JP2025504625A5 - - Google Patents
Info
- Publication number
- JP2025504625A5 JP2025504625A5 JP2024534166A JP2024534166A JP2025504625A5 JP 2025504625 A5 JP2025504625 A5 JP 2025504625A5 JP 2024534166 A JP2024534166 A JP 2024534166A JP 2024534166 A JP2024534166 A JP 2024534166A JP 2025504625 A5 JP2025504625 A5 JP 2025504625A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- iterative
- designed
- repeating
- module
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21214519 | 2021-12-14 | ||
| EP21214519.7 | 2021-12-14 | ||
| PCT/EP2022/085794 WO2023110983A1 (en) | 2021-12-14 | 2022-12-14 | Designed repeat domains with dual binding specificity and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025504625A JP2025504625A (ja) | 2025-02-14 |
| JP2025504625A5 true JP2025504625A5 (https=) | 2025-12-17 |
Family
ID=80112165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024534166A Pending JP2025504625A (ja) | 2021-12-14 | 2022-12-14 | 二重結合特異性を有する設計された反復ドメイン及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20250042957A1 (https=) |
| EP (1) | EP4447990A1 (https=) |
| JP (1) | JP2025504625A (https=) |
| KR (1) | KR20240122764A (https=) |
| CN (1) | CN118354784A (https=) |
| AU (1) | AU2022413461A1 (https=) |
| CA (1) | CA3239407A1 (https=) |
| IL (1) | IL313411A (https=) |
| WO (1) | WO2023110983A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240279290A1 (en) | 2020-05-14 | 2024-08-22 | Molecular Partners Ag | Multispecific proteins |
| WO2025050026A1 (en) * | 2023-08-30 | 2025-03-06 | The Board Of Trustees Of The Leland Stanford Junior University | Polypeptides for inducible and repressible binding to targets of interest and methods of use |
| WO2025146491A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent |
| WO2025146487A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Multispecific binding proteins |
| WO2025146490A1 (en) * | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Recombinant cd117 binding proteins and their use |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1332209B1 (en) | 2000-09-08 | 2009-11-11 | Universität Zürich | Collections of repeat proteins comprising repeat modules |
| US8492122B2 (en) | 2002-03-11 | 2013-07-23 | The Johns Hopkins University | Molecular switches and methods for making and using the same |
| US9365629B2 (en) | 2007-09-24 | 2016-06-14 | University Of Zurich | Designed armadillo repeat proteins |
| BRPI0921469B1 (pt) | 2008-11-03 | 2022-01-18 | Molecular Partners Ag | Proteínas de ligação que inibem a interação com o receptor de vegf-a, composição farmacêutica |
| AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
| PL2643349T3 (pl) | 2010-11-26 | 2020-03-31 | Molecular Partners Ag | Zaprojektowane białka z powtórzeniami wiążące się z albuminą surowicy |
| WO2014001442A1 (en) | 2012-06-28 | 2014-01-03 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
| EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| CN105209483B (zh) | 2013-05-31 | 2021-07-27 | 分子组合公司 | 与肝细胞生长因子结合的设计锚蛋白重复蛋白 |
| WO2015067302A1 (en) | 2013-11-05 | 2015-05-14 | Ecole Polytechnique Federale De Lausanne (Epfl) | Sensor molecules and uses thereof |
| KR102427117B1 (ko) | 2015-04-02 | 2022-07-29 | 몰리큘라 파트너스 아게 | 혈청 알부민에 대한 결합 특이성을 갖는 설계된 안키린 반복 도메인 |
| US11261250B2 (en) * | 2016-07-22 | 2022-03-01 | Fred Hutchinson Cancer Research Center | Bi-specific molecule for cell-specific Notch inhibition and related methods and compositions |
| CN109790206A (zh) | 2016-09-22 | 2019-05-21 | 分子组合公司 | 重组结合蛋白及其用途 |
| US12049482B2 (en) | 2017-10-31 | 2024-07-30 | The Brigham And Women's Hospital, Inc. | Molecular switch-mediated control of engineered cells |
| WO2020190852A2 (en) | 2019-03-17 | 2020-09-24 | Jorge Fallas | Topological control of receptor signaling using synthetic homo- and hetero-dimeric cytokine mimetics |
| IL293698A (en) | 2019-12-11 | 2022-08-01 | Molecular Partners Ag | Recombinant peptide-mhc complex binding proteins, their production and use |
| US20240279290A1 (en) * | 2020-05-14 | 2024-08-22 | Molecular Partners Ag | Multispecific proteins |
| AU2021403658A1 (en) | 2020-12-16 | 2023-06-29 | Molecular Partners Ag | Recombinant cd3 binding proteins and their use |
-
2022
- 2022-12-14 WO PCT/EP2022/085794 patent/WO2023110983A1/en not_active Ceased
- 2022-12-14 US US18/719,008 patent/US20250042957A1/en active Pending
- 2022-12-14 IL IL313411A patent/IL313411A/en unknown
- 2022-12-14 CA CA3239407A patent/CA3239407A1/en active Pending
- 2022-12-14 AU AU2022413461A patent/AU2022413461A1/en active Pending
- 2022-12-14 JP JP2024534166A patent/JP2025504625A/ja active Pending
- 2022-12-14 KR KR1020247019411A patent/KR20240122764A/ko active Pending
- 2022-12-14 EP EP22839170.2A patent/EP4447990A1/en active Pending
- 2022-12-14 CN CN202280080610.XA patent/CN118354784A/zh active Pending
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