JP2004535195A5 - - Google Patents

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Publication number
JP2004535195A5
JP2004535195A5 JP2003507263A JP2003507263A JP2004535195A5 JP 2004535195 A5 JP2004535195 A5 JP 2004535195A5 JP 2003507263 A JP2003507263 A JP 2003507263A JP 2003507263 A JP2003507263 A JP 2003507263A JP 2004535195 A5 JP2004535195 A5 JP 2004535195A5
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JP
Japan
Prior art keywords
fusion protein
slyd
fkpa
group
fkbp chaperone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003507263A
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English (en)
Japanese (ja)
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JP2004535195A (ja
JP4174422B2 (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/EP2002/006957 external-priority patent/WO2003000878A2/en
Publication of JP2004535195A publication Critical patent/JP2004535195A/ja
Publication of JP2004535195A5 publication Critical patent/JP2004535195A5/ja
Application granted granted Critical
Publication of JP4174422B2 publication Critical patent/JP4174422B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2003507263A 2001-06-22 2002-06-24 発現ツールとしてのfkbpシャペロンの使用 Expired - Fee Related JP4174422B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01115225 2001-06-22
EP01120939 2001-08-31
PCT/EP2002/006957 WO2003000878A2 (en) 2001-06-22 2002-06-24 Use of fkbp chaperones as expression tool

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006326846A Division JP4309910B2 (ja) 2001-06-22 2006-12-04 発現ツールとしてのfkbpシャペロンの使用

Publications (3)

Publication Number Publication Date
JP2004535195A JP2004535195A (ja) 2004-11-25
JP2004535195A5 true JP2004535195A5 (https=) 2005-08-25
JP4174422B2 JP4174422B2 (ja) 2008-10-29

Family

ID=26076626

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2003507263A Expired - Fee Related JP4174422B2 (ja) 2001-06-22 2002-06-24 発現ツールとしてのfkbpシャペロンの使用
JP2003507262A Expired - Fee Related JP4262594B2 (ja) 2001-06-22 2002-06-24 レトロウイルス表面糖タンパク質を含む可溶性複合体
JP2006326846A Expired - Fee Related JP4309910B2 (ja) 2001-06-22 2006-12-04 発現ツールとしてのfkbpシャペロンの使用
JP2007183508A Expired - Fee Related JP4320351B2 (ja) 2001-06-22 2007-07-12 レトロウイルス表面糖タンパク質を含む可溶性複合体
JP2008286959A Withdrawn JP2009102320A (ja) 2001-06-22 2008-11-07 レトロウイルス表面糖タンパク質を含む可溶性複合体
JP2009025509A Expired - Fee Related JP4523660B2 (ja) 2001-06-22 2009-02-06 発現ツールとしてのfkbpシャペロンの使用

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2003507262A Expired - Fee Related JP4262594B2 (ja) 2001-06-22 2002-06-24 レトロウイルス表面糖タンパク質を含む可溶性複合体
JP2006326846A Expired - Fee Related JP4309910B2 (ja) 2001-06-22 2006-12-04 発現ツールとしてのfkbpシャペロンの使用
JP2007183508A Expired - Fee Related JP4320351B2 (ja) 2001-06-22 2007-07-12 レトロウイルス表面糖タンパク質を含む可溶性複合体
JP2008286959A Withdrawn JP2009102320A (ja) 2001-06-22 2008-11-07 レトロウイルス表面糖タンパク質を含む可溶性複合体
JP2009025509A Expired - Fee Related JP4523660B2 (ja) 2001-06-22 2009-02-06 発現ツールとしてのfkbpシャペロンの使用

Country Status (15)

Country Link
US (2) US7244819B2 (https=)
EP (3) EP2267452B8 (https=)
JP (6) JP4174422B2 (https=)
KR (2) KR100702373B1 (https=)
CN (1) CN100510068C (https=)
AT (2) ATE522603T1 (https=)
AU (2) AU2002317841A1 (https=)
BR (1) BRPI0210598B8 (https=)
CA (3) CA2770453C (https=)
DE (1) DE60233942D1 (https=)
DK (2) DK1402015T3 (https=)
ES (3) ES2391623T3 (https=)
MX (1) MXPA03011455A (https=)
PL (2) PL215170B1 (https=)
WO (2) WO2003000877A2 (https=)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03011455A (es) * 2001-06-22 2004-04-05 Hoffmann La Roche Complejo soluble que comprende glucoproteina de superficie retroviral.
EP1516928B1 (en) * 2002-06-25 2010-02-17 Sekisui Chemical Co., Ltd. Expression vector, host, fused protein, process for producing fused protein and process for producing protein
DK1567195T3 (da) * 2002-11-26 2011-02-14 Upfront Chromatography As Dendrimerkonjugater til selektiv opløsning af proteinaggregater
AU2004230803A1 (en) * 2003-04-18 2004-10-28 Chiba, Joe Immunogen, composition for immunological use and process for producing antibody using the same
US9057061B2 (en) * 2003-12-23 2015-06-16 Novozymes Biopharma Dk A/S Gene expression technique
US7604935B2 (en) 2005-10-26 2009-10-20 Roche Diagnostics Operations, Inc. Soluble rubella E1 envelope protein variants
WO2007077008A1 (en) 2006-01-03 2007-07-12 Roche Diagnostics Gmbh Chimaeric fusion protein with superior chaperone and folding activities
WO2007141650A2 (en) * 2006-01-17 2007-12-13 Instituto De Medicina Molecular Compositions and methods for diagnosing hiv-2 infection
JP2009536958A (ja) 2006-05-11 2009-10-22 ベクトン・ディキンソン・アンド・カンパニー 細胞からのタンパク質抽出方法
GB0611405D0 (en) 2006-06-09 2006-07-19 Univ Belfast FKBP-L: A novel inhibitor of angiogenesis
ATE529436T1 (de) 2007-04-20 2011-11-15 Hoffmann La Roche Erkennung von primären infektionen mit krankheitserregern
WO2009031852A2 (en) * 2007-09-06 2009-03-12 Korea University Industry and Academy Cooperation Foundation Preparation method of recombinant protein by use of a fusion expression partner
US9207240B2 (en) 2007-11-14 2015-12-08 Arbor Vita Corporation Method of efficient extraction of protein from cells
ES2450998T3 (es) 2007-12-13 2014-03-26 F. Hoffmann-La Roche Ag Nuevas variantes de proteína de cubierta E1 de rubéola y su utilización en la detección de anticuerpos anti-rubéola
EP2127678A1 (en) 2008-05-26 2009-12-02 Roche Diagnostics GmbH SlpA as a tool for recombinant protein and enzyme technology
AU2011230619C1 (en) 2010-03-25 2016-06-23 Oregon Health & Science University CMV glycoproteins and recombinant vectors
AU2012212047A1 (en) * 2011-02-03 2013-08-22 Xoma Technology Ltd. Methods and materials for enhancing functional protein expression in bacteria
AR086250A1 (es) 2011-05-05 2013-11-27 Hoffmann La Roche Polipeptido de fusion presentador de una secuencia de aminoacidos y utilizacion del mismo
HUE037408T2 (hu) 2011-06-10 2018-08-28 Univ Oregon Health & Science CMV glikoproteinek és rekombináns vektorok
CA2789539A1 (en) 2011-09-12 2013-03-12 International Aids Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
EP2617731A1 (en) 2012-01-19 2013-07-24 Roche Diagnostics GmbH Soluble immunoreactive Treponema pallidum TpN47 antigens
ES2631608T3 (es) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Variante de la glicoproteína Env del VIH-1
EP2706115A1 (en) 2012-09-06 2014-03-12 Roche Diagnostics GmbH Chaperone-chaperone fusion polypeptides for reduction of interference and stabilization of immunoassays
AR093778A1 (es) 2012-11-08 2015-06-24 Hoffmann La Roche PROTEINAS LIGANTES DE ANTIGENO ANTI-HER3/HER4 DE UNION A LA HORQUILLA b DE HER3 Y A LA HORQUILLA b DE HER4
MA38165A1 (fr) 2012-11-08 2018-07-31 Hoffmann La Roche Protéines de liaison à l'antigène her3 se liant à l'épingle à cheveux beta de her3
ES2603589T3 (es) 2012-11-08 2017-02-28 F. Hoffmann-La Roche Ag Ácidos nucleicos que codifican polipéptidos quiméricos para la identificación sistemática de bibliotecas
EP2827146A1 (en) 2013-07-18 2015-01-21 Roche Diagnostics GmbH Vibrio cholerae lipoprotein 15 (Lp15) variants as anti-interference additive in TpN17-based immunoassays for detection of anti-Treponema antibodies
EP2848937A1 (en) 2013-09-05 2015-03-18 International Aids Vaccine Initiative Methods of identifying novel HIV-1 immunogens
WO2015044083A1 (en) * 2013-09-27 2015-04-02 F. Hoffmann-La Roche Ag Thermus thermophilus slyd fkbp domain specific antibodies
US10058604B2 (en) 2013-10-07 2018-08-28 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
EP2913338A1 (en) 2014-02-28 2015-09-02 Roche Diagniostics GmbH Soluable and immunoreactive variants of HTLV capsid antigen p24
JP2015215244A (ja) * 2014-05-12 2015-12-03 富士レビオ株式会社 免疫測定における抗htlv抗体の検出感度を向上させる方法
MX2016014416A (es) 2014-05-14 2017-02-23 Hoffmann La Roche Anticuerpos anti-her3 que se unen a la horquilla beta de her3.
BR112016025056A2 (pt) 2014-05-14 2018-02-20 F. Hoffmann-La Roche Ag uso de pelo menos um polipeptídeo, anticorpo biespecífico, anticorpo biespecífico isolado, anticorpo her3/her2 biespecífico, célula hospedeira, método de produção do anticorpo biespecífico her3/her2, imunoconjugado e formulação farmacêutica
CN107532190B (zh) 2014-12-01 2021-07-09 菲尼克斯公司 用于肽生产的融合伴侣
CA2974343A1 (en) * 2015-02-13 2016-08-18 Sekisui Chemical Co., Ltd. Nucleic acid, fusion protein, recombined cell, and isoprene or cyclic terpene production method
EP3069730A3 (en) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
US9931394B2 (en) 2015-03-23 2018-04-03 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
JP6967002B2 (ja) * 2015-12-15 2021-11-17 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft トランスグルタミナーゼ認識部位を有するfkbpドメイン
ES2796479T3 (es) 2016-05-31 2020-11-27 Hoffmann La Roche Procedimiento de pretratamiento para la detección rápida del antígeno central del VHC
JP2019523863A (ja) 2016-05-31 2019-08-29 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft ウイルス抗原の血清学的検出方法
EP3472322B1 (en) * 2016-06-20 2022-01-05 MetGen Oy Method for obtaining active insoluble xylose isomerase
JP7068323B2 (ja) 2017-02-02 2022-05-16 エフ.ホフマン-ラ ロシュ アーゲー 少なくとも2種のペグ化された分析物特異的結合剤を使用する免疫アッセイ
CN110709410B (zh) 2017-04-26 2024-07-02 豪夫迈·罗氏有限公司 可溶性和免疫反应性寨卡病毒ns1多肽
CN110996986B (zh) 2017-07-27 2024-07-19 豪夫迈·罗氏有限公司 Hcv抗原的多表位融合蛋白及其用途
CN110066343B (zh) * 2019-05-23 2021-04-09 北京新创生物工程有限公司 一种用于检测hiv新发感染的重组抗原及其应用
CN115843334B (zh) 2020-04-23 2026-01-13 豪夫迈·罗氏有限公司 用于抗体免疫测定的冠状核衣壳抗原
WO2023012321A1 (en) 2021-08-06 2023-02-09 Roche Diagnostics Gmbh Chimeric igg-fc-binding ligand polypeptide and uses thereof for igg affinity purification
US20250298022A1 (en) 2022-05-03 2025-09-25 Roche Diagnostics Operations, Inc. Hiv gp41 variants for immunodiagnostic assays
WO2025098623A1 (en) 2023-11-09 2025-05-15 Roche Diagnostics Gmbh Transglutaminase substrates for labeling

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2095818B (en) 1981-03-27 1985-10-02 Exxon Research Engineering Co Staged adsorption/resorption heat pump
US4735896A (en) 1986-03-04 1988-04-05 United Biomedical, Inc. Synthetic peptide and process of using same for the detection and diagnosis of AIDS and pre-AIDS conditions
US4879212A (en) 1986-04-02 1989-11-07 United Biomedical Inc. Peptide composition and method for the detection of antibodies to HTLV-III
US6024983A (en) 1986-10-24 2000-02-15 Southern Research Institute Composition for delivering bioactive agents for immune response and its preparation
DE3705686C2 (de) 1987-02-23 1995-11-30 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von Antikörpern
NZ224663A (en) 1987-05-28 1990-11-27 Amrad Corp Ltd Fusion proteins containing glutathione-s-transferase and expression of foreign polypeptides using glutathione-s-transferase encoding vectors
SE8704185L (sv) 1987-10-28 1989-04-29 Ferring Ab Nya peptider, artificiella antigener och immunoanalystestsatser
CA2003383A1 (en) * 1988-11-23 1990-05-23 Sushil G. Devare Synthetic dna derived recombinant hiv antigens
ATE160358T1 (de) 1991-06-14 1997-12-15 St Vincents Inst Med Res Detektion des immunschwäche-virus aus felis
WO1993013200A1 (en) * 1991-12-20 1993-07-08 Novo Nordisk A/S A process for the preparation of lipase
JP2001504572A (ja) 1992-04-09 2001-04-03 アボツト・ラボラトリーズ Hiv抗原及びhiv抗体を検出するためのアッセイ
WO1993025533A1 (en) 1992-06-05 1993-12-23 Abbott Laboratories Methods and reagents for the determination of immunosuppressive agents
ATE195347T1 (de) 1992-10-02 2000-08-15 Res Corp Technologies Inc Methoden der erhöhung der sekretion von überexpremierten proteinen
US5459051A (en) 1993-03-26 1995-10-17 Celtrix Pharmaceuticals, Inc. Methods and vectors for over-expression of ubiquitin fusion proteins in host cells
DE4428705A1 (de) * 1994-08-12 1996-02-15 Boehringer Mannheim Gmbh Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus
AU3968595A (en) 1994-10-25 1996-05-15 Board Of Trustees Of The Leland Stanford Junior University Conditional transformation of genetically engineered cells
WO1996041865A1 (en) 1995-06-07 1996-12-27 Ariad Gene Therapeutics, Inc. Rapamcycin-based regulation of biological events
WO1997010502A1 (en) 1995-09-15 1997-03-20 Merck & Co., Inc. A high throughput assay using fusion proteins
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
GB9614114D0 (en) 1996-07-05 1996-09-04 Amcor Packaging Uk Ltd New packages
JP2001501093A (ja) 1996-09-26 2001-01-30 メディカル リサーチ カウンシル シャペロン断片
US6225082B1 (en) * 1997-05-09 2001-05-01 Research Corporation Technologies, Inc. Myelin basic protein MRNA transport and translation enhancer sequences
US5989868A (en) * 1997-09-12 1999-11-23 The Board Of Regents Of The University Of Oklahoma Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli
JP2002508971A (ja) 1998-01-15 2002-03-26 アリアド・ジーン・セラピューティクス・インコーポレーテッド 多量体キメラ蛋白質を使用する生物学的イベントの調節
DE19913117A1 (de) * 1998-05-06 1999-11-11 Roche Diagnostics Gmbh Entstörung durch Rheumafaktoren
US6248329B1 (en) * 1998-06-01 2001-06-19 Ramaswamy Chandrashekar Parasitic helminth cuticlin nucleic acid molecules and uses thereof
ATE473755T1 (de) 1998-10-02 2010-07-15 Rhein Biotech Proz & Prod Gmbh Methode zur herstellung von (poly)peptiden unter verwendung von verkürzten varianten von sv40 large t antigen mit einem intakten n terminus
EP1127140A2 (en) 1998-11-06 2001-08-29 President And Fellows Of Harvard College Fk506-based regulation of biological events
AU3305100A (en) 1999-03-17 2000-10-04 Medical Research Council Method for refolding molecules of polypeptides containing ig domains
AU4933200A (en) 1999-05-14 2000-12-05 Medical Research Council Oligomeric chaperone proteins
GB9913437D0 (en) 1999-06-09 1999-08-11 Medical Res Council Fusion proteins
EP1077263A1 (de) * 1999-07-29 2001-02-21 F.Hoffmann-La Roche Ag Verfahren zur Herstellung von natürlich gefalteten und sekretierten Proteinen durch Co-Sekretion von Chaperonen
CA2403718A1 (en) * 2000-03-17 2001-09-27 Panacos Pharmaceuticals, Inc. A method for generating immunogens that elicit neutralizing antibodies against fusion-active regions of hiv envelope proteins
JP2002262883A (ja) * 2001-03-13 2002-09-17 Sekisui Chem Co Ltd モノクローナル抗体の製造方法
MXPA03011455A (es) * 2001-06-22 2004-04-05 Hoffmann La Roche Complejo soluble que comprende glucoproteina de superficie retroviral.

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