JP2013513377A5 - - Google Patents
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- Publication number
- JP2013513377A5 JP2013513377A5 JP2012542587A JP2012542587A JP2013513377A5 JP 2013513377 A5 JP2013513377 A5 JP 2013513377A5 JP 2012542587 A JP2012542587 A JP 2012542587A JP 2012542587 A JP2012542587 A JP 2012542587A JP 2013513377 A5 JP2013513377 A5 JP 2013513377A5
- Authority
- JP
- Japan
- Prior art keywords
- identity
- functionally equivalent
- component
- equivalent variant
- fusion protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 229920001184 polypeptide Polymers 0.000 claims 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims 14
- 102000018619 Apolipoproteins A Human genes 0.000 claims 12
- 108010027004 Apolipoproteins A Proteins 0.000 claims 12
- 102000003812 Interleukin-15 Human genes 0.000 claims 12
- 108090000172 Interleukin-15 Proteins 0.000 claims 12
- 108020001507 fusion proteins Proteins 0.000 claims 11
- 102000037865 fusion proteins Human genes 0.000 claims 11
- 102000040430 polynucleotide Human genes 0.000 claims 10
- 108091033319 polynucleotide Proteins 0.000 claims 10
- 239000002157 polynucleotide Substances 0.000 claims 10
- 102000004556 Interleukin-15 Receptors Human genes 0.000 claims 8
- 108010017535 Interleukin-15 Receptors Proteins 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 241001529936 Murinae Species 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 210000004698 lymphocyte Anatomy 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- YTPUIQCGRWDPTM-UHFFFAOYSA-N 2-acetyloxybenzoic acid;5-(2-methylpropyl)-5-prop-2-enyl-1,3-diazinane-2,4,6-trione;1,3,7-trimethylpurine-2,6-dione Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O.CN1C(=O)N(C)C(=O)C2=C1N=CN2C.CC(C)CC1(CC=C)C(=O)NC(=O)NC1=O YTPUIQCGRWDPTM-UHFFFAOYSA-N 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200931158A ES2362062B1 (es) | 2009-12-11 | 2009-12-11 | Nuevos conjugados y composiciones para inmunoterapia y tratamiento anti-tumoral. |
| ESP200931158 | 2009-12-11 | ||
| ES201030813 | 2010-05-27 | ||
| ESP201030813 | 2010-05-27 | ||
| PCT/ES2010/070818 WO2011070214A2 (es) | 2009-12-11 | 2010-12-10 | Conjugados y composiciones para inmunoterapia y tratamiento anti-tumoral |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013513377A JP2013513377A (ja) | 2013-04-22 |
| JP2013513377A5 true JP2013513377A5 (https=) | 2014-01-30 |
| JP5784626B2 JP5784626B2 (ja) | 2015-09-24 |
Family
ID=43927978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012542587A Expired - Fee Related JP5784626B2 (ja) | 2009-12-11 | 2010-12-10 | 免疫療法および抗腫瘍治療のための新規な結合体および組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8771664B2 (https=) |
| EP (1) | EP2511294B1 (https=) |
| JP (1) | JP5784626B2 (https=) |
| CN (1) | CN102753574B (https=) |
| AU (1) | AU2010329805B2 (https=) |
| BR (1) | BR112012013868A8 (https=) |
| CA (1) | CA2783876C (https=) |
| ES (1) | ES2463016T3 (https=) |
| MX (1) | MX2012006691A (https=) |
| RU (1) | RU2597989C2 (https=) |
| WO (1) | WO2011070214A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2665486B1 (en) | 2011-01-18 | 2019-12-25 | Bioniz, LLC | Compositions for modulating gamma-c-cytokine activity |
| EP2537933A1 (en) * | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
| US11401312B2 (en) * | 2013-04-19 | 2022-08-02 | Cytune Pharma | Cytokine derived treatment with reduced vascular leak syndrome |
| WO2015054701A2 (en) * | 2013-10-13 | 2015-04-16 | Nova Southeastern University | Analyzing immune signaling networks for identification of therapeutic targets in complex chronic medical disorders, identification of a natural killer cell population as a potential therapeutic target for gulf war illness & myalgic encephalomyelitis/chronic fatigue syndrome, and modulation of natural killer cell function by stimulation with interleukin 15 |
| US9959384B2 (en) | 2013-12-10 | 2018-05-01 | Bioniz, Llc | Methods of developing selective peptide antagonists |
| PL3094351T3 (pl) * | 2014-01-15 | 2022-06-27 | Kadmon Corporation, Llc | Środki immunomodulujące |
| EP2915569A1 (en) | 2014-03-03 | 2015-09-09 | Cytune Pharma | IL-15/IL-15Ralpha based conjugates purification method |
| US10464982B2 (en) | 2014-04-23 | 2019-11-05 | Emory University | Compositions of GM-CSF and interleukin fusions for immune modulation and uses related thereto |
| EP3307783B1 (en) * | 2015-06-10 | 2021-01-06 | Emory University | Compositions and conjugates comprising an interleukin and polypeptides that specifically bind tgf-beta |
| CN106317225A (zh) * | 2015-06-28 | 2017-01-11 | 复旦大学 | 具有靶向性长效白细胞介素22融合蛋白及其制备方法和用途 |
| WO2017062685A1 (en) | 2015-10-09 | 2017-04-13 | Bioniz, Llc | Modulating gamma - c -cytokine activity |
| US11446398B2 (en) | 2016-04-11 | 2022-09-20 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| CN109715196A (zh) | 2016-06-13 | 2019-05-03 | 转矩医疗股份有限公司 | 用于促进免疫细胞功能的组合物和方法 |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| US12600757B2 (en) | 2017-04-07 | 2026-04-14 | Bioniz Therapeutics, Inc. | Peptides inhibiting gamma-c-cytokine activity and methods of use |
| EP3612210A4 (en) | 2017-04-19 | 2021-01-27 | Board Of Regents, The University Of Texas System | MANIPULATED ANTIGEN RECEPTORS EXPRESSING IMMUNE CELLS |
| CA3074826A1 (en) | 2017-09-05 | 2019-03-14 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
| CA3086040A1 (en) | 2017-12-19 | 2019-06-27 | Blaze Bioscience, Inc. | Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof |
| US12473336B2 (en) | 2018-02-21 | 2025-11-18 | Board Of Regents, The University Of Texas System | Methods for activation and expansion of natural killer cells and uses thereof |
| CA3137971A1 (en) | 2019-05-03 | 2020-11-12 | Bioniz, Llc | Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders |
| WO2023064469A1 (en) * | 2021-10-13 | 2023-04-20 | Modernatx, Inc. | Compositions of mrna-encoded il15 fusion proteins and methods of use thereof |
| WO2024036145A1 (en) * | 2022-08-07 | 2024-02-15 | Protean Bio, Inc. | Peptides for beta-cell survival and insulin production |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6408586A (en) * | 1985-10-03 | 1987-04-24 | Biotechnology Research Partners Limited | Novel lipoprotein-based drug-delivery systems |
| US4999403A (en) | 1988-10-28 | 1991-03-12 | Exxon Chemical Patents Inc. | Graft polymers of functionalized ethylene-alpha-olefin copolymer with polypropylene, methods of preparation, and use in polypropylene compositions |
| US5747024A (en) | 1993-03-08 | 1998-05-05 | Immunex Corporation | Vaccine adjuvant comprising interleukin-15 |
| CA2214649C (en) | 1995-03-08 | 2007-06-12 | Zeling Cai | Antigen presenting system and methods for activation of t-cells |
| US6787154B2 (en) | 1998-10-20 | 2004-09-07 | Salvatore Albani | Artificial antigen presenting cells |
| AU2008201887B2 (en) * | 2000-11-10 | 2011-06-30 | F. Hoffmann-La Roche Ltd. | Apolipoprotein analogues |
| BR0115257A (pt) | 2000-11-10 | 2003-08-12 | Proteopharma Aps | Análogos de apolipoproteìna |
| US8097283B2 (en) | 2004-01-15 | 2012-01-17 | Mount Sinai School Of Medicine | Methods and compositions for imaging |
| WO2006135436A2 (en) | 2004-10-22 | 2006-12-21 | University Of Florida Research Foundation, Inc. | Inhibition of gene expression and therapeutic uses thereof |
| US20060257361A1 (en) | 2005-04-12 | 2006-11-16 | Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services | Novel form of interleukin-15, Fc-IL-15, and methods of use |
| EP1969000A2 (en) | 2005-12-06 | 2008-09-17 | Centre National de la Recherche Scientifique | Cell penetrating peptides for intracellular delivery of molecules |
| EP2049560B1 (en) | 2006-07-13 | 2013-05-15 | Novozymes Biopharma DK A/S | Process for preparing particles of proteinaceous material |
| KR100817024B1 (ko) | 2006-11-09 | 2008-03-26 | 재단법인 목암생명공학연구소 | 핵산 또는 약물을 간에 특이적으로 전달하는 복합체 및이를 포함하는 약학적 조성물 |
| US20110293557A1 (en) | 2008-06-13 | 2011-12-01 | Proyecto De Biomedicina Cima, S.L. | Conjugates for the administration of biologically active compounds |
-
2010
- 2010-12-10 CN CN201080061939.9A patent/CN102753574B/zh not_active Expired - Fee Related
- 2010-12-10 WO PCT/ES2010/070818 patent/WO2011070214A2/es not_active Ceased
- 2010-12-10 JP JP2012542587A patent/JP5784626B2/ja not_active Expired - Fee Related
- 2010-12-10 US US13/514,855 patent/US8771664B2/en not_active Expired - Fee Related
- 2010-12-10 BR BR112012013868A patent/BR112012013868A8/pt not_active Application Discontinuation
- 2010-12-10 MX MX2012006691A patent/MX2012006691A/es active IP Right Grant
- 2010-12-10 EP EP10814739.8A patent/EP2511294B1/en active Active
- 2010-12-10 CA CA2783876A patent/CA2783876C/en not_active Expired - Fee Related
- 2010-12-10 RU RU2012129208/10A patent/RU2597989C2/ru not_active IP Right Cessation
- 2010-12-10 AU AU2010329805A patent/AU2010329805B2/en not_active Ceased
- 2010-12-10 ES ES10814739.8T patent/ES2463016T3/es active Active
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