|
|
SG10202002898RA
(en)
|
2018-08-01 |
2020-05-28 |
Chugai Pharmaceutical Co Ltd |
A Pharmaceutical Composition For Use In The Treatment Or Prevention Of A C5-Related Disease And A Method For Treating Or Preventing A C5-Related Disease
|
|
JP7538113B2
(ja)
|
2018-08-20 |
2024-08-21 |
アキリオン ファーマシューティカルズ，インコーポレーテッド |
補体ｄ因子の医学的障害の治療のための医薬化合物
|
|
CN112839945A
(zh)
|
2018-09-06 |
2021-05-25 |
艾其林医药公司 |
补体因子d抑制剂的形态形式
|
|
US11814391B2
(en)
|
2018-09-06 |
2023-11-14 |
Achillion Pharmaceuticals, Inc. |
Macrocyclic compounds for the treatment of medical disorders
|
|
JP2022500427A
(ja)
|
2018-09-17 |
2022-01-04 |
国立大学法人京都大学 |
肝傷害又は肝不全の処置のための抗ｃ５剤の投与
|
|
US20200095307A1
(en)
|
2018-09-21 |
2020-03-26 |
Alexion Pharmaceuticals, Inc. |
Compositions and methods for the treatment of neuromyelitis optica
|
|
MX2021003425A
(es)
|
2018-09-25 |
2021-07-16 |
Achillion Pharmaceuticals Inc |
Formas morficas de los inhibidores del factor d del complemento.
|
|
KR20210084533A
(ko)
|
2018-10-30 |
2021-07-07 |
알렉시온 파마슈티칼스, 인코포레이티드 |
발작성 야간 혈색소뇨증 (pnh)의 치료를 위한 항-c5 항체의 피하 투여량 및 투여
|
|
US20210388070A1
(en)
|
2018-10-30 |
2021-12-16 |
Alexion Pharmaceuticals, Inc. |
Co-administration of a hyaluronidase and anti-c5 antibody for treatment of complement-associated conditions
|
|
US20220002393A1
(en)
|
2018-11-20 |
2022-01-06 |
Alexion Pharmaceuticals, Inc. |
Methods for treatment of refractory generalized myasthenia gravis in pediatric patients
|
|
CA3119234A1
(en)
|
2018-11-23 |
2020-05-28 |
Silence Therapeutics Gmbh |
Nucleic acids for inhibiting expression of c3 in a cell
|
|
EP3730617A1
(en)
|
2019-04-26 |
2020-10-28 |
Silence Therapeutics GmbH |
Nucleic acids for inhibiting expression of c3 in a cell
|
|
GB2583560A
(en)
|
2018-12-11 |
2020-11-04 |
Admirx Inc |
Fusion protein constructs for complement associated disease
|
|
AU2019406830A1
(en)
|
2018-12-17 |
2021-07-08 |
Achillion Pharmaceuticals, Inc. |
Targeted dosing for the treatment of complement mediated disorders
|
|
KR20210119420A
(ko)
|
2019-01-25 |
2021-10-05 |
알렉시온 파마슈티칼스, 인코포레이티드 |
비정형 용혈성 요독증후군(ahus)의 치료를 위한 항-c5 항체의 복용량 및 투여
|
|
EP3941462A4
(en)
|
2019-03-22 |
2023-04-05 |
Achillion Pharmaceuticals, Inc. |
PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT-MEDIED DISEASES
|
|
US20220227851A1
(en)
|
2019-05-24 |
2022-07-21 |
Alexion Pharmaceuticals, Inc. |
Methods of treating vitiligo using an anti-c5 antibody
|
|
CA3144923A1
(en)
|
2019-07-31 |
2021-02-04 |
Alexandre Antoine Bernard SOSTELLY |
Dosage and administration regimen for the treatment or prevention of c5-related diseases by the use of the anti-c5 antibody crovalimab
|
|
TWI886139B
(zh)
|
2019-07-31 |
2025-06-11 |
瑞士商赫孚孟拉羅股份公司 |
藉由使用抗c5抗體克羅伐單抗（crovalimab）之治療或預防c5相關疾病之劑量及投藥療程
|
|
WO2021026160A1
(en)
|
2019-08-05 |
2021-02-11 |
Alexion Pharmaceuticals, Inc. |
Methods for treatment of refractory generalized myasthenia gravis with eculizumab
|
|
EP4022060A1
(en)
|
2019-08-27 |
2022-07-06 |
Silence Therapeutics GmbH |
Nucleic acids for inhibiting expression of c3 in a cell
|
|
AU2020369515A1
(en)
|
2019-10-22 |
2022-04-21 |
Alnylam Pharmaceuticals, Inc. |
Complement component C3 iRNA compositions and methods of use thereof
|
|
EP4081805A1
(en)
|
2019-12-23 |
2022-11-02 |
Alexion Pharmaceuticals, Inc. |
Methods of treating pregnancy-associated atypical hemolytic uremic syndrome using an anti-c5 antibody
|
|
WO2021154941A1
(en)
|
2020-01-31 |
2021-08-05 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
|
|
CN115362162A
(zh)
|
2020-02-20 |
2022-11-18 |
艾其林医药公司 |
用于治疗补体因子d介导的障碍的杂芳基化合物
|
|
WO2021178607A1
(en)
|
2020-03-05 |
2021-09-10 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases
|
|
WO2021190770A1
(en)
|
2020-03-27 |
2021-09-30 |
Inflarx Gmbh |
INHIBITORS OF C5A FOR THE TREATMENT OF CORONA VIRUS Infection
|
|
EP4135837A1
(en)
|
2020-04-16 |
2023-02-22 |
Assistance Publique, Hopitaux De Paris |
Methods for treating a complement mediated disorder caused by viruses
|
|
IL297680A
(en)
|
2020-04-30 |
2022-12-01 |
Alnylam Pharmaceuticals Inc |
Complement factor b (cfb) irna compositions and methods of use thereof
|
|
AU2021270867A1
(en)
|
2020-05-12 |
2022-12-08 |
Alexion Pharmaceuticals, Inc. |
Use of complement factor D inhibitors alone or in combination with anti-C5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria
|
|
US20230235080A1
(en)
|
2020-06-03 |
2023-07-27 |
Bionecure Therapeutics, Inc. |
Trophoblast cell-surface antigen-2 (trop-2) antibodies
|
|
KR102836238B1
(ko)
|
2020-06-16 |
2025-07-18 |
에프. 호프만-라 로슈 아게 |
샘플에서 항체의 유리 항원 측정 방법
|
|
CA3173011A1
(en)
|
2020-06-24 |
2021-12-30 |
Alexion Pharmaceuticals, Inc. |
Subcutaneous (sc) administration of anti-c5 antibodies for treatment of complement-associated conditions
|
|
US20230256114A1
(en)
|
2020-07-07 |
2023-08-17 |
Bionecure Therapeutics, Inc. |
Novel maytansinoids as adc payloads and their use for the treatment of cancer
|
|
US20230357438A1
(en)
*
|
2020-07-15 |
2023-11-09 |
Biosion Inc. |
Antibodies binding c5 and uses thereof
|
|
US20250171423A1
(en)
|
2020-09-23 |
2025-05-29 |
Achillion Pharmaceuticals, Inc. |
Pharmaceutical compounds for the treatment of complement mediated disorders
|
|
WO2022150260A1
(en)
|
2021-01-05 |
2022-07-14 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT 9 (C9) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
US20240092881A1
(en)
|
2021-01-22 |
2024-03-21 |
Alexion Pharmaceuticals, Inc. |
Methods of treating complement mediated thrombotic microangiopathy using an anti-c5 antibody
|
|
CN116917326A
(zh)
|
2021-01-22 |
2023-10-20 |
博泰康医药公司 |
抗her-2/trop-2构建体及其用途
|
|
EP4342497A1
(en)
|
2021-05-10 |
2024-03-27 |
Kawasaki Institute of Industrial Promotion |
Antibody having reduced binding affinity for antigen
|
|
CA3220629A1
(en)
|
2021-05-28 |
2022-12-01 |
Tobin J. CAMMETT |
Methods for detecting cm-tma biomarkers
|
|
WO2023023220A1
(en)
|
2021-08-20 |
2023-02-23 |
Alexion Pharmaceuticals, Inc. |
Methods for treating sickle cell disease or beta thalassemia using a complement alternative pathway inhibitor
|
|
EP4396346A1
(en)
|
2021-09-02 |
2024-07-10 |
Silence Therapeutics GmbH |
Nucleic acids for inhibiting expression of complement factor b (cfb) in a cell
|
|
WO2023044048A1
(en)
|
2021-09-17 |
2023-03-23 |
Novartis Ag |
Methods for prevention of graft rejection in xenotransplantation
|
|
JP2024535850A
(ja)
|
2021-09-17 |
2024-10-02 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
補体成分（Ｃ３）をサイレンシングするためのｉＲＮＡ組成物および方法
|
|
IL312399A
(en)
|
2021-10-29 |
2024-06-01 |
Alnylam Pharmaceuticals Inc |
Complement factor B (CFB) iRNA compositions and methods of using them
|
|
KR20230105972A
(ko)
|
2022-01-05 |
2023-07-12 |
주식회사 카나프테라퓨틱스 |
혈관신생 억제제가 결합된 항-C3b 항체 또는 항-C5 항체 및 이의 용도
|
|
US12180274B2
(en)
|
2023-05-26 |
2024-12-31 |
Inflarx Gmbh |
Treatment of pneumonia and ARDS with inhibitors of C5a and IL-6 activity
|
|
CN116712390B
(zh)
*
|
2023-08-04 |
2023-11-14 |
上海览屹医药科技有限公司 |
一种高浓度高稳定性的抗体制剂及其制备方法
|