JP2018171063A5 - - Google Patents
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- Publication number
- JP2018171063A5 JP2018171063A5 JP2018115294A JP2018115294A JP2018171063A5 JP 2018171063 A5 JP2018171063 A5 JP 2018171063A5 JP 2018115294 A JP2018115294 A JP 2018115294A JP 2018115294 A JP2018115294 A JP 2018115294A JP 2018171063 A5 JP2018171063 A5 JP 2018171063A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- isolated
- protein
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000004169 proteins and genes Human genes 0.000 claims description 22
- 108090000623 proteins and genes Proteins 0.000 claims description 22
- 239000012867 bioactive agent Substances 0.000 claims description 10
- 102000002090 Fibronectin type III Human genes 0.000 claims description 4
- 108050009401 Fibronectin type III Proteins 0.000 claims description 4
- 108091033319 polynucleotide Proteins 0.000 claims 14
- 239000002157 polynucleotide Substances 0.000 claims 14
- 102000040430 polynucleotide Human genes 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 108020001507 fusion proteins Proteins 0.000 claims 8
- 102000037865 fusion proteins Human genes 0.000 claims 8
- 150000001413 amino acids Chemical class 0.000 claims 4
- 108091035707 Consensus sequence Proteins 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229940126586 small molecule drug Drugs 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 description 5
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 150000007857 hydrazones Chemical class 0.000 description 1
- 108010094020 polyglycine Proteins 0.000 description 1
- 150000007659 semicarbazones Chemical class 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261651642P | 2012-05-25 | 2012-05-25 | |
| US61/651,642 | 2012-05-25 | ||
| US201361776918P | 2013-03-12 | 2013-03-12 | |
| US61/776,918 | 2013-03-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514183A Division JP2015519345A (ja) | 2012-05-25 | 2013-05-23 | 非天然コンセンサスアルブミン結合ドメイン |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020158256A Division JP2021019595A (ja) | 2012-05-25 | 2020-09-23 | 非天然コンセンサスアルブミン結合ドメイン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018171063A JP2018171063A (ja) | 2018-11-08 |
| JP2018171063A5 true JP2018171063A5 (https=) | 2020-11-12 |
| JP7166081B2 JP7166081B2 (ja) | 2022-11-07 |
Family
ID=49622071
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514183A Withdrawn JP2015519345A (ja) | 2012-05-25 | 2013-05-23 | 非天然コンセンサスアルブミン結合ドメイン |
| JP2018115294A Active JP7166081B2 (ja) | 2012-05-25 | 2018-06-18 | 非天然コンセンサスアルブミン結合ドメイン |
| JP2020158256A Pending JP2021019595A (ja) | 2012-05-25 | 2020-09-23 | 非天然コンセンサスアルブミン結合ドメイン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514183A Withdrawn JP2015519345A (ja) | 2012-05-25 | 2013-05-23 | 非天然コンセンサスアルブミン結合ドメイン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020158256A Pending JP2021019595A (ja) | 2012-05-25 | 2020-09-23 | 非天然コンセンサスアルブミン結合ドメイン |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US9156887B2 (https=) |
| EP (1) | EP2855509B1 (https=) |
| JP (3) | JP2015519345A (https=) |
| KR (1) | KR102053674B1 (https=) |
| CN (1) | CN104470944B (https=) |
| AU (2) | AU2013266215B2 (https=) |
| BR (1) | BR112014029409B1 (https=) |
| CA (1) | CA2874646C (https=) |
| DK (1) | DK2855509T3 (https=) |
| EA (1) | EA036487B1 (https=) |
| ES (1) | ES2670442T3 (https=) |
| IL (2) | IL235808A (https=) |
| MX (1) | MX355041B (https=) |
| PT (1) | PT2855509T (https=) |
| WO (1) | WO2013177398A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9695228B2 (en) | 2012-11-21 | 2017-07-04 | Janssen Biotech, Inc. | EGFR and c-Met fibronectin type III domain binding molecules |
| WO2014140882A2 (en) * | 2013-03-14 | 2014-09-18 | The Governing Council Of The University Of Toronto | Scaffolded peptidic libraries and methods of making and screening the same |
| JP2018518945A (ja) * | 2015-04-29 | 2018-07-19 | メディオラヌム・ファルマチェウティチ・ソチエタ・ペル・アツィオーニ | 可溶性キメラインターロイキン−１０受容体およびその療法使用 |
| US10456442B2 (en) * | 2015-06-18 | 2019-10-29 | Albert Einstein College Of Medicine | FGF receptor ligands for treating diabetes and obesity |
| EP3374504B1 (en) * | 2015-11-09 | 2025-03-19 | CureVac SE | Optimized nucleic acid molecules |
| CN106699842B (zh) * | 2015-11-17 | 2020-06-12 | 上海交通大学 | 一种新的抗炎小分子多肽及其应用 |
| CA3054286A1 (en) | 2016-03-01 | 2017-09-08 | The Board Of Trustees Of The University Of Illinois | L-asparaginase variants and fusion proteins with reduced l-glutaminase activity and enhanced stability |
| CN110225770B (zh) | 2016-12-14 | 2022-04-26 | 杨森生物科技公司 | 结合cd8a的纤连蛋白iii型结构域 |
| EP3554561B1 (en) | 2016-12-14 | 2023-06-28 | Janssen Biotech, Inc. | Cd137 binding fibronectin type iii domains |
| WO2018140456A1 (en) | 2017-01-24 | 2018-08-02 | Northwestern University | Active low molecular weight variants of angiotensin converting enzyme 2 (ace2) |
| JP7744621B2 (ja) | 2017-08-11 | 2025-09-26 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ | 切断されたモルモットｌ－アスパラギナーゼバリアントおよび使用の方法 |
| JP7545894B2 (ja) | 2018-03-13 | 2024-09-05 | アフィボディ アクティエボラーグ | 新規足場に基づくポリペプチド |
| KR102282240B1 (ko) * | 2018-12-06 | 2021-07-28 | 경상국립대학교산학협력단 | 지속형 엑센딘-4 및 이의 용도 |
| WO2021076543A1 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Epcam binding fibronectin type iii domains |
| US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
| CN119119240A (zh) | 2019-10-14 | 2024-12-13 | Aro生物疗法公司 | 结合cd71的纤维粘连蛋白iii型结构域 |
| CN115175691B (zh) | 2019-12-18 | 2026-02-10 | Aro生物疗法公司 | 结合血清白蛋白的纤连蛋白iii型结构域及其应用 |
| US12123036B2 (en) | 2020-02-26 | 2024-10-22 | Northwestern University | Soluble ACE2 variants and uses therefor |
| US20240293487A1 (en) * | 2020-03-25 | 2024-09-05 | Jin-Woo Choi | Immunoevasive anti-tumor adenovirus |
| CA3214552A1 (en) | 2021-04-14 | 2022-10-20 | Russell C. Addis | Cd71 binding fibronectin type iii domains |
| EP4323008A4 (en) | 2021-04-14 | 2026-02-25 | Aro Biotherapeutics Company | FN3-ARNSI DOMAIN CONJUGATES AND THEIR USES |
| CN113336860B (zh) * | 2021-06-02 | 2022-07-01 | 北京大学 | 一种具有靶向和长效功能的重组水蛭素融合蛋白及其编码基因和应用 |
| KR20250087648A (ko) * | 2022-11-09 | 2025-06-16 | 리플리겐 코포레이션 | 친화도 제제 |
| EP4634216A1 (en) | 2022-12-16 | 2025-10-22 | Repertoire Immune Medicines, Inc. | T cell receptors binding hpv-16 epitopes |
| WO2025073871A1 (en) | 2023-10-03 | 2025-04-10 | Bicycletx Limited | Bicyclic peptide ligand complexes specific for tfr1 |
| WO2025125378A1 (en) * | 2023-12-12 | 2025-06-19 | Navigo Proteins Gmbh | Novel serum albumin-binding fusion proteins |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6267964B1 (en) | 1989-08-01 | 2001-07-31 | Affibody Technology Sweden Ab | Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives |
| DE69329877T2 (de) * | 1992-05-07 | 2001-04-26 | Affitech A/S, Oslo | Von L Protein abgeleitete Immunoglobulin-bindende Proteine und deren anwendungen |
| WO1994012520A1 (en) | 1992-11-20 | 1994-06-09 | Enzon, Inc. | Linker for linked fusion polypeptides |
| US6670127B2 (en) | 1997-09-16 | 2003-12-30 | Egea Biosciences, Inc. | Method for assembly of a polynucleotide encoding a target polypeptide |
| PT1015576E (pt) | 1997-09-16 | 2005-09-30 | Egea Biosciences Llc | Metodo para a sintese quimica completa e montagem de genes e de genomas |
| US20050287153A1 (en) | 2002-06-28 | 2005-12-29 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
| EP1240337B1 (en) | 1999-12-24 | 2006-08-23 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| EP2190863B1 (en) | 2007-07-31 | 2015-09-02 | Affibody AB | New albumin binding compositions, methods and uses |
| CA2729567C (en) | 2008-06-30 | 2018-04-24 | Kyowa Hakko Kirin Co., Ltd. | Anti-cd27 antibody |
| ES2705714T3 (es) * | 2008-10-31 | 2019-03-26 | Janssen Biotech Inc | Métodos y usos de dominio de Fibronectina tipo III basado en estructuras de composiciones |
| WO2010092963A1 (ja) * | 2009-02-10 | 2010-08-19 | 国立大学法人 琉球大学 | 薬物運搬体並びにこれを利用したアジュバントおよびワクチン |
| BRPI1008532B1 (pt) | 2009-02-12 | 2021-12-14 | Janssen Biotech, Inc | Arcabouço de proteína isolada, método para construção de uma biblioteca de arcabouço de proteína isolada, molécula de ácido nucleico isolada, vetor de ácido nucleico isolado, célula hospedeira de bactéria ou fungo, composição, dispositivo médico e artigo de manufatura para uso farmacêutico ou de diagnóstico em seres humanos |
| EP2437767B1 (en) * | 2009-06-01 | 2015-07-08 | MedImmune, LLC | Molecules with extended half-lives and uses thereof |
| EA201690310A1 (ru) | 2010-04-13 | 2016-12-30 | Селлдекс Терапьютикс Инк. | Антитела, связывающие cd27 человека, и их применение |
| US8569227B2 (en) | 2010-04-30 | 2013-10-29 | Janssen Biotech, Inc. | Stabilized fibronectin domain compositions, methods and uses |
| US9695228B2 (en) | 2012-11-21 | 2017-07-04 | Janssen Biotech, Inc. | EGFR and c-Met fibronectin type III domain binding molecules |
-
2013
- 2013-05-23 CN CN201380039335.8A patent/CN104470944B/zh active Active
- 2013-05-23 ES ES13793564.9T patent/ES2670442T3/es active Active
- 2013-05-23 JP JP2015514183A patent/JP2015519345A/ja not_active Withdrawn
- 2013-05-23 PT PT137935649T patent/PT2855509T/pt unknown
- 2013-05-23 CA CA2874646A patent/CA2874646C/en active Active
- 2013-05-23 DK DK13793564.9T patent/DK2855509T3/en active
- 2013-05-23 EP EP13793564.9A patent/EP2855509B1/en active Active
- 2013-05-23 EA EA201590136A patent/EA036487B1/ru unknown
- 2013-05-23 KR KR1020147035989A patent/KR102053674B1/ko active Active
- 2013-05-23 WO PCT/US2013/042429 patent/WO2013177398A2/en not_active Ceased
- 2013-05-23 US US13/901,013 patent/US9156887B2/en active Active
- 2013-05-23 BR BR112014029409-7A patent/BR112014029409B1/pt active IP Right Grant
- 2013-05-23 AU AU2013266215A patent/AU2013266215B2/en active Active
- 2013-05-23 MX MX2014014384A patent/MX355041B/es active IP Right Grant
-
2014
- 2014-11-20 IL IL235808A patent/IL235808A/en active IP Right Grant
-
2015
- 2015-09-01 US US14/842,218 patent/US20160083436A1/en not_active Abandoned
-
2017
- 2017-09-20 US US15/710,385 patent/US10280200B2/en active Active
- 2017-09-24 IL IL254652A patent/IL254652B/en active IP Right Grant
- 2017-11-17 AU AU2017261625A patent/AU2017261625B2/en active Active
-
2018
- 2018-06-18 JP JP2018115294A patent/JP7166081B2/ja active Active
-
2020
- 2020-09-23 JP JP2020158256A patent/JP2021019595A/ja active Pending
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