JP2024509241A5 - - Google Patents
Info
- Publication number
- JP2024509241A5 JP2024509241A5 JP2023554813A JP2023554813A JP2024509241A5 JP 2024509241 A5 JP2024509241 A5 JP 2024509241A5 JP 2023554813 A JP2023554813 A JP 2023554813A JP 2023554813 A JP2023554813 A JP 2023554813A JP 2024509241 A5 JP2024509241 A5 JP 2024509241A5
- Authority
- JP
- Japan
- Prior art keywords
- repeat domain
- ankyrin repeat
- human
- binding specificity
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163158539P | 2021-03-09 | 2021-03-09 | |
| US63/158,539 | 2021-03-09 | ||
| US202163173227P | 2021-04-09 | 2021-04-09 | |
| US63/173,227 | 2021-04-09 | ||
| US202163265187P | 2021-12-09 | 2021-12-09 | |
| US63/265,187 | 2021-12-09 | ||
| PCT/IB2022/052128 WO2022190018A1 (en) | 2021-03-09 | 2022-03-09 | Novel darpin based cd123 engagers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024509241A JP2024509241A (ja) | 2024-02-29 |
| JP2024509241A5 true JP2024509241A5 (https=) | 2025-03-18 |
Family
ID=80820043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023554813A Pending JP2024509241A (ja) | 2021-03-09 | 2022-03-09 | 新規のＤＡＲＰｉｎに基づくＣＤ１２３エンゲージャ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240150475A1 (https=) |
| EP (1) | EP4304729A1 (https=) |
| JP (1) | JP2024509241A (https=) |
| AU (1) | AU2022233791A1 (https=) |
| CA (1) | CA3211368A1 (https=) |
| WO (1) | WO2022190018A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240279290A1 (en) | 2020-05-14 | 2024-08-22 | Molecular Partners Ag | Multispecific proteins |
| BR112023018293A2 (pt) | 2021-03-09 | 2023-10-31 | Molecular Partners Ag | Acopladores de célula t multiespecíficos à base de darpin |
| EP4673159A1 (en) * | 2023-02-27 | 2026-01-07 | Molecular Partners AG | Darpins for use in reducing renal accumulation of drugs |
| EP4724460A1 (en) * | 2023-06-06 | 2026-04-15 | Molecular Partners AG | Recombinant cd16a binding proteins and their use |
| WO2025163083A1 (en) * | 2024-01-31 | 2025-08-07 | Molecular Partners Ag | Recobminant dll3 binding proteins and their use |
| WO2025181039A1 (en) | 2024-03-01 | 2025-09-04 | Molecular Partners Ag | Therapeutic combinations comprising a multi-specific t cell engager |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| EP1332209B1 (en) | 2000-09-08 | 2009-11-11 | Universität Zürich | Collections of repeat proteins comprising repeat modules |
| US20050053973A1 (en) | 2001-04-26 | 2005-03-10 | Avidia Research Institute | Novel proteins with targeted binding |
| US20050048512A1 (en) | 2001-04-26 | 2005-03-03 | Avidia Research Institute | Combinatorial libraries of monomer domains |
| US20040175756A1 (en) | 2001-04-26 | 2004-09-09 | Avidia Research Institute | Methods for using combinatorial libraries of monomer domains |
| WO2005063815A2 (en) | 2003-11-12 | 2005-07-14 | Biogen Idec Ma Inc. | Fcϝ receptor-binding polypeptide variants and methods related thereto |
| US20060008844A1 (en) | 2004-06-17 | 2006-01-12 | Avidia Research Institute | c-Met kinase binding proteins |
| US9365629B2 (en) | 2007-09-24 | 2016-06-14 | University Of Zurich | Designed armadillo repeat proteins |
| BRPI0921469B1 (pt) | 2008-11-03 | 2022-01-18 | Molecular Partners Ag | Proteínas de ligação que inibem a interação com o receptor de vegf-a, composição farmacêutica |
| AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
| PL2643349T3 (pl) | 2010-11-26 | 2020-03-31 | Molecular Partners Ag | Zaprojektowane białka z powtórzeniami wiążące się z albuminą surowicy |
| WO2014001442A1 (en) | 2012-06-28 | 2014-01-03 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
| EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| EP2789630A1 (en) | 2013-04-09 | 2014-10-15 | EngMab AG | Bispecific antibodies against CD3e and ROR1 |
| CN105209483B (zh) | 2013-05-31 | 2021-07-27 | 分子组合公司 | 与肝细胞生长因子结合的设计锚蛋白重复蛋白 |
| EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
| KR102427117B1 (ko) | 2015-04-02 | 2022-07-29 | 몰리큘라 파트너스 아게 | 혈청 알부민에 대한 결합 특이성을 갖는 설계된 안키린 반복 도메인 |
| CN109790206A (zh) | 2016-09-22 | 2019-05-21 | 分子组合公司 | 重组结合蛋白及其用途 |
| US20220040284A1 (en) * | 2018-09-28 | 2022-02-10 | The Chancellor, Masters And Scholars Of The University Cambridge | Vaccines and methods |
| CA3138805A1 (en) * | 2019-06-04 | 2020-12-10 | Johannes Schilling | Designed ankyrin repeat domain with improved stability |
| CN114222757A (zh) * | 2019-06-04 | 2022-03-22 | 分子伴侣公司 | 重组4-1bb结合蛋白及其用途 |
| JP7611173B2 (ja) * | 2019-06-04 | 2025-01-09 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 組換えｆａｐ結合タンパク質及びそれらの使用 |
-
2022
- 2022-03-09 CA CA3211368A patent/CA3211368A1/en active Pending
- 2022-03-09 AU AU2022233791A patent/AU2022233791A1/en not_active Abandoned
- 2022-03-09 EP EP22711618.3A patent/EP4304729A1/en active Pending
- 2022-03-09 JP JP2023554813A patent/JP2024509241A/ja active Pending
- 2022-03-09 US US18/281,161 patent/US20240150475A1/en active Pending
- 2022-03-09 WO PCT/IB2022/052128 patent/WO2022190018A1/en not_active Ceased