JP2012520059A5 - - Google Patents
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- JP2012520059A5 JP2012520059A5 JP2011551304A JP2011551304A JP2012520059A5 JP 2012520059 A5 JP2012520059 A5 JP 2012520059A5 JP 2011551304 A JP2011551304 A JP 2011551304A JP 2011551304 A JP2011551304 A JP 2011551304A JP 2012520059 A5 JP2012520059 A5 JP 2012520059A5
- Authority
- JP
- Japan
- Prior art keywords
- functional protein
- binding partner
- protein
- item
- peptide mask
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000004169 proteins and genes Human genes 0.000 claims description 111
- 108090000623 proteins and genes Proteins 0.000 claims description 111
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 98
- 238000000034 method Methods 0.000 claims description 29
- 239000000758 substrate Substances 0.000 claims description 26
- 102000004190 Enzymes Human genes 0.000 claims description 24
- 108090000790 Enzymes Proteins 0.000 claims description 24
- 229940088598 enzyme Drugs 0.000 claims description 24
- 239000012634 fragment Substances 0.000 claims description 22
- 102000014150 Interferons Human genes 0.000 claims description 19
- 108010050904 Interferons Proteins 0.000 claims description 19
- 108010070047 Notch Receptors Proteins 0.000 claims description 16
- 102000005650 Notch Receptors Human genes 0.000 claims description 16
- 102000005962 receptors Human genes 0.000 claims description 13
- 108020003175 receptors Proteins 0.000 claims description 13
- 150000001413 amino acids Chemical group 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims description 10
- 230000001225 therapeutic effect Effects 0.000 claims description 10
- 108010047761 Interferon-alpha Proteins 0.000 claims description 9
- 102000006992 Interferon-alpha Human genes 0.000 claims description 9
- 108010091175 Matriptase Proteins 0.000 claims description 9
- 102100037942 Suppressor of tumorigenicity 14 protein Human genes 0.000 claims description 9
- 238000010494 dissociation reaction Methods 0.000 claims description 8
- 230000005593 dissociations Effects 0.000 claims description 8
- 239000003446 ligand Substances 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 108091035707 Consensus sequence Proteins 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 5
- 208000035475 disorder Diseases 0.000 claims description 5
- 229940012957 plasmin Drugs 0.000 claims description 5
- 101000852870 Homo sapiens Interferon alpha/beta receptor 1 Proteins 0.000 claims description 4
- 102100036714 Interferon alpha/beta receptor 1 Human genes 0.000 claims description 4
- 108010074328 Interferon-gamma Proteins 0.000 claims description 4
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims description 4
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 102000030431 Asparaginyl endopeptidase Human genes 0.000 claims description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 3
- 108010055066 asparaginylendopeptidase Proteins 0.000 claims description 3
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 238000005859 coupling reaction Methods 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 210000004185 liver Anatomy 0.000 claims description 3
- 150000008574 D-amino acids Chemical class 0.000 claims description 2
- 101000994439 Danio rerio Protein jagged-1a Proteins 0.000 claims description 2
- 102100036462 Delta-like protein 1 Human genes 0.000 claims description 2
- 102100036466 Delta-like protein 3 Human genes 0.000 claims description 2
- 102100033553 Delta-like protein 4 Human genes 0.000 claims description 2
- 108010088842 Fibrinolysin Proteins 0.000 claims description 2
- 101000928537 Homo sapiens Delta-like protein 1 Proteins 0.000 claims description 2
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 claims description 2
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 claims description 2
- 101000852865 Homo sapiens Interferon alpha/beta receptor 2 Proteins 0.000 claims description 2
- 101001001420 Homo sapiens Interferon gamma receptor 1 Proteins 0.000 claims description 2
- 101000599613 Homo sapiens Interferon lambda receptor 1 Proteins 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 102000002227 Interferon Type I Human genes 0.000 claims description 2
- 108010014726 Interferon Type I Proteins 0.000 claims description 2
- 102100036718 Interferon alpha/beta receptor 2 Human genes 0.000 claims description 2
- 102100026720 Interferon beta Human genes 0.000 claims description 2
- 102100037850 Interferon gamma Human genes 0.000 claims description 2
- 102100035678 Interferon gamma receptor 1 Human genes 0.000 claims description 2
- 102100037971 Interferon lambda receptor 1 Human genes 0.000 claims description 2
- 108090000467 Interferon-beta Proteins 0.000 claims description 2
- 102000008070 Interferon-gamma Human genes 0.000 claims description 2
- 102000018697 Membrane Proteins Human genes 0.000 claims description 2
- 108010052285 Membrane Proteins Proteins 0.000 claims description 2
- 108010072610 N-acetyl-gamma-glutamyl-phosphate reductase Proteins 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 102100032702 Protein jagged-1 Human genes 0.000 claims description 2
- 102100032733 Protein jagged-2 Human genes 0.000 claims description 2
- 101710170213 Protein jagged-2 Proteins 0.000 claims description 2
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims description 2
- 230000033115 angiogenesis Effects 0.000 claims description 2
- 150000001576 beta-amino acids Chemical class 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 229940127276 delta-like ligand 3 Drugs 0.000 claims description 2
- 102000034238 globular proteins Human genes 0.000 claims description 2
- 108091005896 globular proteins Proteins 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 108010018844 interferon type III Proteins 0.000 claims description 2
- 108020001756 ligand binding domains Proteins 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 30
- 229920001184 polypeptide Polymers 0.000 claims 29
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 108010010648 interferon alfacon-1 Proteins 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 51
- 238000012216 screening Methods 0.000 description 8
- 210000005228 liver tissue Anatomy 0.000 description 4
- 208000005176 Hepatitis C Diseases 0.000 description 3
- 229940079322 interferon Drugs 0.000 description 3
- 108020004511 Recombinant DNA Proteins 0.000 description 2
- 230000000779 depleting effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- -1 IFN-ω Proteins 0.000 description 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 208000010710 hepatitis C virus infection Diseases 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15473009P | 2009-02-23 | 2009-02-23 | |
| US61/154,730 | 2009-02-23 | ||
| PCT/US2010/025121 WO2010096838A2 (en) | 2009-02-23 | 2010-02-23 | Proproteins and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015146309A Division JP2015193653A (ja) | 2009-02-23 | 2015-07-24 | プロタンパク質およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012520059A JP2012520059A (ja) | 2012-09-06 |
| JP2012520059A5 true JP2012520059A5 (https=) | 2012-12-06 |
| JP5861223B2 JP5861223B2 (ja) | 2016-02-16 |
Family
ID=42634501
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551304A Active JP5861223B2 (ja) | 2009-02-23 | 2010-02-23 | プロタンパク質およびその使用方法 |
| JP2015146309A Pending JP2015193653A (ja) | 2009-02-23 | 2015-07-24 | プロタンパク質およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015146309A Pending JP2015193653A (ja) | 2009-02-23 | 2015-07-24 | プロタンパク質およびその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US8399219B2 (https=) |
| EP (1) | EP2398494A4 (https=) |
| JP (2) | JP5861223B2 (https=) |
| CN (1) | CN102481341B (https=) |
| AU (2) | AU2010215761B2 (https=) |
| BR (1) | BRPI1011384A2 (https=) |
| CA (1) | CA2753294A1 (https=) |
| RU (1) | RU2011138951A (https=) |
| WO (1) | WO2010096838A2 (https=) |
Families Citing this family (119)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8293685B2 (en) | 2007-07-26 | 2012-10-23 | The Regents Of The University Of California | Methods for enhancing bacterial cell display of proteins and peptides |
| US20090304719A1 (en) | 2007-08-22 | 2009-12-10 | Patrick Daugherty | Activatable binding polypeptides and methods of identification and use thereof |
| EP2310534B1 (en) | 2008-07-07 | 2018-09-05 | Oxford Nanopore Technologies Limited | Base-detecting pore |
| US20110229877A1 (en) | 2008-07-07 | 2011-09-22 | Oxford Nanopore Technologies Limited | Enzyme-pore constructs |
| GB0820927D0 (en) | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
| RU2636046C2 (ru) | 2009-01-12 | 2017-11-17 | Сайтомкс Терапьютикс, Инк | Композиции модифицированных антител, способы их получения и применения |
| KR20110125226A (ko) * | 2009-01-30 | 2011-11-18 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 혼성화 링커 |
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| JP6298404B2 (ja) | 2011-07-25 | 2018-03-20 | オックスフォード ナノポール テクノロジーズ リミテッド | 膜貫通ポアを用いる二重鎖ポリヌクレオチド配列決定のためのヘアピンループ方法 |
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| KR102083695B1 (ko) | 2012-04-10 | 2020-03-02 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 리세닌 기공 |
| JP6429773B2 (ja) | 2012-07-19 | 2018-11-28 | オックスフォード ナノポール テクノロジーズ リミテッド | 酵素構築物 |
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| RU2010107199A (ru) * | 2007-07-31 | 2011-09-10 | Дзе Джонс Хопкинс Юниверсити (Us) | Конъюгат полипептид-нуклеиновая кислота для иммунопрофилактики или иммунотерапии для неопластических или инфекционных нарушений |
| US20090304719A1 (en) | 2007-08-22 | 2009-12-10 | Patrick Daugherty | Activatable binding polypeptides and methods of identification and use thereof |
| US8865875B2 (en) | 2007-08-22 | 2014-10-21 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions |
| CN101868246A (zh) | 2007-09-21 | 2010-10-20 | 加利福尼亚大学董事会 | 被导靶的干扰素显示强的细胞凋亡和抗肿瘤活性 |
| KR101658247B1 (ko) | 2008-01-03 | 2016-09-22 | 더 스크립스 리서치 인스티튜트 | 모듈 인식 도메인을 통한 항체 표적화 |
| WO2010077643A1 (en) | 2008-12-08 | 2010-07-08 | Tegopharm Corporation | Masking ligands for reversible inhibition of multivalent compounds |
| RU2636046C2 (ru) | 2009-01-12 | 2017-11-17 | Сайтомкс Терапьютикс, Инк | Композиции модифицированных антител, способы их получения и применения |
| AU2010215761B2 (en) | 2009-02-23 | 2017-04-06 | Cytomx Therapeutics, Inc | Proproteins and methods of use thereof |
| EP3955957A1 (en) * | 2019-04-15 | 2022-02-23 | Qwixel Therapeutics LLC | Fusion protein composition(s) comprising targeted masked type i interferons (ifna and ifnb) and an antibody against tumor antigen, for use in the treatment of cancer |
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2010
- 2010-02-23 AU AU2010215761A patent/AU2010215761B2/en not_active Ceased
- 2010-02-23 CN CN201080017140.XA patent/CN102481341B/zh not_active Expired - Fee Related
- 2010-02-23 JP JP2011551304A patent/JP5861223B2/ja active Active
- 2010-02-23 US US12/711,199 patent/US8399219B2/en not_active Expired - Fee Related
- 2010-02-23 EP EP10744488.7A patent/EP2398494A4/en not_active Withdrawn
- 2010-02-23 BR BRPI1011384A patent/BRPI1011384A2/pt active Search and Examination
- 2010-02-23 RU RU2011138951/10A patent/RU2011138951A/ru not_active Application Discontinuation
- 2010-02-23 CA CA2753294A patent/CA2753294A1/en not_active Abandoned
- 2010-02-23 WO PCT/US2010/025121 patent/WO2010096838A2/en not_active Ceased
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2012
- 2012-12-20 US US13/721,528 patent/US8993266B2/en active Active
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2015
- 2015-03-30 US US14/673,175 patent/US9644016B2/en active Active
- 2015-07-24 JP JP2015146309A patent/JP2015193653A/ja active Pending
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2017
- 2017-03-10 AU AU2017201682A patent/AU2017201682A1/en not_active Abandoned
- 2017-05-08 US US15/589,464 patent/US10513549B2/en not_active Expired - Fee Related
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2019
- 2019-11-11 US US16/680,279 patent/US20200308243A1/en not_active Abandoned
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2022
- 2022-03-21 US US17/699,846 patent/US20230035290A1/en not_active Abandoned
- 2022-12-19 US US18/068,104 patent/US20230183308A1/en active Pending
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