JP2024069465A5 - - Google Patents
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- JP2024069465A5 JP2024069465A5 JP2024039818A JP2024039818A JP2024069465A5 JP 2024069465 A5 JP2024069465 A5 JP 2024069465A5 JP 2024039818 A JP2024039818 A JP 2024039818A JP 2024039818 A JP2024039818 A JP 2024039818A JP 2024069465 A5 JP2024069465 A5 JP 2024069465A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- seq
- linker
- composition
- albumin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 102000009027 Albumins Human genes 0.000 claims 9
- 108010088751 Albumins Proteins 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 230000002519 immonomodulatory effect Effects 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 230000001965 increasing effect Effects 0.000 claims 4
- 208000035473 Communicable disease Diseases 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 230000005867 T cell response Effects 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 102000008100 Human Serum Albumin Human genes 0.000 claims 2
- 108091006905 Human Serum Albumin Proteins 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000003308 immunostimulating effect Effects 0.000 claims 2
- 238000000099 in vitro assay Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 238000003259 recombinant expression Methods 0.000 claims 2
- 238000009825 accumulation Methods 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 210000004324 lymphatic system Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762543163P | 2017-08-09 | 2017-08-09 | |
| US62/543,163 | 2017-08-09 | ||
| JP2020506750A JP2020530453A (ja) | 2017-08-09 | 2018-08-09 | アルブミン結合ペプチド結合体及びその方法 |
| PCT/US2018/046011 WO2019032827A1 (en) | 2017-08-09 | 2018-08-09 | PEPTIDE ALBUMIN BINDING CONJUGATES AND METHODS THEREOF |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020506750A Division JP2020530453A (ja) | 2017-08-09 | 2018-08-09 | アルブミン結合ペプチド結合体及びその方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024069465A JP2024069465A (ja) | 2024-05-21 |
| JP2024069465A5 true JP2024069465A5 (https=) | 2025-01-23 |
Family
ID=63371811
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020506750A Withdrawn JP2020530453A (ja) | 2017-08-09 | 2018-08-09 | アルブミン結合ペプチド結合体及びその方法 |
| JP2024039818A Pending JP2024069465A (ja) | 2017-08-09 | 2024-03-14 | アルブミン結合ペプチド結合体及びその方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020506750A Withdrawn JP2020530453A (ja) | 2017-08-09 | 2018-08-09 | アルブミン結合ペプチド結合体及びその方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US11077199B2 (https=) |
| EP (1) | EP3665202A1 (https=) |
| JP (2) | JP2020530453A (https=) |
| CN (1) | CN111164104A (https=) |
| WO (1) | WO2019032827A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111164104A (zh) | 2017-08-09 | 2020-05-15 | 麻省理工学院 | 白蛋白结合肽缀合物及其方法 |
| CN115590974A (zh) * | 2022-05-27 | 2023-01-13 | 苏州大学（Cn） | 功能化靶向制剂及其制备方法、应用 |
| CN115590947B (zh) * | 2022-05-27 | 2025-11-21 | 苏州大学 | 联合免疫用药物、温敏凝胶组合物、趋化因子颗粒及其应用 |
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| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| DE3474511D1 (en) | 1983-11-01 | 1988-11-17 | Terumo Corp | Pharmaceutical composition containing urokinase |
| US5521063A (en) | 1985-03-15 | 1996-05-28 | Antivirals Inc. | Polynucleotide reagent containing chiral subunits and methods of use |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| WO1986005519A1 (en) | 1985-03-15 | 1986-09-25 | James Summerton | Polynucleotide assay reagent and method |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| US5525491A (en) | 1991-02-27 | 1996-06-11 | Creative Biomolecules, Inc. | Serine-rich peptide linkers |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5527675A (en) | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| DE4331012A1 (de) | 1993-09-13 | 1995-03-16 | Bayer Ag | Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik |
| US5786571A (en) | 1997-05-09 | 1998-07-28 | Lexmark International, Inc. | Wrapped temperature sensing assembly |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US20040001827A1 (en) * | 2002-06-28 | 2004-01-01 | Dennis Mark S. | Serum albumin binding peptides for tumor targeting |
| US20060228364A1 (en) * | 1999-12-24 | 2006-10-12 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
| EP1240337B1 (en) | 1999-12-24 | 2006-08-23 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| JP5634008B2 (ja) * | 2004-04-06 | 2014-12-03 | アフィボディ・アーベー | 新規の使用および方法 |
| GB0412181D0 (en) | 2004-06-01 | 2004-06-30 | Celltech R&D Ltd | Biological products |
| MX2007003907A (es) | 2004-10-05 | 2007-05-21 | Genentech Inc | Agentes terapeuticos con toxicidad reducida. |
| US8992928B2 (en) | 2006-02-11 | 2015-03-31 | Victor Raso | Isolated monoclonal antibody or antigen-binding fragment that cleaves octanoylated native ghrelin |
| GB0621973D0 (en) | 2006-11-03 | 2006-12-13 | Philogen Spa | Binding molecules and uses thereof |
| EP2190863B1 (en) | 2007-07-31 | 2015-09-02 | Affibody AB | New albumin binding compositions, methods and uses |
| WO2009089295A2 (en) | 2008-01-07 | 2009-07-16 | Government Of The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Anti-hiv domain antibodies and method of making and using same |
| US20100075897A1 (en) * | 2008-09-23 | 2010-03-25 | Jinan University | Method for sustainedly releasing bioactive peptides and application thereof |
| EP2437767B1 (en) | 2009-06-01 | 2015-07-08 | MedImmune, LLC | Molecules with extended half-lives and uses thereof |
| CA2799540A1 (en) * | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| CN103003296A (zh) | 2010-07-09 | 2013-03-27 | 阿菲博迪公司 | 多肽 |
| BR112013029892A2 (pt) | 2011-05-21 | 2016-12-20 | Macrogenics Inc | polipeptídeo, molécula de ligação a antígeno, diacorpo e uso de uma porção polipeptídica de uma proteína de ligação a soro desimunizada |
| EP2723772A1 (en) | 2011-06-23 | 2014-04-30 | Ablynx N.V. | Immunoglobulin single variable domains directed against ige |
| EP2758434A2 (en) | 2011-09-23 | 2014-07-30 | Technophage, Investigação E Desenvolvimento Em Biotecnologia, SA | Anti-tumor necrosis factor-alpha agents and uses thereof |
| CN103958542A (zh) | 2011-09-23 | 2014-07-30 | 抗菌技术,生物技术研究与发展股份有限公司 | 经修饰的白蛋白结合结构域及其用于改善药代动力学的用途 |
| HK1208155A1 (en) | 2012-03-28 | 2016-02-26 | Amylin Pharmaceuticals, Llc | Transmucosal delivery of engineered polypeptides |
| JP6375289B2 (ja) * | 2012-04-05 | 2018-08-15 | マサチューセッツ インスティテュート オブ テクノロジー | 免疫刺激組成物およびその使用方法 |
| WO2013180295A1 (ja) | 2012-06-01 | 2013-12-05 | 日本電信電話株式会社 | パケット転送処理方法およびパケット転送処理装置 |
| EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
| US9300829B2 (en) | 2014-04-04 | 2016-03-29 | Canon Kabushiki Kaisha | Image reading apparatus and correction method thereof |
| EP2940128A1 (en) | 2014-04-30 | 2015-11-04 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Adenovirus comprising an albumin-binding moiety |
| EP4299595A3 (en) | 2014-05-02 | 2024-03-13 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc constructs |
| WO2015177175A2 (en) | 2014-05-22 | 2015-11-26 | Pieris Ag | Novel specific-binding polypeptides and uses thereof |
| EP3157547A1 (en) * | 2014-06-18 | 2017-04-26 | Prorec Bio AB | Prolactin receptor antagonists for treatment of glioblastoma |
| WO2016025647A1 (en) * | 2014-08-12 | 2016-02-18 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2, a therapeutic antibody, and a cancer vaccine |
| IL252192B2 (en) | 2014-11-10 | 2024-03-01 | Del Mar Pharmaceuticals | Dianhydrogalactitol together with radiation to treat non-small-cell carcinoma of the lung and glioblastoma multiforme |
| AU2016274175B2 (en) * | 2015-06-12 | 2021-02-18 | Mackay Medical Foundation The Presbyterian Church In Taiwan Mackay Memorial Hospital | Methods and polypeptides for modulation of immunoresponse |
| CN111164104A (zh) | 2017-08-09 | 2020-05-15 | 麻省理工学院 | 白蛋白结合肽缀合物及其方法 |
-
2018
- 2018-08-09 CN CN201880064127.6A patent/CN111164104A/zh active Pending
- 2018-08-09 EP EP18759824.8A patent/EP3665202A1/en active Pending
- 2018-08-09 US US16/059,523 patent/US11077199B2/en active Active
- 2018-08-09 JP JP2020506750A patent/JP2020530453A/ja not_active Withdrawn
- 2018-08-09 WO PCT/US2018/046011 patent/WO2019032827A1/en not_active Ceased
-
2021
- 2021-07-09 US US17/371,367 patent/US11642416B2/en active Active
-
2023
- 2023-04-18 US US18/302,655 patent/US20230248840A1/en not_active Abandoned
-
2024
- 2024-03-14 JP JP2024039818A patent/JP2024069465A/ja active Pending
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