JP2023518596A5 - - Google Patents
Info
- Publication number
- JP2023518596A5 JP2023518596A5 JP2022558063A JP2022558063A JP2023518596A5 JP 2023518596 A5 JP2023518596 A5 JP 2023518596A5 JP 2022558063 A JP2022558063 A JP 2022558063A JP 2022558063 A JP2022558063 A JP 2022558063A JP 2023518596 A5 JP2023518596 A5 JP 2023518596A5
- Authority
- JP
- Japan
- Prior art keywords
- fragment
- protein
- polynucleotide
- split
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20382236.6A EP3885440A1 (en) | 2020-03-26 | 2020-03-26 | Split inteins and their uses |
| EP20382236.6 | 2020-03-26 | ||
| PCT/EP2021/058016 WO2021191447A1 (en) | 2020-03-26 | 2021-03-26 | Split inteins and their uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023518596A JP2023518596A (ja) | 2023-05-02 |
| JP2023518596A5 true JP2023518596A5 (https=) | 2024-04-05 |
Family
ID=70292931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022558063A Pending JP2023518596A (ja) | 2020-03-26 | 2021-03-26 | スプリットインテイン及びその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230116688A1 (https=) |
| EP (2) | EP3885440A1 (https=) |
| JP (1) | JP2023518596A (https=) |
| KR (1) | KR20220160052A (https=) |
| CN (1) | CN115698307A (https=) |
| AU (1) | AU2021241899A1 (https=) |
| BR (1) | BR112022019167A2 (https=) |
| CA (1) | CA3175696A1 (https=) |
| IL (1) | IL296712A (https=) |
| WO (1) | WO2021191447A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3847254A4 (en) | 2018-09-07 | 2022-08-10 | Beam Therapeutics Inc. | COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM |
| JP7579844B2 (ja) * | 2019-08-28 | 2024-11-08 | ザ・トラスティーズ・オブ・プリンストン・ユニバーシティ | 非定型スプリットインテインおよびそれらの使用 |
| KR20220157944A (ko) | 2020-02-21 | 2022-11-29 | 아카우오스, 인크. | 인간 대상체에서 비-연령-연관 청각 장애를 치료하기 위한 조성물 및 방법 |
| US20250319126A1 (en) * | 2021-10-29 | 2025-10-16 | Shanghai Sinobay Biotechnology Co., Ltd. | Condition-controlled spliceable chimeric antigen receptor molecule and application thereof |
| JP2025530726A (ja) * | 2022-05-17 | 2025-09-17 | 復旦大学附属眼耳鼻喉科医院 | 聴力障害を治療するためのデュアルベクターシステム及びその使用 |
| JP2026504390A (ja) * | 2023-02-01 | 2026-02-05 | アレン インスティテュート | インテインを介した電位依存性ナトリウムチャネルの機能の再構築 |
| EP4726045A1 (en) | 2023-06-07 | 2026-04-15 | Peking University Third Hospital (The Third Clinical Medical School of Peking University) | Expression cassette combination and use thereof |
| WO2025038955A1 (en) * | 2023-08-16 | 2025-02-20 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Systems and methods for improving safety of split intein aav mediated gene therapy |
| CN121909039A (zh) | 2023-09-04 | 2026-04-21 | 斯普莱斯生物有限责任公司 | 分裂内含肽用于治疗scn1a相关疾病的用途 |
| WO2025153705A1 (en) | 2024-01-18 | 2025-07-24 | Splicebio, Sl | Use of split intein for the treatment of myo7a-associated disease |
| WO2025193938A1 (en) * | 2024-03-13 | 2025-09-18 | Oregon Health & Science University | Delivery of type iv collagen alpha chain using a split intein dual aav vector |
| WO2026013288A1 (en) | 2024-07-12 | 2026-01-15 | Splicebio, Sl | Split intein for use in the treatment of cep290-associated disease |
| WO2026057767A1 (en) * | 2024-09-13 | 2026-03-19 | Splicebio, Sl | Use of split intein for the treatment of abca3-associated disease |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5100792A (en) | 1984-11-13 | 1992-03-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5036006A (en) | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| FR2714830B1 (fr) | 1994-01-10 | 1996-03-22 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucléiques, préparation et utilisations. |
| FR2715847B1 (fr) | 1994-02-08 | 1996-04-12 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucléiques, préparation et utilisations. |
| FR2727679B1 (fr) | 1994-12-05 | 1997-01-03 | Rhone Poulenc Rorer Sa | Nouveaux agents de transfection et leurs applications pharmaceutiques |
| FR2730637B1 (fr) | 1995-02-17 | 1997-03-28 | Rhone Poulenc Rorer Sa | Composition pharmaceutique contenant des acides nucleiques, et ses utilisations |
| WO2007127428A2 (en) | 2006-04-28 | 2007-11-08 | University Of Florida Research Foundation, Inc. | Double-stranded/self-complementary vectors with a truncated cba promoter and methods of gene delivery |
| SI3265571T1 (sl) * | 2015-03-03 | 2022-10-28 | Fondazione Telethon | Več vektorski sistem in njegove uporabe |
| EP3312279B1 (en) * | 2015-06-19 | 2020-10-14 | Riken | pH-RESPONSIVE PROTEOLYSIS PROBE |
| PT3408292T (pt) * | 2016-01-29 | 2023-07-19 | Univ Princeton | Inteínas divididas com excecional atividade de splicing |
| IL282362B2 (en) * | 2018-10-15 | 2025-10-01 | Fond Telethon Ets | Intein proteins and their uses |
-
2020
- 2020-03-26 EP EP20382236.6A patent/EP3885440A1/en active Pending
-
2021
- 2021-03-26 EP EP21713447.7A patent/EP4127194A1/en active Pending
- 2021-03-26 CA CA3175696A patent/CA3175696A1/en active Pending
- 2021-03-26 KR KR1020227037261A patent/KR20220160052A/ko active Pending
- 2021-03-26 JP JP2022558063A patent/JP2023518596A/ja active Pending
- 2021-03-26 WO PCT/EP2021/058016 patent/WO2021191447A1/en not_active Ceased
- 2021-03-26 CN CN202180038835.4A patent/CN115698307A/zh active Pending
- 2021-03-26 US US17/914,212 patent/US20230116688A1/en active Pending
- 2021-03-26 BR BR112022019167A patent/BR112022019167A2/pt unknown
- 2021-03-26 AU AU2021241899A patent/AU2021241899A1/en active Pending
- 2021-03-26 IL IL296712A patent/IL296712A/en unknown
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