JP2023506765A5 - - Google Patents
Info
- Publication number
- JP2023506765A5 JP2023506765A5 JP2022535453A JP2022535453A JP2023506765A5 JP 2023506765 A5 JP2023506765 A5 JP 2023506765A5 JP 2022535453 A JP2022535453 A JP 2022535453A JP 2022535453 A JP2022535453 A JP 2022535453A JP 2023506765 A5 JP2023506765 A5 JP 2023506765A5
- Authority
- JP
- Japan
- Prior art keywords
- ankyrin repeat
- designed ankyrin
- repeat domain
- acid sequence
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19215435 | 2019-12-11 | ||
| EP19215434.2 | 2019-12-11 | ||
| EP19215433.4 | 2019-12-11 | ||
| EP19215436.7 | 2019-12-11 | ||
| EP19215434 | 2019-12-11 | ||
| EP19215435.9 | 2019-12-11 | ||
| EP19215433 | 2019-12-11 | ||
| EP19215436 | 2019-12-11 | ||
| EP20161059.9 | 2020-03-04 | ||
| EP20161059 | 2020-03-04 | ||
| EP20181234.4 | 2020-06-19 | ||
| EP20181234 | 2020-06-19 | ||
| PCT/EP2020/085855 WO2021116462A1 (en) | 2019-12-11 | 2020-12-11 | Designed ankyrin repeat domains with altered surface residues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023506765A JP2023506765A (ja) | 2023-02-20 |
| JP2023506765A5 true JP2023506765A5 (https=) | 2023-12-18 |
Family
ID=73790118
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022535443A Active JP7794740B2 (ja) | 2019-12-11 | 2020-12-11 | 組換えペプチド－ｍｈｃ複合体結合タンパク質並びにそれらの生成及び使用 |
| JP2022535453A Pending JP2023506765A (ja) | 2019-12-11 | 2020-12-11 | 変化した表面残基を有する設計されたアンキリン反復ドメイン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022535443A Active JP7794740B2 (ja) | 2019-12-11 | 2020-12-11 | 組換えペプチド－ｍｈｃ複合体結合タンパク質並びにそれらの生成及び使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20220106707A1 (https=) |
| EP (2) | EP4073091A1 (https=) |
| JP (2) | JP7794740B2 (https=) |
| KR (2) | KR20220113492A (https=) |
| CN (2) | CN115003689A (https=) |
| AU (2) | AU2020402581A1 (https=) |
| BR (2) | BR112022011456A2 (https=) |
| CA (2) | CA3161326A1 (https=) |
| IL (2) | IL293698A (https=) |
| MX (2) | MX2022007120A (https=) |
| WO (2) | WO2021116469A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL293698A (en) | 2019-12-11 | 2022-08-01 | Molecular Partners Ag | Recombinant peptide-mhc complex binding proteins, their production and use |
| JP2023525518A (ja) | 2020-05-06 | 2023-06-16 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 新規アンキリンリピート結合タンパク質とその用途 |
| US20240279290A1 (en) | 2020-05-14 | 2024-08-22 | Molecular Partners Ag | Multispecific proteins |
| US11981710B2 (en) | 2020-08-18 | 2024-05-14 | Athebio Ag | N-terminal capping modules of ankyrin repeat domains |
| EP3957649A1 (en) | 2020-08-18 | 2022-02-23 | Athebio AG | Improved n-terminal capping modules of ankyrin repeat domains |
| BR112023018293A2 (pt) | 2021-03-09 | 2023-10-31 | Molecular Partners Ag | Acopladores de célula t multiespecíficos à base de darpin |
| US12435444B2 (en) | 2021-03-09 | 2025-10-07 | Cdr-Life Ag | Rabbit-derived antigen binding protein nucleic acid libraries and methods of making the same |
| WO2023021050A1 (en) * | 2021-08-17 | 2023-02-23 | Athebio Ag | Variants of ankyrin repeat domains |
| EP4137508A1 (en) * | 2021-08-17 | 2023-02-22 | Athebio AG | Variants of ankyrin repeat domains |
| WO2023110983A1 (en) | 2021-12-14 | 2023-06-22 | Molecular Partners Ag | Designed repeat domains with dual binding specificity and their use |
| MX2024007473A (es) * | 2021-12-14 | 2024-09-10 | Cdr Life Ag | Activador del linfocito t dirigido al mhc doble. |
| WO2024028278A1 (en) | 2022-08-01 | 2024-02-08 | Molecular Partners Ag | Charge modified designed repeat domains and their use |
| CA3264474A1 (en) | 2022-09-14 | 2024-03-21 | Cdr-Life Ag | MAGE-A4 DOUBLE T LYMPHOCYTE ENGAGEMENT |
| EP4673159A1 (en) | 2023-02-27 | 2026-01-07 | Molecular Partners AG | Darpins for use in reducing renal accumulation of drugs |
| WO2024216244A2 (en) | 2023-04-13 | 2024-10-17 | Regenxbio Inc. | Targeting aav capsids, methods of manufacturing and using same |
| EP4724460A1 (en) * | 2023-06-06 | 2026-04-15 | Molecular Partners AG | Recombinant cd16a binding proteins and their use |
| WO2025146491A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent |
| WO2025163144A1 (en) * | 2024-01-31 | 2025-08-07 | Molecular Partners Ag | Recombinant mesothelin binding proteins and their use |
| WO2025163083A1 (en) | 2024-01-31 | 2025-08-07 | Molecular Partners Ag | Recobminant dll3 binding proteins and their use |
| DE202024101891U1 (de) | 2024-04-16 | 2025-07-18 | Igus Gmbh | Leitungsführungsvorrichtung für Reinraumanwendungen sowie Halteelement dafür |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804381A (en) | 1996-10-03 | 1998-09-08 | Cornell Research Foundation | Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof |
| EP1332209B1 (en) | 2000-09-08 | 2009-11-11 | Universität Zürich | Collections of repeat proteins comprising repeat modules |
| AU2003216341A1 (en) | 2002-02-20 | 2003-09-09 | Dyax Corporation | Mhc-peptide complex binding ligands |
| JP2008519590A (ja) | 2004-11-12 | 2008-06-12 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 組換えニューカッスル病ウィルス |
| BRPI0613593A2 (pt) | 2005-07-08 | 2011-01-18 | Univ Zuerich | método de teste "phage display" filamentoso, vetor de fago ou de fagomìdeo e biblioteca de vetores de fago ou fagomìdeo |
| CN103864893B (zh) | 2007-07-27 | 2017-01-04 | 伊玛提克斯生物技术有限公司 | 免疫疗法的免疫抗原表位 |
| US9365629B2 (en) | 2007-09-24 | 2016-06-14 | University Of Zurich | Designed armadillo repeat proteins |
| BRPI0921469B1 (pt) | 2008-11-03 | 2022-01-18 | Molecular Partners Ag | Proteínas de ligação que inibem a interação com o receptor de vegf-a, composição farmacêutica |
| AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
| PL2643349T3 (pl) | 2010-11-26 | 2020-03-31 | Molecular Partners Ag | Zaprojektowane białka z powtórzeniami wiążące się z albuminą surowicy |
| EA201391607A1 (ru) * | 2011-04-29 | 2014-04-30 | Янссен Байотек, Инк. | Связывающие il4/il13 белки с повторами и их применение |
| WO2014001442A1 (en) | 2012-06-28 | 2014-01-03 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
| WO2014060365A1 (en) | 2012-10-15 | 2014-04-24 | Universität Zürich Prorektorat Mnw | Bispecific her2 ligands for cancer therapy |
| EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| CN105209483B (zh) | 2013-05-31 | 2021-07-27 | 分子组合公司 | 与肝细胞生长因子结合的设计锚蛋白重复蛋白 |
| NZ724320A (en) | 2014-03-14 | 2022-05-27 | Adaptimmune Ltd | Tcr libraries |
| WO2016023898A2 (en) * | 2014-08-11 | 2016-02-18 | Medimmune Limited | Intracellular antigen binding |
| WO2016154246A1 (en) | 2015-03-23 | 2016-09-29 | The Johns Hopkins University | Hla-restricted epitopes encoded by somatically mutated genes |
| KR102427117B1 (ko) | 2015-04-02 | 2022-07-29 | 몰리큘라 파트너스 아게 | 혈청 알부민에 대한 결합 특이성을 갖는 설계된 안키린 반복 도메인 |
| US11827688B2 (en) | 2016-06-02 | 2023-11-28 | Immunocore Limited | Dosing regimen for GP100-specific TCR—anti-CD3 SCFV fusion protein |
| CN109790206A (zh) | 2016-09-22 | 2019-05-21 | 分子组合公司 | 重组结合蛋白及其用途 |
| US12065479B2 (en) | 2017-11-16 | 2024-08-20 | The Regents Of The University Of California | Force sensor cleavage domain containing chimeric polypeptides and methods of use thereof |
| JP7611173B2 (ja) | 2019-06-04 | 2025-01-09 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 組換えｆａｐ結合タンパク質及びそれらの使用 |
| CA3138805A1 (en) | 2019-06-04 | 2020-12-10 | Johannes Schilling | Designed ankyrin repeat domain with improved stability |
| WO2020245746A1 (en) | 2019-06-04 | 2020-12-10 | Molecular Partners Ag | Multispecific proteins |
| CN114222757A (zh) | 2019-06-04 | 2022-03-22 | 分子伴侣公司 | 重组4-1bb结合蛋白及其用途 |
| WO2021116470A2 (en) | 2019-12-11 | 2021-06-17 | Molecular Partners Ag | Recombinant peptide-mhc complex binding proteins and their generation and use |
| IL293698A (en) * | 2019-12-11 | 2022-08-01 | Molecular Partners Ag | Recombinant peptide-mhc complex binding proteins, their production and use |
| JP2023525518A (ja) * | 2020-05-06 | 2023-06-16 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 新規アンキリンリピート結合タンパク質とその用途 |
| US20240279290A1 (en) | 2020-05-14 | 2024-08-22 | Molecular Partners Ag | Multispecific proteins |
| US20240279309A1 (en) | 2020-05-14 | 2024-08-22 | Molecular Partners Ag | Recombinant cd40 binding proteins and their use |
-
2020
- 2020-12-11 IL IL293698A patent/IL293698A/en unknown
- 2020-12-11 AU AU2020402581A patent/AU2020402581A1/en active Pending
- 2020-12-11 WO PCT/EP2020/085863 patent/WO2021116469A2/en not_active Ceased
- 2020-12-11 BR BR112022011456A patent/BR112022011456A2/pt not_active Application Discontinuation
- 2020-12-11 MX MX2022007120A patent/MX2022007120A/es unknown
- 2020-12-11 WO PCT/EP2020/085855 patent/WO2021116462A1/en not_active Ceased
- 2020-12-11 BR BR112022011177A patent/BR112022011177A2/pt not_active Application Discontinuation
- 2020-12-11 JP JP2022535443A patent/JP7794740B2/ja active Active
- 2020-12-11 KR KR1020227023764A patent/KR20220113492A/ko not_active Withdrawn
- 2020-12-11 KR KR1020227023763A patent/KR20220113491A/ko not_active Withdrawn
- 2020-12-11 MX MX2022007122A patent/MX2022007122A/es unknown
- 2020-12-11 EP EP20821220.9A patent/EP4073091A1/en active Pending
- 2020-12-11 CA CA3161326A patent/CA3161326A1/en active Pending
- 2020-12-11 JP JP2022535453A patent/JP2023506765A/ja active Pending
- 2020-12-11 CN CN202080093076.7A patent/CN115003689A/zh active Pending
- 2020-12-11 IL IL293704A patent/IL293704A/en unknown
- 2020-12-11 AU AU2020399230A patent/AU2020399230A1/en active Pending
- 2020-12-11 CN CN202080093012.7A patent/CN114929730A/zh active Pending
- 2020-12-11 CA CA3161321A patent/CA3161321A1/en active Pending
- 2020-12-11 EP EP20821221.7A patent/EP4073092A2/en not_active Withdrawn
-
2021
- 2021-08-02 US US17/392,204 patent/US20220106707A1/en not_active Abandoned
- 2021-08-12 US US17/400,471 patent/US11578427B2/en active Active
-
2023
- 2023-01-12 US US18/153,576 patent/US12435445B2/en active Active
- 2023-02-24 US US18/174,086 patent/US20230243070A1/en active Pending
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