JP2012520059A5 - - Google Patents
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- JP2012520059A5 JP2012520059A5 JP2011551304A JP2011551304A JP2012520059A5 JP 2012520059 A5 JP2012520059 A5 JP 2012520059A5 JP 2011551304 A JP2011551304 A JP 2011551304A JP 2011551304 A JP2011551304 A JP 2011551304A JP 2012520059 A5 JP2012520059 A5 JP 2012520059A5
- Authority
- JP
- Japan
- Prior art keywords
- functional protein
- binding partner
- protein
- item
- peptide mask
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000004169 proteins and genes Human genes 0.000 claims description 111
- 108090000623 proteins and genes Proteins 0.000 claims description 111
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 98
- 238000000034 method Methods 0.000 claims description 29
- 239000000758 substrate Substances 0.000 claims description 26
- 102000004190 Enzymes Human genes 0.000 claims description 24
- 108090000790 Enzymes Proteins 0.000 claims description 24
- 229940088598 enzyme Drugs 0.000 claims description 24
- 239000012634 fragment Substances 0.000 claims description 22
- 102000014150 Interferons Human genes 0.000 claims description 19
- 108010050904 Interferons Proteins 0.000 claims description 19
- 108010070047 Notch Receptors Proteins 0.000 claims description 16
- 102000005650 Notch Receptors Human genes 0.000 claims description 16
- 102000005962 receptors Human genes 0.000 claims description 13
- 108020003175 receptors Proteins 0.000 claims description 13
- 150000001413 amino acids Chemical group 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims description 10
- 230000001225 therapeutic effect Effects 0.000 claims description 10
- 108010047761 Interferon-alpha Proteins 0.000 claims description 9
- 102000006992 Interferon-alpha Human genes 0.000 claims description 9
- 108010091175 Matriptase Proteins 0.000 claims description 9
- 102100037942 Suppressor of tumorigenicity 14 protein Human genes 0.000 claims description 9
- 238000010494 dissociation reaction Methods 0.000 claims description 8
- 230000005593 dissociations Effects 0.000 claims description 8
- 239000003446 ligand Substances 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 108091035707 Consensus sequence Proteins 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 5
- 208000035475 disorder Diseases 0.000 claims description 5
- 229940012957 plasmin Drugs 0.000 claims description 5
- 101000852870 Homo sapiens Interferon alpha/beta receptor 1 Proteins 0.000 claims description 4
- 102100036714 Interferon alpha/beta receptor 1 Human genes 0.000 claims description 4
- 108010074328 Interferon-gamma Proteins 0.000 claims description 4
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims description 4
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 102000030431 Asparaginyl endopeptidase Human genes 0.000 claims description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 3
- 108010055066 asparaginylendopeptidase Proteins 0.000 claims description 3
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 238000005859 coupling reaction Methods 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 210000004185 liver Anatomy 0.000 claims description 3
- 150000008574 D-amino acids Chemical class 0.000 claims description 2
- 101000994439 Danio rerio Protein jagged-1a Proteins 0.000 claims description 2
- 102100036462 Delta-like protein 1 Human genes 0.000 claims description 2
- 102100036466 Delta-like protein 3 Human genes 0.000 claims description 2
- 102100033553 Delta-like protein 4 Human genes 0.000 claims description 2
- 108010088842 Fibrinolysin Proteins 0.000 claims description 2
- 101000928537 Homo sapiens Delta-like protein 1 Proteins 0.000 claims description 2
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 claims description 2
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 claims description 2
- 101000852865 Homo sapiens Interferon alpha/beta receptor 2 Proteins 0.000 claims description 2
- 101001001420 Homo sapiens Interferon gamma receptor 1 Proteins 0.000 claims description 2
- 101000599613 Homo sapiens Interferon lambda receptor 1 Proteins 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 102000002227 Interferon Type I Human genes 0.000 claims description 2
- 108010014726 Interferon Type I Proteins 0.000 claims description 2
- 102100036718 Interferon alpha/beta receptor 2 Human genes 0.000 claims description 2
- 102100026720 Interferon beta Human genes 0.000 claims description 2
- 102100037850 Interferon gamma Human genes 0.000 claims description 2
- 102100035678 Interferon gamma receptor 1 Human genes 0.000 claims description 2
- 102100037971 Interferon lambda receptor 1 Human genes 0.000 claims description 2
- 108090000467 Interferon-beta Proteins 0.000 claims description 2
- 102000008070 Interferon-gamma Human genes 0.000 claims description 2
- 102000018697 Membrane Proteins Human genes 0.000 claims description 2
- 108010052285 Membrane Proteins Proteins 0.000 claims description 2
- 108010072610 N-acetyl-gamma-glutamyl-phosphate reductase Proteins 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 102100032702 Protein jagged-1 Human genes 0.000 claims description 2
- 102100032733 Protein jagged-2 Human genes 0.000 claims description 2
- 101710170213 Protein jagged-2 Proteins 0.000 claims description 2
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims description 2
- 230000033115 angiogenesis Effects 0.000 claims description 2
- 150000001576 beta-amino acids Chemical class 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 229940127276 delta-like ligand 3 Drugs 0.000 claims description 2
- 102000034238 globular proteins Human genes 0.000 claims description 2
- 108091005896 globular proteins Proteins 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 108010018844 interferon type III Proteins 0.000 claims description 2
- 108020001756 ligand binding domains Proteins 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 30
- 229920001184 polypeptide Polymers 0.000 claims 29
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 108010010648 interferon alfacon-1 Proteins 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 51
- 238000012216 screening Methods 0.000 description 8
- 210000005228 liver tissue Anatomy 0.000 description 4
- 208000005176 Hepatitis C Diseases 0.000 description 3
- 229940079322 interferon Drugs 0.000 description 3
- 108020004511 Recombinant DNA Proteins 0.000 description 2
- 230000000779 depleting effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- -1 IFN-ω Proteins 0.000 description 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 208000010710 hepatitis C virus infection Diseases 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15473009P | 2009-02-23 | 2009-02-23 | |
| US61/154,730 | 2009-02-23 | ||
| PCT/US2010/025121 WO2010096838A2 (en) | 2009-02-23 | 2010-02-23 | Proproteins and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015146309A Division JP2015193653A (ja) | 2009-02-23 | 2015-07-24 | プロタンパク質およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012520059A JP2012520059A (ja) | 2012-09-06 |
| JP2012520059A5 true JP2012520059A5 (https=) | 2012-12-06 |
| JP5861223B2 JP5861223B2 (ja) | 2016-02-16 |
Family
ID=42634501
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551304A Active JP5861223B2 (ja) | 2009-02-23 | 2010-02-23 | プロタンパク質およびその使用方法 |
| JP2015146309A Pending JP2015193653A (ja) | 2009-02-23 | 2015-07-24 | プロタンパク質およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015146309A Pending JP2015193653A (ja) | 2009-02-23 | 2015-07-24 | プロタンパク質およびその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US8399219B2 (https=) |
| EP (1) | EP2398494A4 (https=) |
| JP (2) | JP5861223B2 (https=) |
| CN (1) | CN102481341B (https=) |
| AU (2) | AU2010215761B2 (https=) |
| BR (1) | BRPI1011384A2 (https=) |
| CA (1) | CA2753294A1 (https=) |
| RU (1) | RU2011138951A (https=) |
| WO (1) | WO2010096838A2 (https=) |
Families Citing this family (119)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8293685B2 (en) | 2007-07-26 | 2012-10-23 | The Regents Of The University Of California | Methods for enhancing bacterial cell display of proteins and peptides |
| CA2697032C (en) * | 2007-08-22 | 2021-09-14 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
| WO2010004265A1 (en) | 2008-07-07 | 2010-01-14 | Oxford Nanopore Technologies Limited | Enzyme-pore constructs |
| JP2011527191A (ja) | 2008-07-07 | 2011-10-27 | オックスフォード ナノポア テクノロジーズ リミテッド | 塩基検出細孔 |
| GB0820927D0 (en) | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
| US20100189651A1 (en) * | 2009-01-12 | 2010-07-29 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
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| JP5861223B2 (ja) | 2009-02-23 | 2016-02-16 | サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. | プロタンパク質およびその使用方法 |
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| ES2536772T3 (es) | 2007-09-21 | 2015-05-28 | The Regents Of The University Of California | El interferón dirigido demuestra potentes actividades apoptóticas y antitumorales |
| CA2711256C (en) | 2008-01-03 | 2019-01-15 | The Scripps Research Institute | Antibody targeting through a modular recognition domain |
| EP2356131A4 (en) | 2008-12-08 | 2012-09-12 | Tegopharm Corp | MASKING LIGANDS FOR REVERSIBLE INHIBITION OF VERSATILE COMPOUNDS |
| US20100189651A1 (en) * | 2009-01-12 | 2010-07-29 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
| JP5861223B2 (ja) | 2009-02-23 | 2016-02-16 | サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. | プロタンパク質およびその使用方法 |
| WO2020214690A1 (en) * | 2019-04-15 | 2020-10-22 | Qwixel Therapeutics | Fusion protein composition(s) comprising targeted masked type i interferons (ifna and ifnb) and an antibody against tumor antigen, for use in the treatment of cancer |
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2010
- 2010-02-23 JP JP2011551304A patent/JP5861223B2/ja active Active
- 2010-02-23 RU RU2011138951/10A patent/RU2011138951A/ru not_active Application Discontinuation
- 2010-02-23 AU AU2010215761A patent/AU2010215761B2/en not_active Ceased
- 2010-02-23 US US12/711,199 patent/US8399219B2/en not_active Expired - Fee Related
- 2010-02-23 WO PCT/US2010/025121 patent/WO2010096838A2/en not_active Ceased
- 2010-02-23 EP EP10744488.7A patent/EP2398494A4/en not_active Withdrawn
- 2010-02-23 CA CA2753294A patent/CA2753294A1/en not_active Abandoned
- 2010-02-23 CN CN201080017140.XA patent/CN102481341B/zh not_active Expired - Fee Related
- 2010-02-23 BR BRPI1011384A patent/BRPI1011384A2/pt active Search and Examination
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2012
- 2012-12-20 US US13/721,528 patent/US8993266B2/en active Active
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2015
- 2015-03-30 US US14/673,175 patent/US9644016B2/en active Active
- 2015-07-24 JP JP2015146309A patent/JP2015193653A/ja active Pending
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2017
- 2017-03-10 AU AU2017201682A patent/AU2017201682A1/en not_active Abandoned
- 2017-05-08 US US15/589,464 patent/US10513549B2/en not_active Expired - Fee Related
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2019
- 2019-11-11 US US16/680,279 patent/US20200308243A1/en not_active Abandoned
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2022
- 2022-03-21 US US17/699,846 patent/US20230035290A1/en not_active Abandoned
- 2022-12-19 US US18/068,104 patent/US20230183308A1/en active Pending
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